ES2080064T3 - Derivados de piridazinona. - Google Patents

Derivados de piridazinona.

Info

Publication number
ES2080064T3
ES2080064T3 ES89201716T ES89201716T ES2080064T3 ES 2080064 T3 ES2080064 T3 ES 2080064T3 ES 89201716 T ES89201716 T ES 89201716T ES 89201716 T ES89201716 T ES 89201716T ES 2080064 T3 ES2080064 T3 ES 2080064T3
Authority
ES
Spain
Prior art keywords
alkyl
halogen
independently
substitutes
piridazinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89201716T
Other languages
English (en)
Inventor
James Redpath
Robert Thomas Logan
Robert Gibson Roy
George Mcgarry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of ES2080064T3 publication Critical patent/ES2080064T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

LA INEVNCION SE REFIERE A COMPUESTOS DE PIRIDAZINONA DE FORMULA GENERAL (I), DONDE R1 REPRESENTA 1-4 SUSTITUYENTES, QUE PUEDEN SER EL MISMO O DIFERENTES, Y SE ELIGEN DE H, OH, HALOGENO, NO2, AMINO SIN SUSTITUIR O SUSTITUIDO POR ALQUILO C1-C4, ALQUILO C1-C4, ALQUILO C1-C4 SUSTITUIDO POR HALOGENO, O-ALQ-NR4R5, ALCOXI C1-C4, DONDE 2 SUSTITUYENTES JUNTOS TAMBIEN PUEDEN REPRESENTAR UN GRUPO METILENDIOXI; R2 Y R3 SON, INDEPENDIENTEMENTE, H O ALQUILO C1-C4; R4 Y R5 SON, INDEPENDIENTEMENTE, H O ALQUILO C1-C4, O JUNTO CON EL N FORMAN UN ANILLO DE 5 O 6 MIEMBROS; X ES O O S; LA LINES DE PUNTOS REPRESENTA UN ENLACE OPCIONAL; Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. LOS COMPUESTOS SEGUN LA INVENCION TIENEN UNA ACTIVIDAD CARDIOTONICA, DE INHIBICION DE PLAQUETAS DE LA SANGRE, VASODILATADORES SISTEMICOS, VASODILATADORES PULMONARES Y BROCODILATADORES, Y MAS ESPECIALMENTE PRESENTAN UN AUMENTO MUY GRANDE DE LA FUERZA DE LAS CONTRACCIONES MUSCULARES DEL CORAZON, LA POSTCARGA EN EL CORAZON, MEJORAN EL FLUJOSANGUINEO PULMONAR, Y MEJORAN LA VENTILACION DE LAS VIAS DE AIRE.
ES89201716T 1988-07-11 1989-06-29 Derivados de piridazinona. Expired - Lifetime ES2080064T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88306295 1988-07-11

Publications (1)

Publication Number Publication Date
ES2080064T3 true ES2080064T3 (es) 1996-02-01

Family

ID=8200131

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89201716T Expired - Lifetime ES2080064T3 (es) 1988-07-11 1989-06-29 Derivados de piridazinona.

Country Status (16)

Country Link
US (1) US4952571A (es)
EP (1) EP0350990B1 (es)
JP (1) JPH0285281A (es)
KR (1) KR900001691A (es)
AT (1) ATE128135T1 (es)
AU (1) AU617489B2 (es)
CA (1) CA1308413C (es)
DE (1) DE68924308T2 (es)
DK (1) DK340889A (es)
ES (1) ES2080064T3 (es)
FI (1) FI97295C (es)
GR (1) GR3018356T3 (es)
IE (1) IE68680B1 (es)
NZ (1) NZ229876A (es)
PT (1) PT91117B (es)
ZA (1) ZA895087B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94394A (en) * 1989-05-17 1994-10-21 Nissan Chemical Ind Ltd History of pyridazinone, process for their preparation and preparations for controlling and / or preventing insects, mites, nematodes and mollusks
KR100226053B1 (ko) * 1996-06-18 1999-10-15 권태웅 공장제어 시스템의 비데오 카피어 인터페이스 모듈
US6276721B1 (en) * 2000-03-14 2001-08-21 Simula, Inc. Pivoting seat belt upper anchor point attachment
FR2829977B1 (fr) * 2001-09-24 2003-12-12 Valeo Vision Projecteur d'eclairage ou de signalisation a controleur integre pour vehicule et systeme d'eclairage ou de signalisation equipe d'au moins un tel projecteur
BR112019006816A8 (pt) * 2016-10-04 2023-02-07 Merck Sharp & Dohme Compostos de benzo[b]tiofeno como agonistas de sting, composição farmacêutica e uso dos mesmos
JP2020529421A (ja) 2017-08-04 2020-10-08 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． がんの処置のためのＰＤ−１アンタゴニストおよびベンゾ［ｂ］チオフェンＳＴＩＮＧアゴニストの組み合わせ
AU2018311966A1 (en) 2017-08-04 2020-02-13 Merck Sharp & Dohme Llc Benzo[b]thiophene sting agonists for cancer treatment
CA3095646A1 (en) 2018-04-03 2019-10-10 Merck Sharp & Dohme Corp. Benzothiophenes and related compounds as sting agonists
WO2019195063A1 (en) * 2018-04-03 2019-10-10 Merck Sharp & Dohme Corp. Aza-benzothiophene compounds as sting agonists
CN113861161A (zh) * 2020-06-30 2021-12-31 上海海和药物研究开发股份有限公司 一种芳基并芳杂环衍生物及其制备方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES482789A0 (es) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
US4225711A (en) * 1978-10-02 1980-09-30 Schering Corporation Substituted 2-[(methylsulfinyl)acetyl]-3-heterocyclicindoles and their use as immunosuppressants
DE3129447A1 (de) * 1981-07-25 1983-02-10 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benztriazole, ihre herstellung und ihre verwendung als arzneimittel"
CA1199027A (en) * 1981-11-12 1986-01-07 Stuart D. Mills Heterocyclic derivatives of pyridazinone, thiadiazinone, oxadiazinone and triazinone
US4666902A (en) * 1983-06-20 1987-05-19 Cassella Aktiengesellschaft Tetrahydropyridazinone derivatives, processes for their preparation and their use
US4647564A (en) * 1984-05-14 1987-03-03 Eli Lilly And Company Inotropic agents
DE3511110A1 (de) * 1985-03-27 1986-10-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pyridazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3631085A1 (de) * 1986-09-12 1988-03-24 Boehringer Mannheim Gmbh Heterocyclisch substituierte indolinone, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte

Also Published As

Publication number Publication date
JPH0285281A (ja) 1990-03-26
DK340889A (da) 1990-01-12
KR900001691A (ko) 1990-02-27
DE68924308T2 (de) 1996-04-04
US4952571A (en) 1990-08-28
FI893345A (fi) 1990-01-12
IE68680B1 (en) 1996-07-10
NZ229876A (en) 1991-03-26
FI97295C (fi) 1996-11-25
CA1308413C (en) 1992-10-06
DE68924308D1 (de) 1995-10-26
GR3018356T3 (en) 1996-03-31
PT91117A (pt) 1990-02-08
IE892148L (en) 1990-01-11
EP0350990B1 (en) 1995-09-20
PT91117B (pt) 1995-07-06
AU617489B2 (en) 1991-11-28
FI97295B (fi) 1996-08-15
ATE128135T1 (de) 1995-10-15
FI893345A0 (fi) 1989-07-10
DK340889D0 (da) 1989-07-10
AU3796789A (en) 1990-01-11
EP0350990A1 (en) 1990-01-17
ZA895087B (en) 1990-03-28

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