ATE128135T1 - Pyridazinon-derivate. - Google Patents

Pyridazinon-derivate.

Info

Publication number
ATE128135T1
ATE128135T1 AT89201716T AT89201716T ATE128135T1 AT E128135 T1 ATE128135 T1 AT E128135T1 AT 89201716 T AT89201716 T AT 89201716T AT 89201716 T AT89201716 T AT 89201716T AT E128135 T1 ATE128135 T1 AT E128135T1
Authority
AT
Austria
Prior art keywords
alkyl
heart
improve
vasodilator
substituents
Prior art date
Application number
AT89201716T
Other languages
English (en)
Inventor
James Redpath
Robert Thomas Logan
Robert Gibson Roy
George Mcgarry
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Application granted granted Critical
Publication of ATE128135T1 publication Critical patent/ATE128135T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT89201716T 1988-07-11 1989-06-29 Pyridazinon-derivate. ATE128135T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88306295 1988-07-11

Publications (1)

Publication Number Publication Date
ATE128135T1 true ATE128135T1 (de) 1995-10-15

Family

ID=8200131

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89201716T ATE128135T1 (de) 1988-07-11 1989-06-29 Pyridazinon-derivate.

Country Status (16)

Country Link
US (1) US4952571A (de)
EP (1) EP0350990B1 (de)
JP (1) JPH0285281A (de)
KR (1) KR900001691A (de)
AT (1) ATE128135T1 (de)
AU (1) AU617489B2 (de)
CA (1) CA1308413C (de)
DE (1) DE68924308T2 (de)
DK (1) DK340889A (de)
ES (1) ES2080064T3 (de)
FI (1) FI97295C (de)
GR (1) GR3018356T3 (de)
IE (1) IE68680B1 (de)
NZ (1) NZ229876A (de)
PT (1) PT91117B (de)
ZA (1) ZA895087B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94394A (en) * 1989-05-17 1994-10-21 Nissan Chemical Ind Ltd History of pyridazinone, process for their preparation and preparations for controlling and / or preventing insects, mites, nematodes and mollusks
KR100226053B1 (ko) * 1996-06-18 1999-10-15 권태웅 공장제어 시스템의 비데오 카피어 인터페이스 모듈
US6276721B1 (en) * 2000-03-14 2001-08-21 Simula, Inc. Pivoting seat belt upper anchor point attachment
FR2829977B1 (fr) * 2001-09-24 2003-12-12 Valeo Vision Projecteur d'eclairage ou de signalisation a controleur integre pour vehicule et systeme d'eclairage ou de signalisation equipe d'au moins un tel projecteur
UA125223C2 (uk) * 2016-10-04 2022-02-02 Мерк Шарп І Доум Корп. СПОЛУКИ БЕНЗО[b]ТІОФЕНУ ЯК АГОНІСТИ STING
US11285131B2 (en) 2017-08-04 2022-03-29 Merck Sharp & Dohme Corp. Benzo[b]thiophene STING agonists for cancer treatment
RU2020109328A (ru) 2017-08-04 2021-09-06 Мерк Шарп И Доум Корп. Комбинации антагонистов pd-1 и бензо[b]тиофеновых агонистов sting для лечения рака
EP3774765A4 (de) 2018-04-03 2021-12-29 Merck Sharp & Dohme Corp. Aza-benzothiophenverbindungen als sting-agonisten
CA3095646A1 (en) * 2018-04-03 2019-10-10 Merck Sharp & Dohme Corp. Benzothiophenes and related compounds as sting agonists
CN113861161A (zh) * 2020-06-30 2021-12-31 上海海和药物研究开发股份有限公司 一种芳基并芳杂环衍生物及其制备方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES482789A0 (es) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
US4225711A (en) * 1978-10-02 1980-09-30 Schering Corporation Substituted 2-[(methylsulfinyl)acetyl]-3-heterocyclicindoles and their use as immunosuppressants
DE3129447A1 (de) * 1981-07-25 1983-02-10 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benztriazole, ihre herstellung und ihre verwendung als arzneimittel"
CA1199027A (en) * 1981-11-12 1986-01-07 Stuart D. Mills Heterocyclic derivatives of pyridazinone, thiadiazinone, oxadiazinone and triazinone
US4666902A (en) * 1983-06-20 1987-05-19 Cassella Aktiengesellschaft Tetrahydropyridazinone derivatives, processes for their preparation and their use
US4647564A (en) * 1984-05-14 1987-03-03 Eli Lilly And Company Inotropic agents
DE3511110A1 (de) * 1985-03-27 1986-10-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pyridazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3631085A1 (de) * 1986-09-12 1988-03-24 Boehringer Mannheim Gmbh Heterocyclisch substituierte indolinone, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte

Also Published As

Publication number Publication date
FI893345A0 (fi) 1989-07-10
PT91117B (pt) 1995-07-06
AU617489B2 (en) 1991-11-28
IE892148L (en) 1990-01-11
KR900001691A (ko) 1990-02-27
EP0350990B1 (de) 1995-09-20
DE68924308T2 (de) 1996-04-04
CA1308413C (en) 1992-10-06
PT91117A (pt) 1990-02-08
FI893345A (fi) 1990-01-12
ZA895087B (en) 1990-03-28
FI97295C (fi) 1996-11-25
GR3018356T3 (en) 1996-03-31
DK340889D0 (da) 1989-07-10
NZ229876A (en) 1991-03-26
JPH0285281A (ja) 1990-03-26
ES2080064T3 (es) 1996-02-01
IE68680B1 (en) 1996-07-10
FI97295B (fi) 1996-08-15
DE68924308D1 (de) 1995-10-26
DK340889A (da) 1990-01-12
AU3796789A (en) 1990-01-11
US4952571A (en) 1990-08-28
EP0350990A1 (de) 1990-01-17

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee