KR850006406A - 4,7-디히드로피라졸[3,4-b] 피리딘 유도체의 제조방법 - Google Patents

4,7-디히드로피라졸[3,4-b] 피리딘 유도체의 제조방법 Download PDF

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KR850006406A
KR850006406A KR1019850001788A KR850001788A KR850006406A KR 850006406 A KR850006406 A KR 850006406A KR 1019850001788 A KR1019850001788 A KR 1019850001788A KR 850001788 A KR850001788 A KR 850001788A KR 850006406 A KR850006406 A KR 850006406A
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South Korea
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dihydropyrazole
preparing
cycloalkyl
substituted
alkyl
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KR1019850001788A
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KR910006646B1 (ko
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아다찌 이꾸오 (외 2)
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요시또미 가즈오
시오노기 세이야꾸 가부시기 가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

4,7-디히드로피라졸[3,4-b] 피리딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음식(Ⅱ)로 표시되는 화합물과 다음식(Ⅲ)으로 표시되는 화합물을 반응시킴을 특징으로 하는 다음 식(Ⅰ)로 표시되는 4,7-디히드로피라졸로[3,4-b] 피리딘 유도체의 제조방법.
    상기 식에서, R1은 C5이상을 갖는 알킬, 치환될 수 있는 시클로알킬, 하나 또는 2개의 치환체로 치환될 수 있는 시클로알킬, 하나 또는 2개의 치환체로 치환될 수 있는 시클로알킬알킬, 알콕시알킬, 시클로알킬옥시알킬, 아릴옥시알킬, 알킬티오알킬, 시클로알킬티오알킬, (모노- 또는 디-알킬아미노)알킬, 테트라히드로푸릴알킬, 아랄킬, N-벤질피롤리디닐, 또는 N-벤질피페리디닐이고; R2는 알킬이고; R3는 시클로알킬 또는 시클로알킬알킬이다.
    상기 식에서, R은 상기에 정의한 바와 같다.
    상기 식에서, R2및 R3는 상기에 정의한 바와 같다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850001788A 1984-03-19 1985-03-19 4,7-디히드로피라졸[3,4-b]피리딘 유도체의 제조방법 KR910006646B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP53118/84 1984-03-19
JP59053118A JPS60197685A (ja) 1984-03-19 1984-03-19 ４，７―ジヒドロピラゾロ［３，４―ｂ］ピリジン誘導体とその製造法
JP53118 1987-03-10

Publications (2)

Publication Number Publication Date
KR850006406A true KR850006406A (ko) 1985-10-05
KR910006646B1 KR910006646B1 (ko) 1991-08-30

Family

ID=12933883

Family Applications (1)

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KR1019850001788A KR910006646B1 (ko) 1984-03-19 1985-03-19 4,7-디히드로피라졸[3,4-b]피리딘 유도체의 제조방법

Country Status (8)

Country Link
EP (1) EP0157260B1 (ko)
JP (1) JPS60197685A (ko)
KR (1) KR910006646B1 (ko)
AU (1) AU575134B2 (ko)
DE (1) DE3578177D1 (ko)
DK (1) DK122385A (ko)
ES (1) ES8602787A1 (ko)
GB (1) GB2156348B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6056979A (ja) * 1983-09-08 1985-04-02 Shionogi & Co Ltd ４，７−ジヒドロピラゾロ〔３，４−ｂ〕ピリジン誘導体およびその製造法
US6977262B2 (en) 2001-02-02 2005-12-20 Mitsubishi Pharma Corporation Dihydropyrazolopyridine compounds and pharmaceutical use thereof
WO2002062795A2 (en) * 2001-02-02 2002-08-15 Mitsubishi Pharma Corporation Dihydropyrazolopyridine compounds and pharmaceutical use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3403158A (en) * 1966-03-11 1968-09-24 Upjohn Co 1h-pyrazolo[3, 4-b]pyridines
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
US4038283A (en) * 1975-04-30 1977-07-26 E. R. Squibb & Sons, Inc. 4-Alkoxy or hydroxy derivatives of 2H-pyrazolo[3,4-b]pyridine-5-carboxylic acids and esters
US3985757A (en) * 1975-09-17 1976-10-12 E. R. Squibb & Sons, Inc. Pyrazolopyridine ketones
CH635840A5 (en) * 1978-01-01 1983-04-29 Thomae Gmbh Dr K 1H-Pyrazolo[3,4-b]pyridines
JPS5965089A (ja) * 1982-10-05 1984-04-13 Shionogi & Co Ltd ジヒドロピラゾロ〔３，４−ｂ〕ピリジン誘導体およびその製造法
GR79111B (ko) * 1982-12-20 1984-10-02 Lepetit Spa

Also Published As

Publication number Publication date
ES541910A0 (es) 1985-12-01
ES8602787A1 (es) 1985-12-01
KR910006646B1 (ko) 1991-08-30
JPS60197685A (ja) 1985-10-07
AU4007085A (en) 1985-09-26
GB2156348B (en) 1988-05-05
GB2156348A (en) 1985-10-09
DK122385A (da) 1985-09-20
EP0157260B1 (en) 1990-06-13
AU575134B2 (en) 1988-07-21
DK122385D0 (da) 1985-03-18
DE3578177D1 (de) 1990-07-19
EP0157260A1 (en) 1985-10-09
JPH0437834B2 (ko) 1992-06-22
GB8507008D0 (en) 1985-04-24

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