KR870008840A - 1-스티렌술포닐-2-옥소-5-히드록시 피롤리딘 유도체의 제조방법 - Google Patents
1-스티렌술포닐-2-옥소-5-히드록시 피롤리딘 유도체의 제조방법 Download PDFInfo
- Publication number
- KR870008840A KR870008840A KR870002830A KR870002830A KR870008840A KR 870008840 A KR870008840 A KR 870008840A KR 870002830 A KR870002830 A KR 870002830A KR 870002830 A KR870002830 A KR 870002830A KR 870008840 A KR870008840 A KR 870008840A
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- KR
- South Korea
- Prior art keywords
- compound
- formula
- iii
- group
- preparing
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 4
- FSXXIZVBPWNJGV-UHFFFAOYSA-N 5-hydroxy-1-(2-phenylethenylsulfonyl)pyrrolidin-2-one Chemical class OC1CCC(=O)N1S(=O)(=O)C=CC1=CC=CC=C1 FSXXIZVBPWNJGV-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000007858 starting material Substances 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 다음 식(Ⅱ)을 갖는 화합물을 다음 식(Ⅲ)을 갖는 화합물과 반응시킴을 특징으로 하는 다음 일반식(Ⅰ)을 갖는 화합물의 제조방법:상기식에서, R1은 C8이하를 함유하는 직쇄 또는 측쇄 알킬기, C1내지 C6을 함유하는 아실기 또는 C3내지 C6을 함유하는 시클로알킬기를 나타내고, R은 임의로 치환된 C14이하를 함유하는 아릴기 또는 임의로 치환된 단일-또는 다고리형인 헤테로 고리기를 나타낸다.상기식에서, R1은 상기에 정의한 바와 같다.RCH=CH-SO2Hal (Ⅲ)상기식에서, Hal은 염소 또는 브롬원자를 나타내고, R은 상기에 정의한 바와 같다.
- 제 1 항에 있어서, R이 C4이하를 함유하는 알콕시기에 의해 임의로 치환된 페닐기를 나타내는 식(Ⅲ)을 갖는 화합물을 출발물질로서 사용함을 특징으로 하는 방법.
- 제 1 항 또는 2항에 있어서, R1이 에틸기를 나타내는 식(Ⅱ)을 갖는 화합물을 출발물질로서 사용함을 특징으로 하는 방법.
- 제 1 항, 2항 또는 3항에 있어서, R이 페닐기를 나타내는 식(Ⅲ)을 갖는 화합물 및 R1이 에틸기를 나타내는 식(Ⅱ)을 갖는 화합물을 출발물질로 사용함을 특징으로 하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19916/86A IT1204494B (it) | 1986-03-28 | 1986-03-28 | Derivati della 1-stirene solfonil 2-osso 5-alcossi pirrolidina,loro procedimento di preparazione e loro applicazione come farmaci |
| IT19916A/86 | 1986-03-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR870008840A true KR870008840A (ko) | 1987-10-21 |
Family
ID=11162311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR870002830A KR870008840A (ko) | 1986-03-28 | 1987-03-27 | 1-스티렌술포닐-2-옥소-5-히드록시 피롤리딘 유도체의 제조방법 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4810722A (ko) |
| EP (1) | EP0239500B1 (ko) |
| JP (1) | JPS62270558A (ko) |
| KR (1) | KR870008840A (ko) |
| AT (1) | ATE71936T1 (ko) |
| AU (1) | AU591255B2 (ko) |
| CA (1) | CA1282072C (ko) |
| DE (1) | DE3776171D1 (ko) |
| DK (1) | DK157487A (ko) |
| ES (1) | ES2038191T3 (ko) |
| FI (1) | FI81782C (ko) |
| GR (1) | GR3003643T3 (ko) |
| HU (1) | HU198181B (ko) |
| IE (1) | IE60102B1 (ko) |
| IT (1) | IT1204494B (ko) |
| MX (1) | MX173415B (ko) |
| PT (1) | PT84475B (ko) |
| ZA (1) | ZA871804B (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2873898B2 (ja) * | 1992-04-13 | 1999-03-24 | 富山化学工業株式会社 | ベンゾ［ｂ］チオフェン−５−イル誘導体もしくはその光学活性体またはそれらの塩並びにそれらの製造法 |
| EP0783502A1 (en) * | 1995-08-02 | 1997-07-16 | J. URIACH & CIA. S.A. | New carboxamides with antifungal activity |
| ES2107376B1 (es) * | 1995-08-02 | 1998-07-01 | Uriach & Cia Sa J | Nuevos derivados de pirimidona con actividad antifungica. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3453289A (en) * | 1966-01-21 | 1969-07-01 | American Home Prod | P-substituted-phenylsulfonyl pyrrolidine derivatives |
| US3423426A (en) * | 1966-01-25 | 1969-01-21 | Chevron Res | N-(polyhaloalkylthio) alkenylsuccinimides |
| US3686169A (en) * | 1970-07-20 | 1972-08-22 | Monsanto Co | Thiocycloamides |
| JPS5822111B2 (ja) * | 1977-10-29 | 1983-05-06 | 協和醗酵工業株式会社 | 柑橘類果実の改質剤 |
| FR2553409B1 (fr) * | 1983-10-18 | 1986-04-18 | Choay Sa | Nouveaux benzenesulfonyl-lactames, leur procede de preparation et leur application comme substance active de compositions pharmaceutiques |
| DK167393B1 (da) * | 1985-12-30 | 1993-10-25 | Roussel Uclaf | 1-sulfonyl-2-oxo-pyrrolidinderivater, deres fremstilling og farmaceutiske praeparater med indhold deraf |
-
1986
- 1986-03-28 IT IT19916/86A patent/IT1204494B/it active
-
1987
- 1987-03-12 ZA ZA871804A patent/ZA871804B/xx unknown
- 1987-03-13 PT PT84475A patent/PT84475B/pt not_active IP Right Cessation
- 1987-03-24 JP JP62068156A patent/JPS62270558A/ja active Pending
- 1987-03-26 DE DE8787400689T patent/DE3776171D1/de not_active Expired - Fee Related
- 1987-03-26 AT AT87400689T patent/ATE71936T1/de not_active IP Right Cessation
- 1987-03-26 HU HU871323A patent/HU198181B/hu not_active IP Right Cessation
- 1987-03-26 EP EP87400689A patent/EP0239500B1/fr not_active Expired - Lifetime
- 1987-03-26 US US07/030,113 patent/US4810722A/en not_active Expired - Fee Related
- 1987-03-26 ES ES198787400689T patent/ES2038191T3/es not_active Expired - Lifetime
- 1987-03-27 CA CA000533227A patent/CA1282072C/fr not_active Expired - Fee Related
- 1987-03-27 IE IE79387A patent/IE60102B1/en not_active IP Right Cessation
- 1987-03-27 KR KR870002830A patent/KR870008840A/ko not_active Application Discontinuation
- 1987-03-27 AU AU70737/87A patent/AU591255B2/en not_active Ceased
- 1987-03-27 MX MX005785A patent/MX173415B/es unknown
- 1987-03-27 FI FI871353A patent/FI81782C/fi not_active IP Right Cessation
- 1987-03-27 DK DK157487A patent/DK157487A/da not_active IP Right Cessation
-
1992
- 1992-01-23 GR GR910402205T patent/GR3003643T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK157487A (da) | 1987-09-29 |
| IT8619916A0 (it) | 1986-03-28 |
| DK157487D0 (da) | 1987-03-27 |
| EP0239500A2 (fr) | 1987-09-30 |
| ES2038191T3 (es) | 1993-07-16 |
| FI81782B (fi) | 1990-08-31 |
| US4810722A (en) | 1989-03-07 |
| FI871353A (fi) | 1987-09-29 |
| MX173415B (es) | 1994-03-03 |
| IE870793L (en) | 1987-09-28 |
| FI81782C (fi) | 1990-12-10 |
| JPS62270558A (ja) | 1987-11-24 |
| DE3776171D1 (de) | 1992-03-05 |
| CA1282072C (fr) | 1991-03-26 |
| AU7073787A (en) | 1987-10-01 |
| HUT43816A (en) | 1987-12-28 |
| PT84475B (pt) | 1989-11-10 |
| EP0239500B1 (fr) | 1992-01-22 |
| ATE71936T1 (de) | 1992-02-15 |
| ZA871804B (en) | 1988-05-25 |
| FI871353A0 (fi) | 1987-03-27 |
| HU198181B (en) | 1989-08-28 |
| MX5785A (es) | 1993-10-01 |
| IE60102B1 (en) | 1994-06-01 |
| AU591255B2 (en) | 1989-11-30 |
| GR3003643T3 (ko) | 1993-03-16 |
| IT1204494B (it) | 1989-03-01 |
| PT84475A (fr) | 1987-04-01 |
| EP0239500A3 (en) | 1988-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |