KR840004441A - 포스포리피드 유도체의 제조방법 - Google Patents

포스포리피드 유도체의 제조방법 Download PDF

Info

Publication number
KR840004441A
KR840004441A KR1019830001632A KR830001632A KR840004441A KR 840004441 A KR840004441 A KR 840004441A KR 1019830001632 A KR1019830001632 A KR 1019830001632A KR 830001632 A KR830001632 A KR 830001632A KR 840004441 A KR840004441 A KR 840004441A
Authority
KR
South Korea
Prior art keywords
alkoxy
compound
formula
phospholipid derivative
alkyl
Prior art date
Application number
KR1019830001632A
Other languages
English (en)
Inventor
쓰도무(외 4) 데라지
Original Assignee
후지사와 도모기찌로
후지사와 야꾸힝고교 가부시끼 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 후지사와 도모기찌로, 후지사와 야꾸힝고교 가부시끼 가이샤 filed Critical 후지사와 도모기찌로
Publication of KR840004441A publication Critical patent/KR840004441A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/13—Saturated ethers containing hydroxy or O-metal groups
    • C07C43/135—Saturated ethers containing hydroxy or O-metal groups having more than one ether bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075—Esters with hydroxyalkyl compounds

Abstract

내용 없음

Description

포스포리피드 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음 구조식(Ⅱ)의 화합물 또는 그 염을 다음 구조식(Ⅲ)의 화합물 또는 그 유도체와 반응시켜서 다음 구조식(Ⅰ)의 화합물 또는 그 약학적으로 사용 가능한 염을 제조하는 방법.
    상기식에서, R1은 알킬, 알콕시 또는 알카노일아미노; R2는 저급알킬, 저급알칸설포닐 또는 아렌설포닐; R3,R4및 R5는 각각 저급알킬; n은 0 또는 1; A는 -NHCO-기로 임의로 차단될 수도 있는 저급알킬렌; 및 Q는 옥사이도 또는 저급알콕시이다.
    단, R1이 알콕시이고, R2가 저급알킬인 때, n은 0 또는 A는 -NHCO-기로 차단된 저급알킬렌이고, 또는 Q는 저급알콕시이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830001632A 1982-04-19 1983-04-18 포스포리피드 유도체의 제조방법 KR840004441A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8,211,284 1982-04-19
GB8211284 1982-04-19

Publications (1)

Publication Number Publication Date
KR840004441A true KR840004441A (ko) 1984-10-15

Family

ID=10529776

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830001632A KR840004441A (ko) 1982-04-19 1983-04-18 포스포리피드 유도체의 제조방법

Country Status (7)

Country Link
US (1) US4562179A (ko)
EP (1) EP0092190B1 (ko)
JP (1) JPS58189191A (ko)
KR (1) KR840004441A (ko)
DE (1) DE3366393D1 (ko)
DK (1) DK164383A (ko)
ES (1) ES521635A0 (ko)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3239817A1 (de) * 1982-07-06 1984-01-12 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Neue glycerinderivate zur synthese von phospholipiden
DE3323871A1 (de) * 1983-07-02 1985-01-03 A. Nattermann & Cie GmbH, 5000 Köln Neue 1-o-alkyl-3-amino-propan-1,2-diol-2-o-phospholipide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
CA1264162A (en) * 1984-03-15 1990-01-02 Manfred Breuninger Glycerol ether phosphatides
US4659859A (en) * 1984-07-02 1987-04-21 Eli Lilly And Company 2-alkoxy-1-alkoxy phosphoryl dichlorides
US4647685A (en) * 1985-04-25 1987-03-03 Eli Lilly And Company 2-alkoxy-1-((2-trialkylaminoethoxy)phosphinyloxy)-alkenes and alkynes, hydroxy inner salts
US5290769A (en) * 1989-09-27 1994-03-01 Asta Pharma Aktiengesellschaft Use of hexadecylphosphocholine for the treatment of psoriasis
GR1000688B (el) * 1989-12-22 1992-10-08 Sod Conseils Rech Applic Μεθοδος παρασκευης παραγωγων γλυκερινης.
WO1992019627A2 (en) * 1991-04-25 1992-11-12 The University Of British Columbia Phosphonates and phosphinates as anti-cancer, -inflammatory, -allergy and -myocarditis agents
US5506217A (en) * 1991-04-25 1996-04-09 The University Of British Columbia Phosphonates as anti-cancer agents
US5369097A (en) * 1991-04-25 1994-11-29 The University Of British Columbia Phosphonates as anti-cancer agents
DE4234130A1 (de) * 1992-10-09 1994-04-14 Max Planck Gesellschaft Phospholipase A¶2¶ inhibierende Phosphatidylcholinverbindungen
US6551623B1 (en) 1993-09-09 2003-04-22 Lorus Therapeutics Inc. Immunomodulating compositions from bile
ES2207639T3 (es) 1993-09-09 2004-06-01 Lorus Therapeutics Inc. Composiciones modulares inmunologicas a partir de las bilis.
US5651981A (en) * 1994-03-29 1997-07-29 Northwestern University Cationic phospholipids for transfection
EP0814821A1 (en) 1995-03-16 1998-01-07 Imutec Pharma Inc. Immunomodulating compositions from bile for the treatment of immune system disorders
US20040101569A1 (en) * 1996-05-16 2004-05-27 Lorus Therapeutics Inc. Immunomodulating compositions from bile
EP1320371A2 (en) * 2000-07-31 2003-06-25 Ottawa Heart Institute Research Corporation Charged phospholipid compositions and methods for their use
DK174896B1 (da) 2000-12-08 2004-02-02 Sfk Danfotech As Apparatur for opskæring af bugen på slagtede dyr, fremgangsmåde dertil samt anvendelse af apparatur og fremgangsmåde
WO2004062595A2 (en) * 2003-01-09 2004-07-29 Zeneus Pharma Limited Antineoplastic ether lipid compounds with modifications at the sn-1 carbon
US20060135765A1 (en) * 2003-01-09 2006-06-22 Perkins Walter R Antineoplastic ether lipid compounds
US20060116354A1 (en) * 2003-01-09 2006-06-01 Perkins Walter R Antineoplastic ether lipid compounds with modifications at the sn-3 carbon
US20050187192A1 (en) * 2004-02-20 2005-08-25 Kucera Pharmaceutical Company Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses
WO2005087788A2 (en) * 2004-03-04 2005-09-22 The Regents Of The University Of California Methods for preparation of nucleoside phosphonate esters
WO2005094322A2 (en) 2004-03-29 2005-10-13 University Of South Florida Effective treatment of tumors and cancer with triciribine and related compounds
EP1868628B1 (en) 2005-04-08 2014-06-11 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
WO2009094190A2 (en) 2008-01-25 2009-07-30 Chimerix, Inc. Methods of treating viral infections
US8614200B2 (en) 2009-07-21 2013-12-24 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
EP3216789A1 (en) 2010-02-12 2017-09-13 Chimerix, Inc. Methods of treating viral infection
AU2011248620B2 (en) 2010-04-26 2015-11-26 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2619686C2 (de) * 1976-05-04 1986-08-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Verwendung eines Lysolecithins zur Tumorbehandlung
DE2619715A1 (de) * 1976-05-04 1977-11-24 Max Planck Gesellschaft Tumor-antigen und verfahren zu dessen herstellung
DE2820893C2 (de) * 1978-05-12 1986-02-20 A. Nattermann & Cie GmbH, 5000 Köln Strukturanaloga von natürlichen Phospholipiden und Verfahren zur Herstellung dieser Verbindungen
US4408052A (en) * 1980-02-27 1983-10-04 Takeda Chemical Industries, Ltd. Phospholipid carbamates
JPS5772914A (en) * 1980-10-22 1982-05-07 Takeda Chem Ind Ltd Antitumor agent
US4493832A (en) * 1981-07-03 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. Certain glycerol-phosphoryl choline derivatives, compositions containing same and method of using same
DK328182A (da) * 1981-07-31 1983-02-01 Fujisawa Pharmaceutical Co Fremgangsmaade til fremstilling af phospholipidderivater

Also Published As

Publication number Publication date
DE3366393D1 (en) 1986-10-30
JPS58189191A (ja) 1983-11-04
EP0092190A2 (en) 1983-10-26
DK164383A (da) 1983-10-20
US4562179A (en) 1985-12-31
EP0092190B1 (en) 1986-09-24
ES8406080A1 (es) 1984-07-01
ES521635A0 (es) 1984-07-01
EP0092190A3 (en) 1984-02-01
DK164383D0 (da) 1983-04-14

Similar Documents

Publication Publication Date Title
KR840004441A (ko) 포스포리피드 유도체의 제조방법
KR860003210A (ko) 알킬설폰 아미도 페닐알킬 아민의 제조 방법
KR850004492A (ko) 옥시캄의 엔올 에테르 유도체의 제조방법
KR830006198A (ko) 시클로헥산 유도체의 제조방법
KR840006324A (ko) 2-니트로-1,1-에렌디아민의 제조방법
KR850004470A (ko) 유기 화합물의 제조방법
KR850008159A (ko) 2-페닐-4,5,6,7-테트라히드로-2h-인다졸류의 제조방법
KR860001105A (ko) 2-벤질-4-(4-피리딜)티아졸의 제조방법
KR840004103A (ko) 디아졸릴 알칸올의 제조방법
KR840006238A (ko) 신규 α-아릴-α-피리딜알카노인산 유도체의 제조방법
KR850004760A (ko) 이미다조 퀴놀린 유도체의 제조방법
KR860001815A (ko) 옥타하이드로-옥사졸로[4,5-g]퀴놀린의 제조방법
KR840002821A (ko) N-(2,3-에폭시프로필렌)-n-아르알킬술폰아미드 유도체의 제조방법
KR840004123A (ko) 포스포리피드 유도체의 제조방법
KR850003407A (ko) 유기인산 에스테르 유도체의 제조방법
KR870008840A (ko) 1-스티렌술포닐-2-옥소-5-히드록시 피롤리딘 유도체의 제조방법
KR870007908A (ko) 인덴류 화합물의 제조방법
KR920008012A (ko) 트리아졸 유도체
KR840000496A (ko) 요소유도체 및 그 제조방법
KR850002974A (ko) 설펜아마이드 유도체의 제조방법
KR840003639A (ko) 이속사졸로피리미딘 유도체의 제조방법
KR830005188A (ko) 혈당강하성 구아닐 아미딘의 제조방법
KR830001899A (ko) 4-아미노-3-퀴놀린카복실산 및 에스테르-항분비, 항궤양 화합물
KR850006406A (ko) 4,7-디히드로피라졸[3,4-b] 피리딘 유도체의 제조방법
KR840004418A (ko) N-설페닐화된 카바메이트의 제조방법

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid