KR830005188A - 혈당강하성 구아닐 아미딘의 제조방법 - Google Patents

혈당강하성 구아닐 아미딘의 제조방법 Download PDF

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Publication number
KR830005188A
KR830005188A KR1019810000507A KR810000507A KR830005188A KR 830005188 A KR830005188 A KR 830005188A KR 1019810000507 A KR1019810000507 A KR 1019810000507A KR 810000507 A KR810000507 A KR 810000507A KR 830005188 A KR830005188 A KR 830005188A
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South Korea
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carbon atoms
phenyl
guanyl
amidine
alkyl
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KR1019810000507A
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English (en)
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KR840000930B1 (ko
Inventor
스튜어트 왓트 데이빗
리 아이브즈 제프리
Original Assignee
윌리암 지이. 맥크리리
화이자 인코포레이티드
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Publication of KR830005188A publication Critical patent/KR830005188A/ko
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Publication of KR840000930B1 publication Critical patent/KR840000930B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)

Abstract

내용 없음

Description

혈당강하성 구아닐 아미딘의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음 일반식(a)의 화합물을 다음 일반식(b)의 화합물과 반응시키고, 필요하면 일반식(Ⅰ) 화합물을 약학적으로 무독한 산과 반응시키는 것을 특징으로하여 다음 일반식(Ⅰ) 화합물을 제조하는 방법.
    상기식에서 R1및 R4는 각각 페닐, 클로로, 브로모, 플루오로로 단일 치환된 페닐, 탄소수 1내지 3의 알킬 또는 탄소수 1내지 3의 알콕시, 벤질, 나프틸, 피리딜, 퀴놀릴, 푸릴, 티에닐 및 피리미디닐중 선택하고; Y는또는 -NR2R3인데 n 및 m은 각각 1,2 또는 3이며 단, n 및 m의 합계는 3내지 5이어야 하며, Z는 CH2,O,S,SO,SO2,NH 또는 NCH3이며; R2및 R3는 각각 탄소수 1내지 4의 n-알킬, 알콕시에틸(알콕시그룹의 탄소수는 1내지 3), 페닐 및 클로로, 브로모, 플루오로 단일 치환된 페닐, 탄소수 1내지 3의 알킬 또는 탄소수 1내지 3의 알콕시 가운데 선택되며, X는 할로이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810000507A 1980-02-19 1981-02-18 혈당강하성 구아닐 아미딘의 제조방법 KR840000930B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/122,155 US4269837A (en) 1980-02-19 1980-02-19 Hypoglycemic guanylamidines, compositions and use
US122155 1980-02-19

Publications (2)

Publication Number Publication Date
KR830005188A true KR830005188A (ko) 1983-08-03
KR840000930B1 KR840000930B1 (ko) 1984-06-29

Family

ID=22401029

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810000507A KR840000930B1 (ko) 1980-02-19 1981-02-18 혈당강하성 구아닐 아미딘의 제조방법

Country Status (18)

Country Link
US (1) US4269837A (ko)
EP (1) EP0034495B1 (ko)
JP (1) JPS56147760A (ko)
KR (1) KR840000930B1 (ko)
AR (1) AR229350A1 (ko)
AT (1) ATE3425T1 (ko)
AU (1) AU517843B2 (ko)
CA (1) CA1145334A (ko)
DE (1) DE3160290D1 (ko)
DK (1) DK70881A (ko)
ES (1) ES8201541A1 (ko)
FI (1) FI75343C (ko)
GR (1) GR78339B (ko)
IE (1) IE50924B1 (ko)
IL (1) IL62146A (ko)
PH (1) PH15971A (ko)
PT (1) PT72516B (ko)
YU (1) YU41968B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404219A (en) * 1980-03-31 1983-09-13 Pfizer Inc. Phenylguanidine therapeutic agents
US5268373A (en) * 1992-07-28 1993-12-07 Mcneilab, Inc. Guanidine derivatives, compositions and use
DE69708198T2 (de) * 1996-04-30 2002-03-28 Pfizer Inc., New York Muscarinische Rezeptor-Agonisten
AR008290A1 (es) * 1996-08-15 1999-12-29 Smithkline Beecham Corp Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH478802A (de) 1966-09-06 1969-09-30 Sandoz Ag Verfahren zur Herstellung von Pyrazolderivaten
CS225804B2 (cs) 1976-03-19 1984-02-13 Mcneilab Inc Způsob výroby heterocyklických derivátů guanidinu

Also Published As

Publication number Publication date
US4269837A (en) 1981-05-26
ES499572A0 (es) 1981-12-16
DK70881A (da) 1981-08-20
PH15971A (en) 1983-05-11
AU517843B2 (en) 1981-08-27
AR229350A1 (es) 1983-07-29
JPS56147760A (en) 1981-11-16
EP0034495A3 (en) 1982-01-27
CA1145334A (en) 1983-04-26
PT72516A (en) 1981-03-01
FI810492L (fi) 1981-08-20
ES8201541A1 (es) 1981-12-16
IE810311L (en) 1981-08-19
YU41968B (en) 1988-04-30
FI75343C (fi) 1988-06-09
EP0034495A2 (en) 1981-08-26
DE3160290D1 (en) 1983-07-07
EP0034495B1 (en) 1983-05-18
IL62146A (en) 1984-09-30
FI75343B (fi) 1988-02-29
IL62146A0 (en) 1981-03-31
JPS6348265B2 (ko) 1988-09-28
ATE3425T1 (de) 1983-06-15
PT72516B (en) 1982-10-21
IE50924B1 (en) 1986-08-20
YU39881A (en) 1983-09-30
KR840000930B1 (ko) 1984-06-29
GR78339B (ko) 1984-09-26

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