KR850001199A - 1,8-나프티리딘 유도체의 제조법 - Google Patents

1,8-나프티리딘 유도체의 제조법 Download PDF

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KR850001199A
KR850001199A KR1019840004455A KR840004455A KR850001199A KR 850001199 A KR850001199 A KR 850001199A KR 1019840004455 A KR1019840004455 A KR 1019840004455A KR 840004455 A KR840004455 A KR 840004455A KR 850001199 A KR850001199 A KR 850001199A
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formula
compound
ester
carbon atoms
lower alkyl
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KR1019840004455A
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KR900006750B1 (ko
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준이찌(외 3) 마쯔모도
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후지하라 도미오
다이닛뽕 세이야꾸 가부시끼가이샤
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Priority claimed from JP59117266A external-priority patent/JPS60260577A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

내용 없음

Description

1,8-나프티리딘 유도체의 제조법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. (i) 일반식(II)의 카르복실산 또는 그 에스테르와 일반식(III)의 피롤리딘 유도체를 반응시켜, 일반식(I)의 화합물 또는 그 에스테르를 제조하거나, (ii) 일반식(IV)의 피리딘 유도체를 염기 존재하에 폐환시켜, 다음 일반식(V)의 화합물을 생성시키고, 이어서 탈수소하여, 다음 일반식(I')의 화합물을 생성시키고, 필요한 경우에는 가수분해하여 일반식(I)의 화합물 또는 탄소수 1내지 5의 저급알킬에스테르를 제조하거나, 또는, (iii) 일반식(VI)의 β-아미노아크릴산에스테르를 염기 존재하에 폐환시켜, 일반식(I')의 화합물을 생성시키고, 필요한 경우에는 가수분해하여, 일반식(I)의 화합물 또는 탄소수 1내지 5의 저급알킬에스테르를 제조하거나, (iv) 일반식(VII)의 화합물 또는 그 에스테르를 보호기의 탈리반응에 의해 일반식(I)의 화합물 또는 그 에스테르를 제조하거나, (v) 일반식(I)의 1,8-나프티리딘 유도체의 에스테르를 가수분해하여 일반식(I)의 화합물을 제조하거나, (vi) 일반식(I)의 1,8-나프티리딘 유도체를 에스테르화하여 일반식(I)의 화합물의 에스테르를 제조하거나, (vii) 일반식(VIII)의 화합물 또는 그 에스테르를 염기 존재하에 알킬화하여, 일반식(IX)의 화합물 또는 그 에스테르를 생성시키고, 그 화합물의 보호기를 탈리시켜, 일반식(I)에 있어 R1이 탄소수 1내지 5의 저급알킬기인 화합물 또는 그 에스테르를 제조하거나, (viii) 필요한 경우에는 일반식(I)의 1,8-나프티리딘유도체 또는 그 에스테르를 산, 염기 또는 금속염으로 처리하여 일반식(I)의 화합물 또는 그 에스테르의 염을 제조함을 특징으로 하는 일반식(I)의 화합물 또는 그 에스테르 또는 그 염의 제조방법.
    (식중, R1,R2및 R3는 각각 같거나 다르며, 수소원자 또는 탄소수 1내지 5의 저급알킬기를 의미함.)
    (식중, X는 후기하는 피롤리딘 유도체(III)와 치환할 수 있는 관능기를 의미함.)
    (식중, R1,R2및 R3는 상술한 바와같음.)
    (식중, Y는 같거나 다르며, 탄소수 1내지 5의 저급알킬기를 의미하며, R1,R2및 R3는 상술한 바와같음.)
    (식중, R1,R2,R3및 Y는 상술한 바와 같음)
    (식중, R1,R2,R3및 Y는 상술한 바와 같음)
    (식중, Z는 할로겐원자를 나타내고, R1,R2,R3및 Y는 상술한 바와 같음.)
    (식중, R4는 보호기를 의미하고, R1,R2및 R3는 상술한 바와 같음.)
    (식중, R1,R2,R3및 Y는 상술한 바와 같음.)
    (식중, R1'은 탄소수 1내지 5의 저급알킬기를 의미하며, R2,R3및 R4는 상술한 바와 같음.)
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840004455A 1983-07-27 1984-07-26 1,8-나프티리딘 유도체의 제조법 KR900006750B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP58-133,000 1983-07-27
JP58138000A JPS6028978A (ja) 1983-07-27 1983-07-27 １，８−ナフチリジン誘導体
JP138000 1983-07-27
JP59117266A JPS60260577A (ja) 1984-06-06 1984-06-06 １，８−ナフチリジン誘導体
JP59-117,266 1984-06-06
JP117266 1984-06-06

Publications (2)

Publication Number Publication Date
KR850001199A true KR850001199A (ko) 1985-03-16
KR900006750B1 KR900006750B1 (ko) 1990-09-20

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KR1019840004455A KR900006750B1 (ko) 1983-07-27 1984-07-26 1,8-나프티리딘 유도체의 제조법

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US (1) US4649144A (ko)
EP (1) EP0132845B1 (ko)
KR (1) KR900006750B1 (ko)
AT (1) ATE33494T1 (ko)
AU (1) AU565898B2 (ko)
CA (1) CA1327580C (ko)
CS (1) CS274601B2 (ko)
DD (1) DD228256A5 (ko)
DE (1) DE3470420D1 (ko)
DK (1) DK160276C (ko)
ES (2) ES8603501A1 (ko)
FI (1) FI77862C (ko)
HU (1) HU194561B (ko)
PH (1) PH21696A (ko)
SU (2) SU1482527A3 (ko)
YU (3) YU43371B (ko)

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KR900006750B1 (ko) 1990-09-20
DK160276B (da) 1991-02-18
AU3091084A (en) 1985-01-31
DK160276C (da) 1991-07-22
HUT34976A (en) 1985-05-28
EP0132845A3 (en) 1985-09-11
FI842987A0 (fi) 1984-07-26
FI842987A (fi) 1985-01-28
YU126786A (en) 1987-10-31
SU1445558A3 (ru) 1988-12-15
ES534624A0 (es) 1985-12-16
ES8607287A1 (es) 1986-05-16
ES8603501A1 (es) 1985-12-16
DD228256A5 (de) 1985-10-09
HU194561B (en) 1988-02-29
CS274601B2 (en) 1991-09-15
YU43702B (en) 1989-10-31
PH21696A (en) 1988-01-13
DK365184D0 (da) 1984-07-26
ATE33494T1 (de) 1988-04-15
DE3470420D1 (en) 1988-05-19
DK365184A (da) 1985-01-28
CS557584A2 (en) 1990-11-14
ES545250A0 (es) 1986-05-16
EP0132845B1 (en) 1988-04-13
YU132584A (en) 1986-12-31
FI77862C (fi) 1989-05-10
YU43371B (en) 1989-06-30
FI77862B (fi) 1989-01-31
AU565898B2 (en) 1987-10-01
YU126686A (en) 1987-12-31
US4649144A (en) 1987-03-10
SU1482527A3 (ru) 1989-05-23
EP0132845A2 (en) 1985-02-13
YU43703B (en) 1989-10-31
CA1327580C (en) 1994-03-08

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