ES2061462T3 - Compuestos cefemo, procedimientos para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Compuestos cefemo, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2061462T3
ES2061462T3 ES87113726T ES87113726T ES2061462T3 ES 2061462 T3 ES2061462 T3 ES 2061462T3 ES 87113726 T ES87113726 T ES 87113726T ES 87113726 T ES87113726 T ES 87113726T ES 2061462 T3 ES2061462 T3 ES 2061462T3
Authority
ES
Spain
Prior art keywords
preparation
contain
rent
compounds
cefemo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87113726T
Other languages
English (en)
Inventor
Takao Takaya
Kazuo Sakane
Kenzi Miyai
Kohji Kawabata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868622766A external-priority patent/GB8622766D0/en
Priority claimed from GB868628061A external-priority patent/GB8628061D0/en
Priority claimed from GB878705072A external-priority patent/GB8705072D0/en
Priority claimed from GB878711653A external-priority patent/GB8711653D0/en
Priority claimed from GB878716437A external-priority patent/GB8716437D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2061462T3 publication Critical patent/ES2061462T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

LA INVENCION SE REFIERE A UN COMPUETSO DE FORMULA (I) EN LA QUE R1 Y R4 SON CADA UNO UN GRUPO AMINO O AMINO PROTEGIDO; R2 ES UN GRUPO CARBOXI-ALQUILO DE CADENA CORTA QUE PUEDE ESTAR PROTEGIDO; R3 ES ALQUILO O HIDROXI-ALQUILO DE CADENA CORTA QUE PUEDE ESTAR PROTEGIDO Y R5 ES HIDROGENO O ALQUILO DE CADENA CORTA. TAMBIEN SE REFIERE A UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL COMPUESTO I, A PROCESOS PARA SU PREPARACION Y A PREPARACIONES FARMACEUTICAS QUE LO CONTIENEN COMO INGREDIENTE ACTIVO. ASIMISMO SE DESCRIBEN COMPUESTOS INTERMEDIOS DE FORMULA (II) Y SU PREPARACION.
ES87113726T 1986-09-22 1987-09-19 Compuestos cefemo, procedimientos para su preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2061462T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB868622766A GB8622766D0 (en) 1986-09-22 1986-09-22 Cephem compounds
GB868628061A GB8628061D0 (en) 1986-11-24 1986-11-24 Cephem compounds
GB878705072A GB8705072D0 (en) 1987-03-04 1987-03-04 Cephem compounds
GB878711653A GB8711653D0 (en) 1987-05-18 1987-05-18 Cephem compounds
GB878716437A GB8716437D0 (en) 1987-07-13 1987-07-13 Cephem compounds

Publications (1)

Publication Number Publication Date
ES2061462T3 true ES2061462T3 (es) 1994-12-16

Family

ID=27516672

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87113726T Expired - Lifetime ES2061462T3 (es) 1986-09-22 1987-09-19 Compuestos cefemo, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.

Country Status (19)

Country Link
US (2) US4927818A (es)
EP (1) EP0261615B1 (es)
JP (2) JPH064647B2 (es)
KR (1) KR950013566B1 (es)
CN (1) CN87106452A (es)
AU (2) AU607157B2 (es)
CA (1) CA1293719C (es)
DE (1) DE3788261T2 (es)
DK (1) DK460087A (es)
ES (1) ES2061462T3 (es)
FI (1) FI87925C (es)
HU (1) HU202540B (es)
IE (1) IE872329L (es)
IL (1) IL83760A (es)
NO (1) NO171852C (es)
NZ (1) NZ221843A (es)
OA (1) OA08665A (es)
PH (1) PH23767A (es)
PT (1) PT85762B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ198350A (en) * 1980-09-25 1985-02-28 Toyama Chemical Co Ltd Cephalosporins and intermediates;pharmaceutical compositions
US5162520A (en) * 1986-09-22 1992-11-10 Fujisawa Pharmaceutical Co., Ltd. Intermediates for cephem compounds
CA1293719C (en) * 1986-09-22 1991-12-31 Takao Takaya Cephem compounds and processes for preparation thereof
IL86941A (en) * 1987-07-10 1993-07-08 Gist Brocades Nv Process for the preparation of cephem compounds and some new cephalosporin derivatives prepared by this process
US5210080A (en) * 1987-09-07 1993-05-11 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US5663163A (en) * 1987-09-07 1997-09-02 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and processes for preparation thereof
GB8905301D0 (en) * 1989-03-08 1989-04-19 Fujisawa Pharmaceutical Co New cephem compound and a process for preparation thereof
KR910015587A (ko) * 1990-02-27 1991-09-30 후지사와 토모키치로 세펨 화합물
US5604222A (en) * 1993-12-27 1997-02-18 Lupin Laboratories, Ltd. Method for the preparation of 2-chloro sulfinyl azetidinones
US5578721A (en) * 1994-07-11 1996-11-26 Lupin Laboratories Limited Process for preparation of 3-exomethylene cepham sulfoxide esters
ATE318269T1 (de) * 2001-05-01 2006-03-15 Astellas Pharma Inc Cephem-verbindungen
DK1556389T6 (da) * 2002-10-30 2015-05-11 Astellas Pharma Inc Cephemforbindelser
AU2003902380A0 (en) * 2003-05-16 2003-06-05 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
ES2340928T3 (es) * 2003-09-18 2010-06-11 Astellas Pharma Inc. Compuestos de cefem.
JP4758371B2 (ja) * 2007-02-23 2011-08-24 株式会社荻野精機製作所 動力伝達切換機構
EP2862569A1 (en) 2011-09-09 2015-04-22 Cubist Pharmaceuticals, Inc. Methods for treating intrapulmonary infections
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
CN102875572B (zh) * 2012-10-26 2014-07-30 四川科伦药物研究有限公司 一种硫酸头孢噻利中间体的精制方法
EP3100732A1 (en) 2013-03-15 2016-12-07 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274990A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
EP3012247B1 (en) 2013-06-21 2018-01-10 Kumiai Chemical Industry Co., Ltd. Manufacturing method for 2-amino-2-hydroxyimino-n-alkoxy acetoimidoyl cyanide, and manufacturing intermediate thereof
EP3043797B1 (en) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
US9695196B2 (en) * 2014-06-20 2017-07-04 Merck Sharp & Dohme Corp. Reactions of thiadiazolyl-oximinoacetic acid derivative compounds

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268509A (en) * 1978-07-10 1981-05-19 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
FR2441630A1 (fr) * 1978-11-15 1980-06-13 Glaxo Group Ltd Cephalosporines a activite antibiotique et leur procede de preparation
US4390534A (en) * 1978-12-29 1983-06-28 Fujisawa Pharmaceutical Co., Ltd. Cephem and cepham compounds
US4332800A (en) * 1979-10-12 1982-06-01 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
GR78245B (es) * 1980-09-12 1984-09-26 Ciba Geigy Ag
ZA816321B (en) * 1980-09-12 1982-09-29 Ciba Geigy Ammoniomethyl compounds,processes for their manufacture,pharmaceutical preparations that contain these compounds,and the use of these compounds
US4431642A (en) * 1980-12-01 1984-02-14 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JPS584789A (ja) * 1981-04-03 1983-01-11 Fujisawa Pharmaceut Co Ltd 新規セフエム化合物およびその製造法
DE3279470D1 (en) * 1981-04-03 1989-04-06 Fujisawa Pharmaceutical Co New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds
GR75487B (es) * 1981-06-22 1984-07-23 Fujisawa Pharmaceutical Co
US4521413A (en) * 1981-09-14 1985-06-04 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4563449A (en) * 1982-07-19 1986-01-07 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
DE3419012A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Ss-lactamantibiotika, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel oder wachstumsfoerderer in der tieraufzucht oder als antioxidantien
PH22107A (en) * 1984-06-07 1988-06-01 Takeda Chemical Industries Ltd 3-pyrazolo(1,5-a)pyrdinium cephem compounds
JPS61286389A (ja) * 1985-06-11 1986-12-16 Eisai Co Ltd セフエム系化合物
CN86107947A (zh) * 1985-11-22 1987-05-27 藤沢药品工业株式会社 新的头孢烯化合物及其制备方法
CA1293719C (en) * 1986-09-22 1991-12-31 Takao Takaya Cephem compounds and processes for preparation thereof
IE63094B1 (en) * 1987-09-14 1995-03-22 Fujisawa Pharmaceutical Co Cephem compound and a process for preparation thereof

Also Published As

Publication number Publication date
EP0261615A3 (en) 1989-09-20
PT85762A (en) 1987-10-01
IE872329L (en) 1988-03-22
DK460087D0 (da) 1987-09-03
DK460087A (da) 1988-03-23
EP0261615B1 (en) 1993-11-24
FI874102A0 (fi) 1987-09-21
NO171852B (no) 1993-02-01
DE3788261T2 (de) 1994-04-07
NO171852C (no) 1993-05-12
NZ221843A (en) 1989-08-29
JPH064647B2 (ja) 1994-01-19
PT85762B (pt) 1990-07-31
OA08665A (en) 1988-11-30
PH23767A (en) 1989-11-03
KR950013566B1 (ko) 1995-11-09
AU6707790A (en) 1991-02-14
CN87106452A (zh) 1988-05-04
NO873640D0 (no) 1987-08-28
EP0261615A2 (en) 1988-03-30
AU7867187A (en) 1988-03-24
JPH0680064B2 (ja) 1994-10-12
IL83760A0 (en) 1988-02-29
AU642929B2 (en) 1993-11-04
JPH0656846A (ja) 1994-03-01
DE3788261D1 (de) 1994-01-05
JPS6399079A (ja) 1988-04-30
US4927818A (en) 1990-05-22
HU202540B (en) 1991-03-28
FI87925B (fi) 1992-11-30
US5108997A (en) 1992-04-28
IL83760A (en) 1993-04-04
HUT45071A (en) 1988-05-30
FI874102A (fi) 1988-03-23
FI87925C (fi) 1993-03-10
AU607157B2 (en) 1991-02-28
NO873640L (no) 1988-03-23
KR880003958A (ko) 1988-06-01
CA1293719C (en) 1991-12-31

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