ES2063149T3 - Derivados de eteres ciclicos. - Google Patents

Derivados de eteres ciclicos.

Info

Publication number
ES2063149T3
ES2063149T3 ES89313521T ES89313521T ES2063149T3 ES 2063149 T3 ES2063149 T3 ES 2063149T3 ES 89313521 T ES89313521 T ES 89313521T ES 89313521 T ES89313521 T ES 89313521T ES 2063149 T3 ES2063149 T3 ES 2063149T3
Authority
ES
Spain
Prior art keywords
alkylene
cycle
eteres
derivatives
alkyll
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89313521T
Other languages
English (en)
Inventor
Annie Hammon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca SAS
Imperial Chemical Industries Ltd
Original Assignee
ICI Pharma SA
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ICI Pharma SA, Imperial Chemical Industries Ltd filed Critical ICI Pharma SA
Application granted granted Critical
Publication of ES2063149T3 publication Critical patent/ES2063149T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ELINVENTO CONCIERNE A UN DERIVADO DE ETER CICLICO DE LA FORMULA I EN DONDE AR1 ES FENIL O NAFTIL SUSTITUIDO OPCIONALMENTE; A1 ES ALQUILENO C1-6, ALQUENILENO C3-6, ALQUINILENO C3-6 O ALQUILENO C3-6 CICLO; AR2 ES FENILENO OPCIONALMENTE SUSTITUIDO, O UNA PARTE HETEROCICLENO DE 6 MIEMBROS QUE CONTIENE MAS DE TRES NITROGENOS; R1 Y R2 JUNTOS FORMAN UN GRUPO DE LA FORMULA -A2-X-A3EN DONDE CADA UNO DE A2 Y A3 SON ALQUILENO C1-6 Y X ES OXI, TIO, SULFINIL, SULFONIL O IMINO; Y R3 ES ALQUIL C1-6, ALQUENIL C2-6, ALQUINIL C2-6 O ALQUIL C1-4 SUSTITUIDO; O UNA SAL DE ELLO ACEPTABLE FARMACEUTICAMENTE. LOS COMPONENTES DEL INVENTO SON INHIBIDORES DE LA ENZIMA LIPOXIGENASA-5
ES89313521T 1988-12-23 1989-12-22 Derivados de eteres ciclicos. Expired - Lifetime ES2063149T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88403311 1988-12-23

Publications (1)

Publication Number Publication Date
ES2063149T3 true ES2063149T3 (es) 1995-01-01

Family

ID=8200452

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89313521T Expired - Lifetime ES2063149T3 (es) 1988-12-23 1989-12-22 Derivados de eteres ciclicos.

Country Status (17)

Country Link
US (1) US5098932A (es)
EP (1) EP0375457B1 (es)
JP (1) JPH03135976A (es)
AU (1) AU622965B2 (es)
CA (1) CA2006095A1 (es)
DE (1) DE68913940T2 (es)
DK (1) DK665089A (es)
ES (1) ES2063149T3 (es)
FI (1) FI896015A0 (es)
GB (1) GB8927287D0 (es)
HU (1) HUT52494A (es)
IE (1) IE63211B1 (es)
IL (1) IL92580A (es)
NO (1) NO895087L (es)
NZ (1) NZ231666A (es)
PT (1) PT92701A (es)
ZA (1) ZA899688B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE902113A1 (en) * 1989-07-18 1991-06-19 Ici Plc Diaryl ether cyclic ethers
US5254581A (en) * 1990-06-21 1993-10-19 Imperial Chemical Industries Plc Pyran derivatives and their use as inhibitors of 5-lipoxygenase
IE914005A1 (en) * 1990-12-14 1992-06-17 Zeneca Ltd Novel intermediates
CA2058254A1 (en) * 1991-01-15 1992-07-16 John Francis Kingston Benzodioxole derivatives
AU645159B2 (en) * 1991-01-17 1994-01-06 Ici Pharma Sulphonamide derivatives
US5258399A (en) * 1991-01-17 1993-11-02 Imperial Chemical Industries Plc Sulphonamide derivatives
EP0505122A1 (en) * 1991-03-21 1992-09-23 Zeneca Limited Alpha, alpha-dialkylbenzyl derivatives
DE69206725T2 (de) * 1991-09-10 1996-05-02 Zeneca Ltd Benzolsulfonamidderivate als 5-Lipoxygenasehemmer
GB9300894D0 (en) * 1992-02-07 1993-03-10 Zeneca Ltd Oxime derivatives
EP0555067A1 (en) * 1992-02-07 1993-08-11 Zeneca Limited Hydroxylamine derivatives as 5-lipoxygenase inhibitors
CA2094465A1 (en) * 1992-04-23 1993-10-24 Pierre Andre Raymond Bruneau Cycloalkane derivatives
CA2095005A1 (en) * 1992-05-12 1993-11-13 Philip Neil Edwards Hydroxylamine derivatives
CA2095006A1 (en) * 1992-05-12 1993-11-13 Philip Neil Edwards Oxime derivatives
US5231197A (en) * 1992-06-01 1993-07-27 General Electric Company Method for producing ethylenically unsaturated graftable orthoesters
DE4228201A1 (de) * 1992-08-25 1994-03-03 Schering Ag Neue Leukotrien-B¶4¶-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AU4444393A (en) * 1992-09-01 1994-03-10 Zeneca Limited Pyrrolidine derivatives
WO1994005638A1 (en) * 1992-09-02 1994-03-17 Abbott Laboratories Trans 1,4-diether cyclohexane inhibitors of 5-lipoxygenase
US5407959A (en) * 1993-11-12 1995-04-18 Abbott Laboratories (Trans-1,4-dialkoxycyclohexyl) substituted arylalkylaryl-arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase
US5446062A (en) * 1993-11-12 1995-08-29 Abbott Laboratories ((4-alkoxypyran-4-yl) substituted) ether, arylalkyl-, arylalkenyl-, and arylalkynyl)urea inhibitors of 5-lipoxygenase
US6515014B2 (en) 1995-06-02 2003-02-04 G. D. Searle & Co. Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
WO1996038418A1 (en) 1995-06-02 1996-12-05 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US5643933A (en) * 1995-06-02 1997-07-01 G. D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US6512121B2 (en) 1998-09-14 2003-01-28 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
CA2224517A1 (en) * 1995-06-12 1996-12-27 G.D. Searle & Co. Compositions comprising a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
DE69709069T2 (de) 1996-02-13 2002-07-04 G.D. Searle & Co., Chicago Zusammensetzungen mit immunosuppressiven wirkungen, welche 5-lipoxygenase-inhibitoren und cyclooxygenase-2-inhibitoren enthalten
EP0880363B1 (en) * 1996-02-13 2002-09-11 G.D. SEARLE & CO. Combinations, having immunosuppressive effects, containing a cyclooxygenase-2 inhibitor and a leukotriene a 4 hydrolase inhibitor
US6677364B2 (en) 1998-04-20 2004-01-13 G.D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
AR031722A1 (es) * 2000-10-03 2003-10-01 Syngenta Participations Ag Fenilalquinos herbicidamente activos, proceso para su preparacion, composicion herbicida e inhibidora del crecimiento de las plantas, procedimiento para el control del crecimiento indeseado de las plantas, y procedimiento para inhibir el crecimiento de las plantas
ES2732293T3 (es) 2007-02-22 2019-11-21 Childrens Hospital & Res Center At Oakland Formulaciones de ácidos grasos y métodos para el uso de las mismas
US11760715B2 (en) 2016-03-03 2023-09-19 Université De Moncton Modulators of lipoxygenase and cyclooxygenase enzyme activity

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3743737A (en) * 1970-05-21 1973-07-03 Smith Kline French Lab 3-sulfonamido-4-hydroxyphenyl-2-piperindinylcarbinol compositions
US3661917A (en) * 1970-05-21 1972-05-09 Smith Kline French Lab 3-sulfonamido-4-hydroxyphenyl-2-piperidylcarbinols
CA960676A (en) * 1970-05-21 1975-01-07 Smith Kline And French Canada Ltd. 3-sulfonamido-4-hydroxyphenyl-2-piperidinylcarbinols
IE56702B1 (en) * 1982-12-01 1991-11-06 Usv Pharma Corp Antiinflammatory antiallergic compounds
NZ213986A (en) * 1984-10-30 1989-07-27 Usv Pharma Corp Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
US4625034A (en) * 1985-02-04 1986-11-25 Usv Pharmaceutical Corp. 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives
US4839369A (en) * 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4876346A (en) * 1985-05-02 1989-10-24 American Home Products Corporation Quinoline compounds
EP0271287A3 (en) * 1986-12-11 1990-06-13 Merck Frosst Canada Inc. Quinoline dioic acids and amides
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920130A (en) * 1987-11-02 1990-04-24 Rorer Pharamceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920133A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920131A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4918081A (en) * 1988-06-20 1990-04-17 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene d4
EP0349062A1 (en) * 1988-06-27 1990-01-03 Merck Frosst Canada Inc. Quinoline ether alkanoic acid

Also Published As

Publication number Publication date
NO895087L (no) 1990-06-25
NO895087D0 (no) 1989-12-18
PT92701A (pt) 1990-06-29
AU4714789A (en) 1990-06-28
DK665089D0 (da) 1989-12-22
JPH03135976A (ja) 1991-06-10
IL92580A0 (en) 1990-08-31
DE68913940T2 (de) 1994-07-14
DK665089A (da) 1990-06-24
AU622965B2 (en) 1992-04-30
ZA899688B (en) 1990-08-29
HUT52494A (en) 1990-07-28
EP0375457A3 (en) 1991-01-09
EP0375457B1 (en) 1994-03-16
FI896015A0 (fi) 1989-12-15
DE68913940D1 (de) 1994-04-21
IE893881L (en) 1990-06-23
GB8927287D0 (en) 1990-01-31
US5098932A (en) 1992-03-24
IE63211B1 (en) 1995-04-05
CA2006095A1 (en) 1990-06-23
NZ231666A (en) 1992-01-29
IL92580A (en) 1994-04-12
EP0375457A2 (en) 1990-06-27

Similar Documents

Publication Publication Date Title
ES2063149T3 (es) Derivados de eteres ciclicos.
ES2062051T3 (es) Derivados heterociclicos.
ES2079576T3 (es) Derivados piranicos biciclicos y su uso como inhibidores de 5-lipoxigenasa.
ES520300A0 (es) Procedimiento para la obtencion de 1,4-dihidropiridinas.
ES2192394T3 (es) Profarmacos de inhibidores de la bomba de protones.
ATE168685T1 (de) Aminoheterocyclische derivate als antithrombotische oder antikoagulierende mittel
CO4970713A1 (es) Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen
DK337988A (da) Cykliske aminoforbindelser og farmaceutiske praeparater med indhold af saadanne
HUP0301607A2 (hu) Szelektív neurokinin antagonista hatású nitrogéntartalmú heterociklusos vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP9903405A1 (hu) Metalloproteináz-inhibitor hatású ciklusos és heterociklusos N-szubsztituált-alfa- imino-hidroxámsavak, és -karbonsavak, előállításuk és alkalmazásuk
DE69901006D1 (de) Benzothiophen-, Benzofuran- und Indolderivate, Verfahren zu deren Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
NL180206C (nl) Verbinding en geneesmiddel met analgetische werking.
NO854837L (no) Benzoxazol- og benzotiasolaminderivater.
FI862757A0 (fi) Pyridonkarbonsyraderivat och foerfarande foer framstaellning av dessa.
MX9304215A (es) Nuevos derivados piperidinicos del bencimidazol.
ES2195933T3 (es) Nuevos derivados de flavonas, xantonas y cumarinas.
AR003414A1 (es) Uso de derivados de imidazol [1,2-a]piridina -3-acetamida y una composicion farmaceutica que comprende tal derivado
CO4340623A1 (es) Derivados de indolina, metodo de preparacion y uso
CO5560579A2 (es) 6,7-dihidro-5h-pirazolo[1,2-a]pirazol-1-onas espirociclicas que controlan la citosinas inflamatorias
AR033942A1 (es) Compuestos de monofluoroalquilo aplicables en la potenciacion de los compuestos intermediarios utilizables en la sintesis de dichos compuestos de monofluoralquilo; composiciones farmaceuticas formuladas con dichos compuestos potenciadores y metodos para la potenciacion de las funciones de dichos rec
ATE245157T1 (de) 3,9-diazabicyclo-(3.3.1)-nonanylderivate, verfahren und intermediate für ihre darstellung und sie enthaltende pharmazeutische zusammensetzungen
FR2613719B1 (fr) Derives aromatiques, leur preparation et leur utilisation comme antimicrobiens
ES2057415T3 (es) Derivados biciclicos.
ATE62472T1 (de) Fungizide cyclohexylamine.
KR920008020A (ko) 피레라진 유도체

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 375457

Country of ref document: ES