CO4340623A1 - Derivados de indolina, metodo de preparacion y uso - Google Patents

Derivados de indolina, metodo de preparacion y uso

Info

Publication number
CO4340623A1
CO4340623A1 CO94057739A CO94057739A CO4340623A1 CO 4340623 A1 CO4340623 A1 CO 4340623A1 CO 94057739 A CO94057739 A CO 94057739A CO 94057739 A CO94057739 A CO 94057739A CO 4340623 A1 CO4340623 A1 CO 4340623A1
Authority
CO
Colombia
Prior art keywords
alkyl
same
hydrogen
indoline
derivatives
Prior art date
Application number
CO94057739A
Other languages
English (en)
Inventor
Peter Charles North
Malcolm Clive Carter
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CO4340623A1 publication Critical patent/CO4340623A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REIVINDICACION NUMERO UN COMPUESTO DE LA FORMULA (I) FIGURA 1 CARACTERIZADO PORQUE R1 ES HIDROGENO, HALOGENO O ALQUILO DE C1-6; R2 ES UN GRUPO DE LA FORMULA -CR3R4(CH2)pNR5COR6; R3, R4 y R5, LOS CUALES PUEDER SER IGUALES O DI- FERENTES, SON HIDROGENO O ALQUILO DE C1-6; R6 ES UN ALQUILO DE C1-6 O CICLOALQUILO DE C3-7; n ES UN NUMERO ENTERO DE 2, 3 o 4; p ES UN NUMERO ENTERO DE 1, 2, 3 o 4; Y SUS SALES Y SOLVATOS DEL MISMO, FARMACEUTICA- MENTE ACEPTABLES". REIVINDICACION NUMERO UN COMPUESTO DE LA FORMULA (Ia) FIGURA 2 CARACTERIZADO PORQUE R1 ES HIDROGENO, HALOGENO O ALQUILO DE C1-6; R2 ES UN GRUPO DE LA FORMULA -CR3R4(CH2)pNR5COR6; R3, R4 Y R5, LOS CUALES PUDEN SER IGUALES O DIFE- RENTES, SON HIDROGENO O ALQUILO DE C1-6; R6 ES ALQUILO DE C1-6 O CICLOALQUILO DE C3-7; p ES UN NUMERO ENTERO DE 1, 2, 3 o 4; Y SUS SALES Y SOLVATOS DEL MISMO, FARMACEUTICA- MENTE ACEPTABLES".
CO94057739A 1993-12-22 1994-12-21 Derivados de indolina, metodo de preparacion y uso CO4340623A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939326192A GB9326192D0 (en) 1993-12-22 1993-12-22 Chemical compounds

Publications (1)

Publication Number Publication Date
CO4340623A1 true CO4340623A1 (es) 1996-07-30

Family

ID=10747030

Family Applications (1)

Application Number Title Priority Date Filing Date
CO94057739A CO4340623A1 (es) 1993-12-22 1994-12-21 Derivados de indolina, metodo de preparacion y uso

Country Status (15)

Country Link
US (1) US5633276A (es)
EP (1) EP0736028A1 (es)
JP (1) JPH09507057A (es)
AP (1) AP535A (es)
AU (1) AU684877B2 (es)
CA (1) CA2179402A1 (es)
CO (1) CO4340623A1 (es)
GB (1) GB9326192D0 (es)
IL (1) IL112097A (es)
IS (1) IS4244A (es)
MY (1) MY131641A (es)
SV (1) SV1994000083A (es)
TW (1) TW291479B (es)
WO (1) WO1995017405A1 (es)
ZA (1) ZA9410056B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2741799B1 (fr) * 1995-12-04 1998-01-02 Oreal Utilisation de melatonine dans une composition pour traiter les signes cutanes des etats de fatigue
US6034239A (en) * 1996-03-08 2000-03-07 Takeda Chemical Industries, Ltd. Tricyclic compounds, their production and use
EP0885210B2 (en) * 1996-03-08 2008-06-18 Takeda Pharmaceutical Company Limited Tricylic compounds having binding affinity for melatonin receptors, their production and use
EP1199304A1 (en) * 1997-03-05 2002-04-24 Takeda Chemical Industries, Ltd. Bicyclic compounds and pharmaceutical composition containing tricyclic compound for treating or preventing sleep disorders
US5856529A (en) * 1996-12-10 1999-01-05 Bristol-Myers Squibb Company Benzofuran and dihydrobenzofuran melatonergic agents
AU6540598A (en) * 1997-03-05 1998-09-22 Bristol-Myers Squibb Company Polycyclic ethyl alkylamide melatonergic agents
FR2763335B1 (fr) * 1997-05-16 2000-11-24 Adir Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU727654B2 (en) * 1997-06-13 2000-12-21 Yamanouchi Pharmaceutical Co., Ltd. Tricyclic pyrazole derivative
US6214869B1 (en) 1998-06-05 2001-04-10 Bristol-Myers Squibb Heterocyclic cis cyclopropane derivatives as melatonergic agents
ES2213022T3 (es) 1999-06-30 2004-08-16 Bristol-Myers Squibb Company Derivados de aminopirrolidina heterociclicos utiles como agentes melatonergicos.
GB9918965D0 (en) 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxi
EP1213290B1 (en) 1999-08-20 2005-04-20 Takeda Pharmaceutical Company Limited Dihydrobenzofuran derivatives, process for the preparation thereof and agents
US7012090B1 (en) 2000-03-17 2006-03-14 Alcon, Inc. Pyranoindoles for treating glaucoma
JP4088444B2 (ja) * 2000-03-17 2008-05-21 アルコン，インコーポレイテッド 緑内障を処置するためのピラノインドール
ES2172415B2 (es) 2000-07-28 2003-11-16 Univ Madrid Complutense Tratamiento del glaucoma y la hipertension ocular por medio de un analogo de la melatonina.
CA2431566A1 (en) * 2000-12-11 2002-07-18 Testocreme, Llc Topical testosterone formulations and associated methods
US20030096379A1 (en) * 2001-03-28 2003-05-22 Kilgore James L. Method for producing tryptamine derivatives
KR20080114743A (ko) * 2006-03-20 2008-12-31 다케다 야쿠힌 고교 가부시키가이샤 과민성 장 증후군의 예방제/치료제
CN101605795A (zh) * 2006-12-08 2009-12-16 武田药品工业株式会社 三环化合物及其药物用途
ES2331274B1 (es) 2007-10-25 2010-10-21 Ferrer Internacional, S.A. Compuesto de indolina.
US8227501B2 (en) * 2008-07-30 2012-07-24 Ferrer Internacional, S.A. 1,6-dihydro-2H-3-oxa-6-aza-as-indacene compounds
BR102016024814A2 (pt) 2016-10-24 2018-05-08 Aché Laboratórios Farmacêuticos S.A. composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2485539A1 (fr) * 1980-06-26 1981-12-31 Sori Soc Rech Ind Nouveau derive de pyranno-indole, son procede de preparation et son application en therapeutique
US4703052A (en) * 1985-05-21 1987-10-27 Pfizer Inc. Hypoglycemic thiazolidinediones
US4738972A (en) * 1985-05-21 1988-04-19 Pfizer Inc. Hypoglycemic thiazolidinediones

Also Published As

Publication number Publication date
MY131641A (en) 2007-08-30
CA2179402A1 (en) 1995-06-29
WO1995017405A1 (en) 1995-06-29
IL112097A (en) 1998-06-15
AU1274395A (en) 1995-07-10
IS4244A (is) 1995-06-23
IL112097A0 (en) 1995-03-15
US5633276A (en) 1997-05-27
GB9326192D0 (en) 1994-02-23
ZA9410056B (en) 1995-10-18
AP9400706A0 (en) 1995-01-31
SV1994000083A (es) 1995-07-24
EP0736028A1 (en) 1996-10-09
AU684877B2 (en) 1998-01-08
JPH09507057A (ja) 1997-07-15
AP535A (en) 1996-09-16
TW291479B (es) 1996-11-21

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