ES2193137T3 - Heteroaril aminas como nuevos inhibidors de acetilcolinesterasa. - Google Patents

Heteroaril aminas como nuevos inhibidors de acetilcolinesterasa.

Info

Publication number
ES2193137T3
ES2193137T3 ES92918761T ES92918761T ES2193137T3 ES 2193137 T3 ES2193137 T3 ES 2193137T3 ES 92918761 T ES92918761 T ES 92918761T ES 92918761 T ES92918761 T ES 92918761T ES 2193137 T3 ES2193137 T3 ES 2193137T3
Authority
ES
Spain
Prior art keywords
inhibidors
acetilcolinesterasa
aminas
heteroaril
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92918761T
Other languages
English (en)
Inventor
Yuhpyng L Chen
Arthur A Nagel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ES2193137T3 publication Critical patent/ES2193137T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

COMPUESTOS DE FORMULA (I), EN DONDE ANILLO A, ANILLO B, ANILLO D, R2, R3, R4, R5, R6, R11, R12, R13, E, G, X Y P SON COMO SE DEFINE EN LA MEMORIA. LOS COMPUESTOS DE FORMULA (I) SON INHIBIDORES DE COLINESTERASA Y SE USAN EN MEJORA DE MEMORIA EN PACIENTES QUE SUFREN DE DEMENCIA Y ENFERMEDAD DE ALZHEIMER.
ES92918761T 1991-10-03 1992-08-31 Heteroaril aminas como nuevos inhibidors de acetilcolinesterasa. Expired - Lifetime ES2193137T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77128391A 1991-10-03 1991-10-03

Publications (1)

Publication Number Publication Date
ES2193137T3 true ES2193137T3 (es) 2003-11-01

Family

ID=25091318

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92918761T Expired - Lifetime ES2193137T3 (es) 1991-10-03 1992-08-31 Heteroaril aminas como nuevos inhibidors de acetilcolinesterasa.

Country Status (36)

Country Link
US (4) US5574046A (es)
EP (1) EP0606248B1 (es)
JP (1) JP2546785B2 (es)
KR (1) KR0170458B1 (es)
CN (1) CN1035615C (es)
AP (1) AP314A (es)
AT (1) ATE235490T1 (es)
AU (1) AU667053B2 (es)
BG (1) BG61727B1 (es)
BR (1) BR9206577A (es)
CA (1) CA2119647C (es)
CZ (1) CZ290807B6 (es)
DE (2) DE69232976T2 (es)
DK (1) DK0606248T3 (es)
EG (1) EG21481A (es)
ES (1) ES2193137T3 (es)
FI (1) FI116939B (es)
HU (1) HU225049B1 (es)
IL (1) IL103274A (es)
IS (1) IS1745B (es)
MA (1) MA22672A1 (es)
MX (1) MX9205678A (es)
NO (1) NO308533B1 (es)
NZ (1) NZ244601A (es)
OA (1) OA09895A (es)
PH (1) PH31290A (es)
PL (3) PL171669B1 (es)
PT (1) PT100917B (es)
RO (1) RO112868B1 (es)
RU (1) RU2100357C1 (es)
SG (1) SG52618A1 (es)
TW (1) TW263504B (es)
UA (1) UA41290C2 (es)
UY (1) UY23484A1 (es)
WO (1) WO1993007140A1 (es)
ZA (1) ZA927589B (es)

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EP0976404A3 (en) * 1998-07-30 2001-06-27 Pfizer Products Inc. A pharmaceutical composition for the prevention and treatment of diseases of cognitive dysfunction in a mammal
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
CN1535682A (zh) 1998-09-30 2004-10-13 ����ҩƷ��ҵ��ʽ���� 改善膀胱排泄能力的药物
CN1317276C (zh) * 2000-09-29 2007-05-23 中国科学院上海药物研究所 一类吲哚基哌啶类化合物及其制备方法和用途
KR100823908B1 (ko) * 2000-10-20 2008-04-21 바이오비트럼 에이비(피유비엘) 2-, 3-, 4-, 또는 5-치환-ｎ1-(벤젠술포닐)인돌 및 이의치료 용도
US20050215614A1 (en) * 2002-10-15 2005-09-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
US20060014801A1 (en) * 2002-11-22 2006-01-19 The Johns Hopkins University Prevention and treatment of cognitive impairment using (R)-(-)-5-methyl-1-nicotynoyl-2-pyrazoline (MNP) and analogs
WO2005112908A1 (en) * 2004-05-14 2005-12-01 The Johns Hopkins University Method for improving cognitive function
EP1600447A1 (en) * 2004-05-28 2005-11-30 Neuropharma S.A.U. Butyrylcholinesterase selective inhibitors
DE602005010698D1 (de) 2004-06-09 2008-12-11 Glaxo Group Ltd Pyrrolopyridinderivate
EP1827468B1 (en) * 2004-12-23 2012-08-22 Curaxis Pharmaceutical Corporation Acetylcholinesterase Inhibitors and leuprolide acetate for the treatment of Alzheimer's disease
CN1808106B (zh) * 2005-01-21 2010-11-24 中国科学院上海药物研究所 一种用核磁共振筛选乙酰胆碱酯酶抑制剂的方法
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
SG193793A1 (en) 2008-08-12 2013-10-30 Zinfandel Pharmaceuticals Inc Method of identifying disease risk factors
CN101503414B (zh) * 2009-03-04 2013-10-30 沈阳药科大学 噻唑并[3,2-b]-1,2,4-三嗪衍生物及其应用
CN103772312B (zh) 2009-10-02 2016-08-17 埃维克辛公司 抗炎症的2-羰基噻唑和2-羰基恶唑
JP6082250B2 (ja) 2010-02-09 2017-02-15 ザ・ジョンズ・ホプキンス・ユニバーシティー 認知機能を改善するための方法および組成物
KR20180050420A (ko) 2011-01-10 2018-05-14 진판델 파마슈티컬스 인코포레이티드 알츠하이머 병 치료를 위한 방법 및 약품
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
KR102268357B1 (ko) 2013-01-29 2021-06-23 아벡신 에이에스 항염증성 및 항종양성 2-옥소티아졸 및 2-옥소티오펜 화합물
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
EP2968220B1 (en) 2013-03-15 2021-05-05 Agenebio, Inc. Methods and compositions for improving cognitive function
CN103333163A (zh) * 2013-07-09 2013-10-02 广州中医药大学 一种苯并呋喃类衍生物及其制备方法和应用
GB201413695D0 (en) 2014-08-01 2014-09-17 Avexxin As Compound
CA2986598C (en) 2015-05-22 2023-09-26 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
GB201604318D0 (en) 2016-03-14 2016-04-27 Avexxin As Combination therapy
CN107141266B (zh) * 2017-06-28 2019-04-09 佳木斯大学附属第一医院 一种用于治疗阿尔茨海默病的杂环化合物及其制备方法
CN115466211B (zh) * 2022-06-09 2024-02-23 中国人民解放军空军军医大学 一种n-苯基喹啉-4-胺类化合物及其应用

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NL100127C (es) * 1954-04-28
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
US4122265A (en) * 1976-05-21 1978-10-24 Hoffmann-La Roche Inc. Derivatives of 3-phenylisoindole-1-carboxylic acid
ZA815541B (en) * 1980-08-12 1983-03-30 Glaxo Group Ltd Heterocyclic compounds
GB8615562D0 (en) * 1986-06-25 1986-07-30 Maggioni Farma Aminoalcohols
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
IT1226100B (it) * 1988-07-07 1990-12-10 Dompe Farmaceutici Spa Derivati benzimidazolici farmacologicamente attivi.
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
US4908372A (en) * 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
JP2969359B2 (ja) * 1989-01-13 1999-11-02 武田薬品工業株式会社 環状アミン化合物
US5064840A (en) * 1989-08-03 1991-11-12 Merrell Dow Pharmaceuticals Anti-psychotic piperidylbenzimidazole compounds
TW197442B (es) * 1990-02-08 1993-01-01 Pfizer
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TW197435B (es) * 1990-11-22 1993-01-01 Takeda Pharm Industry Co Ltd
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
AU669156B2 (en) * 1992-02-13 1996-05-30 Merrell Dow Pharmaceuticals Inc. Piperidinyl thiacyclic derivatives
CA2092112A1 (en) * 1992-03-23 1993-09-24 Nobuyoshi Iwata Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use

Also Published As

Publication number Publication date
CN1035615C (zh) 1997-08-13
EP0606248B1 (en) 2003-03-26
MA22672A1 (fr) 1993-07-01
CZ78594A3 (en) 1995-07-12
DE69232976T2 (de) 2003-10-02
US6303633B1 (en) 2001-10-16
OA09895A (en) 1995-09-15
BG98689A (bg) 1995-03-31
SG52618A1 (en) 1998-09-28
ZA927589B (en) 1994-04-05
HU225049B1 (en) 2006-05-29
US20020049210A1 (en) 2002-04-25
JP2546785B2 (ja) 1996-10-23
RO112868B1 (ro) 1998-01-30
PH31290A (en) 1998-07-06
NO308533B1 (no) 2000-09-25
NZ244601A (en) 1995-03-28
BR9206577A (pt) 1995-10-10
EP0606248A1 (en) 1994-07-20
PL171984B1 (pl) 1997-07-31
PT100917B (pt) 1999-07-30
DE9290112U1 (de) 1994-06-01
CN1071166A (zh) 1993-04-21
MX9205678A (es) 1993-04-01
IS3919A (is) 1993-04-04
IL103274A (en) 1996-11-14
UY23484A1 (es) 1993-03-11
RU2100357C1 (ru) 1997-12-27
AP9200421A0 (en) 1992-10-31
IL103274A0 (en) 1993-02-21
BG61727B1 (bg) 1998-04-30
DE69232976D1 (de) 2003-04-30
CZ290807B6 (cs) 2002-10-16
ATE235490T1 (de) 2003-04-15
JPH06510788A (ja) 1994-12-01
HU9400952D0 (en) 1994-06-28
PT100917A (pt) 1993-11-30
FI941518A (fi) 1994-03-31
TW263504B (es) 1995-11-21
EG21481A (en) 2001-11-28
US6124321A (en) 2000-09-26
DK0606248T3 (da) 2003-06-23
PL171693B1 (pl) 1997-06-30
AU2519692A (en) 1993-05-03
US5574046A (en) 1996-11-12
FI941518A0 (fi) 1994-03-31
UA41290C2 (uk) 2001-09-17
IS1745B (is) 2000-05-18
PL171669B1 (en) 1997-06-30
CA2119647C (en) 1998-08-04
NO941179L (no) 1994-03-30
AP314A (en) 1994-02-04
WO1993007140A1 (en) 1993-04-15
KR0170458B1 (ko) 1999-02-18
NO941179D0 (no) 1994-03-30
HUT70544A (en) 1995-10-30
AU667053B2 (en) 1996-03-07
CA2119647A1 (en) 1993-04-15
FI116939B (fi) 2006-04-13

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