UA41290C2 - Гетероариламіни, фармацевтична композиція, спосіб інгібування холінестерази у ссавців, спосіб покращення пам'яті - Google Patents

Гетероариламіни, фармацевтична композиція, спосіб інгібування холінестерази у ссавців, спосіб покращення пам'яті

Info

Publication number
UA41290C2
UA41290C2 UA94005424A UA94005424A UA41290C2 UA 41290 C2 UA41290 C2 UA 41290C2 UA 94005424 A UA94005424 A UA 94005424A UA 94005424 A UA94005424 A UA 94005424A UA 41290 C2 UA41290 C2 UA 41290C2
Authority
UA
Ukraine
Prior art keywords
phenyl
heteroarylamines
alkyl
ring
mentioned
Prior art date
Application number
UA94005424A
Other languages
English (en)
Russian (ru)
Inventor
Юнінг Л. ЧЕН
Юпинг Л. ЧЕН
Артур А. НЕЙДЖЕЛ
Original Assignee
Ейсай Ко., Лтд.
Файзер Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ейсай Ко., Лтд., Файзер Ко., Лтд. filed Critical Ейсай Ко., Лтд.
Publication of UA41290C2 publication Critical patent/UA41290C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Гетероаріламіни загальної формули (I): де один з R2, R3 і бічний ланцюг, що містить >C=Z , можуть бути, необов'язково, приєднані переважно до атому вуглецю, відміченому зірочкою, в кільці В, ніж до атому кільця А кільце А представляє бензо R1 представляє фенил, фенил(С1-С6) алкіл, циннаміл або гетероарилметил, де гетероарильний залишок зазначеного гетероарилметилу, вибраний з імідазоло, тіазоло, тієно, піридо і ізоксазоло, і де зазначені фенил і зазначений гетероарильний залишок можуть бути, необов'язково, заміщені одним або двома замісниками, незалежно вибраними з (С1-С6) алкілу, (С1-С4) алкокси і галоїду, R2 і R3 незалежно вибрані з водню, (С1-С6) алкокси, (С1-С6) алкілу, необов'язково заміщеного від одного до трьох атомів фтору, бензилокси, гідрокси, фенилом, бензилом, галоїдом, нітро, ціано, COOR4, CONHR4, NR4R5, NR4 СOR5, SОрСН2фенилом, де р дорівнює 0,1 або 2.
UA94005424A 1991-10-03 1992-08-31 Гетероариламіни, фармацевтична композиція, спосіб інгібування холінестерази у ссавців, спосіб покращення пам'яті UA41290C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77128391A 1991-10-03 1991-10-03
PCT/US1992/007230 WO1993007140A1 (en) 1991-10-03 1992-08-31 Heteroaryl amines as novel acetyl cholinesterase inhibitors

Publications (1)

Publication Number Publication Date
UA41290C2 true UA41290C2 (uk) 2001-09-17

Family

ID=25091318

Family Applications (1)

Application Number Title Priority Date Filing Date
UA94005424A UA41290C2 (uk) 1991-10-03 1992-08-31 Гетероариламіни, фармацевтична композиція, спосіб інгібування холінестерази у ссавців, спосіб покращення пам'яті

Country Status (36)

Country Link
US (4) US5574046A (uk)
EP (1) EP0606248B1 (uk)
JP (1) JP2546785B2 (uk)
KR (1) KR0170458B1 (uk)
CN (1) CN1035615C (uk)
AP (1) AP314A (uk)
AT (1) ATE235490T1 (uk)
AU (1) AU667053B2 (uk)
BG (1) BG61727B1 (uk)
BR (1) BR9206577A (uk)
CA (1) CA2119647C (uk)
CZ (1) CZ290807B6 (uk)
DE (2) DE69232976T2 (uk)
DK (1) DK0606248T3 (uk)
EG (1) EG21481A (uk)
ES (1) ES2193137T3 (uk)
FI (1) FI116939B (uk)
HU (1) HU225049B1 (uk)
IL (1) IL103274A (uk)
IS (1) IS1745B (uk)
MA (1) MA22672A1 (uk)
MX (1) MX9205678A (uk)
NO (1) NO308533B1 (uk)
NZ (1) NZ244601A (uk)
OA (1) OA09895A (uk)
PH (1) PH31290A (uk)
PL (3) PL171669B1 (uk)
PT (1) PT100917B (uk)
RO (1) RO112868B1 (uk)
RU (1) RU2100357C1 (uk)
SG (1) SG52618A1 (uk)
TW (1) TW263504B (uk)
UA (1) UA41290C2 (uk)
UY (1) UY23484A1 (uk)
WO (1) WO1993007140A1 (uk)
ZA (1) ZA927589B (uk)

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CN1808106B (zh) * 2005-01-21 2010-11-24 中国科学院上海药物研究所 一种用核磁共振筛选乙酰胆碱酯酶抑制剂的方法
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CN101503414B (zh) * 2009-03-04 2013-10-30 沈阳药科大学 噻唑并[3,2-b]-1,2,4-三嗪衍生物及其应用
CN103772312B (zh) 2009-10-02 2016-08-17 埃维克辛公司 抗炎症的2-羰基噻唑和2-羰基恶唑
JP6082250B2 (ja) 2010-02-09 2017-02-15 ザ・ジョンズ・ホプキンス・ユニバーシティー 認知機能を改善するための方法および組成物
KR20180050420A (ko) 2011-01-10 2018-05-14 진판델 파마슈티컬스 인코포레이티드 알츠하이머 병 치료를 위한 방법 및 약품
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
KR102268357B1 (ko) 2013-01-29 2021-06-23 아벡신 에이에스 항염증성 및 항종양성 2-옥소티아졸 및 2-옥소티오펜 화합물
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
EP2968220B1 (en) 2013-03-15 2021-05-05 Agenebio, Inc. Methods and compositions for improving cognitive function
CN103333163A (zh) * 2013-07-09 2013-10-02 广州中医药大学 一种苯并呋喃类衍生物及其制备方法和应用
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Also Published As

Publication number Publication date
CN1035615C (zh) 1997-08-13
EP0606248B1 (en) 2003-03-26
MA22672A1 (fr) 1993-07-01
CZ78594A3 (en) 1995-07-12
DE69232976T2 (de) 2003-10-02
US6303633B1 (en) 2001-10-16
OA09895A (en) 1995-09-15
BG98689A (bg) 1995-03-31
SG52618A1 (en) 1998-09-28
ZA927589B (en) 1994-04-05
HU225049B1 (en) 2006-05-29
US20020049210A1 (en) 2002-04-25
JP2546785B2 (ja) 1996-10-23
RO112868B1 (ro) 1998-01-30
PH31290A (en) 1998-07-06
NO308533B1 (no) 2000-09-25
NZ244601A (en) 1995-03-28
BR9206577A (pt) 1995-10-10
EP0606248A1 (en) 1994-07-20
PL171984B1 (pl) 1997-07-31
PT100917B (pt) 1999-07-30
DE9290112U1 (de) 1994-06-01
CN1071166A (zh) 1993-04-21
MX9205678A (es) 1993-04-01
IS3919A (is) 1993-04-04
IL103274A (en) 1996-11-14
UY23484A1 (es) 1993-03-11
RU2100357C1 (ru) 1997-12-27
AP9200421A0 (en) 1992-10-31
IL103274A0 (en) 1993-02-21
BG61727B1 (bg) 1998-04-30
DE69232976D1 (de) 2003-04-30
CZ290807B6 (cs) 2002-10-16
ATE235490T1 (de) 2003-04-15
JPH06510788A (ja) 1994-12-01
HU9400952D0 (en) 1994-06-28
ES2193137T3 (es) 2003-11-01
PT100917A (pt) 1993-11-30
FI941518A (fi) 1994-03-31
TW263504B (uk) 1995-11-21
EG21481A (en) 2001-11-28
US6124321A (en) 2000-09-26
DK0606248T3 (da) 2003-06-23
PL171693B1 (pl) 1997-06-30
AU2519692A (en) 1993-05-03
US5574046A (en) 1996-11-12
FI941518A0 (fi) 1994-03-31
IS1745B (is) 2000-05-18
PL171669B1 (en) 1997-06-30
CA2119647C (en) 1998-08-04
NO941179L (no) 1994-03-30
AP314A (en) 1994-02-04
WO1993007140A1 (en) 1993-04-15
KR0170458B1 (ko) 1999-02-18
NO941179D0 (no) 1994-03-30
HUT70544A (en) 1995-10-30
AU667053B2 (en) 1996-03-07
CA2119647A1 (en) 1993-04-15
FI116939B (fi) 2006-04-13

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