ATE218142T1 - Nitratester von corticoid verbindungen und die therapeutische verwendungen davon - Google Patents
Nitratester von corticoid verbindungen und die therapeutische verwendungen davonInfo
- Publication number
- ATE218142T1 ATE218142T1 AT97910409T AT97910409T ATE218142T1 AT E218142 T1 ATE218142 T1 AT E218142T1 AT 97910409 T AT97910409 T AT 97910409T AT 97910409 T AT97910409 T AT 97910409T AT E218142 T1 ATE218142 T1 AT E218142T1
- Authority
- AT
- Austria
- Prior art keywords
- tester
- nitrate
- therapeutic uses
- compounds
- corticoid compounds
- Prior art date
Links
- 229910002651 NO3 Inorganic materials 0.000 title 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 title 1
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical class C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI002048A IT1285770B1 (it) | 1996-10-04 | 1996-10-04 | Composti corticoidei |
| PCT/EP1997/005426 WO1998015568A2 (en) | 1996-10-04 | 1997-10-02 | Nitrate esters of corticoid compounds and pharmaceutical applications thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE218142T1 true ATE218142T1 (de) | 2002-06-15 |
Family
ID=11374972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97910409T ATE218142T1 (de) | 1996-10-04 | 1997-10-02 | Nitratester von corticoid verbindungen und die therapeutische verwendungen davon |
Country Status (18)
| Country | Link |
|---|---|
| US (8) | US6610676B1 (de) |
| EP (1) | EP0929565B1 (de) |
| JP (1) | JP4388600B2 (de) |
| KR (1) | KR100487898B1 (de) |
| CN (1) | CN1142939C (de) |
| AT (1) | ATE218142T1 (de) |
| AU (1) | AU719250B2 (de) |
| BR (1) | BR9711586A (de) |
| CA (1) | CA2267630C (de) |
| DE (1) | DE69712900T2 (de) |
| DK (1) | DK0929565T3 (de) |
| ES (1) | ES2177952T3 (de) |
| HU (1) | HUP9904149A3 (de) |
| IT (1) | IT1285770B1 (de) |
| PT (1) | PT929565E (de) |
| RU (1) | RU2186781C2 (de) |
| SI (1) | SI0929565T1 (de) |
| WO (1) | WO1998015568A2 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824669A (en) | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| IT1285770B1 (it) * | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
| IT1311922B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1314184B1 (it) | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
| IT1320176B1 (it) * | 2000-12-22 | 2003-11-26 | Nicox Sa | Dispersioni solide di principi attivi nitrati. |
| EP1219306A1 (de) | 2000-12-29 | 2002-07-03 | Nicox S.A. | Zyklodextrin und NO-abgebende Arzneimittlen enthaltende Zusammensetzungen |
| US6696592B2 (en) | 2001-05-22 | 2004-02-24 | Nicox-S.A. | Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof |
| CA2462456C (en) | 2001-10-03 | 2010-05-04 | Merck & Co., Inc. | Androstane 17-beta-carboxamides as androgen receptor modulators |
| ITMI20020148A1 (it) | 2002-01-29 | 2003-07-29 | Nicox Sa | Nuovi corticosteroidi |
| RU2261481C2 (ru) * | 2003-03-26 | 2005-09-27 | ФГУ Омская государственная медицинская академия | Способ моделирования септического шока и полиорганной недостаточности у мелких лабораторных животных |
| CN100513415C (zh) * | 2005-08-03 | 2009-07-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 胆汁酸衍生物及其医药用途 |
| SG158916A1 (en) * | 2005-09-02 | 2010-02-26 | Nicox Sa | Nitrooxy derivatives op glucocorticoids |
| US8802726B2 (en) | 2006-02-03 | 2014-08-12 | Nicox S.A. | Use of nitrooxyderivative of drug for the treatment of muscular dystrophies |
| US7893058B2 (en) * | 2006-05-15 | 2011-02-22 | Janssen Pharmaceutica Nv | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
| NZ579067A (en) * | 2007-02-05 | 2012-02-24 | Nicox Sa | Nitric oxide releasing steroids |
| EP2205248A2 (de) * | 2007-08-10 | 2010-07-14 | Nicox S.A. | Kombination aus einem nitroderivatisierten steroid und einem bronchodilator zur behandlung von atemwegserkrankungen |
| WO2009071990A2 (en) * | 2007-08-31 | 2009-06-11 | Topigen Pharmaceuticals Inc. | No-donating cordicosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties |
| MX2011001119A (es) * | 2008-07-31 | 2011-03-02 | Nicox Sa | Glucocorticoides unidos a esteres de nitrato por medio de un enlazador aromatico en la posicion 21 y su uso en oftalmololgia. |
| CA2731477A1 (en) * | 2008-08-05 | 2010-02-11 | Nicox S.A. | New no releasing steroids derivatives |
| CA2731520A1 (en) | 2008-08-05 | 2010-02-11 | Nicox S.A. | New no-releasing steroids for the treatment of retina and macula lutea diseases |
| EP2560634A1 (de) | 2010-04-23 | 2013-02-27 | Piramal Enterprises Limited | Stickoxidfreisetzende prodrugs aus therapeutika |
| US8716268B2 (en) | 2010-06-07 | 2014-05-06 | Chao Liu | Nitrate esters of corticoid compounds useful as diuretics |
| US9844599B2 (en) | 2013-01-21 | 2017-12-19 | Apparao Satyam | Nitric oxide releasing produgs of therapeutic agents |
| CN108191938B (zh) * | 2018-01-11 | 2019-07-05 | 湖南新合新生物医药有限公司 | 9,11烯烃甾族化合物的制备方法 |
| CN113069460B (zh) * | 2021-03-24 | 2022-02-08 | 兰州大学 | 哈西奈德及其衍生物用于制备治疗和/或预防脑血管疾病药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2990401A (en) * | 1958-06-18 | 1961-06-27 | American Cyanamid Co | 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids |
| GB1054290A (de) * | 1963-05-01 | |||
| US3183252A (en) * | 1963-09-05 | 1965-05-11 | Syntex Corp | 16-nitratoalkyl-pregnanes |
| US3494941A (en) * | 1967-12-04 | 1970-02-10 | American Home Prod | Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones |
| HU164115B (de) * | 1971-05-07 | 1973-12-28 | ||
| NZ177056A (en) * | 1974-03-27 | 1978-09-20 | Plurichemie Anstalt | Certain 9 -(chloro or flruoro)-16( or )-methyl-11 ,17 -dihydroxypregna-1,4-diene-3,20-dione 17 -acylates or 11 ,17 -diacylates and certain preparature processes |
| CA1058161A (en) * | 1975-09-08 | 1979-07-10 | Ravi K. Varma | 3,20-DIKETOPREGNENES HAVING AN 11.beta.-ACETAL GROUP AND DERIVATIVES THEREOF |
| IT1256345B (it) | 1992-08-20 | 1995-12-01 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione | |
| IT1256450B (it) | 1992-11-26 | 1995-12-05 | Soldato Piero Del | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
| US5457207A (en) | 1993-10-05 | 1995-10-10 | Regents Of The University Of Minnesota | Spirovesamicols |
| HU218923B (hu) | 1993-10-06 | 2000-12-28 | Nicox S.A. | Gyulladásgátló és/vagy fájdalomcsillapító hatású nitrát-észterek, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására |
| ES2139199T3 (es) | 1994-05-10 | 2000-02-01 | Nicox Sa | Compuestos nitro y composiciones que los contienen que presentan una actividad anti-inflamatoria, analgesica y antitrombotica. |
| US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| US5985862A (en) * | 1996-05-02 | 1999-11-16 | G.D. Searle & Co. | Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs |
| US5837698A (en) * | 1996-05-02 | 1998-11-17 | G. D. Searle & Co. | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs |
| IT1285770B1 (it) * | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
-
1996
- 1996-10-04 IT IT96MI002048A patent/IT1285770B1/it active IP Right Grant
-
1997
- 1997-10-02 ES ES97910409T patent/ES2177952T3/es not_active Expired - Lifetime
- 1997-10-02 WO PCT/EP1997/005426 patent/WO1998015568A2/en not_active Ceased
- 1997-10-02 EP EP97910409A patent/EP0929565B1/de not_active Expired - Lifetime
- 1997-10-02 BR BR9711586A patent/BR9711586A/pt not_active Application Discontinuation
- 1997-10-02 AT AT97910409T patent/ATE218142T1/de active
- 1997-10-02 CA CA002267630A patent/CA2267630C/en not_active Expired - Fee Related
- 1997-10-02 SI SI9730333T patent/SI0929565T1/xx unknown
- 1997-10-02 JP JP51715498A patent/JP4388600B2/ja not_active Expired - Fee Related
- 1997-10-02 AU AU47803/97A patent/AU719250B2/en not_active Ceased
- 1997-10-02 DE DE69712900T patent/DE69712900T2/de not_active Expired - Lifetime
- 1997-10-02 US US09/269,729 patent/US6610676B1/en not_active Expired - Fee Related
- 1997-10-02 PT PT97910409T patent/PT929565E/pt unknown
- 1997-10-02 KR KR10-1999-7002942A patent/KR100487898B1/ko not_active Expired - Fee Related
- 1997-10-02 RU RU99108661/04A patent/RU2186781C2/ru not_active IP Right Cessation
- 1997-10-02 CN CNB97180284XA patent/CN1142939C/zh not_active Expired - Fee Related
- 1997-10-02 DK DK97910409T patent/DK0929565T3/da active
- 1997-10-02 HU HU9904149A patent/HUP9904149A3/hu unknown
-
2003
- 2003-06-17 US US10/462,637 patent/US7056905B2/en not_active Expired - Fee Related
-
2006
- 2006-03-14 US US11/374,220 patent/US7160871B2/en not_active Expired - Fee Related
- 2006-03-14 US US11/374,315 patent/US7196075B2/en not_active Expired - Fee Related
- 2006-03-14 US US11/374,219 patent/US7157450B2/en not_active Expired - Fee Related
- 2006-06-02 US US11/445,140 patent/US7205288B2/en not_active Expired - Fee Related
-
2007
- 2007-03-07 US US11/714,724 patent/US7368442B2/en not_active Expired - Fee Related
-
2008
- 2008-03-19 US US12/051,434 patent/US7605151B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE218142T1 (de) | Nitratester von corticoid verbindungen und die therapeutische verwendungen davon | |
| CY1108610T1 (el) | Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες | |
| DK0944643T3 (da) | Oxyiminopregnancarbolactoner. | |
| DE69735367D1 (de) | THERAPEUTISCHE MULTISPEZIFISCHE VERBINDUNGEN, DIE ANTIKÖRPER GEGEN DEN FCalpha-REZEPTOR ENTHALTEN | |
| TR200100918T2 (tr) | Aril ve heteroaril sübstitüentli üreler kullanılarak RAF kinazın inhibe edilmesi | |
| DE69812159D1 (de) | Derivate des adamantan | |
| ES2170252T3 (es) | Tetrahidroimidazopiridoindoldionas como inhibidores de cgmp especifico pde. | |
| FI935585A0 (fi) | Pyrrolopyrimidiner | |
| TR199901174T2 (xx) | Yeni heterosiklilmetil-ikameli pirazol t�revleri. | |
| IS4073A (is) | Nýtt fjölvirknislyf gegn aukningu mótstöðu | |
| DE69510940D1 (de) | Pyrazolo und pyrrolopyridine | |
| DK1193270T3 (da) | Pyrrolobenzodiazepiner | |
| BG103399A (en) | New heterocycle-substituted benzamides and their application for the treatment of diseases | |
| ATE126215T1 (de) | Anti-entzündende 4-aminophenol-derivate. | |
| ATE231872T1 (de) | Thiazolopyrimidinderivate | |
| BG103219A (bg) | Бензамидинови производни и използването им като лекарствени средства с ltb4-антагонистично действие | |
| DE69531098D1 (de) | Piperidine und pyrrolidine | |
| SE9902765D0 (sv) | Novel compounds | |
| RU95101375A (ru) | Производные n-(3-аминопропил)-n-фенил-5,6,7,8-тетрагидронафталин-2-карбоксамида, их получение и применение в терапии | |
| DE69907926D1 (de) | 1,2,4-triazol-3-thion verbindungen | |
| SE9902551D0 (sv) | Novel compounds | |
| TR199901385T2 (xx) | Piperidin t�revleri. | |
| GEP20002271B (en) | Bicyclic Tachykinins Antagonists, Pharmaceutical Composition on Its Basis and Their Use | |
| NO984651L (no) | Anvendelse av benzonaftalenderivater for fremstilling av medikamenter for behandling av sykdommer i sentralnervesystemet | |
| TR200000916T2 (tr) | İkameli piperidin türevleri. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |