ATE218142T1 - Nitratester von corticoid verbindungen und die therapeutische verwendungen davon - Google Patents
Nitratester von corticoid verbindungen und die therapeutische verwendungen davonInfo
- Publication number
- ATE218142T1 ATE218142T1 AT97910409T AT97910409T ATE218142T1 AT E218142 T1 ATE218142 T1 AT E218142T1 AT 97910409 T AT97910409 T AT 97910409T AT 97910409 T AT97910409 T AT 97910409T AT E218142 T1 ATE218142 T1 AT E218142T1
- Authority
- AT
- Austria
- Prior art keywords
- tester
- nitrate
- therapeutic uses
- compounds
- corticoid compounds
- Prior art date
Links
- 229910002651 NO3 Inorganic materials 0.000 title 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 title 1
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical class C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI002048A IT1285770B1 (it) | 1996-10-04 | 1996-10-04 | Composti corticoidei |
| PCT/EP1997/005426 WO1998015568A2 (en) | 1996-10-04 | 1997-10-02 | Nitrate esters of corticoid compounds and pharmaceutical applications thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE218142T1 true ATE218142T1 (de) | 2002-06-15 |
Family
ID=11374972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97910409T ATE218142T1 (de) | 1996-10-04 | 1997-10-02 | Nitratester von corticoid verbindungen und die therapeutische verwendungen davon |
Country Status (18)
| Country | Link |
|---|---|
| US (8) | US6610676B1 (de) |
| EP (1) | EP0929565B1 (de) |
| JP (1) | JP4388600B2 (de) |
| KR (1) | KR100487898B1 (de) |
| CN (1) | CN1142939C (de) |
| AT (1) | ATE218142T1 (de) |
| AU (1) | AU719250B2 (de) |
| BR (1) | BR9711586A (de) |
| CA (1) | CA2267630C (de) |
| DE (1) | DE69712900T2 (de) |
| DK (1) | DK0929565T3 (de) |
| ES (1) | ES2177952T3 (de) |
| HU (1) | HUP9904149A3 (de) |
| IT (1) | IT1285770B1 (de) |
| PT (1) | PT929565E (de) |
| RU (1) | RU2186781C2 (de) |
| SI (1) | SI0929565T1 (de) |
| WO (1) | WO1998015568A2 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824669A (en) | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| IT1285770B1 (it) * | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
| IT1311922B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1314184B1 (it) | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
| IT1320176B1 (it) * | 2000-12-22 | 2003-11-26 | Nicox Sa | Dispersioni solide di principi attivi nitrati. |
| EP1219306A1 (de) | 2000-12-29 | 2002-07-03 | Nicox S.A. | Zyklodextrin und NO-abgebende Arzneimittlen enthaltende Zusammensetzungen |
| US6696592B2 (en) | 2001-05-22 | 2004-02-24 | Nicox-S.A. | Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof |
| WO2003029268A1 (en) | 2001-10-03 | 2003-04-10 | Merck & Co., Inc. | Androstane 17-beta-carboxamides as androgen receptor modulators |
| ITMI20020148A1 (it) * | 2002-01-29 | 2003-07-29 | Nicox Sa | Nuovi corticosteroidi |
| RU2261481C2 (ru) * | 2003-03-26 | 2005-09-27 | ФГУ Омская государственная медицинская академия | Способ моделирования септического шока и полиорганной недостаточности у мелких лабораторных животных |
| CN100513415C (zh) * | 2005-08-03 | 2009-07-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 胆汁酸衍生物及其医药用途 |
| JP5216589B2 (ja) * | 2005-09-02 | 2013-06-19 | ニコックス エス エイ | ステロイドのニトロオキシ誘導体 |
| US8802726B2 (en) | 2006-02-03 | 2014-08-12 | Nicox S.A. | Use of nitrooxyderivative of drug for the treatment of muscular dystrophies |
| US7893058B2 (en) * | 2006-05-15 | 2011-02-22 | Janssen Pharmaceutica Nv | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
| RU2442790C2 (ru) | 2007-02-05 | 2012-02-20 | Никокс С.А. | Стероиды, высвобождающие оксид азота |
| JP2011501730A (ja) * | 2007-08-10 | 2011-01-13 | ニコックス エス エイ | 呼吸器系疾患を治療するためのニトロ誘導されたステロイドと気管支拡張剤との組合せ |
| WO2009071990A2 (en) * | 2007-08-31 | 2009-06-11 | Topigen Pharmaceuticals Inc. | No-donating cordicosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties |
| CA2731513C (en) * | 2008-07-31 | 2016-09-20 | Nicox S.A. | Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology |
| EP2321334A1 (de) * | 2008-08-05 | 2011-05-18 | Nicox S.A. | Neue no-freisetzende steroidderivate |
| CA2731520A1 (en) | 2008-08-05 | 2010-02-11 | Nicox S.A. | New no-releasing steroids for the treatment of retina and macula lutea diseases |
| CA2796963A1 (en) | 2010-04-23 | 2011-10-27 | Piramal Enterprises Limited | Nitric oxide releasing prodrugs of therapeutic agents |
| US8716268B2 (en) | 2010-06-07 | 2014-05-06 | Chao Liu | Nitrate esters of corticoid compounds useful as diuretics |
| CA2897571C (en) | 2013-01-21 | 2018-12-18 | Apparao Satyam | Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group |
| CN108191938B (zh) * | 2018-01-11 | 2019-07-05 | 湖南新合新生物医药有限公司 | 9,11烯烃甾族化合物的制备方法 |
| CN113069460B (zh) * | 2021-03-24 | 2022-02-08 | 兰州大学 | 哈西奈德及其衍生物用于制备治疗和/或预防脑血管疾病药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2990401A (en) * | 1958-06-18 | 1961-06-27 | American Cyanamid Co | 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids |
| US3172896A (en) * | 1963-05-01 | 1965-03-09 | Aminoethers of s-androstenes | |
| US3183252A (en) * | 1963-09-05 | 1965-05-11 | Syntex Corp | 16-nitratoalkyl-pregnanes |
| US3494941A (en) * | 1967-12-04 | 1970-02-10 | American Home Prod | Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones |
| HU164115B (de) * | 1971-05-07 | 1973-12-28 | ||
| GB1510617A (en) * | 1974-03-27 | 1978-05-10 | Plurichemie Anstalt | 16-methyl-9alpha-halo steroid esters and ethers and preparation thereof |
| CA1058161A (en) * | 1975-09-08 | 1979-07-10 | Ravi K. Varma | 3,20-DIKETOPREGNENES HAVING AN 11.beta.-ACETAL GROUP AND DERIVATIVES THEREOF |
| IT1256345B (it) | 1992-08-20 | 1995-12-01 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione | |
| IT1256450B (it) | 1992-11-26 | 1995-12-05 | Soldato Piero Del | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
| US5457207A (en) | 1993-10-05 | 1995-10-10 | Regents Of The University Of Minnesota | Spirovesamicols |
| DK0722434T3 (da) | 1993-10-06 | 1998-11-16 | Nicox Sa | Salpetersyreestere, der har anti-inflammatorisk og/eller analgetisk aktivitet og fremgangsmåder til deres fremstilling |
| ES2139199T3 (es) | 1994-05-10 | 2000-02-01 | Nicox Sa | Compuestos nitro y composiciones que los contienen que presentan una actividad anti-inflamatoria, analgesica y antitrombotica. |
| US5824669A (en) | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| US5837698A (en) * | 1996-05-02 | 1998-11-17 | G. D. Searle & Co. | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs |
| US5985862A (en) * | 1996-05-02 | 1999-11-16 | G.D. Searle & Co. | Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs |
| IT1285770B1 (it) * | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
-
1996
- 1996-10-04 IT IT96MI002048A patent/IT1285770B1/it active IP Right Grant
-
1997
- 1997-10-02 RU RU99108661/04A patent/RU2186781C2/ru not_active IP Right Cessation
- 1997-10-02 EP EP97910409A patent/EP0929565B1/de not_active Expired - Lifetime
- 1997-10-02 DK DK97910409T patent/DK0929565T3/da active
- 1997-10-02 WO PCT/EP1997/005426 patent/WO1998015568A2/en not_active Ceased
- 1997-10-02 HU HU9904149A patent/HUP9904149A3/hu unknown
- 1997-10-02 PT PT97910409T patent/PT929565E/pt unknown
- 1997-10-02 CN CNB97180284XA patent/CN1142939C/zh not_active Expired - Fee Related
- 1997-10-02 JP JP51715498A patent/JP4388600B2/ja not_active Expired - Fee Related
- 1997-10-02 DE DE69712900T patent/DE69712900T2/de not_active Expired - Lifetime
- 1997-10-02 SI SI9730333T patent/SI0929565T1/xx unknown
- 1997-10-02 US US09/269,729 patent/US6610676B1/en not_active Expired - Fee Related
- 1997-10-02 AT AT97910409T patent/ATE218142T1/de active
- 1997-10-02 KR KR10-1999-7002942A patent/KR100487898B1/ko not_active Expired - Fee Related
- 1997-10-02 ES ES97910409T patent/ES2177952T3/es not_active Expired - Lifetime
- 1997-10-02 CA CA002267630A patent/CA2267630C/en not_active Expired - Fee Related
- 1997-10-02 BR BR9711586A patent/BR9711586A/pt not_active Application Discontinuation
- 1997-10-02 AU AU47803/97A patent/AU719250B2/en not_active Ceased
-
2003
- 2003-06-17 US US10/462,637 patent/US7056905B2/en not_active Expired - Fee Related
-
2006
- 2006-03-14 US US11/374,315 patent/US7196075B2/en not_active Expired - Fee Related
- 2006-03-14 US US11/374,220 patent/US7160871B2/en not_active Expired - Fee Related
- 2006-03-14 US US11/374,219 patent/US7157450B2/en not_active Expired - Fee Related
- 2006-06-02 US US11/445,140 patent/US7205288B2/en not_active Expired - Fee Related
-
2007
- 2007-03-07 US US11/714,724 patent/US7368442B2/en not_active Expired - Fee Related
-
2008
- 2008-03-19 US US12/051,434 patent/US7605151B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |