IT1256345B - Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione - Google Patents
Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazioneInfo
- Publication number
- IT1256345B IT1256345B ITMI922006A ITMI922006A IT1256345B IT 1256345 B IT1256345 B IT 1256345B IT MI922006 A ITMI922006 A IT MI922006A IT MI922006 A ITMI922006 A IT MI922006A IT 1256345 B IT1256345 B IT 1256345B
- Authority
- IT
- Italy
- Prior art keywords
- halo
- preparation
- phenylacetic
- derivatives
- phenylamin
- Prior art date
Links
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
Abstract
La presente invenzione ha per oggetto esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino)fenilacetico aventi la seguente formula generale: (FORMULA I) Loro impiego farmaceutico e procedimento per la loro preparazione
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI922006A IT1256345B (it) | 1992-08-20 | 1992-08-20 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione |
UA94005348A UA39172C2 (uk) | 1992-08-20 | 1993-07-20 | Похідні 2-(2,6-дигалофеніламіно) фенілоцтової кислоти і спосіб їх одержання |
ES93917596T ES2093979T3 (es) | 1992-08-20 | 1993-07-20 | Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino)fenilacetico y su procedimiento de preparacion. |
US08/211,447 US5597847A (en) | 1992-08-20 | 1993-07-20 | Nitric esters of derivatives of the 2-(2,6-di-halo-phenylamino) phenylacetic acid and process for their preparation |
EP93917596A EP0609415B1 (en) | 1992-08-20 | 1993-07-20 | Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation |
DE69305322T DE69305322T2 (de) | 1992-08-20 | 1993-07-20 | Salpetersäureester von 2-(2,6-dihalophenylamino)phenylessigsäurederivaten und verfahren zu ihrer herstellung |
KR1019940701286A KR100269727B1 (ko) | 1992-08-20 | 1993-07-20 | 2-(2,6-디-할로페닐아미노)페닐아세트산의 유도체의 니트릭에스테르 및 그들의 제조방법 |
AT93917596T ATE143941T1 (de) | 1992-08-20 | 1993-07-20 | Salpetersäureester von 2-(2,6- dihalophenylamino)phenylessigsäurederivaten und verfahren zu ihrer herstellung |
DK93917596.4T DK0609415T3 (da) | 1992-08-20 | 1993-07-20 | Salpetersyreestere af 2-(2,6-di-halogen-phenylamino)phenyleddikesyrederivater og fremgangsmåde til deres fremstilling |
JP50582694A JP3231042B2 (ja) | 1992-08-20 | 1993-07-20 | 2−(2,6−ジ−ハロ−フェニルアミノ)フェニル酢酸の誘導体の硝酸エステルおよびその製造法 |
RU94046148A RU2109009C1 (ru) | 1992-08-20 | 1993-07-20 | Производные 2-(2,6-дигалофениламино)фенилуксусной кислоты и способ их получения |
PCT/EP1993/001906 WO1994004484A1 (en) | 1992-08-20 | 1993-07-20 | Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation |
CA002120942A CA2120942C (en) | 1992-08-20 | 1993-07-20 | Nitric esters of derivatives of the 2-(2,6-di-halo-phenylamino)phenyl-acetic acid and process for their preparation |
GR960402711T GR3021404T3 (en) | 1992-08-20 | 1996-10-21 | Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation. |
HK98106190A HK1006967A1 (en) | 1992-08-20 | 1998-06-23 | Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI922006A IT1256345B (it) | 1992-08-20 | 1992-08-20 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI922006A0 ITMI922006A0 (it) | 1992-08-20 |
ITMI922006A1 ITMI922006A1 (it) | 1994-02-20 |
IT1256345B true IT1256345B (it) | 1995-12-01 |
Family
ID=11363881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI922006A IT1256345B (it) | 1992-08-20 | 1992-08-20 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione |
Country Status (15)
Country | Link |
---|---|
US (1) | US5597847A (it) |
EP (1) | EP0609415B1 (it) |
JP (1) | JP3231042B2 (it) |
KR (1) | KR100269727B1 (it) |
AT (1) | ATE143941T1 (it) |
CA (1) | CA2120942C (it) |
DE (1) | DE69305322T2 (it) |
DK (1) | DK0609415T3 (it) |
ES (1) | ES2093979T3 (it) |
GR (1) | GR3021404T3 (it) |
HK (1) | HK1006967A1 (it) |
IT (1) | IT1256345B (it) |
RU (1) | RU2109009C1 (it) |
UA (1) | UA39172C2 (it) |
WO (1) | WO1994004484A1 (it) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE168986T1 (de) * | 1993-10-06 | 1998-08-15 | Nicox Sa | Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung |
CA2190087C (en) * | 1994-05-10 | 2005-08-02 | Piero Del Soldato | Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities |
ES2092962B1 (es) * | 1995-04-19 | 1997-07-16 | Prodes Sa | Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino) fenilacetoxiacetico y sus procedimientos de preparacion. |
US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
US6043232A (en) * | 1997-07-23 | 2000-03-28 | Nitromed, Inc. | Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
US5792758A (en) * | 1995-12-08 | 1998-08-11 | G. D. Searle & Co. | Steroid nitrite ester derivatives useful as anti-inflammatory drugs |
SE9600070D0 (sv) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
US6355680B1 (en) * | 1996-02-20 | 2002-03-12 | Exocell, Inc. | Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies |
IT1282686B1 (it) | 1996-02-26 | 1998-03-31 | Nicox Sa | Composti in grado di ridurre la tossicita' da farmaci |
AU714258B2 (en) * | 1996-08-16 | 1999-12-23 | Handforth Investments Ltd. | Non-ulcerogenic analgesic/antiinflammatory clonixin derivative |
IT1288123B1 (it) * | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
IT1285770B1 (it) | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
IT1295694B1 (it) | 1996-11-14 | 1999-05-27 | Nicox Sa | Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica |
FR2757159B1 (fr) * | 1996-12-12 | 1999-12-17 | Hoechst Marion Roussel Inc | Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments |
CO4960662A1 (es) | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
EP1126838A4 (en) | 1998-10-30 | 2005-02-16 | Nitromed Inc | NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE |
IT1308633B1 (it) * | 1999-03-02 | 2002-01-09 | Nicox Sa | Nitrossiderivati. |
IT1311923B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
TWI243672B (en) * | 1999-06-01 | 2005-11-21 | Astrazeneca Ab | New use of compounds as antibacterial agents |
IT1312115B1 (it) * | 1999-06-24 | 2002-04-04 | Nicox Sa | Composti amorfi e relative composizioni farmaceutiche |
IT1314184B1 (it) * | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
US6713454B1 (en) | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
US6436990B1 (en) | 1999-10-27 | 2002-08-20 | Nobex Corporation | 6-methoxy-2-naphthylacetic acid prodrugs |
TWI262791B (en) | 1999-10-27 | 2006-10-01 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
US6552078B2 (en) | 1999-10-27 | 2003-04-22 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
AP2002002582A0 (en) | 1999-12-23 | 2002-09-30 | Nitromed Inc | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
SE0000773D0 (sv) * | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
SE0000774D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
IT1319201B1 (it) * | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per il diabete. |
IT1319202B1 (it) | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per le malattie a base infiammatoria. |
WO2002060378A2 (en) | 2000-12-21 | 2002-08-08 | Nitromed, Inc. | Substituted aryl compounds as cyclooxygenase-2 selective inhibitors, compositions and methods of use |
ITMI20010985A1 (it) * | 2001-05-15 | 2002-11-15 | Nicox Sa | Farmaci per il morbo di alzheimer |
ITMI20011744A1 (it) * | 2001-08-09 | 2003-02-09 | Nicox Sa | Farmaci per le vasculopatie |
SE0102993D0 (sv) | 2001-09-07 | 2001-09-07 | Astrazeneca Ab | New self emulsifying drug delivery system |
AU2003248642A1 (en) | 2002-06-11 | 2003-12-22 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
JP2005535642A (ja) | 2002-06-28 | 2005-11-24 | ニトロメッド インコーポレーティッド | オキシムおよび/またはヒドラゾンを含有するニトロソ化および/またはニトロシル化シクロオキシゲナーゼ−2選択的阻害剤、組成物、および使用方法 |
CA2491127A1 (en) | 2002-07-03 | 2004-01-15 | Nitromed, Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
AU2003261281A1 (en) | 2002-07-29 | 2004-02-16 | Nicox S.A. | Cyclooxygenase- 2 selective inhibitors, compositions and methods of use |
SE0203093D0 (en) * | 2002-10-18 | 2002-10-18 | Astrazeneca Uk Ltd | New use |
PE20040844A1 (es) | 2002-11-26 | 2004-12-30 | Novartis Ag | Acidos fenilaceticos y derivados como inhibidores de la cox-2 |
WO2006041855A2 (en) | 2004-10-04 | 2006-04-20 | Nitromed, Inc. | Compositions and methods using apocynin compounds and nitric oxide donors |
AR061623A1 (es) | 2006-06-26 | 2008-09-10 | Novartis Ag | Derivados de acido fenilacetico |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3558690A (en) * | 1965-04-08 | 1971-01-26 | Gelgy Chemical Corp | Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation |
DE3407507A1 (de) * | 1984-03-01 | 1985-09-05 | A. Nattermann & Cie GmbH, 5000 Köln | Neue o-(2,6-dichloranilino)-phenylessigsaeureester, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
US5021576A (en) * | 1989-10-27 | 1991-06-04 | American Home Products Corporation | 2-Anilino phenylacetic acid derivatives |
-
1992
- 1992-08-20 IT ITMI922006A patent/IT1256345B/it active IP Right Grant
-
1993
- 1993-07-20 RU RU94046148A patent/RU2109009C1/ru not_active IP Right Cessation
- 1993-07-20 UA UA94005348A patent/UA39172C2/uk unknown
- 1993-07-20 KR KR1019940701286A patent/KR100269727B1/ko not_active IP Right Cessation
- 1993-07-20 EP EP93917596A patent/EP0609415B1/en not_active Expired - Lifetime
- 1993-07-20 CA CA002120942A patent/CA2120942C/en not_active Expired - Fee Related
- 1993-07-20 DE DE69305322T patent/DE69305322T2/de not_active Expired - Lifetime
- 1993-07-20 ES ES93917596T patent/ES2093979T3/es not_active Expired - Lifetime
- 1993-07-20 AT AT93917596T patent/ATE143941T1/de not_active IP Right Cessation
- 1993-07-20 JP JP50582694A patent/JP3231042B2/ja not_active Expired - Fee Related
- 1993-07-20 WO PCT/EP1993/001906 patent/WO1994004484A1/en active IP Right Grant
- 1993-07-20 DK DK93917596.4T patent/DK0609415T3/da active
- 1993-07-20 US US08/211,447 patent/US5597847A/en not_active Expired - Lifetime
-
1996
- 1996-10-21 GR GR960402711T patent/GR3021404T3/el unknown
-
1998
- 1998-06-23 HK HK98106190A patent/HK1006967A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
UA39172C2 (uk) | 2001-06-15 |
EP0609415B1 (en) | 1996-10-09 |
RU2109009C1 (ru) | 1998-04-20 |
CA2120942C (en) | 2005-09-27 |
DK0609415T3 (da) | 1996-11-18 |
ATE143941T1 (de) | 1996-10-15 |
US5597847A (en) | 1997-01-28 |
JP3231042B2 (ja) | 2001-11-19 |
CA2120942A1 (en) | 1994-03-03 |
ES2093979T3 (es) | 1997-01-01 |
JPH07500355A (ja) | 1995-01-12 |
EP0609415A1 (en) | 1994-08-10 |
ITMI922006A1 (it) | 1994-02-20 |
KR100269727B1 (ko) | 2000-10-16 |
DE69305322T2 (de) | 1997-02-20 |
WO1994004484A1 (en) | 1994-03-03 |
DE69305322D1 (de) | 1996-11-14 |
GR3021404T3 (en) | 1997-01-31 |
HK1006967A1 (en) | 1999-03-26 |
ITMI922006A0 (it) | 1992-08-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IT1256345B (it) | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione | |
NO180719C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive A-nor-steroid-3-carboxylsyrederivater | |
IT1256450B (it) | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione | |
IT1254915B (it) | Derivati di adenosina ad attivita' a2 agonista | |
FI951614A (fi) | D-vitamiinisarjan 25-karboksyylihappojohdannaisia, menetelmät niiden valmistamiseksi, näissä menetelmissä käytettävät välituotteet, näitä johdansia sisältävät farmaseuttiset valmisteet ja näiden johdannaisten käyttö lääkeaineiden valmistukseen | |
PT89111A (pt) | Processo de preparacao de analogos de camptotecina hidrossoluveis, dos seus intermediarios e de composicoes que os contem | |
ATE131173T1 (de) | Fluorierte gallensäure-derivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen daraus. | |
TNSN87012A1 (fr) | Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques | |
IT8847794A0 (it) | Derivati dell'acido furanuronico, loro preparazione e loro impiego come medicamenti | |
PT90351A (pt) | Processo de preparacao de derivados da fenilpiridona e de composicoes farmaceuticas que os contem | |
IT1255704B (it) | Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree | |
IT8748404A0 (it) | O-alcanoil derivati dell'acido 3ammino-2-idrossipropansolfonico adattivita'anticonvulsivante e loro composizioni farmaceutiche per il trattamento terapeutico dell'epilessia | |
IT1190987B (it) | Tioesteri dell'acido acetilsalicilico,procedimento per la loro preparazione e composizioni farmaceutiche che li conttengono | |
SE8107524L (sv) | Heterocykliska foreningar | |
IT1193955B (it) | Derivati ammidici dell'acido p-isobutilfenilpropionico, procedimento per la loro preparazione e relative composizioni farmaceutici | |
IT8620703A1 (it) | Derivati dell'acido 4-fenil 4-osso 2-butenoico, loro procedimento di preparazione e loro impiego come prodotti medicinali | |
ITMI920560A1 (it) | Procedimento per la preparazione di acido iodesossicolico ad elevata purezza per impiego farmaceutico | |
IT1122375B (it) | Esteri o-alcossicarbonfenilici dell'acido antranilico ad attivita'terapeutica,metodo per la loro preparazione e relative composizioni farmaceutiche | |
IT1199994B (it) | Derivati dell'acido d-2-(6-metossi-2-naftil)-propionico ad attivita'terapeutica,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono | |
ES8300747A1 (es) | Procedimiento para la preparacion de derivados de acido in- dolacetico | |
ATE210445T1 (de) | Verwendung von 2-aminopurinderivaten zur behandlung und prophylaxe der menschlichen herpesvirus 7 infektionen | |
IT8719093A0 (it) | Derivati di esteri dell'acido immidazol-1-il-carbossilico, procedimenti per la loro preparazione e composizioni fungicide che contengono il derivato come componente attivo. | |
ITMI910581A0 (it) | Derivati dell'acido 5-fenil-1h-pirazol-4-propionico, loro preparazione e loro impiego come medicamenti | |
IT1263913B (it) | Composti terapeuticamente attivi, utili per il trattamento di malattieconnesse con alterata funzionalita' del sistema immunitario, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono | |
ATE210985T1 (de) | Verwendung von 2-aminopurinderivaten zur behandlung und prophylaxe der menschlichen herpesvirus 6 infektionen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970723 |