IT1282686B1 - Composti in grado di ridurre la tossicita' da farmaci - Google Patents
Composti in grado di ridurre la tossicita' da farmaciInfo
- Publication number
- IT1282686B1 IT1282686B1 IT96MI000352A ITMI960352A IT1282686B1 IT 1282686 B1 IT1282686 B1 IT 1282686B1 IT 96MI000352 A IT96MI000352 A IT 96MI000352A IT MI960352 A ITMI960352 A IT MI960352A IT 1282686 B1 IT1282686 B1 IT 1282686B1
- Authority
- IT
- Italy
- Prior art keywords
- compounds
- drug toxicity
- reduce drug
- reduce
- compounds containing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI000352A IT1282686B1 (it) | 1996-02-26 | 1996-02-26 | Composti in grado di ridurre la tossicita' da farmaci |
ES97906115T ES2180938T3 (es) | 1996-02-26 | 1997-02-24 | Donadores de oxido nitrico capaces de reducir la toxicidad de los farmacos. |
DE69714253T DE69714253T2 (de) | 1996-02-26 | 1997-02-24 | Stickstoffoxydabgebendes präparat zur reduzierung der toxizität von wirkstoffen |
RU98117618/14A RU2192247C2 (ru) | 1996-02-26 | 1997-02-24 | Доноры окиси азота, способные снижать токсичность от лекарственных препаратов |
DK97906115T DK0904110T3 (da) | 1996-02-26 | 1997-02-24 | Nitrogenoxid-afgivende sammensætninger til nedsættelse af lægemidlers toksicitet |
AT97906115T ATE220920T1 (de) | 1996-02-26 | 1997-02-24 | Stickstoffoxydabgebendes präparat zur reduzierung der toxizität von wirkstoffen |
PCT/EP1997/000873 WO1997031654A1 (en) | 1996-02-26 | 1997-02-24 | Nitric oxide donors capable of reducing toxicity from drugs |
BR9707739A BR9707739A (pt) | 1996-02-26 | 1997-02-24 | Utilizacão de compostos orgânicos |
KR1019980706501A KR19990087113A (ko) | 1996-02-26 | 1997-02-24 | 약품으로 인한 독성을 경감할 수 있는 산화질소 도너 |
SI9730286T SI0904110T1 (en) | 1996-02-26 | 1997-02-24 | Nitric oxide donors capable of reducing toxicity from drugs |
PT97906115T PT904110E (pt) | 1996-02-26 | 1997-02-24 | Dadores de oxido nitrico capazes de reduzir a toxicidade causada por farmacos |
CA002247848A CA2247848C (en) | 1996-02-26 | 1997-02-24 | Nitric oxide donors capable of reducing toxicity from drugs |
JP9530576A JP2000506133A (ja) | 1996-02-26 | 1997-02-24 | 薬剤由来の毒性を減少させることができる酸化窒素供与体 |
EP97906115A EP0904110B1 (en) | 1996-02-26 | 1997-02-24 | Nitric oxide donors capable of reducing toxicity from drugs |
HU9900993A HUP9900993A3 (en) | 1996-02-26 | 1997-02-24 | Nitric oxide donors capable of reducing toxicity from drugs |
AU20924/97A AU706591B2 (en) | 1996-02-26 | 1997-02-24 | Nitric oxide donors capable of reducing toxicity from drugs |
EP02008079A EP1221326A3 (en) | 1996-02-26 | 1997-02-24 | Nitric oxide donors capable of reducing toxicity from drugs |
US10/885,121 US7087588B2 (en) | 1996-02-26 | 2004-07-07 | Nitric oxide donors capable of reducing toxicity from drugs |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI000352A IT1282686B1 (it) | 1996-02-26 | 1996-02-26 | Composti in grado di ridurre la tossicita' da farmaci |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI960352A0 ITMI960352A0 (it) | 1996-02-26 |
ITMI960352A1 ITMI960352A1 (it) | 1997-08-26 |
IT1282686B1 true IT1282686B1 (it) | 1998-03-31 |
Family
ID=11373387
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT96MI000352A IT1282686B1 (it) | 1996-02-26 | 1996-02-26 | Composti in grado di ridurre la tossicita' da farmaci |
Country Status (16)
Country | Link |
---|---|
US (1) | US7087588B2 (it) |
EP (2) | EP0904110B1 (it) |
JP (1) | JP2000506133A (it) |
KR (1) | KR19990087113A (it) |
AT (1) | ATE220920T1 (it) |
AU (1) | AU706591B2 (it) |
BR (1) | BR9707739A (it) |
CA (1) | CA2247848C (it) |
DE (1) | DE69714253T2 (it) |
DK (1) | DK0904110T3 (it) |
ES (1) | ES2180938T3 (it) |
HU (1) | HUP9900993A3 (it) |
IT (1) | IT1282686B1 (it) |
PT (1) | PT904110E (it) |
RU (1) | RU2192247C2 (it) |
WO (1) | WO1997031654A1 (it) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6043232A (en) * | 1997-07-23 | 2000-03-28 | Nitromed, Inc. | Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
GB9801398D0 (en) | 1998-01-22 | 1998-03-18 | Anggard Erik E | Chemical compounds |
IT1298338B1 (it) * | 1998-03-05 | 1999-12-20 | Nicox Sa | Composizioni farmaceutiche per l'ulcera |
AU763000B2 (en) | 1998-10-30 | 2003-07-10 | Nicox S.A. | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use |
TWI243672B (en) * | 1999-06-01 | 2005-11-21 | Astrazeneca Ab | New use of compounds as antibacterial agents |
US6552078B2 (en) | 1999-10-27 | 2003-04-22 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
TWI262791B (en) | 1999-10-27 | 2006-10-01 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
US6436990B1 (en) | 1999-10-27 | 2002-08-20 | Nobex Corporation | 6-methoxy-2-naphthylacetic acid prodrugs |
MXPA02006312A (es) | 1999-12-23 | 2004-06-21 | Nitromed Inc | Inhibidores de ciclooxigenasa-2 nitrosilatados y nitrosados, composiciones y metodos para utilizarse. |
JP2004508279A (ja) * | 2000-01-26 | 2004-03-18 | シーダース シナイ メディカル センター | 薬剤を異常脳領域及び/又は悪性腫瘍にデリバリーするためにカリウムチャンネル活性化を用いる方法 |
US7018979B1 (en) | 2000-01-26 | 2006-03-28 | Cedars-Sinai Medical Center | Method for using potassium channel agonists for delivering a medicant to an abnormal brain region and/or a malignant tumor |
EP1406609B1 (en) | 2000-12-21 | 2006-09-06 | Nitromed, Inc. | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
EP1219306A1 (en) * | 2000-12-29 | 2002-07-03 | Nicox S.A. | Compositions comprising cyclodextrins and NO- releasing drugs |
US7211561B2 (en) | 2001-10-12 | 2007-05-01 | Cedars-Sinai Medical Center | Method for inducing selective cell death of malignant cells by activation of calcium-activated potassium channels (KCa) |
DE60302454T2 (de) | 2002-04-19 | 2006-08-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Beta-agonisten-verbindungen mit stickoxid-donatoren-gruppen und reaktionsfähige sauerstoffspezies-fängergruppen und ihre verwendung bei der behandlung von atemwegsstörungen |
CA2487414A1 (en) | 2002-06-11 | 2003-12-18 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
JP2005535642A (ja) | 2002-06-28 | 2005-11-24 | ニトロメッド インコーポレーティッド | オキシムおよび/またはヒドラゾンを含有するニトロソ化および/またはニトロシル化シクロオキシゲナーゼ−2選択的阻害剤、組成物、および使用方法 |
WO2004004648A2 (en) | 2002-07-03 | 2004-01-15 | Nitromed, Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
US7244753B2 (en) | 2002-07-29 | 2007-07-17 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
SE0300971D0 (sv) * | 2003-04-03 | 2003-04-03 | Aga Ab | Nitric oxide in treatment of inflammation |
CA2554332A1 (en) * | 2004-01-27 | 2005-08-04 | Merck Frosst Company | Combination therapy for treating cyclooxygenase-2 mediated diseases or conditions in patients at risk of thrombotic cardiovascular events |
DE602005018222D1 (it) * | 2004-06-10 | 2010-01-21 | Nippon Kayaku Kk | |
JP2007325501A (ja) * | 2004-08-25 | 2007-12-20 | Tottori Univ | 非ステロイド性抗炎症薬による動物の消化管副作用の予防・治療方法 |
AU2006249323B2 (en) | 2005-05-27 | 2012-08-30 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications |
US20100240745A1 (en) * | 2009-03-20 | 2010-09-23 | Nicox S.A. | Method of treatment of inflammation in hypertensive patients |
CN102711729B (zh) | 2009-08-21 | 2015-04-01 | 诺万公司 | 局部用凝胶 |
DK2467173T3 (da) | 2009-08-21 | 2019-07-29 | Novan Inc | Sårbandager, fremgangsmåder til anvendelse heraf og fremgangsmåder til dannelse deraf |
US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
EP2681286B1 (en) | 2011-02-28 | 2018-08-15 | Novan, Inc. | Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same |
JO3350B1 (ar) | 2011-03-07 | 2019-03-13 | Merck Sharp & Dohme | مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات |
RU2539630C1 (ru) * | 2013-07-09 | 2015-01-20 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Способ профилактики ишемии сетчатки в эксперименте |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5570683A (en) * | 1990-12-05 | 1996-11-05 | The General Hospital Corporation | Methods and devices for treating pulmonary vasoconstriction and asthma |
IT1256345B (it) | 1992-08-20 | 1995-12-01 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione | |
IT1256450B (it) | 1992-11-26 | 1995-12-05 | Soldato Piero Del | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
US5700947A (en) | 1993-10-06 | 1997-12-23 | Nicox S.A. | Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation |
EP0759899B1 (en) | 1994-05-10 | 1999-09-15 | Nicox S.A. | Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities |
US5597809A (en) * | 1994-06-23 | 1997-01-28 | Massachusetts Eye & Ear Infirmary | Treatment of optic neuritis |
US5703073A (en) | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
US5620416A (en) | 1995-06-07 | 1997-04-15 | North Carolina State University | Methods of using topical agents with systemically administered active agents |
-
1996
- 1996-02-26 IT IT96MI000352A patent/IT1282686B1/it active IP Right Grant
-
1997
- 1997-02-24 ES ES97906115T patent/ES2180938T3/es not_active Expired - Lifetime
- 1997-02-24 PT PT97906115T patent/PT904110E/pt unknown
- 1997-02-24 KR KR1019980706501A patent/KR19990087113A/ko not_active Application Discontinuation
- 1997-02-24 EP EP97906115A patent/EP0904110B1/en not_active Revoked
- 1997-02-24 WO PCT/EP1997/000873 patent/WO1997031654A1/en not_active Application Discontinuation
- 1997-02-24 RU RU98117618/14A patent/RU2192247C2/ru not_active IP Right Cessation
- 1997-02-24 CA CA002247848A patent/CA2247848C/en not_active Expired - Fee Related
- 1997-02-24 AU AU20924/97A patent/AU706591B2/en not_active Ceased
- 1997-02-24 JP JP9530576A patent/JP2000506133A/ja active Pending
- 1997-02-24 BR BR9707739A patent/BR9707739A/pt not_active Application Discontinuation
- 1997-02-24 HU HU9900993A patent/HUP9900993A3/hu unknown
- 1997-02-24 DE DE69714253T patent/DE69714253T2/de not_active Revoked
- 1997-02-24 DK DK97906115T patent/DK0904110T3/da active
- 1997-02-24 AT AT97906115T patent/ATE220920T1/de not_active IP Right Cessation
- 1997-02-24 EP EP02008079A patent/EP1221326A3/en not_active Withdrawn
-
2004
- 2004-07-07 US US10/885,121 patent/US7087588B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2247848C (en) | 2008-07-15 |
CA2247848A1 (en) | 1997-09-04 |
EP0904110B1 (en) | 2002-07-24 |
EP1221326A2 (en) | 2002-07-10 |
DE69714253T2 (de) | 2003-03-06 |
RU2192247C2 (ru) | 2002-11-10 |
HUP9900993A2 (hu) | 1999-09-28 |
JP2000506133A (ja) | 2000-05-23 |
EP0904110A1 (en) | 1999-03-31 |
HUP9900993A3 (en) | 2000-10-30 |
PT904110E (pt) | 2002-12-31 |
DK0904110T3 (da) | 2002-11-11 |
EP1221326A3 (en) | 2004-01-14 |
ITMI960352A0 (it) | 1996-02-26 |
US20040242651A1 (en) | 2004-12-02 |
KR19990087113A (ko) | 1999-12-15 |
WO1997031654A1 (en) | 1997-09-04 |
ITMI960352A1 (it) | 1997-08-26 |
AU706591B2 (en) | 1999-06-17 |
ES2180938T3 (es) | 2003-02-16 |
DE69714253D1 (de) | 2002-08-29 |
US7087588B2 (en) | 2006-08-08 |
BR9707739A (pt) | 1999-07-27 |
AU2092497A (en) | 1997-09-16 |
ATE220920T1 (de) | 2002-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |