DE3887014T2 - Nukleoside, ihre Herstellung und pharmazeutische Zusammenstellungen. - Google Patents

Nukleoside, ihre Herstellung und pharmazeutische Zusammenstellungen.

Info

Publication number
DE3887014T2
DE3887014T2 DE3887014T DE3887014T DE3887014T2 DE 3887014 T2 DE3887014 T2 DE 3887014T2 DE 3887014 T DE3887014 T DE 3887014T DE 3887014 T DE3887014 T DE 3887014T DE 3887014 T2 DE3887014 T2 DE 3887014T2
Authority
DE
Germany
Prior art keywords
nucleosides
preparation
pharmaceutical compositions
infections
dideoxynucleosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3887014T
Other languages
English (en)
Other versions
DE3887014D1 (de
Inventor
Samuel Broder
Hiroaki Mitsuya
Steve Tam
Manfred Weigele
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
US Department of Health and Human Services
Original Assignee
F Hoffmann La Roche AG
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, US Department of Health and Human Services filed Critical F Hoffmann La Roche AG
Publication of DE3887014D1 publication Critical patent/DE3887014D1/de
Application granted granted Critical
Publication of DE3887014T2 publication Critical patent/DE3887014T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE3887014T 1987-06-22 1988-06-22 Nukleoside, ihre Herstellung und pharmazeutische Zusammenstellungen. Expired - Fee Related DE3887014T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/064,631 US4837311A (en) 1987-06-22 1987-06-22 Anti-retroviral compounds

Publications (2)

Publication Number Publication Date
DE3887014D1 DE3887014D1 (de) 1994-02-24
DE3887014T2 true DE3887014T2 (de) 1994-05-19

Family

ID=22057259

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3887014T Expired - Fee Related DE3887014T2 (de) 1987-06-22 1988-06-22 Nukleoside, ihre Herstellung und pharmazeutische Zusammenstellungen.

Country Status (6)

Country Link
US (1) US4837311A (de)
EP (1) EP0296573B1 (de)
JP (1) JPH02262587A (de)
AT (1) ATE100098T1 (de)
DE (1) DE3887014T2 (de)
DK (1) DK336688A (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187163A (en) * 1987-03-27 1993-02-16 Baker Norton Pharmaceuticals, Inc. Anti-viral compounds, dosage forms and methods
ZA886890B (en) * 1987-10-09 1989-05-30 Hoffmann La Roche Novel dideoxycytidine derivatives
FR2631964B1 (fr) * 1988-05-31 1990-09-07 Pasteur Institut Glucosyl phosphotriesters de derives de thymidine ayant une activite contre les retrovirus
US5216141A (en) * 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
USRE38416E1 (en) 1988-09-28 2004-02-03 Epoch Biosciences, Inc. Cross-linking oligonucleotides
US5849482A (en) * 1988-09-28 1998-12-15 Epoch Pharmaceuticals, Inc. Crosslinking oligonucleotides
US5824796A (en) * 1988-09-28 1998-10-20 Epoch Pharmaceuticals, Inc. Cross-linking oligonucleotides
NZ232912A (en) * 1989-03-17 1992-06-25 Oncogen Ltd Lp Synergistic composition of nucleoside derivatives for inhibiting hiv
US5585364A (en) * 1989-04-13 1996-12-17 British Technology Group Limited Antiviral compounds
WO1990014353A1 (en) * 1989-05-18 1990-11-29 Microprobe Corporation Crosslinking oligonucleotides
JPH05505941A (ja) * 1990-03-29 1993-09-02 ギリード　サイエンシズ　インコーポレーテッド オリゴヌクレオチド―輸送剤ジスルフィド結合体
US5430138A (en) * 1990-07-27 1995-07-04 Chiron Corporation Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable
US5561225A (en) * 1990-09-19 1996-10-01 Southern Research Institute Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
JPH06510020A (ja) * 1991-03-29 1994-11-10 ユニバーシティ・オブ・フロリダ 混成リン酸エステル誘導体を経た標的への薬剤供給
EP0550714B1 (de) * 1991-06-21 1996-02-28 Acic (Canada) Inc. Verfahren zur herstellung von zidovudine
US6136601A (en) * 1991-08-21 2000-10-24 Epoch Pharmaceuticals, Inc. Targeted mutagenesis in living cells using modified oligonucleotides
US5693791A (en) * 1995-04-11 1997-12-02 Truett; William L. Antibiotics and process for preparation
WO1999028308A1 (en) * 1997-11-29 1999-06-10 Truett William L Antibiotics and process for preparation
KR101004224B1 (ko) 2002-02-01 2010-12-27 어리어드 파마슈티칼스, 인코포레이티드 인 함유 화합물 및 이의 용도
IL149298A0 (en) * 2002-04-23 2002-11-10 Lycored Natural Prod Ind Ltd Tomato product and method for obtaining same
JP5116972B2 (ja) * 2002-12-12 2013-01-09 イデニクス（ケイマン）リミテツド ２’−分枝ヌクレオシドの製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
AU578809B2 (en) * 1985-03-16 1988-11-03 Wellcome Foundation Limited, The Therapeutic nucleosides
NZ216172A (en) * 1985-05-15 1989-08-29 Wellcome Found Nucleosides and pharmaceutical compositions
ATE190064T1 (de) * 1985-09-17 2000-03-15 Wellcome Found Kombination therapeutische nukleoside mit weiteren therapeutisch wirksamen komponenten.
CA1330794C (en) * 1987-03-27 1994-07-19 Phillip Frost Anti-viral compounds, dosage forms and methods

Also Published As

Publication number Publication date
DK336688A (da) 1988-12-23
JPH02262587A (ja) 1990-10-25
EP0296573A3 (en) 1990-07-04
DE3887014D1 (de) 1994-02-24
ATE100098T1 (de) 1994-01-15
EP0296573B1 (de) 1994-01-12
EP0296573A2 (de) 1988-12-28
DK336688D0 (da) 1988-06-20
US4837311A (en) 1989-06-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee