DE3650130T3 - Antivirale Nukleoside. - Google Patents
Antivirale Nukleoside.Info
- Publication number
- DE3650130T3 DE3650130T3 DE3650130T DE3650130T DE3650130T3 DE 3650130 T3 DE3650130 T3 DE 3650130T3 DE 3650130 T DE3650130 T DE 3650130T DE 3650130 T DE3650130 T DE 3650130T DE 3650130 T3 DE3650130 T3 DE 3650130T3
- Authority
- DE
- Germany
- Prior art keywords
- antiviral nucleosides
- nucleosides
- antiviral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858506869A GB8506869D0 (en) | 1985-03-16 | 1985-03-16 | Antiviral compound |
GB858511774A GB8511774D0 (en) | 1985-05-09 | 1985-05-09 | Antiviral compounds |
US06/776,899 US4724232A (en) | 1985-03-16 | 1985-09-17 | Treatment of human viral infections |
GB858523881A GB8523881D0 (en) | 1985-09-27 | 1985-09-27 | Antiviral compounds |
GB868603450A GB8603450D0 (en) | 1986-02-12 | 1986-02-12 | Antiviral compounds |
Publications (3)
Publication Number | Publication Date |
---|---|
DE3650130D1 DE3650130D1 (de) | 1994-12-08 |
DE3650130T2 DE3650130T2 (de) | 1995-03-16 |
DE3650130T3 true DE3650130T3 (de) | 2003-07-24 |
Family
ID=27516579
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19863608606 Withdrawn DE3608606A1 (de) | 1985-03-16 | 1986-03-14 | 3'-azido-3'-deoxythymidin oder eine, ein pharmazeutisch vertraegliches derivat davon enthaltende pharmazeutische formulierung, verfahren zu ihrer herstellung und ihre verwendung |
DE3650130T Expired - Lifetime DE3650130T3 (de) | 1985-03-16 | 1986-03-14 | Antivirale Nukleoside. |
DE198686301897T Pending DE196185T1 (de) | 1985-03-16 | 1986-03-14 | Antivirale nukleoside. |
DE8888101790T Expired - Lifetime DE3687069T2 (de) | 1985-03-16 | 1986-03-14 | Verwendung von 3'-azido-3'-deoxythymidin zur behandlung oder vorbeugung von menschlichen retrovirus-infektionen. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19863608606 Withdrawn DE3608606A1 (de) | 1985-03-16 | 1986-03-14 | 3'-azido-3'-deoxythymidin oder eine, ein pharmazeutisch vertraegliches derivat davon enthaltende pharmazeutische formulierung, verfahren zu ihrer herstellung und ihre verwendung |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE198686301897T Pending DE196185T1 (de) | 1985-03-16 | 1986-03-14 | Antivirale nukleoside. |
DE8888101790T Expired - Lifetime DE3687069T2 (de) | 1985-03-16 | 1986-03-14 | Verwendung von 3'-azido-3'-deoxythymidin zur behandlung oder vorbeugung von menschlichen retrovirus-infektionen. |
Country Status (21)
Country | Link |
---|---|
EP (2) | EP0291633B1 (de) |
JP (1) | JPH0780898B2 (de) |
AP (1) | AP11A (de) |
AT (4) | AT390000B (de) |
AU (1) | AU572019B2 (de) |
CA (1) | CA1238277A (de) |
CS (1) | CS385191A3 (de) |
CY (2) | CY1508A (de) |
DE (4) | DE3608606A1 (de) |
DK (1) | DK164392C (de) |
FI (1) | FI85978C (de) |
GR (1) | GR860712B (de) |
HK (2) | HK85789A (de) |
IE (1) | IE56503B1 (de) |
IL (1) | IL78158A (de) |
MC (1) | MC1742A1 (de) |
MY (1) | MY102693A (de) |
NZ (1) | NZ215486A (de) |
PH (1) | PH24388A (de) |
PT (1) | PT82199B (de) |
SG (1) | SG62889G (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE190064T1 (de) * | 1985-09-17 | 2000-03-15 | Wellcome Found | Kombination therapeutische nukleoside mit weiteren therapeutisch wirksamen komponenten. |
US4916122A (en) * | 1987-01-28 | 1990-04-10 | University Of Georgia Research Foundation, Inc. | 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition |
US5077279A (en) * | 1986-05-01 | 1991-12-31 | University Of Georgia Research Foundation, Inc. | 3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition |
US4841039A (en) * | 1986-05-01 | 1989-06-20 | Emory University | 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents |
US5084445A (en) * | 1986-05-01 | 1992-01-28 | University Of Georgia Research Foundation, Inc. | 3'-azido-2',3'-dideoxy-5-methylcytidine |
US4880782A (en) * | 1986-11-21 | 1989-11-14 | Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. | Method of treating viral infections in humans and compositions therefor |
EP0332626A1 (de) * | 1986-11-21 | 1989-09-20 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Zubereitungen zur behandlung viraler infektionen bei menschen |
SE8605503D0 (sv) * | 1986-12-19 | 1986-12-19 | Astra Laekemedel Ab | Novel medicinal use |
US5190926A (en) * | 1987-01-28 | 1993-03-02 | University Of Georgia Research Foundation, Inc. | 3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents |
PT86982B (pt) * | 1987-03-16 | 1992-06-30 | Wellcome Found | Processo para a preparacao de nucleosidos |
EP0282618A1 (de) * | 1987-03-18 | 1988-09-21 | Vereniging Het Nederlands Kanker Instituut | 1-Deoxynojirimycin als Anti-HIV-Therapeutikum |
EP0286825A3 (de) * | 1987-03-18 | 1989-04-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Verwendung von 3'-fluro-3'-deoxythymidine zur Herstellung von medicamenten zur Behandlung von Viruskrankheiten |
US4950652A (en) * | 1987-03-23 | 1990-08-21 | Hem Research, Inc. | dsRNAs for combination therapy in the treatment of viral diseases |
DK161788A (da) * | 1987-03-25 | 1988-09-26 | Wellcome Found | Fremgangsmaade til fremstilling af zidovudin |
GB8707421D0 (en) * | 1987-03-27 | 1987-04-29 | Wellcome Found | Pharmaceutical formulations |
US5185437A (en) * | 1987-04-09 | 1993-02-09 | Burroughs Wellcome Co. | Therapeutic nucleosides |
IL86007A0 (en) * | 1987-04-09 | 1988-09-30 | Wellcome Found | 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them |
IL86009A (en) * | 1987-04-10 | 1991-09-16 | Us Health | Liposome-encapsulated phosphorylated nucleosides for treatment of retroviral diseases |
US5215970A (en) * | 1987-04-16 | 1993-06-01 | Medivir Ab | Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds |
SE8701605D0 (sv) * | 1987-04-16 | 1987-04-16 | Astra Ab | Novel medicinal compounds |
EP0289229B1 (de) * | 1987-04-24 | 1992-01-29 | The Wellcome Foundation Limited | Antivirale Mischungen |
US4863927A (en) * | 1987-05-11 | 1989-09-05 | Merck & Co., Inc. | 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils |
YU110888A (en) * | 1987-06-10 | 1989-08-31 | Wellcome Found | Process for obtaining timine derivatives |
USRE33887E (en) * | 1987-06-22 | 1992-04-14 | Hoffmann-La Roche Inc. | Anti-retroviral compounds |
SU1548182A1 (ru) * | 1987-12-29 | 1990-03-07 | Институт молекулярной биологии АН СССР | 5 @ -Фосфонаты 3 @ -азидо-2 @ ,3 @ -дидезоксинуклеозидов, вл ющиес специфическими ингибиторами вируса СПИД в культуре лимфоцитов человека Н9/ШВ |
US5384396A (en) * | 1988-02-23 | 1995-01-24 | The University Of Georgia Research Foundation, Inc. | Process for the deoxygenation of nucleosides |
DE3824669C2 (de) * | 1988-07-20 | 1999-05-06 | Wondrak Ewald M | Verwendung von Trinatrium-Phosphonoformat |
US4987224A (en) * | 1988-08-02 | 1991-01-22 | University Of Georgia Research Foundation, Inc. | Method of preparation of 2',3'-dideoxynucleosides |
EP0355245A1 (de) * | 1988-08-26 | 1990-02-28 | Michel Vandevelde | Anwendung von Inhibitoren der reversen Transcriptase von Retroviren |
HU205089B (en) * | 1989-05-31 | 1992-03-30 | Biogal Gyogyszergyar | Process for producing new thymine derivatives and pharmaceutical compositions comprising same |
LU87834A1 (de) * | 1989-11-09 | 1991-05-07 | Asta Pharma Ag | Arzneimittel,welche als wirkstoff schwefel enthaltende carbonsaeuren enthalten sowie deren verwendung zur bekaempfung von retroviren |
US5585367A (en) * | 1990-04-19 | 1996-12-17 | Previsan S.A. | Method of treating humans and animals infected with viruses of the retrovirus group |
WO1991016054A1 (fr) * | 1990-04-19 | 1991-10-31 | Previsan S.A. | Derives azoiques, compositions pharmaceutiques et desinfectantes les contenant et leurs utilisations contre le sida |
US6812233B1 (en) | 1991-03-06 | 2004-11-02 | Emory University | Therapeutic nucleosides |
GB9104740D0 (en) * | 1991-03-06 | 1991-04-17 | Wellcome Found | Antiviral nucleoside combination |
IL102548A (en) * | 1991-08-02 | 1998-08-16 | Medivir Ab | Use of painting derivatives in the preparation of drugs for VIH inhibition and treatment of SDIA and new compounds |
US5593993A (en) * | 1991-08-02 | 1997-01-14 | Medivir Ab | Method for inhibition of HIV related viruses |
US6177435B1 (en) | 1992-05-13 | 2001-01-23 | Glaxo Wellcome Inc. | Therapeutic combinations |
EP0639971B1 (de) * | 1992-05-13 | 1999-09-22 | The Wellcome Foundation Limited | Therapeutische kombinationen |
GR920100326A (el) * | 1992-07-21 | 1994-03-31 | Medivir Ag | Ενώσεις και μέ?οδοι αναστολής του HIV και των σχετικών ιών. |
DE4336640A1 (de) * | 1993-10-22 | 1995-04-27 | Deutsches Rheuma Forschungszen | Neue Metallchelate, Verfahren zu deren Herstellung sowie deren Verwendung als antivirale Arzneimittel |
CA2270600A1 (en) | 1999-05-03 | 2000-11-03 | Infectio Recherche Inc. | Method and formulations for the treatment of diseases, particularly those caused by human immunodeficiency virus and leishmania |
PL212914B1 (pl) | 2001-10-26 | 2012-12-31 | Angeletti P Ist Richerche Bio | N-podstawione hydroksypirymidynonokarboksyamidy jako inhibitory integrazy HIV |
EP2266590A3 (de) | 2002-02-22 | 2011-04-20 | Shire LLC | Wirkstoff-Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Wirkstoffen |
EP1579862A1 (de) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Verwendung von PDE III Ihibitoren zur Reduktion der Herzgrösse in an Herzversagen leidenden Säugern |
US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
WO2022008025A1 (en) * | 2020-07-05 | 2022-01-13 | Since & Technology Development Fund Authority | 2-hydroxyiminopyrimidine nucleosides and derivitives and antiviral uses thereto |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1285935C (en) * | 1985-03-16 | 1991-07-09 | Janet Lister Rideout | Therapeutic nucleosides |
-
1986
- 1986-03-14 AT AT0068386A patent/AT390000B/de not_active IP Right Cessation
- 1986-03-14 IE IE677/86A patent/IE56503B1/en not_active IP Right Cessation
- 1986-03-14 AP APAP/P/1986/000027A patent/AP11A/en active
- 1986-03-14 GR GR860712A patent/GR860712B/el unknown
- 1986-03-14 EP EP88101790A patent/EP0291633B1/de not_active Expired - Lifetime
- 1986-03-14 AT AT88101790T patent/ATE81978T1/de not_active IP Right Cessation
- 1986-03-14 IL IL78158A patent/IL78158A/xx unknown
- 1986-03-14 PH PH33532A patent/PH24388A/en unknown
- 1986-03-14 AT AT88101795T patent/ATE113603T1/de not_active IP Right Cessation
- 1986-03-14 MC MC861828A patent/MC1742A1/xx unknown
- 1986-03-14 FI FI861069A patent/FI85978C/fi not_active IP Right Cessation
- 1986-03-14 CA CA000504126A patent/CA1238277A/en not_active Expired
- 1986-03-14 NZ NZ215486A patent/NZ215486A/xx unknown
- 1986-03-14 DE DE19863608606 patent/DE3608606A1/de not_active Withdrawn
- 1986-03-14 PT PT82199A patent/PT82199B/pt unknown
- 1986-03-14 DE DE3650130T patent/DE3650130T3/de not_active Expired - Lifetime
- 1986-03-14 AU AU54758/86A patent/AU572019B2/en not_active Expired
- 1986-03-14 DK DK118086A patent/DK164392C/da not_active IP Right Cessation
- 1986-03-14 EP EP86301897A patent/EP0196185B1/de not_active Expired
- 1986-03-14 CY CY1508A patent/CY1508A/xx unknown
- 1986-03-14 DE DE198686301897T patent/DE196185T1/de active Pending
- 1986-03-14 AT AT86301897T patent/ATE44464T1/de not_active IP Right Cessation
- 1986-03-14 DE DE8888101790T patent/DE3687069T2/de not_active Expired - Lifetime
-
1987
- 1987-09-25 MY MYPI87001943A patent/MY102693A/en unknown
-
1988
- 1988-03-29 JP JP63073488A patent/JPH0780898B2/ja not_active Expired - Lifetime
-
1989
- 1989-09-11 SG SG628/89A patent/SG62889G/en unknown
- 1989-10-26 HK HK857/89A patent/HK85789A/xx not_active IP Right Cessation
-
1991
- 1991-12-17 CS CS913851A patent/CS385191A3/cs unknown
-
1995
- 1995-10-19 HK HK164395A patent/HK164395A/xx not_active IP Right Cessation
-
1996
- 1996-11-22 CY CY188996A patent/CY1889A/xx unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8366 | Restricted maintained after opposition proceedings |