AP11A - Antiviral nucleosides. - Google Patents

Antiviral nucleosides. Download PDF

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Publication number
AP11A
AP11A APAP/P/1986/000027A AP8600027A AP11A AP 11 A AP11 A AP 11A AP 8600027 A AP8600027 A AP 8600027A AP 11 A AP11 A AP 11A
Authority
AP
ARIPO
Prior art keywords
azido
active ingredient
deoxythymidine
compound
bad original
Prior art date
Application number
APAP/P/1986/000027A
Other languages
English (en)
Other versions
AP8600027A0 (en
Inventor
Janet Litster Rideout
David Walter Barry
Sandra Nusinoff Lehrman
Phillip Allen Furman
George Andrew Freeman
Original Assignee
The Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27516579&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP11(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB858506869A external-priority patent/GB8506869D0/en
Priority claimed from GB858511774A external-priority patent/GB8511774D0/en
Priority claimed from US06/776,899 external-priority patent/US4724232A/en
Priority claimed from GB858523881A external-priority patent/GB8523881D0/en
Publication of AP8600027A0 publication Critical patent/AP8600027A0/xx
Priority claimed from GB868603450A external-priority patent/GB8603450D0/en
Application filed by The Wellcome Foundation Ltd filed Critical The Wellcome Foundation Ltd
Application granted granted Critical
Publication of AP11A publication Critical patent/AP11A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
APAP/P/1986/000027A 1985-03-16 1986-03-14 Antiviral nucleosides. AP11A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB858506869A GB8506869D0 (en) 1985-03-16 1985-03-16 Antiviral compound
GB858511774A GB8511774D0 (en) 1985-05-09 1985-05-09 Antiviral compounds
US06/776,899 US4724232A (en) 1985-03-16 1985-09-17 Treatment of human viral infections
GB858523881A GB8523881D0 (en) 1985-09-27 1985-09-27 Antiviral compounds
GB868603450A GB8603450D0 (en) 1986-02-12 1986-02-12 Antiviral compounds

Publications (2)

Publication Number Publication Date
AP8600027A0 AP8600027A0 (en) 1986-02-01
AP11A true AP11A (en) 1987-12-22

Family

ID=27516579

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1986/000027A AP11A (en) 1985-03-16 1986-03-14 Antiviral nucleosides.

Country Status (21)

Country Link
EP (2) EP0196185B1 (de)
JP (1) JPH0780898B2 (de)
AP (1) AP11A (de)
AT (4) ATE44464T1 (de)
AU (1) AU572019B2 (de)
CA (1) CA1238277A (de)
CS (1) CS385191A3 (de)
CY (2) CY1508A (de)
DE (4) DE196185T1 (de)
DK (1) DK164392C (de)
FI (1) FI85978C (de)
GR (1) GR860712B (de)
HK (2) HK85789A (de)
IE (1) IE56503B1 (de)
IL (1) IL78158A (de)
MC (1) MC1742A1 (de)
MY (1) MY102693A (de)
NZ (1) NZ215486A (de)
PH (1) PH24388A (de)
PT (1) PT82199B (de)
SG (1) SG62889G (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0217580A3 (de) * 1985-09-17 1990-11-07 The Wellcome Foundation Limited Therapeutische Nukleoside
US4841039A (en) * 1986-05-01 1989-06-20 Emory University 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US5077279A (en) * 1986-05-01 1991-12-31 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition
US5084445A (en) * 1986-05-01 1992-01-28 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxy-5-methylcytidine
US4916122A (en) * 1987-01-28 1990-04-10 University Of Georgia Research Foundation, Inc. 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
WO1988003804A2 (en) * 1986-11-21 1988-06-02 Max-Planck-Gesellschaft Zur Förderung Der Wissensc Method of treating viral infections in humans and compositions therefor
US4880782A (en) * 1986-11-21 1989-11-14 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Method of treating viral infections in humans and compositions therefor
SE8605503D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel medicinal use
US5190926A (en) * 1987-01-28 1993-03-02 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents
NO881135L (no) * 1987-03-16 1988-09-19 Wellcome Found Fremgangsmaate for fremstilling av 1-(3-azido-2,3-dideoksy-betad-erytro-pentofuranosyl)-5-metyl-2(1h)-pyrimidinon.
EP0286825A3 (de) * 1987-03-18 1989-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verwendung von 3'-fluro-3'-deoxythymidine zur Herstellung von medicamenten zur Behandlung von Viruskrankheiten
EP0282618A1 (de) * 1987-03-18 1988-09-21 Vereniging Het Nederlands Kanker Instituut 1-Deoxynojirimycin als Anti-HIV-Therapeutikum
US4950652A (en) * 1987-03-23 1990-08-21 Hem Research, Inc. dsRNAs for combination therapy in the treatment of viral diseases
IL85852A0 (en) * 1987-03-25 1988-09-30 Wellcome Found Process and intermediates for the manufacture of zidovudine
GB8707421D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
US5185437A (en) * 1987-04-09 1993-02-09 Burroughs Wellcome Co. Therapeutic nucleosides
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
IL86009A (en) * 1987-04-10 1991-09-16 Us Health Liposome-encapsulated phosphorylated nucleosides for treatment of retroviral diseases
US5215970A (en) * 1987-04-16 1993-06-01 Medivir Ab Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds
DE3868125D1 (de) * 1987-04-24 1992-03-12 Wellcome Found Antivirale mischungen.
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
YU110888A (en) * 1987-06-10 1989-08-31 Wellcome Found Process for obtaining timine derivatives
USRE33887E (en) * 1987-06-22 1992-04-14 Hoffmann-La Roche Inc. Anti-retroviral compounds
SU1548182A1 (ru) * 1987-12-29 1990-03-07 Институт молекулярной биологии АН СССР 5 @ -Фосфонаты 3 @ -азидо-2 @ ,3 @ -дидезоксинуклеозидов, вл ющиес специфическими ингибиторами вируса СПИД в культуре лимфоцитов человека Н9/ШВ
US5384396A (en) * 1988-02-23 1995-01-24 The University Of Georgia Research Foundation, Inc. Process for the deoxygenation of nucleosides
DE3824669C2 (de) * 1988-07-20 1999-05-06 Wondrak Ewald M Verwendung von Trinatrium-Phosphonoformat
US4987224A (en) * 1988-08-02 1991-01-22 University Of Georgia Research Foundation, Inc. Method of preparation of 2',3'-dideoxynucleosides
EP0355245A1 (de) * 1988-08-26 1990-02-28 Michel Vandevelde Anwendung von Inhibitoren der reversen Transcriptase von Retroviren
HU205089B (en) * 1989-05-31 1992-03-30 Biogal Gyogyszergyar Process for producing new thymine derivatives and pharmaceutical compositions comprising same
BE1003834A5 (fr) * 1989-11-09 1992-06-23 Asta Medica Ag Medicaments qui contiennent, comme substance active, des acides carboxyliques contenant du soufre, ainsi que leur utilisation pour lutter contre des retrovirus.
WO1991016054A1 (fr) * 1990-04-19 1991-10-31 Previsan S.A. Derives azoiques, compositions pharmaceutiques et desinfectantes les contenant et leurs utilisations contre le sida
US5585367A (en) * 1990-04-19 1996-12-17 Previsan S.A. Method of treating humans and animals infected with viruses of the retrovirus group
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
US6812233B1 (en) 1991-03-06 2004-11-02 Emory University Therapeutic nucleosides
US5593993A (en) * 1991-08-02 1997-01-14 Medivir Ab Method for inhibition of HIV related viruses
IL102548A (en) * 1991-08-02 1998-08-16 Medivir Ab Thiourea derivatives for use in the preparation of medicaments for the inhibition of hiv and the treatment of aids and some such novel compounds
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
DK0639971T3 (da) * 1992-05-13 2000-03-20 Wellcome Found Terapeutiske kombinationer
GR920100326A (el) * 1992-07-21 1994-03-31 Medivir Ag Ενώσεις και μέ?οδοι αναστολής του HIV και των σχετικών ιών.
DE4336640A1 (de) * 1993-10-22 1995-04-27 Deutsches Rheuma Forschungszen Neue Metallchelate, Verfahren zu deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
CA2270600A1 (en) 1999-05-03 2000-11-03 Infectio Recherche Inc. Method and formulations for the treatment of diseases, particularly those caused by human immunodeficiency virus and leishmania
WO2003079972A2 (en) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
CA2463976C (en) 2001-10-26 2007-02-13 Benedetta Crescenzi N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase
EP1579862A1 (de) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Verwendung von PDE III Ihibitoren zur Reduktion der Herzgrösse in an Herzversagen leidenden Säugern
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
JP6272475B2 (ja) 2013-07-19 2018-01-31 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーＢｏｅｈｒｉｎｇｅｒ Ｉｎｇｅｌｈｅｉｍ Ｖｅｔｍｅｄｉｃａ ＧｍｂＨ 防腐エーテル化シクロデキストリン誘導体含有液体水性医薬組成物
WO2022008025A1 (en) * 2020-07-05 2022-01-13 Since & Technology Development Fund Authority 2-hydroxyiminopyrimidine nucleosides and derivitives and antiviral uses thereto

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1285935C (en) * 1985-03-16 1991-07-09 Janet Lister Rideout Therapeutic nucleosides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Biochemistry (BICHAW): 74 Vol. 13 (6) pp 1179-1185 *

Also Published As

Publication number Publication date
DE3687069D1 (de) 1992-12-10
DE3608606A1 (de) 1986-09-18
DK118086A (da) 1986-09-17
EP0291633A1 (de) 1988-11-23
DK118086D0 (da) 1986-03-14
IL78158A0 (en) 1986-07-31
DE3650130D1 (de) 1994-12-08
HK164395A (en) 1995-10-27
ATA68386A (de) 1989-08-15
EP0196185A2 (de) 1986-10-01
JPS63290895A (ja) 1988-11-28
MC1742A1 (fr) 1987-02-26
AU5475886A (en) 1986-09-18
PT82199A (en) 1986-04-01
NZ215486A (en) 1988-09-29
CA1238277A (en) 1988-06-21
FI85978B (fi) 1992-03-13
PT82199B (pt) 1990-11-07
IE860677L (en) 1986-09-16
ATE44464T1 (de) 1989-07-15
AU572019B2 (en) 1988-04-28
DK164392C (da) 1992-11-09
FI861069L (fi) 1986-09-17
PH24388A (en) 1990-06-13
AT390000B (de) 1990-02-26
FI861069A0 (fi) 1986-03-14
JPH0780898B2 (ja) 1995-08-30
CS385191A3 (en) 1992-05-13
ATE81978T1 (de) 1992-11-15
IL78158A (en) 1988-04-29
CY1889A (en) 1996-11-22
DE3650130T3 (de) 2003-07-24
EP0196185B1 (de) 1989-07-12
IE56503B1 (en) 1991-08-14
AP8600027A0 (en) 1986-02-01
SG62889G (en) 1990-01-26
DK164392B (da) 1992-06-22
DE196185T1 (de) 1987-04-30
MY102693A (en) 1992-09-30
EP0196185A3 (en) 1988-01-13
GR860712B (en) 1986-07-16
EP0291633B1 (de) 1992-11-04
HK85789A (en) 1989-11-03
CY1508A (en) 1990-08-03
DE3650130T2 (de) 1995-03-16
DE3687069T2 (de) 1993-03-25
FI85978C (fi) 1992-06-25
ATE113603T1 (de) 1994-11-15

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