DE3687069T2 - Verwendung von 3'-azido-3'-deoxythymidin zur behandlung oder vorbeugung von menschlichen retrovirus-infektionen. - Google Patents

Verwendung von 3'-azido-3'-deoxythymidin zur behandlung oder vorbeugung von menschlichen retrovirus-infektionen.

Info

Publication number
DE3687069T2
DE3687069T2 DE8888101790T DE3687069T DE3687069T2 DE 3687069 T2 DE3687069 T2 DE 3687069T2 DE 8888101790 T DE8888101790 T DE 8888101790T DE 3687069 T DE3687069 T DE 3687069T DE 3687069 T2 DE3687069 T2 DE 3687069T2
Authority
DE
Germany
Prior art keywords
deoxythymidine
azido
treating
preventing human
human retrovirus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8888101790T
Other languages
English (en)
Other versions
DE3687069D1 (de
Inventor
Janes Litster Rideout
David Walter Barry
Sandra Nusinoff Lehrman
Clair Martha Heider St
Phillip Allen Furman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27516579&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3687069(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB858506869A external-priority patent/GB8506869D0/en
Priority claimed from GB858511774A external-priority patent/GB8511774D0/en
Priority claimed from US06/776,899 external-priority patent/US4724232A/en
Priority claimed from GB858523881A external-priority patent/GB8523881D0/en
Priority claimed from GB868603450A external-priority patent/GB8603450D0/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of DE3687069D1 publication Critical patent/DE3687069D1/de
Application granted granted Critical
Publication of DE3687069T2 publication Critical patent/DE3687069T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
DE8888101790T 1985-03-16 1986-03-14 Verwendung von 3'-azido-3'-deoxythymidin zur behandlung oder vorbeugung von menschlichen retrovirus-infektionen. Expired - Lifetime DE3687069T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB858506869A GB8506869D0 (en) 1985-03-16 1985-03-16 Antiviral compound
GB858511774A GB8511774D0 (en) 1985-05-09 1985-05-09 Antiviral compounds
US06/776,899 US4724232A (en) 1985-03-16 1985-09-17 Treatment of human viral infections
GB858523881A GB8523881D0 (en) 1985-09-27 1985-09-27 Antiviral compounds
GB868603450A GB8603450D0 (en) 1986-02-12 1986-02-12 Antiviral compounds

Publications (2)

Publication Number Publication Date
DE3687069D1 DE3687069D1 (de) 1992-12-10
DE3687069T2 true DE3687069T2 (de) 1993-03-25

Family

ID=27516579

Family Applications (4)

Application Number Title Priority Date Filing Date
DE3650130T Expired - Lifetime DE3650130T3 (de) 1985-03-16 1986-03-14 Antivirale Nukleoside.
DE19863608606 Withdrawn DE3608606A1 (de) 1985-03-16 1986-03-14 3'-azido-3'-deoxythymidin oder eine, ein pharmazeutisch vertraegliches derivat davon enthaltende pharmazeutische formulierung, verfahren zu ihrer herstellung und ihre verwendung
DE8888101790T Expired - Lifetime DE3687069T2 (de) 1985-03-16 1986-03-14 Verwendung von 3'-azido-3'-deoxythymidin zur behandlung oder vorbeugung von menschlichen retrovirus-infektionen.
DE198686301897T Pending DE196185T1 (de) 1985-03-16 1986-03-14 Antivirale nukleoside.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE3650130T Expired - Lifetime DE3650130T3 (de) 1985-03-16 1986-03-14 Antivirale Nukleoside.
DE19863608606 Withdrawn DE3608606A1 (de) 1985-03-16 1986-03-14 3'-azido-3'-deoxythymidin oder eine, ein pharmazeutisch vertraegliches derivat davon enthaltende pharmazeutische formulierung, verfahren zu ihrer herstellung und ihre verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE198686301897T Pending DE196185T1 (de) 1985-03-16 1986-03-14 Antivirale nukleoside.

Country Status (21)

Country Link
EP (2) EP0196185B1 (de)
JP (1) JPH0780898B2 (de)
AP (1) AP11A (de)
AT (4) ATE81978T1 (de)
AU (1) AU572019B2 (de)
CA (1) CA1238277A (de)
CS (1) CS385191A3 (de)
CY (2) CY1508A (de)
DE (4) DE3650130T3 (de)
DK (1) DK164392C (de)
FI (1) FI85978C (de)
GR (1) GR860712B (de)
HK (2) HK85789A (de)
IE (1) IE56503B1 (de)
IL (1) IL78158A (de)
MC (1) MC1742A1 (de)
MY (1) MY102693A (de)
NZ (1) NZ215486A (de)
PH (1) PH24388A (de)
PT (1) PT82199B (de)
SG (1) SG62889G (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2181128A (en) * 1985-09-17 1987-04-15 Wellcome Found 3'-azidonucleosides
US4841039A (en) * 1986-05-01 1989-06-20 Emory University 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US4916122A (en) * 1987-01-28 1990-04-10 University Of Georgia Research Foundation, Inc. 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US5084445A (en) * 1986-05-01 1992-01-28 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxy-5-methylcytidine
US5077279A (en) * 1986-05-01 1991-12-31 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition
US4880782A (en) * 1986-11-21 1989-11-14 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Method of treating viral infections in humans and compositions therefor
EP0332626A1 (de) * 1986-11-21 1989-09-20 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Zubereitungen zur behandlung viraler infektionen bei menschen
SE8605503D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel medicinal use
US5190926A (en) * 1987-01-28 1993-03-02 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents
CA1321387C (en) * 1987-03-16 1993-08-17 Sammy R. Shaver Therapeutic nucleosides
EP0286825A3 (de) * 1987-03-18 1989-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verwendung von 3'-fluro-3'-deoxythymidine zur Herstellung von medicamenten zur Behandlung von Viruskrankheiten
EP0282618A1 (de) * 1987-03-18 1988-09-21 Vereniging Het Nederlands Kanker Instituut 1-Deoxynojirimycin als Anti-HIV-Therapeutikum
US4950652A (en) * 1987-03-23 1990-08-21 Hem Research, Inc. dsRNAs for combination therapy in the treatment of viral diseases
IL85852A0 (en) * 1987-03-25 1988-09-30 Wellcome Found Process and intermediates for the manufacture of zidovudine
GB8707421D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
US5185437A (en) * 1987-04-09 1993-02-09 Burroughs Wellcome Co. Therapeutic nucleosides
IL86009A (en) * 1987-04-10 1991-09-16 Us Health Liposome-encapsulated phosphorylated nucleosides for treatment of retroviral diseases
US5215970A (en) * 1987-04-16 1993-06-01 Medivir Ab Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds
JPS63280026A (ja) * 1987-04-24 1988-11-17 ザ　ウエルカム　フアウンデーション　リミテッド 抗ウイルス配合組成物
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
YU110888A (en) * 1987-06-10 1989-08-31 Wellcome Found Process for obtaining timine derivatives
USRE33887E (en) * 1987-06-22 1992-04-14 Hoffmann-La Roche Inc. Anti-retroviral compounds
SU1548182A1 (ru) * 1987-12-29 1990-03-07 Институт молекулярной биологии АН СССР 5 @ -Фосфонаты 3 @ -азидо-2 @ ,3 @ -дидезоксинуклеозидов, вл ющиес специфическими ингибиторами вируса СПИД в культуре лимфоцитов человека Н9/ШВ
US5384396A (en) * 1988-02-23 1995-01-24 The University Of Georgia Research Foundation, Inc. Process for the deoxygenation of nucleosides
DE3824669C2 (de) * 1988-07-20 1999-05-06 Wondrak Ewald M Verwendung von Trinatrium-Phosphonoformat
US4987224A (en) * 1988-08-02 1991-01-22 University Of Georgia Research Foundation, Inc. Method of preparation of 2',3'-dideoxynucleosides
EP0355245A1 (de) * 1988-08-26 1990-02-28 Michel Vandevelde Anwendung von Inhibitoren der reversen Transcriptase von Retroviren
HU205089B (en) * 1989-05-31 1992-03-30 Biogal Gyogyszergyar Process for producing new thymine derivatives and pharmaceutical compositions comprising same
NL9002438A (nl) * 1989-11-09 1991-06-03 Asta Pharma Ag Geneesmiddelen, welke als werkzame stof zwavel bevattende carbonzuren bevatten alsmede hun gebruik bij de bestrijding van retrovirussen.
EP0524961B1 (de) * 1990-04-19 1994-07-06 Previsan S.A. Azoische derivate, pharmazeutische und desinfektierende zusammensetzungen diese substanzen enthaltend, und deren verwendung gegen aids
US5585367A (en) * 1990-04-19 1996-12-17 Previsan S.A. Method of treating humans and animals infected with viruses of the retrovirus group
US6812233B1 (en) 1991-03-06 2004-11-02 Emory University Therapeutic nucleosides
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
IL102548A (en) * 1991-08-02 1998-08-16 Medivir Ab Use of painting derivatives in the preparation of drugs for VIH inhibition and treatment of SDIA and new compounds
US5593993A (en) * 1991-08-02 1997-01-14 Medivir Ab Method for inhibition of HIV related viruses
DK0639971T3 (da) * 1992-05-13 2000-03-20 Wellcome Found Terapeutiske kombinationer
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
GR920100326A (el) * 1992-07-21 1994-03-31 Medivir Ag Ενώσεις και μέ?οδοι αναστολής του HIV και των σχετικών ιών.
DE4336640A1 (de) * 1993-10-22 1995-04-27 Deutsches Rheuma Forschungszen Neue Metallchelate, Verfahren zu deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
CA2270600A1 (en) 1999-05-03 2000-11-03 Infectio Recherche Inc. Method and formulations for the treatment of diseases, particularly those caused by human immunodeficiency virus and leishmania
DK1441735T3 (da) 2001-10-26 2006-06-12 Angeletti P Ist Richerche Bio N-substituerede hydroxypyrimidinon-carboxamid-inhibitorer af HIV-integrase
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
EP1579862A1 (de) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Verwendung von PDE III Ihibitoren zur Reduktion der Herzgrösse in an Herzversagen leidenden Säugern
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
WO2022008025A1 (en) * 2020-07-05 2022-01-13 Since & Technology Development Fund Authority 2-hydroxyiminopyrimidine nucleosides and derivitives and antiviral uses thereto

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK166805B1 (da) * 1985-03-16 1993-07-19 Wellcome Found Threo-isomeren af 3'-azido-3'-deoxythymidin til anvendelse ved behandling af eller profylakse for humane retrovirusinfektioner, anvendelse af forbindelsen til fremstilling af et laegemiddel med naevnte indikation og farmaceutisk praeparat indeholdende forbindelsen

Also Published As

Publication number Publication date
MC1742A1 (fr) 1987-02-26
IL78158A0 (en) 1986-07-31
DE3650130D1 (de) 1994-12-08
HK164395A (en) 1995-10-27
AU5475886A (en) 1986-09-18
DE3608606A1 (de) 1986-09-18
PT82199B (pt) 1990-11-07
GR860712B (en) 1986-07-16
DE3687069D1 (de) 1992-12-10
FI85978C (fi) 1992-06-25
EP0291633A1 (de) 1988-11-23
SG62889G (en) 1990-01-26
AT390000B (de) 1990-02-26
CS385191A3 (en) 1992-05-13
ATE44464T1 (de) 1989-07-15
ATE81978T1 (de) 1992-11-15
CY1508A (en) 1990-08-03
EP0196185B1 (de) 1989-07-12
DE3650130T3 (de) 2003-07-24
IE860677L (en) 1986-09-16
IE56503B1 (en) 1991-08-14
DK164392B (da) 1992-06-22
ATA68386A (de) 1989-08-15
EP0291633B1 (de) 1992-11-04
DK118086D0 (da) 1986-03-14
AU572019B2 (en) 1988-04-28
PT82199A (en) 1986-04-01
ATE113603T1 (de) 1994-11-15
DE3650130T2 (de) 1995-03-16
IL78158A (en) 1988-04-29
CA1238277A (en) 1988-06-21
MY102693A (en) 1992-09-30
JPH0780898B2 (ja) 1995-08-30
FI85978B (fi) 1992-03-13
EP0196185A2 (de) 1986-10-01
FI861069A (fi) 1986-09-17
FI861069A0 (fi) 1986-03-14
DK164392C (da) 1992-11-09
CY1889A (en) 1996-11-22
EP0196185A3 (en) 1988-01-13
DE196185T1 (de) 1987-04-30
AP8600027A0 (en) 1986-02-01
PH24388A (en) 1990-06-13
HK85789A (en) 1989-11-03
JPS63290895A (ja) 1988-11-28
NZ215486A (en) 1988-09-29
DK118086A (da) 1986-09-17
AP11A (en) 1987-12-22

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Legal Events

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