DE69425574T2 - L-2',3'-dideoxy-nukleosidanaloga als anti-hepatitis b-(hbv) und anti-hiv-wirkstoffe - Google Patents
L-2',3'-dideoxy-nukleosidanaloga als anti-hepatitis b-(hbv) und anti-hiv-wirkstoffeInfo
- Publication number
- DE69425574T2 DE69425574T2 DE69425574T DE69425574T DE69425574T2 DE 69425574 T2 DE69425574 T2 DE 69425574T2 DE 69425574 T DE69425574 T DE 69425574T DE 69425574 T DE69425574 T DE 69425574T DE 69425574 T2 DE69425574 T2 DE 69425574T2
- Authority
- DE
- Germany
- Prior art keywords
- hbv
- dideoxy
- present
- hepatitis
- hiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6729993A | 1993-05-25 | 1993-05-25 | |
US08/098,650 US5627160A (en) | 1993-05-25 | 1993-07-28 | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents |
PCT/US1994/005790 WO1994027616A1 (en) | 1993-05-25 | 1994-05-23 | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis b (hbv) and anti-hiv agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69425574D1 DE69425574D1 (en) | 2000-09-21 |
DE69425574T2 true DE69425574T2 (de) | 2001-01-04 |
Family
ID=26747712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69425574T Expired - Lifetime DE69425574T2 (de) | 1993-05-25 | 1994-05-23 | L-2',3'-dideoxy-nukleosidanaloga als anti-hepatitis b-(hbv) und anti-hiv-wirkstoffe |
Country Status (14)
Country | Link |
---|---|
US (1) | US5627160A (de) |
EP (1) | EP0707481B1 (de) |
JP (2) | JPH08510747A (de) |
KR (1) | KR100279953B1 (de) |
CN (1) | CN1076021C (de) |
AT (1) | ATE195423T1 (de) |
CA (1) | CA2163520C (de) |
DE (1) | DE69425574T2 (de) |
DK (1) | DK0707481T3 (de) |
ES (1) | ES2150993T3 (de) |
GR (1) | GR3034379T3 (de) |
HK (1) | HK1013257A1 (de) |
PT (1) | PT707481E (de) |
WO (1) | WO1994027616A1 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
US6346627B1 (en) | 1990-02-01 | 2002-02-12 | Emory University | Intermediates in the synthesis of 1,3-oxathiolane nucleoside enantiomers |
US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
US5817667A (en) * | 1991-04-17 | 1998-10-06 | University Of Georgia Research Foudation | Compounds and methods for the treatment of cancer |
US20020120130A1 (en) * | 1993-09-10 | 2002-08-29 | Gilles Gosselin | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents |
EP0717628A4 (de) * | 1993-09-10 | 1999-05-26 | Univ Emory | Nukleoside mit aktivität gegen das hepatitis-b-virus |
US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
US5512431A (en) * | 1994-06-29 | 1996-04-30 | Darwin Molecular Corporation | Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase and cause incorrect base pairing |
IL115156A (en) | 1994-09-06 | 2000-07-16 | Univ Georgia | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
US5559101A (en) * | 1994-10-24 | 1996-09-24 | Genencor International, Inc. | L-ribofuranosyl nucleosides |
US5703058A (en) * | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
US6391859B1 (en) | 1995-01-27 | 2002-05-21 | Emory University | [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides |
US5808040A (en) * | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
WO1996028162A1 (en) * | 1995-03-14 | 1996-09-19 | University Of Medicine & Dentistry Of New Jersey | New drug combination for the treatment of viral diseases |
US5869461A (en) * | 1995-03-16 | 1999-02-09 | Yale University | Reducing toxicity of L-nucleosides with D-nucleosides |
ATE346651T1 (de) | 1995-06-07 | 2006-12-15 | Univ Emory | Nucleoside mit anti-hepatitis b virus wirksamkeit |
US5753789A (en) * | 1996-07-26 | 1998-05-19 | Yale University | Oligonucleotides containing L-nucleosides |
EP1132393B1 (de) * | 1996-10-16 | 2003-04-09 | ICN Pharmaceuticals, Inc. | L-Ribavirin und dessen Verwendung |
US6509320B1 (en) * | 1996-10-16 | 2003-01-21 | Icn Pharmaceuticals, Inc. | Purine L-nucleosides, analogs and uses thereof |
PL187107B1 (pl) * | 1996-10-16 | 2004-05-31 | Icn Pharmaceuticals | L-nukleozydy monocykliczne, kompozycja farmaceutyczna zawierająca te związki oraz ich zastosowanie |
KR100412480B1 (ko) * | 1996-10-16 | 2003-12-31 | 아이씨엔 파마슈티컬스, 인코포레이티드 | 푸린 l-누클레오시드, 이의 유사체 및 이들의 용도 |
US6090602A (en) | 1998-02-18 | 2000-07-18 | Promelas Research Corporation | Levo-monosaccharide in a nucleoside analog for use as an anti-retroviral agent |
DK2415776T3 (en) * | 1998-08-10 | 2016-07-04 | Novartis Ag | Beta-L-2'-deoxy nucleosides for the treatment of Hepatitis B |
US7635690B2 (en) | 1999-01-22 | 2009-12-22 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
US7115584B2 (en) * | 1999-01-22 | 2006-10-03 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
US6525191B1 (en) * | 1999-05-11 | 2003-02-25 | Kanda S. Ramasamy | Conformationally constrained L-nucleosides |
US6436948B1 (en) | 2000-03-03 | 2002-08-20 | University Of Georgia Research Foundation Inc. | Method for the treatment of psoriasis and genital warts |
AU2002255707A1 (en) | 2001-03-15 | 2002-10-03 | Trustees Of Boston College, The | Selective anti-viral nucleoside chain terminators |
EP1495040A4 (de) * | 2002-04-12 | 2006-01-25 | Achillion Pharmaceuticals Inc | Verfahren zur synthese von beta-l-fluor-2 ,3 -didehydrocytidin (beta-l-fd4c) |
US20040067877A1 (en) * | 2002-08-01 | 2004-04-08 | Schinazi Raymond F. | 2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections |
EP1668023A1 (de) * | 2003-09-12 | 2006-06-14 | Max-Delbrück-Centrum Für Molekulare Medizin | B-l-nucleoside und ihre verwendung als pharmazeutische mittel zur behandlung viraler erkrankungen |
EP1802315A2 (de) | 2004-10-19 | 2007-07-04 | Achillion Pharmaceuticals, Inc. | Kombinationstherapie zur behandlung von virusinfektionen |
GB0513835D0 (en) * | 2005-07-07 | 2005-08-10 | Medivir Ab | HIV inhibitors |
EP2159224B1 (de) | 2007-06-18 | 2012-08-01 | Sunshine Lake Pharma Co., Ltd | Bromphenylsubstituierte thiazolyldihydropyrimidine |
US8816074B2 (en) * | 2009-11-16 | 2014-08-26 | University of Georgia Foundation, Inc. | 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections |
CN102666562A (zh) * | 2009-12-17 | 2012-09-12 | 诺威戴克斯医药公司 | 新颖的3’-脱氧-3‘-亚甲基-β-L-核苷 |
CN102234280B (zh) * | 2010-04-26 | 2014-01-08 | 北京大学 | D,l-鸟嘌呤核苷类似物及其制备方法和应用 |
EP3543238B1 (de) | 2016-11-16 | 2021-05-19 | National Center for Global Health and Medicine | Nukleosidderivate mit antiviraler aktivität |
KR102077833B1 (ko) | 2018-12-10 | 2020-02-14 | 류형준 | 기능성 식품조성물 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3817982A (en) * | 1971-12-29 | 1974-06-18 | Syntex Inc | 2{40 ,3{40 -unsaturated nucleosides and method of making |
DE3689976T2 (de) * | 1985-05-15 | 1995-03-16 | Wellcome Found | Therapeutische Nucleoside und deren Herstellung. |
JPS62501712A (ja) * | 1985-08-26 | 1987-07-09 | アメリカ合衆国 | 2′、3′―ジデオキシイノシン、2′,3′―ジデオキシグアノシンまたは2′,3′―ジデオキシアデノシンを含有する抗htlv―3/lav剤 |
US4879277A (en) * | 1985-08-26 | 1989-11-07 | The United States Of America As Represented By The Department Of Health And Human Services | Antiviral compositions and methods |
SE8602981D0 (sv) * | 1986-07-04 | 1986-07-04 | Astra Laekemedel Ab | Novel medicinal use |
US4788181A (en) * | 1986-09-29 | 1988-11-29 | The United States Of America As Represented By The Department Of Health And Human Services | 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity |
IL85778A0 (en) * | 1987-03-20 | 1988-09-30 | Bristol Myers Co | Production of 2',3'-dideoxynucleosides and certain such novel compounds |
JPH01100191A (ja) * | 1987-10-13 | 1989-04-18 | Sanyo Kokusaku Pulp Co Ltd | 2′,3′−ジデオキシシチジン類の製造方法 |
SE8704298D0 (sv) * | 1987-11-03 | 1987-11-03 | Astra Ab | Compounds for use in therapy |
US4997926A (en) * | 1987-11-18 | 1991-03-05 | Scripps Clinic And Research Foundation | Deaminase-stable anti-retroviral 2-halo-2',3'-dideoxy |
JPH07103149B2 (ja) * | 1987-11-30 | 1995-11-08 | ヤマサ醤油株式会社 | シトシン誘導体の製造法 |
JPH02152976A (ja) * | 1988-05-06 | 1990-06-12 | Bristol Myers Co | 2´,3´―ジデヒドロ―2´,3´―ジデオキシヌクレオシドのプロドラッグ |
SE8802687D0 (sv) * | 1988-07-20 | 1988-07-20 | Astra Ab | Nucleoside derivatives |
JPH0269476A (ja) * | 1988-09-06 | 1990-03-08 | Kohjin Co Ltd | ピリミジン誘導体の製法 |
DD293498A5 (de) * | 1989-07-20 | 1991-09-05 | Zi Fuer Molekularbiologie Der Adw,De | Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier |
US5128458A (en) * | 1990-04-20 | 1992-07-07 | Southern Research Institute | 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents |
US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
NZ241625A (en) * | 1991-02-22 | 1996-03-26 | Univ Emory | 1,3-oxathiolane derivatives, anti-viral compositions containing such and method of resolving racemic mixture of enantiomers |
ZA923640B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
CA2135498A1 (en) * | 1992-05-13 | 1993-11-25 | Leonid Beigelman | Synthesis of nucleotide monomers |
DE4224737A1 (de) * | 1992-07-27 | 1994-02-03 | Herbert Prof Dr Schott | Neue Cytosinnucleosidanaloga, Verfahren zu ihrer Herstellung und ihre Verwendung |
CA2105112C (en) * | 1992-09-01 | 2005-08-02 | Thomas C. Britton | A process for anomerizing nucleosides |
GB9226927D0 (en) * | 1992-12-24 | 1993-02-17 | Iaf Biochem Int | Dideoxy nucleoside analogues |
-
1993
- 1993-07-28 US US08/098,650 patent/US5627160A/en not_active Expired - Lifetime
-
1994
- 1994-05-23 DK DK94919207T patent/DK0707481T3/da active
- 1994-05-23 WO PCT/US1994/005790 patent/WO1994027616A1/en active IP Right Grant
- 1994-05-23 DE DE69425574T patent/DE69425574T2/de not_active Expired - Lifetime
- 1994-05-23 KR KR1019950705353A patent/KR100279953B1/ko not_active IP Right Cessation
- 1994-05-23 JP JP7500872A patent/JPH08510747A/ja active Pending
- 1994-05-23 CA CA002163520A patent/CA2163520C/en not_active Expired - Fee Related
- 1994-05-23 EP EP94919207A patent/EP0707481B1/de not_active Expired - Lifetime
- 1994-05-23 ES ES94919207T patent/ES2150993T3/es not_active Expired - Lifetime
- 1994-05-23 AT AT94919207T patent/ATE195423T1/de not_active IP Right Cessation
- 1994-05-23 PT PT94919207T patent/PT707481E/pt unknown
- 1994-05-24 CN CN94106188A patent/CN1076021C/zh not_active Expired - Lifetime
-
1998
- 1998-12-22 HK HK98114607A patent/HK1013257A1/xx not_active IP Right Cessation
-
2000
- 2000-09-08 GR GR20000402067T patent/GR3034379T3/el unknown
-
2004
- 2004-03-31 JP JP2004106919A patent/JP2004244422A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1100303A (zh) | 1995-03-22 |
JPH08510747A (ja) | 1996-11-12 |
HK1013257A1 (en) | 1999-10-22 |
JP2004244422A (ja) | 2004-09-02 |
KR100279953B1 (ko) | 2001-02-01 |
US5627160A (en) | 1997-05-06 |
DE69425574D1 (en) | 2000-09-21 |
EP0707481B1 (de) | 2000-08-16 |
EP0707481A4 (de) | 1996-05-29 |
ES2150993T3 (es) | 2000-12-16 |
EP0707481A1 (de) | 1996-04-24 |
CA2163520A1 (en) | 1994-12-08 |
DK0707481T3 (da) | 2000-10-30 |
WO1994027616A1 (en) | 1994-12-08 |
CA2163520C (en) | 2006-01-10 |
ATE195423T1 (de) | 2000-09-15 |
PT707481E (pt) | 2001-02-28 |
AU693795B2 (en) | 1998-07-09 |
GR3034379T3 (en) | 2000-12-29 |
CN1076021C (zh) | 2001-12-12 |
AU7043094A (en) | 1994-12-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |