ES2150993T3 - Analogos de l-2',3'-didesoxi nucleosidos utilizados como agentes anti-hepatitis b (vhb) y anti-vih. - Google Patents
Analogos de l-2',3'-didesoxi nucleosidos utilizados como agentes anti-hepatitis b (vhb) y anti-vih.Info
- Publication number
- ES2150993T3 ES2150993T3 ES94919207T ES94919207T ES2150993T3 ES 2150993 T3 ES2150993 T3 ES 2150993T3 ES 94919207 T ES94919207 T ES 94919207T ES 94919207 T ES94919207 T ES 94919207T ES 2150993 T3 ES2150993 T3 ES 2150993T3
- Authority
- ES
- Spain
- Prior art keywords
- hbv
- present
- analogs
- hepatitis
- didesoxi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE AL DESCUBRIMIENTO DE CIERTOS ANALOGOS DE DIDEOXINUCLEOSIDOS QUE CONTIENEN UNA UNIDAD DIDEOXI RIBOFURANOSILILO QUE TIENE UNA CONFIGURACION EN L (OPUESTA A LA CONFIGURACION EN D QUE SE DA DE MODO NATURAL) EXHIBEN ACTIVIDAD INESPERADA CONTRA EL VIRUS DE LA HEPATITIS B (HHBV).EN PARTICULAR, EL COMPUESTO DE ACUERDO CON LA PRESENTE INVENCION MUESTRAS UNA POTENTE INHIBICION DE LA DUPLICACION DEL VIRUS EN COMBINACION CON UNA TOXICIDAD MUY BAJA EN LA CELULAS HUESPED (POR EJEMPLO TEJIDO ANIMAL O HUMANO). LOS COMPUESTOS DE ACUERDO CON LA PRESENTE INVENCION MUESTRA UN UTILIDAD PRIMARIA COMO AGENTES PARA LA INHIBICION DEL CRECIMIENTO O DUPLICACION DE HBV, VIH Y OTROS RETROVIRUS, PREFERENTEMENTE HBV. EL COMPUESTO 1{(2,2-DIDEOXI-BETA-L-RIBOFURANOSIL)}-5-FLUOROCITOSINA SE PRESENTA POR TENER UN POTENTE AGENTE ANTIVIH CON BAJA TOXICIDAD EN CELULAS HUESPEDES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6729993A | 1993-05-25 | 1993-05-25 | |
US08/098,650 US5627160A (en) | 1993-05-25 | 1993-07-28 | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2150993T3 true ES2150993T3 (es) | 2000-12-16 |
Family
ID=26747712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94919207T Expired - Lifetime ES2150993T3 (es) | 1993-05-25 | 1994-05-23 | Analogos de l-2',3'-didesoxi nucleosidos utilizados como agentes anti-hepatitis b (vhb) y anti-vih. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5627160A (es) |
EP (1) | EP0707481B1 (es) |
JP (2) | JPH08510747A (es) |
KR (1) | KR100279953B1 (es) |
CN (1) | CN1076021C (es) |
AT (1) | ATE195423T1 (es) |
CA (1) | CA2163520C (es) |
DE (1) | DE69425574T2 (es) |
DK (1) | DK0707481T3 (es) |
ES (1) | ES2150993T3 (es) |
GR (1) | GR3034379T3 (es) |
HK (1) | HK1013257A1 (es) |
PT (1) | PT707481E (es) |
WO (1) | WO1994027616A1 (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
US6346627B1 (en) | 1990-02-01 | 2002-02-12 | Emory University | Intermediates in the synthesis of 1,3-oxathiolane nucleoside enantiomers |
US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
US5817667A (en) * | 1991-04-17 | 1998-10-06 | University Of Georgia Research Foudation | Compounds and methods for the treatment of cancer |
US20020120130A1 (en) * | 1993-09-10 | 2002-08-29 | Gilles Gosselin | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents |
EP0717628A4 (en) * | 1993-09-10 | 1999-05-26 | Univ Emory | NUCLEOSIDES ACTIVATED AGAINST HEPATITIS B VIRUS |
US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
US5512431A (en) * | 1994-06-29 | 1996-04-30 | Darwin Molecular Corporation | Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase and cause incorrect base pairing |
IL115156A (en) | 1994-09-06 | 2000-07-16 | Univ Georgia | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
US5559101A (en) * | 1994-10-24 | 1996-09-24 | Genencor International, Inc. | L-ribofuranosyl nucleosides |
US5703058A (en) * | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
US6391859B1 (en) | 1995-01-27 | 2002-05-21 | Emory University | [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides |
US5808040A (en) * | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
WO1996028162A1 (en) * | 1995-03-14 | 1996-09-19 | University Of Medicine & Dentistry Of New Jersey | New drug combination for the treatment of viral diseases |
US5869461A (en) * | 1995-03-16 | 1999-02-09 | Yale University | Reducing toxicity of L-nucleosides with D-nucleosides |
ATE346651T1 (de) | 1995-06-07 | 2006-12-15 | Univ Emory | Nucleoside mit anti-hepatitis b virus wirksamkeit |
US5753789A (en) * | 1996-07-26 | 1998-05-19 | Yale University | Oligonucleotides containing L-nucleosides |
EP1132393B1 (en) * | 1996-10-16 | 2003-04-09 | ICN Pharmaceuticals, Inc. | L-Ribavirin and uses thereof |
US6509320B1 (en) * | 1996-10-16 | 2003-01-21 | Icn Pharmaceuticals, Inc. | Purine L-nucleosides, analogs and uses thereof |
PL187107B1 (pl) * | 1996-10-16 | 2004-05-31 | Icn Pharmaceuticals | L-nukleozydy monocykliczne, kompozycja farmaceutyczna zawierająca te związki oraz ich zastosowanie |
KR100412480B1 (ko) * | 1996-10-16 | 2003-12-31 | 아이씨엔 파마슈티컬스, 인코포레이티드 | 푸린 l-누클레오시드, 이의 유사체 및 이들의 용도 |
US6090602A (en) | 1998-02-18 | 2000-07-18 | Promelas Research Corporation | Levo-monosaccharide in a nucleoside analog for use as an anti-retroviral agent |
DK2415776T3 (en) * | 1998-08-10 | 2016-07-04 | Novartis Ag | Beta-L-2'-deoxy nucleosides for the treatment of Hepatitis B |
US7635690B2 (en) | 1999-01-22 | 2009-12-22 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
US7115584B2 (en) * | 1999-01-22 | 2006-10-03 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
US6525191B1 (en) * | 1999-05-11 | 2003-02-25 | Kanda S. Ramasamy | Conformationally constrained L-nucleosides |
US6436948B1 (en) | 2000-03-03 | 2002-08-20 | University Of Georgia Research Foundation Inc. | Method for the treatment of psoriasis and genital warts |
AU2002255707A1 (en) | 2001-03-15 | 2002-10-03 | Trustees Of Boston College, The | Selective anti-viral nucleoside chain terminators |
EP1495040A4 (en) * | 2002-04-12 | 2006-01-25 | Achillion Pharmaceuticals Inc | PROCESS FOR THE SYNTHESIS OF BETA-L-FLUORO-2 ', 3'-DIDEOXY-DIDEHYDROCYTIDINE (BETA-L-FD4C) |
US20040067877A1 (en) * | 2002-08-01 | 2004-04-08 | Schinazi Raymond F. | 2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections |
EP1668023A1 (de) * | 2003-09-12 | 2006-06-14 | Max-Delbrück-Centrum Für Molekulare Medizin | B-l-nucleoside und ihre verwendung als pharmazeutische mittel zur behandlung viraler erkrankungen |
EP1802315A2 (en) | 2004-10-19 | 2007-07-04 | Achillion Pharmaceuticals, Inc. | Combination therapy for treating viral infections |
GB0513835D0 (en) * | 2005-07-07 | 2005-08-10 | Medivir Ab | HIV inhibitors |
EP2159224B1 (en) | 2007-06-18 | 2012-08-01 | Sunshine Lake Pharma Co., Ltd | Bromo-phenyl substituted thiazolyl dihydropyrimidines |
US8816074B2 (en) * | 2009-11-16 | 2014-08-26 | University of Georgia Foundation, Inc. | 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections |
CN102666562A (zh) * | 2009-12-17 | 2012-09-12 | 诺威戴克斯医药公司 | 新颖的3’-脱氧-3‘-亚甲基-β-L-核苷 |
CN102234280B (zh) * | 2010-04-26 | 2014-01-08 | 北京大学 | D,l-鸟嘌呤核苷类似物及其制备方法和应用 |
EP3543238B1 (en) | 2016-11-16 | 2021-05-19 | National Center for Global Health and Medicine | Nucleoside derivatives having anti-viral activity |
KR102077833B1 (ko) | 2018-12-10 | 2020-02-14 | 류형준 | 기능성 식품조성물 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3817982A (en) * | 1971-12-29 | 1974-06-18 | Syntex Inc | 2{40 ,3{40 -unsaturated nucleosides and method of making |
DE3689976T2 (de) * | 1985-05-15 | 1995-03-16 | Wellcome Found | Therapeutische Nucleoside und deren Herstellung. |
JPS62501712A (ja) * | 1985-08-26 | 1987-07-09 | アメリカ合衆国 | 2′、3′―ジデオキシイノシン、2′,3′―ジデオキシグアノシンまたは2′,3′―ジデオキシアデノシンを含有する抗htlv―3/lav剤 |
US4879277A (en) * | 1985-08-26 | 1989-11-07 | The United States Of America As Represented By The Department Of Health And Human Services | Antiviral compositions and methods |
SE8602981D0 (sv) * | 1986-07-04 | 1986-07-04 | Astra Laekemedel Ab | Novel medicinal use |
US4788181A (en) * | 1986-09-29 | 1988-11-29 | The United States Of America As Represented By The Department Of Health And Human Services | 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity |
IL85778A0 (en) * | 1987-03-20 | 1988-09-30 | Bristol Myers Co | Production of 2',3'-dideoxynucleosides and certain such novel compounds |
JPH01100191A (ja) * | 1987-10-13 | 1989-04-18 | Sanyo Kokusaku Pulp Co Ltd | 2′,3′−ジデオキシシチジン類の製造方法 |
SE8704298D0 (sv) * | 1987-11-03 | 1987-11-03 | Astra Ab | Compounds for use in therapy |
US4997926A (en) * | 1987-11-18 | 1991-03-05 | Scripps Clinic And Research Foundation | Deaminase-stable anti-retroviral 2-halo-2',3'-dideoxy |
JPH07103149B2 (ja) * | 1987-11-30 | 1995-11-08 | ヤマサ醤油株式会社 | シトシン誘導体の製造法 |
JPH02152976A (ja) * | 1988-05-06 | 1990-06-12 | Bristol Myers Co | 2´,3´―ジデヒドロ―2´,3´―ジデオキシヌクレオシドのプロドラッグ |
SE8802687D0 (sv) * | 1988-07-20 | 1988-07-20 | Astra Ab | Nucleoside derivatives |
JPH0269476A (ja) * | 1988-09-06 | 1990-03-08 | Kohjin Co Ltd | ピリミジン誘導体の製法 |
DD293498A5 (de) * | 1989-07-20 | 1991-09-05 | Zi Fuer Molekularbiologie Der Adw,De | Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier |
US5128458A (en) * | 1990-04-20 | 1992-07-07 | Southern Research Institute | 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents |
US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
NZ241625A (en) * | 1991-02-22 | 1996-03-26 | Univ Emory | 1,3-oxathiolane derivatives, anti-viral compositions containing such and method of resolving racemic mixture of enantiomers |
ZA923640B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
CA2135498A1 (en) * | 1992-05-13 | 1993-11-25 | Leonid Beigelman | Synthesis of nucleotide monomers |
DE4224737A1 (de) * | 1992-07-27 | 1994-02-03 | Herbert Prof Dr Schott | Neue Cytosinnucleosidanaloga, Verfahren zu ihrer Herstellung und ihre Verwendung |
CA2105112C (en) * | 1992-09-01 | 2005-08-02 | Thomas C. Britton | A process for anomerizing nucleosides |
GB9226927D0 (en) * | 1992-12-24 | 1993-02-17 | Iaf Biochem Int | Dideoxy nucleoside analogues |
-
1993
- 1993-07-28 US US08/098,650 patent/US5627160A/en not_active Expired - Lifetime
-
1994
- 1994-05-23 DK DK94919207T patent/DK0707481T3/da active
- 1994-05-23 WO PCT/US1994/005790 patent/WO1994027616A1/en active IP Right Grant
- 1994-05-23 DE DE69425574T patent/DE69425574T2/de not_active Expired - Lifetime
- 1994-05-23 KR KR1019950705353A patent/KR100279953B1/ko not_active IP Right Cessation
- 1994-05-23 JP JP7500872A patent/JPH08510747A/ja active Pending
- 1994-05-23 CA CA002163520A patent/CA2163520C/en not_active Expired - Fee Related
- 1994-05-23 EP EP94919207A patent/EP0707481B1/en not_active Expired - Lifetime
- 1994-05-23 ES ES94919207T patent/ES2150993T3/es not_active Expired - Lifetime
- 1994-05-23 AT AT94919207T patent/ATE195423T1/de not_active IP Right Cessation
- 1994-05-23 PT PT94919207T patent/PT707481E/pt unknown
- 1994-05-24 CN CN94106188A patent/CN1076021C/zh not_active Expired - Lifetime
-
1998
- 1998-12-22 HK HK98114607A patent/HK1013257A1/xx not_active IP Right Cessation
-
2000
- 2000-09-08 GR GR20000402067T patent/GR3034379T3/el unknown
-
2004
- 2004-03-31 JP JP2004106919A patent/JP2004244422A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1100303A (zh) | 1995-03-22 |
JPH08510747A (ja) | 1996-11-12 |
HK1013257A1 (en) | 1999-10-22 |
JP2004244422A (ja) | 2004-09-02 |
KR100279953B1 (ko) | 2001-02-01 |
US5627160A (en) | 1997-05-06 |
DE69425574D1 (en) | 2000-09-21 |
EP0707481B1 (en) | 2000-08-16 |
EP0707481A4 (es) | 1996-05-29 |
DE69425574T2 (de) | 2001-01-04 |
EP0707481A1 (en) | 1996-04-24 |
CA2163520A1 (en) | 1994-12-08 |
DK0707481T3 (da) | 2000-10-30 |
WO1994027616A1 (en) | 1994-12-08 |
CA2163520C (en) | 2006-01-10 |
ATE195423T1 (de) | 2000-09-15 |
PT707481E (pt) | 2001-02-28 |
AU693795B2 (en) | 1998-07-09 |
GR3034379T3 (en) | 2000-12-29 |
CN1076021C (zh) | 2001-12-12 |
AU7043094A (en) | 1994-12-20 |
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