SE8704298D0 - Compounds for use in therapy - Google Patents

Compounds for use in therapy

Info

Publication number
SE8704298D0
SE8704298D0 SE8704298A SE8704298A SE8704298D0 SE 8704298 D0 SE8704298 D0 SE 8704298D0 SE 8704298 A SE8704298 A SE 8704298A SE 8704298 A SE8704298 A SE 8704298A SE 8704298 D0 SE8704298 D0 SE 8704298D0
Authority
SE
Sweden
Prior art keywords
therapy
compounds
retrovirus
hepatitis
radicals
Prior art date
Application number
SE8704298A
Other languages
English (en)
Inventor
K N G Johansson
B G Lindborg
U Norinder
G B Stening
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE8704298A priority Critical patent/SE8704298D0/sv
Publication of SE8704298D0 publication Critical patent/SE8704298D0/sv
Priority to DE3855099T priority patent/DE3855099D1/de
Priority to EP88850370A priority patent/EP0322384B1/en
Priority to AT88850370T priority patent/ATE135363T1/de
Priority to DK602988A priority patent/DK602988A/da
Priority to AU24522/88A priority patent/AU615681B2/en
Priority to JP63276363A priority patent/JPH01151595A/ja
Priority to PT88930A priority patent/PT88930B/pt
Priority to US08/354,769 priority patent/US5506215A/en
Priority to HU95P/P00382P priority patent/HU211132A9/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
SE8704298A 1987-11-03 1987-11-03 Compounds for use in therapy SE8704298D0 (sv)

Priority Applications (10)

Application Number Priority Date Filing Date Title
SE8704298A SE8704298D0 (sv) 1987-11-03 1987-11-03 Compounds for use in therapy
DE3855099T DE3855099D1 (de) 1987-11-03 1988-10-27 Nucleoside zur Verwendung für die Therapie
EP88850370A EP0322384B1 (en) 1987-11-03 1988-10-27 Nucleosides for use in therapy
AT88850370T ATE135363T1 (de) 1987-11-03 1988-10-27 Nucleoside zur verwendung für die therapie
DK602988A DK602988A (da) 1987-11-03 1988-10-28 Nukleosidderivater med antiviral virkning og laegemiddelpraeparat indeholdende saadanne forbindelser
AU24522/88A AU615681B2 (en) 1987-11-03 1988-10-31 Nucleoside derivatives useful in treating retroviral infections
JP63276363A JPH01151595A (ja) 1987-11-03 1988-11-02 治療に使用するための化合物
PT88930A PT88930B (pt) 1987-11-03 1988-11-03 Processo para a preparacao de novos analogos de nucleosidos e de composicoes farmaceuticas que os contem
US08/354,769 US5506215A (en) 1987-11-03 1994-12-12 1-(3'-fluoro-2',3'-dideoxy-β-D-ribofuranosyl)-5-substituted pyrimidine nucleosides
HU95P/P00382P HU211132A9 (en) 1987-11-03 1995-06-22 Nucleoside derivatives useful in treating retroviral infections

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8704298A SE8704298D0 (sv) 1987-11-03 1987-11-03 Compounds for use in therapy

Publications (1)

Publication Number Publication Date
SE8704298D0 true SE8704298D0 (sv) 1987-11-03

Family

ID=20370102

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8704298A SE8704298D0 (sv) 1987-11-03 1987-11-03 Compounds for use in therapy

Country Status (9)

Country Link
EP (1) EP0322384B1 (sv)
JP (1) JPH01151595A (sv)
AT (1) ATE135363T1 (sv)
AU (1) AU615681B2 (sv)
DE (1) DE3855099D1 (sv)
DK (1) DK602988A (sv)
HU (1) HU211132A9 (sv)
PT (1) PT88930B (sv)
SE (1) SE8704298D0 (sv)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978655A (en) * 1986-12-17 1990-12-18 Yale University Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
US5506215A (en) * 1987-11-03 1996-04-09 Medivir Ab 1-(3'-fluoro-2',3'-dideoxy-β-D-ribofuranosyl)-5-substituted pyrimidine nucleosides
GB8726136D0 (en) * 1987-11-07 1987-12-09 Wellcome Found Therapeutic nucleosides
EP0346108A3 (en) * 1988-06-09 1991-04-24 The Wellcome Foundation Limited Anti-infective nucleosides
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
GB8823319D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
GR1000522B (el) * 1988-10-11 1992-08-25 Medivir Ab Μεθοδος παρασκευης νεων αναλογων νουκλεοζιτων.
DD293498A5 (de) * 1989-07-20 1991-09-05 Zi Fuer Molekularbiologie Der Adw,De Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
FR2654106B1 (fr) * 1989-11-03 1992-01-10 Synthelabo Derives phosphores de cytosine, leur preparation et leur application en therapeutique.
AU636678B2 (en) * 1989-11-06 1993-05-06 Nycomed Imaging As Nucleoside derivatives
GB9012899D0 (en) * 1990-06-09 1990-08-01 Wellcome Found Anti-hbv pyrimidine nucleoside
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
DE4110977A1 (de) * 1991-04-05 1992-10-08 Bayer Ag Substituierte 2',3'-didesoxy-5-trifluormethyluridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
ZA923641B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9125271D0 (en) * 1991-11-27 1992-01-29 Wellcome Found Anti-hbv pyrimidine nucleoside
FR2684997A1 (fr) * 1991-12-12 1993-06-18 Centre Nat Rech Scient Derives de la 9-(beta-d-xylofurannosyl) adenine et de la 1-(beta-d-xylofurannosyl) cytosine, leur preparation et leur application en therapeutique.
DE4207363A1 (de) * 1992-03-04 1993-09-09 Max Delbrueck Centrum Antivirale nucleosidanaloga, ihre herstellung und ihre pharmazeutische verwendung
FR2691463A1 (fr) * 1992-05-25 1993-11-26 Centre Nat Rech Scient Dérivés nucléotidiques, leur préparation et leur application en thérapeutique.
FR2692265B1 (fr) * 1992-05-25 1996-11-08 Centre Nat Rech Scient Composes biologiquement actifs de type phosphotriesters.
US5770725A (en) * 1992-05-25 1998-06-23 Gosselin; Gilles Phosphotriester type biologically active compounds
US6020482A (en) * 1992-05-25 2000-02-01 Gosselin; Gilles Phosphotriester type biologically active compounds
US5849905A (en) * 1994-11-23 1998-12-15 Centre National De La Recherche Scientifique Biologically active phosphotriester-type nucleosides and methods for preparing same
JPH08508489A (ja) * 1993-03-31 1996-09-10 スターリング ウィンスロップ インコーポレイティド 二官能価ヌクレオシド、それらのオリゴマーならびにそれらの製造方法及び使用方法
US5955591A (en) * 1993-05-12 1999-09-21 Imbach; Jean-Louis Phosphotriester oligonucleotides, amidites and method of preparation
US5627160A (en) * 1993-05-25 1997-05-06 Yale University L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
TW374087B (en) * 1993-05-25 1999-11-11 Univ Yale L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents
CA2637774C (en) * 1993-09-10 2011-07-19 Emory University Nucleosides with anti-hepatitis b virus activity
US5559101A (en) * 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
MX9702927A (es) * 1994-10-24 1998-04-30 Genencor Int L-piranosilnucleosidos.
US5627185A (en) * 1994-11-23 1997-05-06 Gosselin; Gilles Acyclovir derivatives as antiviral agents
US5869461A (en) * 1995-03-16 1999-02-09 Yale University Reducing toxicity of L-nucleosides with D-nucleosides
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
JP2008110983A (ja) * 1999-05-12 2008-05-15 Yamasa Shoyu Co Ltd ４’−ｃ−エチニルヌクレオシド化合物
JP2003523978A (ja) 2000-02-18 2003-08-12 シャイアー・バイオケム・インコーポレイテッド ヌクレオシドアナログを用いるｆｌａｖｉｖｉｒｕｓ感染の処置もしくは予防するための方法
CA2458408A1 (en) 2001-08-24 2003-03-06 Koronis Pharmaceuticals, Inc. Mutagenic nucleoside analogs for the treatment of viral disease
CN104072558B (zh) * 2013-03-26 2016-09-28 河南师范大学 具有抗hiv活性的5-取代嘧啶核苷-四氢噻唑杂化体及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3282921A (en) * 1964-06-04 1966-11-01 Syntex Corp Halo-deoxynucleosides and processes for the preparation thereof
US3687931A (en) * 1970-03-19 1972-08-29 Syntex Corp Halogenated purine and pyrimidine nucleosides and process therefor
DE3045375A1 (de) * 1980-12-02 1982-07-01 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen Neue substituierte pyrimidin-nukleoside mit antiviraler wirkung, verfahren zu deren herstellung und daraus zubereitete arzneiformen
DE3650741T2 (de) * 1985-09-17 2000-10-12 Wellcome Found Kombination therapeutische Nukleoside mit weiteren therapeutisch wirksamen Komponenten.
DD279407A1 (de) * 1986-07-24 1990-06-06 Akad Wissenschaften Ddr Verfahren zur herstellung eines mittels gegen aids

Also Published As

Publication number Publication date
EP0322384A1 (en) 1989-06-28
DE3855099D1 (de) 1996-04-18
ATE135363T1 (de) 1996-03-15
AU615681B2 (en) 1991-10-10
AU2452288A (en) 1989-05-04
PT88930B (pt) 1993-01-29
DK602988A (da) 1989-05-04
DK602988D0 (da) 1988-10-28
JPH01151595A (ja) 1989-06-14
HU211132A9 (en) 1995-10-30
PT88930A (pt) 1988-12-01
EP0322384B1 (en) 1996-03-13

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