DE3855099D1 - Nucleoside zur Verwendung für die Therapie - Google Patents
Nucleoside zur Verwendung für die TherapieInfo
- Publication number
- DE3855099D1 DE3855099D1 DE3855099T DE3855099T DE3855099D1 DE 3855099 D1 DE3855099 D1 DE 3855099D1 DE 3855099 T DE3855099 T DE 3855099T DE 3855099 T DE3855099 T DE 3855099T DE 3855099 D1 DE3855099 D1 DE 3855099D1
- Authority
- DE
- Germany
- Prior art keywords
- therapy
- nucleosides
- retrovirus
- hepatitis
- radicals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8704298A SE8704298D0 (sv) | 1987-11-03 | 1987-11-03 | Compounds for use in therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3855099D1 true DE3855099D1 (de) | 1996-04-18 |
Family
ID=20370102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3855099T Expired - Lifetime DE3855099D1 (de) | 1987-11-03 | 1988-10-27 | Nucleoside zur Verwendung für die Therapie |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0322384B1 (de) |
JP (1) | JPH01151595A (de) |
AT (1) | ATE135363T1 (de) |
AU (1) | AU615681B2 (de) |
DE (1) | DE3855099D1 (de) |
DK (1) | DK602988A (de) |
HU (1) | HU211132A9 (de) |
PT (1) | PT88930B (de) |
SE (1) | SE8704298D0 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4978655A (en) * | 1986-12-17 | 1990-12-18 | Yale University | Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses |
US5506215A (en) * | 1987-11-03 | 1996-04-09 | Medivir Ab | 1-(3'-fluoro-2',3'-dideoxy-β-D-ribofuranosyl)-5-substituted pyrimidine nucleosides |
GB8726136D0 (en) * | 1987-11-07 | 1987-12-09 | Wellcome Found | Therapeutic nucleosides |
EP0346108A3 (de) * | 1988-06-09 | 1991-04-24 | The Wellcome Foundation Limited | Anti-infektiöse Nukleoside |
US5157114A (en) * | 1988-08-19 | 1992-10-20 | Burroughs Wellcome Co. | 2',3'-dideoxy-3'-fluoro-5-ethyngluridine |
GB8823319D0 (en) * | 1988-10-05 | 1988-11-09 | Nycomed As | Chemical compounds |
GR1000522B (el) * | 1988-10-11 | 1992-08-25 | Medivir Ab | Μεθοδος παρασκευης νεων αναλογων νουκλεοζιτων. |
DD293498A5 (de) * | 1989-07-20 | 1991-09-05 | Zi Fuer Molekularbiologie Der Adw,De | Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier |
FR2654106B1 (fr) * | 1989-11-03 | 1992-01-10 | Synthelabo | Derives phosphores de cytosine, leur preparation et leur application en therapeutique. |
AU636678B2 (en) * | 1989-11-06 | 1993-05-06 | Nycomed Imaging As | Nucleoside derivatives |
GB9012899D0 (en) * | 1990-06-09 | 1990-08-01 | Wellcome Found | Anti-hbv pyrimidine nucleoside |
SE9003151D0 (sv) * | 1990-10-02 | 1990-10-02 | Medivir Ab | Nucleoside derivatives |
DE4110977A1 (de) * | 1991-04-05 | 1992-10-08 | Bayer Ag | Substituierte 2',3'-didesoxy-5-trifluormethyluridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
ZA923640B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
GB9125271D0 (en) * | 1991-11-27 | 1992-01-29 | Wellcome Found | Anti-hbv pyrimidine nucleoside |
FR2684997A1 (fr) * | 1991-12-12 | 1993-06-18 | Centre Nat Rech Scient | Derives de la 9-(beta-d-xylofurannosyl) adenine et de la 1-(beta-d-xylofurannosyl) cytosine, leur preparation et leur application en therapeutique. |
DE4207363A1 (de) * | 1992-03-04 | 1993-09-09 | Max Delbrueck Centrum | Antivirale nucleosidanaloga, ihre herstellung und ihre pharmazeutische verwendung |
US5849905A (en) * | 1994-11-23 | 1998-12-15 | Centre National De La Recherche Scientifique | Biologically active phosphotriester-type nucleosides and methods for preparing same |
FR2691463A1 (fr) * | 1992-05-25 | 1993-11-26 | Centre Nat Rech Scient | Dérivés nucléotidiques, leur préparation et leur application en thérapeutique. |
FR2692265B1 (fr) * | 1992-05-25 | 1996-11-08 | Centre Nat Rech Scient | Composes biologiquement actifs de type phosphotriesters. |
US6020482A (en) * | 1992-05-25 | 2000-02-01 | Gosselin; Gilles | Phosphotriester type biologically active compounds |
US5770725A (en) * | 1992-05-25 | 1998-06-23 | Gosselin; Gilles | Phosphotriester type biologically active compounds |
EP0701564A1 (de) * | 1993-03-31 | 1996-03-20 | Sanofi | Bifunktional nukleoside, oligomere davon und verfahren zu ihrer herstellung und zu ihrer verwendung |
US5955591A (en) * | 1993-05-12 | 1999-09-21 | Imbach; Jean-Louis | Phosphotriester oligonucleotides, amidites and method of preparation |
TW374087B (en) * | 1993-05-25 | 1999-11-11 | Univ Yale | L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents |
US5627160A (en) * | 1993-05-25 | 1997-05-06 | Yale University | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents |
JPH09504785A (ja) * | 1993-09-10 | 1997-05-13 | エモリー、ユニバーシティー | 抗b型肝炎ウイルス活性を有するヌクレオシド |
DE69533856T2 (de) * | 1994-10-24 | 2005-12-08 | Genencor International, Inc., Palo Alto | L-pyranosyl-nukleoside |
US5559101A (en) * | 1994-10-24 | 1996-09-24 | Genencor International, Inc. | L-ribofuranosyl nucleosides |
US5627185A (en) * | 1994-11-23 | 1997-05-06 | Gosselin; Gilles | Acyclovir derivatives as antiviral agents |
US5869461A (en) * | 1995-03-16 | 1999-02-09 | Yale University | Reducing toxicity of L-nucleosides with D-nucleosides |
US5869493A (en) | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
JP2008110983A (ja) * | 1999-05-12 | 2008-05-15 | Yamasa Shoyu Co Ltd | 4’−c−エチニルヌクレオシド化合物 |
PL364995A1 (en) | 2000-02-18 | 2004-12-27 | Shire Biochem Inc. | Method for the treatment or prevention of flavivirus |
US7244717B2 (en) | 2001-08-24 | 2007-07-17 | Koronis Pharmaceuticals, Incorporated | Mutagenic nucleoside analogs for the treatment of viral disease |
CN104072558B (zh) * | 2013-03-26 | 2016-09-28 | 河南师范大学 | 具有抗hiv活性的5-取代嘧啶核苷-四氢噻唑杂化体及其制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3282921A (en) * | 1964-06-04 | 1966-11-01 | Syntex Corp | Halo-deoxynucleosides and processes for the preparation thereof |
US3687931A (en) * | 1970-03-19 | 1972-08-29 | Syntex Corp | Halogenated purine and pyrimidine nucleosides and process therefor |
DE3045375A1 (de) * | 1980-12-02 | 1982-07-01 | Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen | Neue substituierte pyrimidin-nukleoside mit antiviraler wirkung, verfahren zu deren herstellung und daraus zubereitete arzneiformen |
GB2181128A (en) * | 1985-09-17 | 1987-04-15 | Wellcome Found | 3'-azidonucleosides |
DD279407A1 (de) * | 1986-07-24 | 1990-06-06 | Akad Wissenschaften Ddr | Verfahren zur herstellung eines mittels gegen aids |
-
1987
- 1987-11-03 SE SE8704298A patent/SE8704298D0/xx unknown
-
1988
- 1988-10-27 DE DE3855099T patent/DE3855099D1/de not_active Expired - Lifetime
- 1988-10-27 AT AT88850370T patent/ATE135363T1/de not_active IP Right Cessation
- 1988-10-27 EP EP88850370A patent/EP0322384B1/de not_active Expired - Lifetime
- 1988-10-28 DK DK602988A patent/DK602988A/da not_active Application Discontinuation
- 1988-10-31 AU AU24522/88A patent/AU615681B2/en not_active Ceased
- 1988-11-02 JP JP63276363A patent/JPH01151595A/ja active Pending
- 1988-11-03 PT PT88930A patent/PT88930B/pt not_active IP Right Cessation
-
1995
- 1995-06-22 HU HU95P/P00382P patent/HU211132A9/hu unknown
Also Published As
Publication number | Publication date |
---|---|
EP0322384B1 (de) | 1996-03-13 |
DK602988D0 (da) | 1988-10-28 |
AU615681B2 (en) | 1991-10-10 |
HU211132A9 (en) | 1995-10-30 |
AU2452288A (en) | 1989-05-04 |
PT88930A (pt) | 1988-12-01 |
PT88930B (pt) | 1993-01-29 |
EP0322384A1 (de) | 1989-06-28 |
ATE135363T1 (de) | 1996-03-15 |
JPH01151595A (ja) | 1989-06-14 |
SE8704298D0 (sv) | 1987-11-03 |
DK602988A (da) | 1989-05-04 |
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EE02995B1 (et) | 1,3-oksatiolaannukleosiidi analoogide kasutamine hepatiit B ravimpreparaatide valmistamiseks | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |