ATE134644T1 - Weitere antivirale pyrimidin-nukleosiden - Google Patents
Weitere antivirale pyrimidin-nukleosidenInfo
- Publication number
- ATE134644T1 ATE134644T1 AT90310857T AT90310857T ATE134644T1 AT E134644 T1 ATE134644 T1 AT E134644T1 AT 90310857 T AT90310857 T AT 90310857T AT 90310857 T AT90310857 T AT 90310857T AT E134644 T1 ATE134644 T1 AT E134644T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxy
- fluoro
- hydrogen
- pyrimidine nucleosides
- monoalkylamino
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title 1
- 239000002718 pyrimidine nucleoside Substances 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000001153 fluoro group Chemical group F* 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000262 haloalkenyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- -1 monoalkylamino Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000005450 thionucleoside Substances 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898922322A GB8922322D0 (en) | 1989-10-04 | 1989-10-04 | Antiviral nucleosides |
| GB898922393A GB8922393D0 (en) | 1989-10-04 | 1989-10-04 | Antiviral pyrimidines |
| GB898922397A GB8922397D0 (en) | 1989-10-04 | 1989-10-04 | Antiviral pentofuranosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE134644T1 true ATE134644T1 (de) | 1996-03-15 |
Family
ID=27264717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90310857T ATE134644T1 (de) | 1989-10-04 | 1990-10-04 | Weitere antivirale pyrimidin-nukleosiden |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0421777B1 (de) |
| JP (1) | JPH05505791A (de) |
| KR (1) | KR927003615A (de) |
| AT (1) | ATE134644T1 (de) |
| AU (1) | AU656122B2 (de) |
| CA (1) | CA2067094A1 (de) |
| DE (1) | DE69025529T2 (de) |
| ES (1) | ES2086376T3 (de) |
| HU (1) | HUT61777A (de) |
| IE (1) | IE74701B1 (de) |
| NZ (1) | NZ235537A (de) |
| PT (1) | PT95510B (de) |
| WO (1) | WO1991004982A1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ234534A (en) * | 1989-07-17 | 1994-12-22 | Univ Birmingham | Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor |
| US5128458A (en) * | 1990-04-20 | 1992-07-07 | Southern Research Institute | 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents |
| GB9009861D0 (en) | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
| US5521163A (en) * | 1990-07-13 | 1996-05-28 | University Of Birmingham | Antiviral pyrimidine nucleosides and methods for using same |
| FR2668153B1 (fr) * | 1990-10-22 | 1995-03-31 | Pasteur Merieux Serums Vacc | Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant. |
| IL100502A (en) * | 1991-01-03 | 1995-12-08 | Iaf Biochem Int | PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (- |
| GB9109186D0 (en) * | 1991-04-29 | 1991-06-19 | Wellcome Found | Preparation of thionucleosides |
| GB9110874D0 (en) * | 1991-05-20 | 1991-07-10 | Iaf Biochem Int | Medicaments |
| WO1994001443A1 (en) * | 1992-07-02 | 1994-01-20 | The Wellcome Foundation Limited | Therapeutic nucleosides |
| GB9218810D0 (en) * | 1992-09-04 | 1992-10-21 | Univ Birmingham | Antiviral pyrimidine nucleosides |
| DK0841344T3 (da) * | 1996-04-09 | 2002-12-23 | Yamasa Corp | 1-(2-Desoxy-2-fluor-4-thio-Beta-D-arabinofuranosyl)cytosiner |
| US6103707A (en) * | 1996-04-09 | 2000-08-15 | Yamasa Corporation | 9-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)purine derivatives |
| WO1999043690A1 (en) * | 1998-02-25 | 1999-09-02 | Rational Drug Design Laboratories | L-4'-arabinofuranonucleoside compound and medicine composition comprising the same |
| AU4125099A (en) * | 1998-06-01 | 1999-12-20 | S & T Science And Technology Inc. | Antiviral phosphorus derivatives of 4'-thio-5-ethyl-2'-deoxyuridine |
| KR20000008131A (ko) * | 1998-07-10 | 2000-02-07 | 정낙신 | 치오뉴클레오시드 유도체 및 그들의 제조방법 |
| ES2402799T3 (es) | 1998-07-23 | 2013-05-09 | Southern Research Institute | Prepreparación de compuestos de tioarabinofuranosilo y utilización de los mismos |
| TWI247609B (en) | 2001-01-23 | 2006-01-21 | Nihon Mediphysics Co Ltd | Agent for diagnosis of tissue proliferation activity or the treatment of proliferative disease |
| WO2005027962A1 (en) | 2003-09-18 | 2005-03-31 | Isis Pharmaceuticals, Inc. | 4’-thionucleosides and oligomeric compounds |
| CN101801390B (zh) * | 2007-09-10 | 2012-11-14 | 雅玛山酱油株式会社 | 针对爱泼斯坦-巴尔病毒相关疾病的药剂 |
| US8859589B2 (en) | 2008-03-12 | 2014-10-14 | Southern Research Institute | Use of 4′-thio-2′-deoxynucleosides as anti orthopoxvirus agents |
| WO2011109012A1 (en) | 2010-03-02 | 2011-09-09 | Southern Research Institute | Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents |
| WO2011109383A1 (en) * | 2010-03-02 | 2011-09-09 | Southern Research Institute | Use of 2'-deoxy -4'-thiocytidine and its analogues as dna hypomethylating anticancer agents |
| TW201340971A (zh) * | 2012-03-09 | 2013-10-16 | Taiho Pharmaceutical Co Ltd | Ｄｎａ損傷劑 |
| AU2013241341B2 (en) | 2012-03-28 | 2016-09-08 | Fujifilm Corporation | Salt of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine |
| DK2883866T3 (da) | 2012-08-13 | 2019-05-13 | Fujifilm Corp | MELLEMPRODUKT TIL SYNTESE AF 1-(2-DEOXY-2-FLUOR-4-THIO-beta-D- ARABINOFURANOSYL)CYTOSIN, MELLEMPRODUKT TIL SYNTESE AF THIONUKLEOSID OG FREMGANGSMÅDER TIL FREMSTILLING AF DISSE MELLEMPRODUKTER |
| WO2015125781A1 (ja) | 2014-02-18 | 2015-08-27 | 富士フイルム株式会社 | チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物 |
| JP6204223B2 (ja) | 2014-02-19 | 2017-09-27 | 富士フイルム株式会社 | チオピラノース化合物等の製造方法 |
| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| EP3508205B1 (de) | 2016-08-31 | 2022-05-18 | FUJIFILM Corporation | Antitumormittel, antitumoreffektverstärker und antitumorkit |
| MX2018002611A (es) | 2018-01-29 | 2019-07-30 | Fujifilm Corp | Agente antitumoral para cancer del tracto biliar y metodo para tratar cancer del tracto biliar. |
| WO2022008025A1 (en) * | 2020-07-05 | 2022-01-13 | Since & Technology Development Fund Authority | 2-hydroxyiminopyrimidine nucleosides and derivitives and antiviral uses thereto |
| EP4319763A4 (de) * | 2021-04-09 | 2025-06-11 | Emory University | Modifizierte nukleoside und nukleotidanaloga als antivirale mittel für corona- und andere viren |
| KR20240108406A (ko) | 2021-10-19 | 2024-07-09 | 아키라바이오, 인크. | 2'-데옥시시티딘 유사체를 포함하는 조성물 및 겸상 적혈구 질환, 지중해빈혈, 및 암의 치료를 위한 그의 용도 |
-
1990
- 1990-10-01 IE IE350290A patent/IE74701B1/en not_active IP Right Cessation
- 1990-10-02 NZ NZ235537A patent/NZ235537A/xx unknown
- 1990-10-04 AT AT90310857T patent/ATE134644T1/de not_active IP Right Cessation
- 1990-10-04 EP EP90310857A patent/EP0421777B1/de not_active Expired - Lifetime
- 1990-10-04 JP JP90513649A patent/JPH05505791A/ja active Pending
- 1990-10-04 KR KR1019920700746A patent/KR927003615A/ko not_active Ceased
- 1990-10-04 DE DE69025529T patent/DE69025529T2/de not_active Expired - Fee Related
- 1990-10-04 PT PT95510A patent/PT95510B/pt not_active IP Right Cessation
- 1990-10-04 AU AU64413/90A patent/AU656122B2/en not_active Ceased
- 1990-10-04 HU HU9201139A patent/HUT61777A/hu unknown
- 1990-10-04 CA CA002067094A patent/CA2067094A1/en not_active Abandoned
- 1990-10-04 ES ES90310857T patent/ES2086376T3/es not_active Expired - Lifetime
- 1990-10-04 WO PCT/GB1990/001518 patent/WO1991004982A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| IE74701B1 (en) | 1997-07-30 |
| NZ235537A (en) | 1992-12-23 |
| IE903502A1 (en) | 1991-04-10 |
| EP0421777B1 (de) | 1996-02-28 |
| PT95510A (pt) | 1991-08-14 |
| CA2067094A1 (en) | 1991-04-05 |
| ES2086376T3 (es) | 1996-07-01 |
| AU656122B2 (en) | 1995-01-27 |
| HUT61777A (en) | 1993-03-01 |
| PT95510B (pt) | 1997-08-29 |
| KR927003615A (ko) | 1992-12-18 |
| WO1991004982A1 (en) | 1991-04-18 |
| DE69025529D1 (de) | 1996-04-04 |
| DE69025529T2 (de) | 1996-10-17 |
| AU6441390A (en) | 1991-04-28 |
| EP0421777A1 (de) | 1991-04-10 |
| JPH05505791A (ja) | 1993-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |