ATE134644T1 - Weitere antivirale pyrimidin-nukleosiden - Google Patents

Weitere antivirale pyrimidin-nukleosiden

Info

Publication number
ATE134644T1
ATE134644T1 AT90310857T AT90310857T ATE134644T1 AT E134644 T1 ATE134644 T1 AT E134644T1 AT 90310857 T AT90310857 T AT 90310857T AT 90310857 T AT90310857 T AT 90310857T AT E134644 T1 ATE134644 T1 AT E134644T1
Authority
AT
Austria
Prior art keywords
hydroxy
fluoro
hydrogen
pyrimidine nucleosides
monoalkylamino
Prior art date
Application number
AT90310857T
Other languages
English (en)
Inventor
Richard Walker
Paul Coe
Saad George Rahim
Original Assignee
Univ Birmingham
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898922393A external-priority patent/GB8922393D0/en
Priority claimed from GB898922397A external-priority patent/GB8922397D0/en
Priority claimed from GB898922322A external-priority patent/GB8922322D0/en
Application filed by Univ Birmingham, Wellcome Found filed Critical Univ Birmingham
Application granted granted Critical
Publication of ATE134644T1 publication Critical patent/ATE134644T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT90310857T 1989-10-04 1990-10-04 Weitere antivirale pyrimidin-nukleosiden ATE134644T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898922393A GB8922393D0 (en) 1989-10-04 1989-10-04 Antiviral pyrimidines
GB898922397A GB8922397D0 (en) 1989-10-04 1989-10-04 Antiviral pentofuranosides
GB898922322A GB8922322D0 (en) 1989-10-04 1989-10-04 Antiviral nucleosides

Publications (1)

Publication Number Publication Date
ATE134644T1 true ATE134644T1 (de) 1996-03-15

Family

ID=27264717

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90310857T ATE134644T1 (de) 1989-10-04 1990-10-04 Weitere antivirale pyrimidin-nukleosiden

Country Status (13)

Country Link
EP (1) EP0421777B1 (de)
JP (1) JPH05505791A (de)
KR (1) KR927003615A (de)
AT (1) ATE134644T1 (de)
AU (1) AU656122B2 (de)
CA (1) CA2067094A1 (de)
DE (1) DE69025529T2 (de)
ES (1) ES2086376T3 (de)
HU (1) HUT61777A (de)
IE (1) IE74701B1 (de)
NZ (1) NZ235537A (de)
PT (1) PT95510B (de)
WO (1) WO1991004982A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE902574A1 (en) * 1989-07-17 1991-02-27 Univ Birmingham Antiviral pyrimidine nucleosides
US5128458A (en) * 1990-04-20 1992-07-07 Southern Research Institute 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents
GB9009861D0 (en) 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
US5521163A (en) * 1990-07-13 1996-05-28 University Of Birmingham Antiviral pyrimidine nucleosides and methods for using same
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
IL100502A (en) * 1991-01-03 1995-12-08 Iaf Biochem Int PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (-
GB9109186D0 (en) * 1991-04-29 1991-06-19 Wellcome Found Preparation of thionucleosides
GB9110874D0 (en) * 1991-05-20 1991-07-10 Iaf Biochem Int Medicaments
MY111746A (en) * 1992-07-02 2000-12-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
GB9218810D0 (en) * 1992-09-04 1992-10-21 Univ Birmingham Antiviral pyrimidine nucleosides
EP0839813A1 (de) * 1996-04-09 1998-05-06 Yamasa Corporation 9-(2-deoxy-2-fluor-4-thio-beta-d-arabinofuranosyl)purin-derivate
WO1997038001A1 (fr) * 1996-04-09 1997-10-16 Yamasa Corporation 1-(2-DESOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINES
WO1999043690A1 (fr) * 1998-02-25 1999-09-02 Rational Drug Design Laboratories Compose de l-4'-arabinofuranonucleoside et composition medicinale le contenant
WO1999062921A1 (en) * 1998-06-01 1999-12-09 S & T Science And Technology Inc. Antiviral phosphorus derivatives of 4'-thio-5-ethyl-2'-deoxyuridine
KR20000008131A (ko) * 1998-07-10 2000-02-07 정낙신 치오뉴클레오시드 유도체 및 그들의 제조방법
ATE531376T1 (de) 1998-07-23 2011-11-15 Southern Res Inst Verwendung von thioarabinofuranosyl-verbindungen
TWI247609B (en) * 2001-01-23 2006-01-21 Nihon Mediphysics Co Ltd Agent for diagnosis of tissue proliferation activity or the treatment of proliferative disease
JP5379347B2 (ja) * 2003-09-18 2013-12-25 アイシス ファーマシューティカルズ， インコーポレーテッド ４’−チオヌクレオシドおよびオリゴマー化合物
WO2009034945A1 (ja) * 2007-09-10 2009-03-19 Yamasa Corporation エプスタイン・バールウイルス関連疾患に対する薬剤およびそのスクリーニング法
US8859589B2 (en) 2008-03-12 2014-10-14 Southern Research Institute Use of 4′-thio-2′-deoxynucleosides as anti orthopoxvirus agents
WO2011109012A1 (en) 2010-03-02 2011-09-09 Southern Research Institute Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents
WO2011109383A1 (en) * 2010-03-02 2011-09-09 Southern Research Institute Use of 2'-deoxy -4'-thiocytidine and its analogues as dna hypomethylating anticancer agents
WO2013133399A1 (ja) * 2012-03-09 2013-09-12 大鵬薬品工業株式会社 Ｄｎａ障害剤
PL2832740T3 (pl) 2012-03-28 2019-09-30 Fujifilm Corporation Sól 1-(2-deoksy-2-fluoro-4-tio-beta-d-arabinofuranozylo)cytozyny
KR102010804B1 (ko) 2012-08-13 2019-08-14 후지필름 가부시키가이샤 1-(2-데옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 합성 중간체, 티오뉴클레오시드의 합성 중간체, 및 그들의 제조법
WO2015125781A1 (ja) 2014-02-18 2015-08-27 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja) 2014-02-19 2017-09-27 富士フイルム株式会社 チオピラノース化合物等の製造方法
TWI678373B (zh) 2014-10-31 2019-12-01 日商富士軟片股份有限公司 硫代核苷衍生物或其鹽及醫藥組合物
KR102198656B1 (ko) 2016-08-31 2021-01-05 후지필름 가부시키가이샤 항종양제, 항종양 효과 증강제 및 항종양용 키트
WO2019146130A1 (ja) 2018-01-29 2019-08-01 富士フイルム株式会社 胆道がん用抗腫瘍剤および胆道がんの処置方法
WO2022008025A1 (en) * 2020-07-05 2022-01-13 Since & Technology Development Fund Authority 2-hydroxyiminopyrimidine nucleosides and derivitives and antiviral uses thereto
WO2022217153A2 (en) * 2021-04-09 2022-10-13 Emory University Nucleosides and nucleotides analogs as antiviral agents
KR20240108406A (ko) 2021-10-19 2024-07-09 아키라바이오, 인크. 2'-데옥시시티딘 유사체를 포함하는 조성물 및 겸상 적혈구 질환, 지중해빈혈, 및 암의 치료를 위한 그의 용도

Also Published As

Publication number Publication date
IE74701B1 (en) 1997-07-30
ES2086376T3 (es) 1996-07-01
DE69025529T2 (de) 1996-10-17
PT95510B (pt) 1997-08-29
IE903502A1 (en) 1991-04-10
JPH05505791A (ja) 1993-08-26
AU656122B2 (en) 1995-01-27
EP0421777A1 (de) 1991-04-10
PT95510A (pt) 1991-08-14
EP0421777B1 (de) 1996-02-28
CA2067094A1 (en) 1991-04-05
KR927003615A (ko) 1992-12-18
DE69025529D1 (de) 1996-04-04
AU6441390A (en) 1991-04-28
HUT61777A (en) 1993-03-01
WO1991004982A1 (en) 1991-04-18
NZ235537A (en) 1992-12-23

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