HUT61777A - Process for producing pyrimidine-nukleozides and pharmaceutical compositions containing them as active components - Google Patents

Process for producing pyrimidine-nukleozides and pharmaceutical compositions containing them as active components

Info

Publication number
HUT61777A
HUT61777A HU9201139A HU113990A HUT61777A HU T61777 A HUT61777 A HU T61777A HU 9201139 A HU9201139 A HU 9201139A HU 113990 A HU113990 A HU 113990A HU T61777 A HUT61777 A HU T61777A
Authority
HU
Hungary
Prior art keywords
hydroxy
nukleozides
pharmaceutical compositions
compositions containing
active components
Prior art date
Application number
HU9201139A
Other languages
English (en)
Inventor
Richard Walker
Paul Coe
Saad George Rahim
Original Assignee
Univ Birmingham
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898922322A external-priority patent/GB8922322D0/en
Priority claimed from GB898922393A external-priority patent/GB8922393D0/en
Priority claimed from GB898922397A external-priority patent/GB8922397D0/en
Application filed by Univ Birmingham, Wellcome Found filed Critical Univ Birmingham
Publication of HUT61777A publication Critical patent/HUT61777A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU9201139A 1989-10-04 1990-10-04 Process for producing pyrimidine-nukleozides and pharmaceutical compositions containing them as active components HUT61777A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898922322A GB8922322D0 (en) 1989-10-04 1989-10-04 Antiviral nucleosides
GB898922393A GB8922393D0 (en) 1989-10-04 1989-10-04 Antiviral pyrimidines
GB898922397A GB8922397D0 (en) 1989-10-04 1989-10-04 Antiviral pentofuranosides

Publications (1)

Publication Number Publication Date
HUT61777A true HUT61777A (en) 1993-03-01

Family

ID=27264717

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9201139A HUT61777A (en) 1989-10-04 1990-10-04 Process for producing pyrimidine-nukleozides and pharmaceutical compositions containing them as active components

Country Status (13)

Country Link
EP (1) EP0421777B1 (hu)
JP (1) JPH05505791A (hu)
KR (1) KR927003615A (hu)
AT (1) ATE134644T1 (hu)
AU (1) AU656122B2 (hu)
CA (1) CA2067094A1 (hu)
DE (1) DE69025529T2 (hu)
ES (1) ES2086376T3 (hu)
HU (1) HUT61777A (hu)
IE (1) IE74701B1 (hu)
NZ (1) NZ235537A (hu)
PT (1) PT95510B (hu)
WO (1) WO1991004982A1 (hu)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE902574A1 (en) * 1989-07-17 1991-02-27 Univ Birmingham Antiviral pyrimidine nucleosides
US5128458A (en) * 1990-04-20 1992-07-07 Southern Research Institute 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents
GB9009861D0 (en) 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
US5521163A (en) * 1990-07-13 1996-05-28 University Of Birmingham Antiviral pyrimidine nucleosides and methods for using same
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
IL100502A (en) * 1991-01-03 1995-12-08 Iaf Biochem Int PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (-
GB9109186D0 (en) * 1991-04-29 1991-06-19 Wellcome Found Preparation of thionucleosides
GB9110874D0 (en) * 1991-05-20 1991-07-10 Iaf Biochem Int Medicaments
MX9303985A (es) * 1992-07-02 1994-02-28 Wellcome Found Nucleosidos terapeuticos.
GB9218810D0 (en) * 1992-09-04 1992-10-21 Univ Birmingham Antiviral pyrimidine nucleosides
WO1997037993A1 (fr) * 1996-04-09 1997-10-16 Yamasa Corporation DERIVES DE 9-(2-DESOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)PURINE
JP3657008B2 (ja) * 1996-04-09 2005-06-08 ヤマサ醤油株式会社 １−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）シトシン
WO1999043690A1 (fr) * 1998-02-25 1999-09-02 Rational Drug Design Laboratories Compose de l-4'-arabinofuranonucleoside et composition medicinale le contenant
WO1999062921A1 (en) * 1998-06-01 1999-12-09 S & T Science And Technology Inc. Antiviral phosphorus derivatives of 4'-thio-5-ethyl-2'-deoxyuridine
KR20000008131A (ko) * 1998-07-10 2000-02-07 정낙신 치오뉴클레오시드 유도체 및 그들의 제조방법
JP4719356B2 (ja) 1998-07-23 2011-07-06 サザン・リサーチ・インスティテュート 抗ガン剤及びｄｎａ複製阻害剤
TWI247609B (en) 2001-01-23 2006-01-21 Nihon Mediphysics Co Ltd Agent for diagnosis of tissue proliferation activity or the treatment of proliferative disease
WO2005027962A1 (en) 2003-09-18 2005-03-31 Isis Pharmaceuticals, Inc. 4’-thionucleosides and oligomeric compounds
US20100330563A1 (en) * 2007-09-10 2010-12-30 Yamasa Corporation Medicinal agent for disease associated with epstein-barr virus, and method for screening of the medicinal agent
US8859589B2 (en) 2008-03-12 2014-10-14 Southern Research Institute Use of 4′-thio-2′-deoxynucleosides as anti orthopoxvirus agents
WO2011109383A1 (en) * 2010-03-02 2011-09-09 Southern Research Institute Use of 2'-deoxy -4'-thiocytidine and its analogues as dna hypomethylating anticancer agents
WO2011109012A1 (en) 2010-03-02 2011-09-09 Southern Research Institute Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents
TW201340971A (zh) * 2012-03-09 2013-10-16 Taiho Pharmaceutical Co Ltd Ｄｎａ損傷劑
MX352423B (es) 2012-03-28 2017-11-24 Fujifilm Corp Sal de 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil) citosina.
RS58568B1 (sr) 2012-08-13 2019-05-31 Fujifilm Corp Intermedijer za sintezu 1-(2-deoksi-2-fluoro-4-tio-beta-d-arabinofuranozil) citozina, intermedijer za sintezu tionukleozida, i metode za proizvodnju ovih intermedijera
WO2015125781A1 (ja) 2014-02-18 2015-08-27 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja) 2014-02-19 2017-09-27 富士フイルム株式会社 チオピラノース化合物等の製造方法
TWI678373B (zh) 2014-10-31 2019-12-01 日商富士軟片股份有限公司 硫代核苷衍生物或其鹽及醫藥組合物
SG11201901815WA (en) 2016-08-31 2019-04-29 Fujifilm Corp Anti-tumor agent, anti-tumor effect enhancer, and anti-tumor kit
WO2019146130A1 (ja) 2018-01-29 2019-08-01 富士フイルム株式会社 胆道がん用抗腫瘍剤および胆道がんの処置方法
WO2022008025A1 (en) * 2020-07-05 2022-01-13 Since & Technology Development Fund Authority 2-hydroxyiminopyrimidine nucleosides and derivitives and antiviral uses thereto
AU2022254108A1 (en) * 2021-04-09 2023-10-26 Emory University Nucleosides and nucleotides analogs as antiviral agents
AU2022370354A1 (en) 2021-10-19 2024-05-30 Akirabio, Inc. Compositions comprising 2'-deoxycytidine analogs and use thereof for the treatment of sickle cell disease, thalassemia, and cancers

Also Published As

Publication number Publication date
WO1991004982A1 (en) 1991-04-18
AU656122B2 (en) 1995-01-27
AU6441390A (en) 1991-04-28
EP0421777B1 (en) 1996-02-28
IE903502A1 (en) 1991-04-10
ES2086376T3 (es) 1996-07-01
DE69025529D1 (de) 1996-04-04
KR927003615A (ko) 1992-12-18
CA2067094A1 (en) 1991-04-05
PT95510A (pt) 1991-08-14
NZ235537A (en) 1992-12-23
PT95510B (pt) 1997-08-29
DE69025529T2 (de) 1996-10-17
EP0421777A1 (en) 1991-04-10
IE74701B1 (en) 1997-07-30
JPH05505791A (ja) 1993-08-26
ATE134644T1 (de) 1996-03-15

Similar Documents

Publication Publication Date Title
HUT61777A (en) Process for producing pyrimidine-nukleozides and pharmaceutical compositions containing them as active components
HUT49113A (en) Process for producing 2-/2-hydroxy-3-phenoxy-propyl-amino/-ethyl-phenoxy-methyl-amido derivatives and pharmaceutical compositions containing them as active components
MA21778A1 (fr) Procede d'obtention de derives de n - ( 3-hydroxy-4 piperidinyl ) dihydro-benzofuranne, dihydro-2h- ,benzopyranne ou dihydro benzodioxin ) carboxamide .
ES2040261T3 (es) Procedimiento para preparar acidos 6-fluor-4-oxo-1,4-dihidroquinolina-3-carboxilicos sustituidos y acidos 9-fluor-3-metil-7-oxo-2,3-dihidro-7h-pirido(1,2,3-de)(1,4)benzoxazina-6-carboxilico sustituidos.
HUT59109A (en) Process for producing hydroxymethyl-(methylenecyclopentyl)-purines and -pyrimidines, their pharmaceutically acceptable salts and pharmaceutical compositions comprising same
HUT43843A (en) Process for production of derivatives of benzimidasole and medical compounds containing thereof
HUT54357A (en) Process for producing benzilidene-(azolylmethyl)-cycloalkane and -cycloalkene derivatives, fungicidal compositions comprising such compounds as active ingredient and intermediates usable for the production of the active ingredients
FI906438A0 (fi) Menetelmä uusien, terapeuttisesti käyttökelpoisten A-nor-steroidi-3-karboksyylihappojohdannaisten valmistamiseksi
ATE103812T1 (de) Zusammensetzung zur behandlung von ischaemischen stoerungen in organen.
HUT67039A (en) Process for preparing 2-substituted saccharin derivatives and pharmaceutical compositions containing them
DK0674634T3 (da) Fremgangsmåde til fremstilling af substituerede 1,3-oxathiolaner med antivirale egenskaber
FI920023A0 (fi) Heteroarylpiperazinfoereningar som antipsykotiska aemnen.
IT1228288B (it) Composti ad attivita' antiserotoninica
HUT52040A (en) Process for producing diaryl-derivatives and pharmaceutical compositions containing them
HUT46536A (en) Process for producing antianxietive pharmaceutical compositions
NO173444C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive 4-(4'- fluorfenyl-)-tienopyridin-derivater
MY105538A (en) Derivatives of thieno-triazolo-diazepine, a preparation process of the same and therapeutic compositions containing them.
HUT52099A (en) Process for producing antiviral tetrahydroimidazo/1,4/benzodiazepin-2-one derivatives and pharmaceutical compositions comprising such compounds as active ingredient
ZA984114B (en) Substituted heterocyclic compounds a process for the preparation thereof and pharmaceutical compositions containing them
EP0318029A3 (en) Cyclic amine and pharmacological composition
ATE267832T1 (de) Substanz gm-95, verfahren zu ihrer herstellung und ihre verwendung
IT1223395B (it) Composti ad attivita' cardiovascolare
HUT46214A (en) Process for producing medical preparation suitable for treatment of peptic ulcer
HUT51622A (en) Process for producing 3-piperidinole-indazole derivatives and pharmaceutical preparations having effect against high blood pressure containing these compounds as active substance
EG19319A (en) Process for preparing of glutaric acid derivatives and preparation there of.

Legal Events

Date Code Title Description
DFC4 Cancellation of temporary protection due to refusal