IT1228288B - Composti ad attivita' antiserotoninica - Google Patents

Composti ad attivita' antiserotoninica

Info

Publication number
IT1228288B
IT1228288B IT8919029A IT1902989A IT1228288B IT 1228288 B IT1228288 B IT 1228288B IT 8919029 A IT8919029 A IT 8919029A IT 1902989 A IT1902989 A IT 1902989A IT 1228288 B IT1228288 B IT 1228288B
Authority
IT
Italy
Prior art keywords
compounds
serotonin activity
formula
serotonin
activity
Prior art date
Application number
IT8919029A
Other languages
English (en)
Other versions
IT8919029A0 (it
Inventor
Giancarlo Benelli
Angelo Carenzi
Dario Chiarino
Mario Fantucci
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Priority to IT8919029A priority Critical patent/IT1228288B/it
Publication of IT8919029A0 publication Critical patent/IT8919029A0/it
Priority to EP90100162A priority patent/EP0378111B1/en
Priority to AT90100162T priority patent/ATE106403T1/de
Priority to DE69009195T priority patent/DE69009195T2/de
Priority to US07/461,807 priority patent/US4988691A/en
Priority to JP2002405A priority patent/JPH0327379A/ja
Application granted granted Critical
Publication of IT1228288B publication Critical patent/IT1228288B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
IT8919029A 1989-01-09 1989-01-09 Composti ad attivita' antiserotoninica IT1228288B (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT8919029A IT1228288B (it) 1989-01-09 1989-01-09 Composti ad attivita' antiserotoninica
EP90100162A EP0378111B1 (en) 1989-01-09 1990-01-04 Isoxazole derivatives having anti-serotonin activity, their preparation process and compositions containing them
AT90100162T ATE106403T1 (de) 1989-01-09 1990-01-04 Isoxazol-derivate mit anti-serotonin-aktivität, deren herstellungsverfahren und diese enthaltende zusammensetzungen.
DE69009195T DE69009195T2 (de) 1989-01-09 1990-01-04 Isoxazol-Derivate mit Anti-Serotonin-Aktivität, deren Herstellungsverfahren und diese enthaltende Zusammensetzungen.
US07/461,807 US4988691A (en) 1989-01-09 1990-01-08 Isoxazole containing compounds exhibiting anti-serotonin activity
JP2002405A JPH0327379A (ja) 1989-01-09 1990-01-08 抗セロトニン活性を有する化合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8919029A IT1228288B (it) 1989-01-09 1989-01-09 Composti ad attivita' antiserotoninica

Publications (2)

Publication Number Publication Date
IT8919029A0 IT8919029A0 (it) 1989-01-09
IT1228288B true IT1228288B (it) 1991-06-07

Family

ID=11153958

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8919029A IT1228288B (it) 1989-01-09 1989-01-09 Composti ad attivita' antiserotoninica

Country Status (6)

Country Link
US (1) US4988691A (it)
EP (1) EP0378111B1 (it)
JP (1) JPH0327379A (it)
AT (1) ATE106403T1 (it)
DE (1) DE69009195T2 (it)
IT (1) IT1228288B (it)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8923590D0 (en) * 1989-10-19 1989-12-06 Pfizer Ltd Antimuscarinic bronchodilators
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
WO1992004346A1 (en) * 1990-09-06 1992-03-19 Pfizer Limited Antimuscarinic bronchodilators
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
WO1994024095A1 (en) * 1993-04-16 1994-10-27 Abbott Laboratories Immunosuppressive agents
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
WO2002016355A2 (en) * 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic) acetylcholine receptor ligands
WO2002017358A2 (en) * 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
AU2001284646A1 (en) * 2000-08-21 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
WO2003018585A1 (en) 2001-08-24 2003-03-06 Pharmacia & Upjohn Company Substituted-heteroaryl-7-aza[2.2.1]bicycloheptanes for the treatment of disease
CA2466375A1 (en) * 2001-11-08 2003-05-15 Pharmacia & Upjohn Company Azabicyclic-substituted-heteroaryl compounds for the treatment of disease
EP1542999A1 (en) 2002-08-01 2005-06-22 Pharmacia & Upjohn Company LLC 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity
DE10307903A1 (de) * 2003-02-18 2004-09-02 Karl Storz Gmbh & Co. Kg Verfahren zum Montieren eines Endoskopes
US7820705B2 (en) * 2004-05-14 2010-10-26 Irm Llc Compounds and compositions as PPAR modulators
NL2000351C2 (nl) 2005-12-22 2007-09-11 Pfizer Prod Inc Estrogeen-modulatoren.
US10165772B2 (en) * 2008-08-21 2019-01-01 Édouard Kouassi Methods and compounds for increasing red blood cell survival
BR112017004589A2 (pt) * 2014-09-10 2018-01-23 Epizyme Inc composto, composição farmacêutica, método para tratar um paciente, uso de um composto, kit, e método para tratar um distúrbio mediado por proteína smyd
WO2018039384A1 (en) * 2016-08-23 2018-03-01 Ardelyx, Inc. Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as fxr activators
EP3681881B1 (en) 2017-09-14 2022-11-02 Ardelyx, Inc. Hormone receptor modulators for treating metabolic mutagenic and fibrotic conditions and disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2655009A1 (de) * 1976-12-04 1978-06-15 Hoechst Ag Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
EP0035285A3 (en) * 1979-08-17 1981-10-14 American Cyanamid Company Novel isoxazole carboxylic acid phenyl esters, pharmaceutical compositions containing certain of said esters, and process for preparing said esters
DE3405727A1 (de) * 1984-02-17 1985-08-22 Hoechst Ag, 6230 Frankfurt Isoxazol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3688296T2 (de) * 1985-03-14 1993-11-04 Beecham Group Plc Arzneimittel zur behandlung von erbrechen.

Also Published As

Publication number Publication date
EP0378111B1 (en) 1994-06-01
EP0378111A1 (en) 1990-07-18
DE69009195D1 (de) 1994-07-07
JPH0327379A (ja) 1991-02-05
ATE106403T1 (de) 1994-06-15
IT8919029A0 (it) 1989-01-09
US4988691A (en) 1991-01-29
DE69009195T2 (de) 1994-10-06

Similar Documents

Publication Publication Date Title
IT1228288B (it) Composti ad attivita&#39; antiserotoninica
IL96882A0 (en) Uracil derivatives and pesticides containing the same as active ingredient
DE69010139T2 (de) Haarkräftigungsmittel.
IL95691A0 (en) Thienylcarboxylates of amino alcohols,their preparation and pharmaceutical compositions containing them
ZA928170B (en) Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-D-neuraminic acid
PH25319A (it)
IL81002A (en) 3,4-diphenyl-pyrazoline-1-carboxamide derivatives,processes for the preparation thereof and insecticidal and acaricidal compositions containing the same
FI920023A0 (fi) Heteroarylpiperazinfoereningar som antipsykotiska aemnen.
DE68906609D1 (de) Dopamin-vorlaeufer.
SE8404065D0 (sv) Novel biologically active compounds
ATE38991T1 (de) In 2-stellung substituierte 1,3propyledendephosphonat-derivate, ihre herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
EP0321968A3 (en) Compounds active on the cardiovascular system
DE68904102D1 (de) Antivirale tetrahydroimidazo(1,4)benzodiazepin-2-one.
SE8600658D0 (sv) Novel composition of matter
IT1216104B (it) Peptidi ad attivita&#39; farmaceutica.
IL94384A0 (en) Pyridazinamines,their preparation and antiviral compositions comprising them
IT1223395B (it) Composti ad attivita&#39; cardiovascolare
ATE97130T1 (de) 13-brom und 13, 14-dibrom-ergoline, ihre herstellung und verwendung in arzneimitteln.
IT1204960B (it) Composti dotati di attivita&#39; antiallergica
IT1204959B (it) Composti dotati di attivita&#39; antiallergica
TW279783B (it)
IT1216103B (it) Peptidi ad attivita&#39; farmaceutica.
EP0321967A3 (en) Compounds active on the cardiovascular system
GR3015002T3 (en) 1,4-Dihydro-4-oxo-3-quinolone derivatives as selectively toxic mammalian antibacterial agents.
MX9702896A (es) Derivados de bencisoxazol y composiciones pesticidas que los contienen.

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19931210