BR0313302A - Processos para a preparação de nucleosìdeos de 1,3-dioxolano - Google Patents

Processos para a preparação de nucleosìdeos de 1,3-dioxolano

Info

Publication number
BR0313302A
BR0313302A BR0313302-8A BR0313302A BR0313302A BR 0313302 A BR0313302 A BR 0313302A BR 0313302 A BR0313302 A BR 0313302A BR 0313302 A BR0313302 A BR 0313302A
Authority
BR
Brazil
Prior art keywords
preparation
processes
dioxolane nucleosides
nucleosides
dioxolane
Prior art date
Application number
BR0313302-8A
Other languages
English (en)
Inventor
Kyoichi A Watanabe
Jinfa Du
Original Assignee
Pharmasset Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmasset Inc filed Critical Pharmasset Inc
Publication of BR0313302A publication Critical patent/BR0313302A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/20—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems

Abstract

"PROCESSOS PARA A PREPARAçãO DE NUCLEOSìDEOS DE 1,3-DIOXOLANO". São revelados novos processos para a preparação de nucleosídeos de 1,3-dioxolano de fórmula geral I e II: onde B é a base de purina ou pirimidina ou um análogo ou derivado dessas. A invenção também fornece intermediários para uso na preparação desses compostos.
BR0313302-8A 2002-08-06 2003-08-06 Processos para a preparação de nucleosìdeos de 1,3-dioxolano BR0313302A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40165502P 2002-08-06 2002-08-06
PCT/US2003/024986 WO2004028445A2 (en) 2002-08-06 2003-08-06 Processes for preparing 1,3-dioxolane nucleosides

Publications (1)

Publication Number Publication Date
BR0313302A true BR0313302A (pt) 2005-06-28

Family

ID=32043165

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0313302-8A BR0313302A (pt) 2002-08-06 2003-08-06 Processos para a preparação de nucleosìdeos de 1,3-dioxolano

Country Status (14)

Country Link
US (1) US6855821B2 (pt)
EP (1) EP1534255B1 (pt)
JP (1) JP4560407B2 (pt)
KR (1) KR101108115B1 (pt)
AT (1) ATE496054T1 (pt)
AU (1) AU2003294212B2 (pt)
BR (1) BR0313302A (pt)
CA (1) CA2494183C (pt)
DE (1) DE60335805D1 (pt)
ES (1) ES2360096T3 (pt)
HK (1) HK1078781A1 (pt)
IL (2) IL166682A0 (pt)
MX (1) MXPA05001451A (pt)
WO (1) WO2004028445A2 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100406017C (zh) * 2002-12-09 2008-07-30 佐治亚大学研究基金会 用于对抗hiv抗性株的二氧戊环基胸腺嘧啶及其组合物
ES2726998T3 (es) 2003-05-30 2019-10-11 Gilead Pharmasset Llc Análogos de nucleósidos fluorados modificados
BRPI0507363A (pt) 2004-02-03 2007-07-03 Univ Emory métodos para manufatura de 1,3-dioxolano nucleosìdeos
US7956087B2 (en) * 2005-04-21 2011-06-07 Kao Corporation Cosmetic composition for skin and wrinkle improver
CN102015582A (zh) * 2008-03-03 2011-04-13 施泰福实验室股份有限公司 光学纯二元醇和二氧戊环化合物的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3028519A1 (de) * 1980-07-28 1982-02-25 Dynamit Nobel Ag, 5210 Troisdorf Substituierte 2,5,7-trioxan-bicyclo (2.2.2) octan-6-one und 3,6,8-trioxa-bicyclo (3.2.1) octan-4-one und verfahren zu deren herstellung
US5047407A (en) 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5276151A (en) 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5204466A (en) 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5925643A (en) * 1990-12-05 1999-07-20 Emory University Enantiomerically pure β-D-dioxolane-nucleosides
IT1244501B (it) 1991-03-22 1994-07-15 Sigma Tau Ind Farmaceuti Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono
ZA923641B (en) 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9525606D0 (en) 1995-12-14 1996-02-14 Iaf Biochem Int Method and compositions for the synthesis of dioxolane nucleosides with › - configuration
US5792773A (en) 1996-11-15 1998-08-11 Yale University L-β-dioxolane uridine analog administration for treating Epstein-Barr virus infection
IT1301977B1 (it) * 1998-07-31 2000-07-20 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di r-(-)-carnitina
CN1141305C (zh) 1998-08-12 2004-03-10 三角药物公司 生产1,3-氧硫戊环核苷的方法
EA004767B1 (ru) 1998-12-23 2004-08-26 Шайре Байокем Инк. Аналоги нуклеозида (варианты) и их применение, комбинация и способ лечения вирусных инфекций, фармацевтическая композиция

Also Published As

Publication number Publication date
JP4560407B2 (ja) 2010-10-13
EP1534255A2 (en) 2005-06-01
WO2004028445A3 (en) 2004-06-10
AU2003294212A1 (en) 2004-04-19
JP2006504703A (ja) 2006-02-09
EP1534255B1 (en) 2011-01-19
KR20050052461A (ko) 2005-06-02
IL166682A0 (en) 2006-01-15
EP1534255A4 (en) 2006-10-18
ATE496054T1 (de) 2011-02-15
US20040087806A1 (en) 2004-05-06
IL166682A (en) 2011-06-30
WO2004028445A2 (en) 2004-04-08
DE60335805D1 (de) 2011-03-03
CA2494183A1 (en) 2004-04-08
HK1078781A1 (en) 2006-03-24
US6855821B2 (en) 2005-02-15
ES2360096T3 (es) 2011-05-31
AU2003294212B2 (en) 2010-01-07
CA2494183C (en) 2012-01-03
KR101108115B1 (ko) 2012-01-31
MXPA05001451A (es) 2005-09-30

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2162 DE 12/06/2012.