IT1244501B - Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono - Google Patents
Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengonoInfo
- Publication number
- IT1244501B IT1244501B ITRM910189A ITRM910189A IT1244501B IT 1244501 B IT1244501 B IT 1244501B IT RM910189 A ITRM910189 A IT RM910189A IT RM910189 A ITRM910189 A IT RM910189A IT 1244501 B IT1244501 B IT 1244501B
- Authority
- IT
- Italy
- Prior art keywords
- arginine
- lysyl
- prolyl
- aspartyl
- pharmaceutical compositions
- Prior art date
Links
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical class OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 title abstract 2
- 230000003308 immunostimulating effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 AMINO Chemical class 0.000 title 1
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 abstract 2
- SHAVAUDERMUSPN-DVRYWGNFSA-N (2s)-2,6-diamino-n-[(2s)-1-[(2-amino-2-oxoethyl)amino]-3-(4h-imidazol-4-yl)-1-oxopropan-2-yl]hexanamide Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(=O)NCC(N)=O)CC1C=NC=N1 SHAVAUDERMUSPN-DVRYWGNFSA-N 0.000 abstract 1
- AFLBTVGQCQLOFJ-UHFFFAOYSA-N 2-[[1-(2,6-diaminohexanoyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound NCCCCC(N)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(O)=O AFLBTVGQCQLOFJ-UHFFFAOYSA-N 0.000 abstract 1
- NTUPOKHATNSWCY-UHFFFAOYSA-N 2-[[1-(2-amino-3-phenylpropanoyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound C1CCC(C(=O)NC(CCCN=C(N)N)C(O)=O)N1C(=O)C(N)CC1=CC=CC=C1 NTUPOKHATNSWCY-UHFFFAOYSA-N 0.000 abstract 1
- UZFHNLYQWMGUHU-UHFFFAOYSA-N 2-[[6-amino-2-[(2-amino-3-carboxypropanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound OC(=O)CC(N)C(=O)NC(CCCCN)C(=O)NC(CCCN=C(N)N)C(O)=O UZFHNLYQWMGUHU-UHFFFAOYSA-N 0.000 abstract 1
- JLMZKEQFMVORMA-UHFFFAOYSA-N 5-(diaminomethylideneamino)-2-[[1-(pyrrolidine-2-carbonyl)pyrrolidine-2-carbonyl]amino]pentanoic acid Chemical compound NC(N)=NCCCC(C(O)=O)NC(=O)C1CCCN1C(=O)C1NCCC1 JLMZKEQFMVORMA-UHFFFAOYSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- PSZNHSNIGMJYOZ-UHFFFAOYSA-N Aspartyl-Arginine Chemical compound OC(=O)CC(N)C(=O)NC(C(O)=O)CCCNC(N)=N PSZNHSNIGMJYOZ-UHFFFAOYSA-N 0.000 abstract 1
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- SCCPDJAQCXWPTF-UHFFFAOYSA-N Glycyl-Aspartate Chemical compound NCC(=O)NC(C(O)=O)CC(O)=O SCCPDJAQCXWPTF-UHFFFAOYSA-N 0.000 abstract 1
- 108010008488 Glycylglycine Proteins 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- LGMBKOAPPTYKLC-JYJNAYRXSA-N Pro-Phe-Arg Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(O)=O)NC(=O)[C@H]1NCCC1)C1=CC=CC=C1 LGMBKOAPPTYKLC-JYJNAYRXSA-N 0.000 abstract 1
- 229940024606 amino acid Drugs 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 108010026970 bursopoietin Proteins 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 229940043257 glycylglycine Drugs 0.000 abstract 1
- 108010089198 phenylalanyl-prolyl-arginine Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Derivati dell'allopurinolo di formula generale (I) e i loro sali con cationi farmacologicamente accettabili in cui n è un numero intero compreso fra 2 e 6 preferibilmente 5, Y è H oppure CO-A, in cui A è il residuo di un amminoacido, di un dipeptide, tripeptide, tetrapeptide, nelle forme racema e chirale, scelto rispettivamente nei gruppi consistenti di:a) arginina, acido aspartico, lisina, leucina b) glicil-aspartato, glicil-glicina, aspartil-arginina, leucil-arginina-alanil-glicina c) arginil-lisil-aspartato, aspartil-lisil-arginina, lisil-prolil-arginina, prolil-prolil-arginina, lisil-istidil-glicinammide, prolil-fenilalanil-arginina, fenilalanil-prolil-arginina d) arginil-lisil-aspartil-valina, valil-aspartil-lisil-arginina, treonil-valil-leucil-istidina e) arginil-lisil-aspartil-valil-tirosina sono dotati di attività immunostimolante e possono venir formulati in composizioni farmaceutiche somministrabili per via orale o parenterale.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM910189A IT1244501B (it) | 1991-03-22 | 1991-03-22 | Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono |
| EP92830136A EP0506628B1 (en) | 1991-03-22 | 1992-03-20 | Aminoacyl and oligopeptidyl derivatives of allopurinol exhibiting immunostimulatory activity, and pharmaceutical formulations containing these substances |
| DE69213794T DE69213794T2 (de) | 1991-03-22 | 1992-03-20 | Aminoacyl und Oligopeptidylderivate von Allopurinol mit immunostimulierender Wirkung und diese enthaltende pharmazeutische Zubereitungen |
| ES92830136T ES2094335T3 (es) | 1991-03-22 | 1992-03-20 | Derivados de alopurinol aminoacilados y oligopeptidos de actividad inmunoestimuladora y composiciones farmaceuticas que los contienen. |
| DK92830136.5T DK0506628T3 (da) | 1991-03-22 | 1992-03-20 | Aminoacyl- og oligopeptidylderivater af allopurinol, der udviser immunostimulerende aktivitet, og farmaceutiske formuleringer indeholdende disse stoffer |
| AT92830136T ATE143024T1 (de) | 1991-03-22 | 1992-03-20 | Aminoacyl und oligopeptidylderivate von allopurinol mit immunostimulierender wirkung und diese enthaltende pharmazeutische zubereitungen |
| US07/854,916 US5272151A (en) | 1991-03-22 | 1992-03-20 | Aminoacyl and oligopeptidyl derivatives of allopurinol exhibiting immunostimulatory activity, and pharmaceutical formulations containing these substances |
| JP4065009A JP3067886B2 (ja) | 1991-03-22 | 1992-03-23 | アロプリノール誘導体および医薬製剤 |
| GR960402931T GR3021556T3 (en) | 1991-03-22 | 1996-11-06 | Aminoacyl and oligopeptidyl derivatives of allopurinol exhibiting immunostimulatory activity, and pharmaceutical formulations containing these substances |
| HK98105617A HK1006462A1 (en) | 1991-03-22 | 1998-06-18 | Aminoacyl and oligopeptidyl derivatives of allopurinol exhibiting immunostimulatory activity, and pharma-ceutical formulations containing these substances |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM910189A IT1244501B (it) | 1991-03-22 | 1991-03-22 | Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM910189A0 ITRM910189A0 (it) | 1991-03-22 |
| ITRM910189A1 ITRM910189A1 (it) | 1992-09-22 |
| IT1244501B true IT1244501B (it) | 1994-07-15 |
Family
ID=11399991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITRM910189A IT1244501B (it) | 1991-03-22 | 1991-03-22 | Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5272151A (it) |
| EP (1) | EP0506628B1 (it) |
| JP (1) | JP3067886B2 (it) |
| AT (1) | ATE143024T1 (it) |
| DE (1) | DE69213794T2 (it) |
| DK (1) | DK0506628T3 (it) |
| ES (1) | ES2094335T3 (it) |
| GR (1) | GR3021556T3 (it) |
| HK (1) | HK1006462A1 (it) |
| IT (1) | IT1244501B (it) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5928191A (en) * | 1993-07-30 | 1999-07-27 | E.P. Technologies, Inc. | Variable curve electrophysiology catheter |
| US6110923A (en) * | 1994-06-22 | 2000-08-29 | Biochem Pharma Inc. | Method for treating cancer using novel substituted purinyl derivatives with immunomodulating activity |
| US6191136B1 (en) | 1997-11-07 | 2001-02-20 | Johns Hopkins University | Methods for treatment of disorders of cardiac contractility |
| EP1104415B1 (en) | 1998-08-12 | 2004-11-10 | Gilead Sciences, Inc. | Method of manufacture of 1,3-oxathiolane nucleosides |
| CN1503796B (zh) | 2001-03-01 | 2012-07-04 | 三角药品公司 | 顺-ftc的多晶型物及其它晶型 |
| US20030162992A1 (en) * | 2001-12-14 | 2003-08-28 | Watanabe Kyoichi A. | Preparation of intermediates useful in the synthesis of antiviral nucleosides |
| EP1534255B1 (en) | 2002-08-06 | 2011-01-19 | Pharmasset, Inc. | Processes for preparing 1,3-dioxolane nucleosides |
| US6953041B2 (en) * | 2002-10-09 | 2005-10-11 | Micell Technologies, Inc. | Compositions of transition metal species in dense phase carbon dioxide and methods of use thereof |
| WO2005066694A2 (en) | 2003-12-29 | 2005-07-21 | Advanced Medical Optics, Inc. | Intraocular lenses having a visible light-selective-transmissive-region |
| US7067659B2 (en) * | 2004-04-23 | 2006-06-27 | Duke University | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof |
| JP2007535708A (ja) | 2004-04-30 | 2007-12-06 | アドバンスト メディカル オプティクス， インコーポレーテッド | 高選択性紫色光透過性フィルターを有する眼用器具 |
| DE602005026554D1 (de) * | 2004-11-22 | 2011-04-07 | Abbott Medical Optics Inc | Copolymerisierbare azoverbindungen und artikel damit |
| BRPI0518030A (pt) | 2004-11-22 | 2008-10-28 | Advanced Medical Optics Inc | compostos de metino e de antraquinona copolimerizáveis e artigos que os contêm |
| US8188098B2 (en) * | 2008-05-19 | 2012-05-29 | Hoffmann-La Roche Inc. | GPR119 receptor agonists |
| US11406713B2 (en) * | 2013-03-15 | 2022-08-09 | Xortx Therapeutics, Inc. | Xanthine oxidase inhibitor formulations |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3165520A (en) * | 1965-01-12 | Certificate of correction | ||
| AU564576B2 (en) * | 1981-09-24 | 1987-08-20 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Purine derivatives |
| US4602089A (en) * | 1982-03-12 | 1986-07-22 | Newport Pharmaceuticals, Inc. | Process for preparing purine compounds |
| DK302883D0 (da) * | 1983-06-30 | 1983-06-30 | Hans Bundgaard | Allopurinol prodrugs |
| US4663326A (en) * | 1985-04-04 | 1987-05-05 | Warner-Lambert Company | Pyrazolo[4,3-d]pyrimidine-5,7-(4H,6H)dione or -5-thione-7-one analogs |
| DE3784483T2 (de) * | 1986-08-11 | 1993-10-21 | Baxter Int | Drehnadellagerdichtung, insbesondere für die kartuschen von kontinuierlich arbeitenden blutfiltersystemen. |
| IT1213495B (it) * | 1986-09-17 | 1989-12-20 | Sigma Tau Ind Farmaceuti | Processo per la preparazione dell'alfa-n-[(ipoxatin-9-il)pentilossicarbonil-]arginina |
-
1991
- 1991-03-22 IT ITRM910189A patent/IT1244501B/it active IP Right Grant
-
1992
- 1992-03-20 US US07/854,916 patent/US5272151A/en not_active Expired - Fee Related
- 1992-03-20 DE DE69213794T patent/DE69213794T2/de not_active Expired - Fee Related
- 1992-03-20 ES ES92830136T patent/ES2094335T3/es not_active Expired - Lifetime
- 1992-03-20 AT AT92830136T patent/ATE143024T1/de not_active IP Right Cessation
- 1992-03-20 DK DK92830136.5T patent/DK0506628T3/da active
- 1992-03-20 EP EP92830136A patent/EP0506628B1/en not_active Expired - Lifetime
- 1992-03-23 JP JP4065009A patent/JP3067886B2/ja not_active Expired - Fee Related
-
1996
- 1996-11-06 GR GR960402931T patent/GR3021556T3/el unknown
-
1998
- 1998-06-18 HK HK98105617A patent/HK1006462A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ITRM910189A0 (it) | 1991-03-22 |
| US5272151A (en) | 1993-12-21 |
| ATE143024T1 (de) | 1996-10-15 |
| EP0506628A2 (en) | 1992-09-30 |
| HK1006462A1 (en) | 1999-02-26 |
| EP0506628B1 (en) | 1996-09-18 |
| ES2094335T3 (es) | 1997-01-16 |
| EP0506628A3 (en) | 1992-10-21 |
| DK0506628T3 (da) | 1996-11-11 |
| GR3021556T3 (en) | 1997-02-28 |
| ITRM910189A1 (it) | 1992-09-22 |
| JPH05117275A (ja) | 1993-05-14 |
| JP3067886B2 (ja) | 2000-07-24 |
| DE69213794D1 (de) | 1996-10-24 |
| DE69213794T2 (de) | 1997-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950131 |