IT1241452B - Derivati oligopeptidici dell'ipoxantina dotati di attivita' immunomodulante e composizioni farmaceutiche che li contengono - Google Patents
Derivati oligopeptidici dell'ipoxantina dotati di attivita' immunomodulante e composizioni farmaceutiche che li contengonoInfo
- Publication number
- IT1241452B IT1241452B IT48102A IT4810290A IT1241452B IT 1241452 B IT1241452 B IT 1241452B IT 48102 A IT48102 A IT 48102A IT 4810290 A IT4810290 A IT 4810290A IT 1241452 B IT1241452 B IT 1241452B
- Authority
- IT
- Italy
- Prior art keywords
- arginine
- lysyl
- prolyl
- aspartyl
- ipoxantine
- Prior art date
Links
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 abstract 2
- SHAVAUDERMUSPN-DVRYWGNFSA-N (2s)-2,6-diamino-n-[(2s)-1-[(2-amino-2-oxoethyl)amino]-3-(4h-imidazol-4-yl)-1-oxopropan-2-yl]hexanamide Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(=O)NCC(N)=O)CC1C=NC=N1 SHAVAUDERMUSPN-DVRYWGNFSA-N 0.000 abstract 1
- AFLBTVGQCQLOFJ-UHFFFAOYSA-N 2-[[1-(2,6-diaminohexanoyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound NCCCCC(N)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(O)=O AFLBTVGQCQLOFJ-UHFFFAOYSA-N 0.000 abstract 1
- NTUPOKHATNSWCY-UHFFFAOYSA-N 2-[[1-(2-amino-3-phenylpropanoyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound C1CCC(C(=O)NC(CCCN=C(N)N)C(O)=O)N1C(=O)C(N)CC1=CC=CC=C1 NTUPOKHATNSWCY-UHFFFAOYSA-N 0.000 abstract 1
- UZFHNLYQWMGUHU-UHFFFAOYSA-N 2-[[6-amino-2-[(2-amino-3-carboxypropanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound OC(=O)CC(N)C(=O)NC(CCCCN)C(=O)NC(CCCN=C(N)N)C(O)=O UZFHNLYQWMGUHU-UHFFFAOYSA-N 0.000 abstract 1
- JLMZKEQFMVORMA-UHFFFAOYSA-N 5-(diaminomethylideneamino)-2-[[1-(pyrrolidine-2-carbonyl)pyrrolidine-2-carbonyl]amino]pentanoic acid Chemical compound NC(N)=NCCCC(C(O)=O)NC(=O)C1CCCN1C(=O)C1NCCC1 JLMZKEQFMVORMA-UHFFFAOYSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- PSZNHSNIGMJYOZ-UHFFFAOYSA-N Aspartyl-Arginine Chemical compound OC(=O)CC(N)C(=O)NC(C(O)=O)CCCNC(N)=N PSZNHSNIGMJYOZ-UHFFFAOYSA-N 0.000 abstract 1
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- SCCPDJAQCXWPTF-UHFFFAOYSA-N Glycyl-Aspartate Chemical compound NCC(=O)NC(C(O)=O)CC(O)=O SCCPDJAQCXWPTF-UHFFFAOYSA-N 0.000 abstract 1
- 108010008488 Glycylglycine Proteins 0.000 abstract 1
- SENJXOPIZNYLHU-IUCAKERBSA-N Leu-Arg Chemical compound CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CCCN=C(N)N SENJXOPIZNYLHU-IUCAKERBSA-N 0.000 abstract 1
- CXISPYVYMQWFLE-UHFFFAOYSA-N alanylglycine Chemical compound CC(N)C(=O)NCC(O)=O CXISPYVYMQWFLE-UHFFFAOYSA-N 0.000 abstract 1
- 108010047495 alanylglycine Proteins 0.000 abstract 1
- 108010026970 bursopoietin Proteins 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 229940043257 glycylglycine Drugs 0.000 abstract 1
- 108010000761 leucylarginine Proteins 0.000 abstract 1
- 108010089198 phenylalanyl-prolyl-arginine Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 108010001055 thymocartin Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT48102A IT1241452B (it) | 1990-06-28 | 1990-06-28 | Derivati oligopeptidici dell'ipoxantina dotati di attivita' immunomodulante e composizioni farmaceutiche che li contengono |
| ES91830284T ES2117003T3 (es) | 1990-06-28 | 1991-06-26 | Derivados oligopeptidicos de hipoxantina dotados de actividad inmunomoduladora, y composiciones farmaceuticas que los contienen. |
| DK91830284T DK0464009T3 (da) | 1990-06-28 | 1991-06-26 | Oligopeptidderivater af ipoxantin udstyret med immunomodulerende aktivitet, og farmaceutiske præparater indeholdende samme |
| AT91830284T ATE166063T1 (de) | 1990-06-28 | 1991-06-26 | Mit ipoxantin ausgestattete oligopeptidderivate mit immunomodulatorischer wirksamkeit und diese enthaltende pharmazeutische zusammensetzungen |
| DE69129387T DE69129387T2 (de) | 1990-06-28 | 1991-06-26 | Mit Ipoxantin ausgestattete Oligopeptidderivate mit immunomodulatorischer Wirksamkeit und diese enthaltende pharmazeutische Zusammensetzungen |
| EP91830284A EP0464009B1 (en) | 1990-06-28 | 1991-06-26 | Oligopeptide derivatives of ipoxantine endowed with immunomodulating activity and pharmaceutical compositions containing same |
| JP3158342A JPH04230298A (ja) | 1990-06-28 | 1991-06-28 | ヒポキサンチンオリゴペプチド誘導体 |
| US07/723,418 US5298621A (en) | 1990-06-28 | 1991-06-28 | Oligopeptide derivatives of ipoxantine endowed with immunomodulating activity and pharmaceutical compositions containing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT48102A IT1241452B (it) | 1990-06-28 | 1990-06-28 | Derivati oligopeptidici dell'ipoxantina dotati di attivita' immunomodulante e composizioni farmaceutiche che li contengono |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IT9048102A0 IT9048102A0 (it) | 1990-06-28 |
| IT9048102A1 IT9048102A1 (it) | 1991-12-28 |
| IT1241452B true IT1241452B (it) | 1994-01-17 |
Family
ID=11264531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT48102A IT1241452B (it) | 1990-06-28 | 1990-06-28 | Derivati oligopeptidici dell'ipoxantina dotati di attivita' immunomodulante e composizioni farmaceutiche che li contengono |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5298621A (it) |
| EP (1) | EP0464009B1 (it) |
| JP (1) | JPH04230298A (it) |
| AT (1) | ATE166063T1 (it) |
| DE (1) | DE69129387T2 (it) |
| DK (1) | DK0464009T3 (it) |
| ES (1) | ES2117003T3 (it) |
| IT (1) | IT1241452B (it) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6110923A (en) * | 1994-06-22 | 2000-08-29 | Biochem Pharma Inc. | Method for treating cancer using novel substituted purinyl derivatives with immunomodulating activity |
| AU717160B2 (en) * | 1994-06-22 | 2000-03-16 | Shire Canada Inc. | Novel substituted purinyl derivatives with immunomodulating activity |
| US5969135A (en) * | 1995-11-02 | 1999-10-19 | Icn Pharmaceuticals, Inc. | Oligonucleotide analogs with an amino acid or a modified amino alcohol residue |
| DE19541264A1 (de) * | 1995-11-06 | 1997-05-07 | Bayer Ag | Purin-6-on-derivate |
| RU2210382C1 (ru) * | 2002-07-09 | 2003-08-20 | Терентьев Александр Александрович | Пептид, обладающий иммунорегуляторным свойством, и его композиция |
| KR100721144B1 (ko) * | 2006-03-22 | 2007-05-25 | (주)아르떼르화장품 | 펩타이드 혼합물을 포함하는 주름개선용 화장료 조성물 |
| FR3021319B1 (fr) | 2014-05-22 | 2018-08-31 | Sederma | Peptides, compositions les comprenant et utilisations notamment cosmetiques |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU564576B2 (en) * | 1981-09-24 | 1987-08-20 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Purine derivatives |
| IT1213495B (it) * | 1986-09-17 | 1989-12-20 | Sigma Tau Ind Farmaceuti | Processo per la preparazione dell'alfa-n-[(ipoxatin-9-il)pentilossicarbonil-]arginina |
| IT1223604B (it) * | 1987-12-24 | 1990-09-29 | Co Pharma Corp Srl | Derivati purinici ad azione farmacologica |
-
1990
- 1990-06-28 IT IT48102A patent/IT1241452B/it active IP Right Grant
-
1991
- 1991-06-26 EP EP91830284A patent/EP0464009B1/en not_active Expired - Lifetime
- 1991-06-26 AT AT91830284T patent/ATE166063T1/de not_active IP Right Cessation
- 1991-06-26 DE DE69129387T patent/DE69129387T2/de not_active Expired - Fee Related
- 1991-06-26 DK DK91830284T patent/DK0464009T3/da active
- 1991-06-26 ES ES91830284T patent/ES2117003T3/es not_active Expired - Lifetime
- 1991-06-28 JP JP3158342A patent/JPH04230298A/ja active Pending
- 1991-06-28 US US07/723,418 patent/US5298621A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE166063T1 (de) | 1998-05-15 |
| IT9048102A1 (it) | 1991-12-28 |
| ES2117003T3 (es) | 1998-08-01 |
| DE69129387D1 (de) | 1998-06-18 |
| EP0464009A3 (en) | 1992-06-17 |
| DK0464009T3 (da) | 1999-03-08 |
| JPH04230298A (ja) | 1992-08-19 |
| DE69129387T2 (de) | 1998-09-17 |
| IT9048102A0 (it) | 1990-06-28 |
| EP0464009B1 (en) | 1998-05-13 |
| US5298621A (en) | 1994-03-29 |
| EP0464009A2 (en) | 1992-01-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2263983A1 (en) | Cyclic amine derivatives for inhibiting blood platelet aggregation | |
| DE69027562D1 (de) | Xanthinverbindungen | |
| ATE26120T1 (de) | Substituierte acyl-derivate von 1,2,3,4tetrahydro-6,7-dimethoxy-3-isoquinolincarbons|ure. | |
| IL117805A0 (en) | Carbonyl piperazinyl and piperidinyl compounds | |
| GR3032311T3 (en) | Stilbene derivatives and pharmaceutical compositions containing them | |
| FI96857B (fi) | Menetelmä valmistaa farmakologisesti käyttökelpoista tiatsoliyhdistettä | |
| IT1244501B (it) | Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono | |
| IT1241452B (it) | Derivati oligopeptidici dell'ipoxantina dotati di attivita' immunomodulante e composizioni farmaceutiche che li contengono | |
| UA8028A1 (uk) | Спосіб отримання похідних птерідіна | |
| BR9610876A (pt) | Inibidores de protease de guanidino | |
| DE69122812D1 (de) | Glutathionderivat | |
| DK0532530T3 (da) | Derivater af 6-amino-octahydroindolizintriol | |
| MY110004A (en) | Biologically active ureido derivatives useful as antimetastatic agents. | |
| PH24709A (en) | Allylmercaptoacetylsydnonimines and pharmaceutical compositions thereof | |
| NZ219012A (en) | Glu-asp-ala tripeptide derivatives and pharmaceutical compositions | |
| IL90559A0 (en) | Analgetic derivatives of phenothiazine | |
| ES525685A0 (es) | Procedimiento para preparar derivados de prolina | |
| TW333528B (en) | Adhesion receptor antagonists | |
| DK113289A (da) | Cephemforbindelser | |
| LV10289A (lv) | Jauns pentapeptids ta iegusanas panemiens kompozicija sunu augsanas inhibesanai inhibesanas panemiens | |
| DK540589A (da) | Pyrrolidinderivater | |
| ATE46347T1 (de) | Immunostimulierende peptide. | |
| HRP20010562B1 (en) | S-nitrosothiols as agents for the treatment of circulatory dysfunctions | |
| TW324719B (en) | Succinamide compound, production thereof and use thereof | |
| IT1242043B (it) | Derivati della 1,2,3,4,-tetraidronaftilammina ad attivita' nootropica e composizioni farmaceutiche che li contengono. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970515 |