FI96857B - Menetelmä valmistaa farmakologisesti käyttökelpoista tiatsoliyhdistettä - Google Patents

Menetelmä valmistaa farmakologisesti käyttökelpoista tiatsoliyhdistettä

Info

Publication number
FI96857B
FI96857B FI903879A FI903879A FI96857B FI 96857 B FI96857 B FI 96857B FI 903879 A FI903879 A FI 903879A FI 903879 A FI903879 A FI 903879A FI 96857 B FI96857 B FI 96857B
Authority
FI
Finland
Prior art keywords
preparation
alkyl
hydroxy
halogen
substituted
Prior art date
Application number
FI903879A
Other languages
English (en)
Swedish (sv)
Other versions
FI903879A0 (fi
FI96857C (fi
Inventor
Masaaki Matsuo
Takashi Ogino
Norihiro Igari
Hachiro Seno
Kyoichi Shimomura
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898918045A external-priority patent/GB8918045D0/en
Priority claimed from GB909003930A external-priority patent/GB9003930D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of FI903879A0 publication Critical patent/FI903879A0/fi
Publication of FI96857B publication Critical patent/FI96857B/fi
Application granted granted Critical
Publication of FI96857C publication Critical patent/FI96857C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
FI903879A 1989-08-07 1990-08-06 Menetelmä valmistaa farmakologisesti käyttökelpoista tiatsoliyhdistettä FI96857C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8918045 1989-08-07
GB898918045A GB8918045D0 (en) 1989-08-07 1989-08-07 Thiazole derivatives,processes for production thereof and pharmaceutical compositions comprising the same
GB909003930A GB9003930D0 (en) 1990-02-21 1990-02-21 Thiazole derivatives,processes for production thereof and pharmaceutical compositions comprising the same
GB9003930 1990-02-21

Publications (3)

Publication Number Publication Date
FI903879A0 FI903879A0 (fi) 1990-08-06
FI96857B true FI96857B (fi) 1996-05-31
FI96857C FI96857C (fi) 1996-09-10

Family

ID=26295715

Family Applications (1)

Application Number Title Priority Date Filing Date
FI903879A FI96857C (fi) 1989-08-07 1990-08-06 Menetelmä valmistaa farmakologisesti käyttökelpoista tiatsoliyhdistettä

Country Status (21)

Country Link
EP (1) EP0412404B1 (fi)
JP (1) JPH0368567A (fi)
KR (1) KR910004582A (fi)
CN (1) CN1027370C (fi)
AT (1) ATE133667T1 (fi)
AU (1) AU635758B2 (fi)
CA (1) CA2022731A1 (fi)
DE (1) DE69025104T2 (fi)
DK (1) DK0412404T3 (fi)
ES (1) ES2082805T3 (fi)
FI (1) FI96857C (fi)
GR (1) GR3019009T3 (fi)
HK (1) HK151596A (fi)
HU (2) HUT57752A (fi)
IE (1) IE902679A1 (fi)
IL (1) IL95281A (fi)
NO (1) NO179638C (fi)
PH (1) PH26766A (fi)
PT (1) PT94925B (fi)
RU (2) RU2010026C1 (fi)
TW (1) TW205041B (fi)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU644281B2 (en) * 1991-04-24 1993-12-02 Sumitomo Pharmaceuticals Company, Limited Novel thiazole derivatives
FR2677021B1 (fr) * 1991-05-31 1993-10-01 Upsa Laboratoires Nouveaux derives de thiazole antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.
DE4119756A1 (de) * 1991-06-15 1992-12-17 Basf Ag Aminoalkylsubstituierte 5-mercaptothiazole, ihre herstellung und verwendung
AT402926B (de) * 1994-12-05 1997-09-25 Hafslund Nycomed Pharma Heterocyclische amide, verfahren zu ihrer herstellung und verwendung
IL117620A0 (en) * 1995-03-27 1996-07-23 Fujisawa Pharmaceutical Co Heterocyclic compounds processes for the preparation thereof and pharmaceutical compositions containing the same
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
US6262096B1 (en) 1997-11-12 2001-07-17 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6414156B2 (en) 1998-10-21 2002-07-02 Bristol-Myers Squibb Company Process for preparing azacycloalkanoylaminothiazoles
US6214852B1 (en) 1998-10-21 2001-04-10 Bristol-Myers Squibb Company N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
GB9823871D0 (en) * 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
CN101481359A (zh) 1999-04-15 2009-07-15 布里斯托尔-迈尔斯斯奎布公司 环状蛋白酪氨酸激酶抑制剂
US6515004B1 (en) 1999-12-15 2003-02-04 Bristol-Myers Squibb Company N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
US6392053B2 (en) 1999-12-15 2002-05-21 Bristol-Myers Squibb Company Process for preparing arylacetylaminothiazoles
CA2419820A1 (en) 2000-08-17 2002-02-21 Lumera Corporation Design and synthesis of advanced nlo materials for electro-optic applications
EP1347971B1 (en) 2000-12-21 2006-03-01 Bristol-Myers Squibb Company Thiazolyl inhibitors of tec family tyrosine kinases
EP1724270A3 (en) 2001-07-19 2007-01-03 Pfizer Italia S.r.l. Phenylacetamido-thiazole derivatives, process for their preparation and their use as antitumor agents
KR101010905B1 (ko) 2002-01-18 2011-01-25 아스텔라스세이야쿠 가부시키가이샤 2-아실아미노티아졸 유도체 또는 그 염
KR100907317B1 (ko) * 2003-07-17 2009-07-13 아스텔라스세이야쿠 가부시키가이샤 2-아실아미노티아졸 유도체 또는 그의 염
JP4774995B2 (ja) * 2005-01-12 2011-09-21 アステラス製薬株式会社 アシルアミノチアゾール誘導体を有効成分とする医薬組成物
EP2024349B1 (en) 2006-05-31 2017-08-02 AbbVie Inc. Compounds as cannabinoid receptor ligands and uses thereof
US8841334B2 (en) 2006-05-31 2014-09-23 Abbvie Inc. Compounds as cannabinoid receptor ligands and uses thereof
CN101454302A (zh) 2006-05-31 2009-06-10 艾博特公司 用作大麻素受体配位体的噻唑化合物及其用途
WO2008028093A1 (en) 2006-08-31 2008-03-06 Abbott Laboratories Compounds as cb2 cannabinoid receptor ligands
US7985768B2 (en) 2006-08-31 2011-07-26 Abbott Laboratories Compounds as cannabinoid receptor ligands
EP2142522A1 (en) 2007-03-28 2010-01-13 Abbott Laboratories 1, 3-thiazol-2 (3h) -ylidene compounds as cannabinoid receptor ligands
US7872033B2 (en) 2007-04-17 2011-01-18 Abbott Laboratories Compounds as cannabinoid receptor ligands
EP2160393A1 (en) 2007-05-18 2010-03-10 Abbott Laboratories Novel compounds as cannabinoid receptor ligands
US9193713B2 (en) 2007-10-12 2015-11-24 Abbvie Inc. Compounds as cannabinoid receptor ligands
TWI437986B (zh) * 2008-01-31 2014-05-21 R Tech Ueno Ltd 噻唑衍生物及使用該衍生物作為ｖａｐ－１抑制劑之用途
CN102036984A (zh) 2008-03-11 2011-04-27 雅培制药有限公司 作为大麻素受体配体的新化合物
US8846730B2 (en) 2008-09-08 2014-09-30 Abbvie Inc. Compounds as cannabinoid receptor ligands
JP2012502917A (ja) 2008-09-16 2012-02-02 アボット・ラボラトリーズ カンナビノイド受容体リガンドとしての置換ベンズアミド類
PA8854001A1 (es) 2008-12-16 2010-07-27 Abbott Lab Compuestos novedosos como ligandos de receptores de canabinoides
CN101768130B (zh) * 2008-12-30 2012-07-04 天津药物研究院 含氨甲基五元芳香杂环4-羧酸类衍生物、其制备方法和用途
CN101768155B (zh) * 2008-12-30 2012-09-05 天津药物研究院 一类含(氨甲基-五元芳香杂环-4-羰基)-吡咯烷-2-羧酸的衍生物、其制备方法和用途
CN104151262B (zh) * 2014-07-07 2016-02-24 浙江大学 4,5-二取代-2-氨基噻唑化合物及其制备方法
CN104163802B (zh) * 2014-07-08 2016-04-27 浙江大学 2-氨基噻唑-4-甲酸乙酯的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB951885A (en) * 1961-05-13 1964-03-11 Sankyo Co A new process for the preparation of thiazole compounds
US4649146A (en) * 1983-01-31 1987-03-10 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivatives and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
HU904912D0 (en) 1991-01-28
PT94925B (pt) 1997-04-30
DK0412404T3 (da) 1996-02-26
DE69025104T2 (de) 1996-07-04
CA2022731A1 (en) 1991-02-08
DE69025104D1 (de) 1996-03-14
KR910004582A (ko) 1991-03-29
HUT57752A (en) 1991-12-30
AU635758B2 (en) 1993-04-01
NO179638B (no) 1996-08-12
ATE133667T1 (de) 1996-02-15
HU211557A9 (en) 1995-12-28
IE902679A1 (en) 1991-02-27
IL95281A0 (en) 1991-06-30
PT94925A (pt) 1991-04-18
CN1049337A (zh) 1991-02-20
PH26766A (en) 1992-09-28
NO903438D0 (no) 1990-08-06
AU6004590A (en) 1991-02-07
ES2082805T3 (es) 1996-04-01
RU2048468C1 (ru) 1995-11-20
EP0412404B1 (en) 1996-01-31
GR3019009T3 (en) 1996-05-31
NO179638C (no) 1996-11-20
TW205041B (fi) 1993-05-01
FI903879A0 (fi) 1990-08-06
HK151596A (en) 1996-08-16
NO903438L (no) 1991-02-08
CN1027370C (zh) 1995-01-11
EP0412404A3 (en) 1991-06-12
RU2010026C1 (ru) 1994-03-30
EP0412404A2 (en) 1991-02-13
IL95281A (en) 1996-06-18
JPH0368567A (ja) 1991-03-25
FI96857C (fi) 1996-09-10

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Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: FUJISAWA PHARMACEUTICAL CO., LTD.