ES2094335T3 - Derivados de alopurinol aminoacilados y oligopeptidos de actividad inmunoestimuladora y composiciones farmaceuticas que los contienen. - Google Patents
Derivados de alopurinol aminoacilados y oligopeptidos de actividad inmunoestimuladora y composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2094335T3 ES2094335T3 ES92830136T ES92830136T ES2094335T3 ES 2094335 T3 ES2094335 T3 ES 2094335T3 ES 92830136 T ES92830136 T ES 92830136T ES 92830136 T ES92830136 T ES 92830136T ES 2094335 T3 ES2094335 T3 ES 2094335T3
- Authority
- ES
- Spain
- Prior art keywords
- alopurinol
- derivatives
- aciled
- oligopeptides
- immuno
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 title abstract 3
- 230000003308 immunostimulating effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 AMINO Chemical class 0.000 title 1
- 102000015636 Oligopeptides Human genes 0.000 title 1
- 108010038807 Oligopeptides Proteins 0.000 title 1
- 239000004475 Arginine Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
DERIVADOS AMINOACIL Y OLIGOPEPTIDIL DE ALOPURINOL QUE EXHIBEN ACTIVIDAD INMUNOESTIMULATORIA, Y FORMULACIONES FARMACEUTICAS QUE CONTIENEN ESTAS SUBSTANCIAS. LA PRESENTE INVENCION SE REFIERE A DERIVADOS AMINOACIL Y OLIOGOPEPTIDIL DE ALOPURINOL (1, 5-DIHIDRO-4H-PIRAZOLO D] ELACIONADAS CON CATIONES FARMACOLOGICAMENTE ACEPTABLES, EN LA MENCIONADA FORMULA N ES UN ENTERO ENTRE 2 Y 6, PREFERIBLEMENTE 5, Y ES H O CO-A, EN DONDE A ES UN ACIDO AMINO RACEMICO O QUIRAL, BIPEPTIDO, TRIPEPTIDO, TETRAPEPTIDO, O PENTAPEPTIDO ESCOGIDO, RESPECTIVAMENTE, ENTRE LOS GRUPOS QUE CONSTAN DE: A) ARGININA, ACIDO ASPARTICO, LISINA, LEUCINA; B) GLICILASPARTATO, GLICILGLICINA, ASPARTILARGININA, LEUCILARGININA, ALANIGLICINA; C) ARGINILLISILASPARTATO, ASPARTILLISILARGININA, LISILPROLILARGININA, PROLILPROLILARGININA, LISILISTIDIGLICINAMIDA, PROLILFENILALANILARGININA, FENILALANILPROLILARGININA; D) ARGINILLISILASPARTILVALINA, VALILASPARTILLISILARGININA, TREONILVALILLEUCILHISTIDINA; E) ARGINILLISILASPARTILVALILTRIOSINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM910189A IT1244501B (it) | 1991-03-22 | 1991-03-22 | Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2094335T3 true ES2094335T3 (es) | 1997-01-16 |
Family
ID=11399991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92830136T Expired - Lifetime ES2094335T3 (es) | 1991-03-22 | 1992-03-20 | Derivados de alopurinol aminoacilados y oligopeptidos de actividad inmunoestimuladora y composiciones farmaceuticas que los contienen. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5272151A (es) |
EP (1) | EP0506628B1 (es) |
JP (1) | JP3067886B2 (es) |
AT (1) | ATE143024T1 (es) |
DE (1) | DE69213794T2 (es) |
DK (1) | DK0506628T3 (es) |
ES (1) | ES2094335T3 (es) |
GR (1) | GR3021556T3 (es) |
HK (1) | HK1006462A1 (es) |
IT (1) | IT1244501B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5928191A (en) * | 1993-07-30 | 1999-07-27 | E.P. Technologies, Inc. | Variable curve electrophysiology catheter |
US5994361A (en) * | 1994-06-22 | 1999-11-30 | Biochem Pharma | Substituted purinyl derivatives with immunomodulating activity |
WO1999024038A1 (en) | 1997-11-07 | 1999-05-20 | Johns Hopkins University | Methods for treatment of disorders of cardiac contractility |
ES2232169T3 (es) | 1998-08-12 | 2005-05-16 | Gilead Sciences, Inc. | Procedimiento de fabricacion de nucleosidos de 1,3-oxatiolano. |
CA2788498C (en) * | 2001-03-01 | 2016-02-16 | Gilead Sciences, Inc. | Polymorphic and other crystalline forms of cis-ftc |
AU2002364160A1 (en) * | 2001-12-14 | 2003-06-30 | Pharmasset Ltd. | Preparation of intermediates useful in the synthesis of antiviral nucleosides |
CA2494183C (en) | 2002-08-06 | 2012-01-03 | Kyoichi A. Watanabe | Processes for preparing 1,3-dioxolane nucleosides |
US6953041B2 (en) * | 2002-10-09 | 2005-10-11 | Micell Technologies, Inc. | Compositions of transition metal species in dense phase carbon dioxide and methods of use thereof |
CA2552122A1 (en) * | 2003-12-29 | 2005-07-21 | Advanced Medical Optics, Inc. | Intraocular lenses having a visible light-selective-transmissive-region |
US7067659B2 (en) * | 2004-04-23 | 2006-06-27 | Duke University | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof |
BRPI0509338B1 (pt) | 2004-04-30 | 2017-10-17 | Abbott Medical Optics Inc. | Detached devices having a highly selective violet light transmitter and related methods |
EP1815275B1 (en) * | 2004-11-22 | 2011-02-23 | Abbott Medical Optics Inc. | Copolymerizable azo compounds and articles containing them |
ATE525664T1 (de) * | 2004-11-22 | 2011-10-15 | Abbott Medical Optics Inc | Copolymerisierbare methin- und anthrachinon- verbindungen und artikel damit |
US8188098B2 (en) * | 2008-05-19 | 2012-05-29 | Hoffmann-La Roche Inc. | GPR119 receptor agonists |
EP3915565A3 (en) * | 2013-03-15 | 2022-03-16 | XORTX Therapeutics Inc. | Xanthine oxidase inhibitor formulations |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3165520A (en) * | 1965-01-12 | Certificate of correction | ||
AU564576B2 (en) * | 1981-09-24 | 1987-08-20 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Purine derivatives |
US4602089A (en) * | 1982-03-12 | 1986-07-22 | Newport Pharmaceuticals, Inc. | Process for preparing purine compounds |
DK302883D0 (da) * | 1983-06-30 | 1983-06-30 | Hans Bundgaard | Allopurinol prodrugs |
US4663326A (en) * | 1985-04-04 | 1987-05-05 | Warner-Lambert Company | Pyrazolo[4,3-d]pyrimidine-5,7-(4H,6H)dione or -5-thione-7-one analogs |
AU611648B2 (en) * | 1986-08-11 | 1991-06-20 | Baxter International Inc. | Pivot pin bearing/seal with loose eyelet especially suited for disposable continuous flow blood filtration system cartridges |
IT1213495B (it) * | 1986-09-17 | 1989-12-20 | Sigma Tau Ind Farmaceuti | Processo per la preparazione dell'alfa-n-[(ipoxatin-9-il)pentilossicarbonil-]arginina |
-
1991
- 1991-03-22 IT ITRM910189A patent/IT1244501B/it active IP Right Grant
-
1992
- 1992-03-20 DE DE69213794T patent/DE69213794T2/de not_active Expired - Fee Related
- 1992-03-20 DK DK92830136.5T patent/DK0506628T3/da active
- 1992-03-20 US US07/854,916 patent/US5272151A/en not_active Expired - Fee Related
- 1992-03-20 AT AT92830136T patent/ATE143024T1/de not_active IP Right Cessation
- 1992-03-20 EP EP92830136A patent/EP0506628B1/en not_active Expired - Lifetime
- 1992-03-20 ES ES92830136T patent/ES2094335T3/es not_active Expired - Lifetime
- 1992-03-23 JP JP4065009A patent/JP3067886B2/ja not_active Expired - Fee Related
-
1996
- 1996-11-06 GR GR960402931T patent/GR3021556T3/el unknown
-
1998
- 1998-06-18 HK HK98105617A patent/HK1006462A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0506628B1 (en) | 1996-09-18 |
DE69213794T2 (de) | 1997-02-06 |
ITRM910189A1 (it) | 1992-09-22 |
ATE143024T1 (de) | 1996-10-15 |
DE69213794D1 (de) | 1996-10-24 |
GR3021556T3 (en) | 1997-02-28 |
EP0506628A3 (en) | 1992-10-21 |
US5272151A (en) | 1993-12-21 |
HK1006462A1 (en) | 1999-02-26 |
JPH05117275A (ja) | 1993-05-14 |
DK0506628T3 (da) | 1996-11-11 |
JP3067886B2 (ja) | 2000-07-24 |
ITRM910189A0 (it) | 1991-03-22 |
IT1244501B (it) | 1994-07-15 |
EP0506628A2 (en) | 1992-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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