MD1688G2 - Benzotiofen, benzofuran şi indoltiazepinone, oxazepinone şi diazepinone, compoziţie farmaceutică, metodă de inhibare a aderării leucocitelor la celulele endoteliale pentru tratamentul proceselor inflamatorii şi metodă de tratament al mamiferelor infectate cu HIV infecţie . - Google Patents
Benzotiofen, benzofuran şi indoltiazepinone, oxazepinone şi diazepinone, compoziţie farmaceutică, metodă de inhibare a aderării leucocitelor la celulele endoteliale pentru tratamentul proceselor inflamatorii şi metodă de tratament al mamiferelor infectate cu HIV infecţie .Info
- Publication number
- MD1688G2 MD1688G2 MD96-0230A MD960230A MD1688G2 MD 1688 G2 MD1688 G2 MD 1688G2 MD 960230 A MD960230 A MD 960230A MD 1688 G2 MD1688 G2 MD 1688G2
- Authority
- MD
- Moldova
- Prior art keywords
- treatment
- inflammatory diseases
- hiv infection
- benzothiophene
- benzofuran
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
Invenţia se referă la domeniul chimiei şi medicinei, în special la compuşii cu formula (I)sau sărurile de adiţie acidă folosite pentru tratamentul proceselor inflamatorii şi infecţieiHIV.Esenţa invenţiei constă în sinteza benzotiofenului, benzofuranului şi indoltiazepinonelor, oxazepinonelor şi diazepinonelor cu formula (I), utilizate ca ingrediente active în compoziţia farmaceutică, care inhibă aderarea leucocitelor la celulele endoteliale, precum şi activitatea HIV. Astfel compuşii revendicaţi pot fi folosiţi la tratamentul proceselor inflamatorii şi infecţiei HIV.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20733094A | 1994-03-07 | 1994-03-07 | |
US08/351,611 US5489586A (en) | 1994-03-07 | 1994-12-12 | Method for treating inflammatory disease in humans |
PCT/US1995/001275 WO1995024408A1 (en) | 1994-03-07 | 1995-01-30 | Benzothiophene, benzofuran and indolethiazepinones, oxazepinones and diazepinones as inhibitors of cell adhesion and as inhibitors of hiv |
Publications (3)
Publication Number | Publication Date |
---|---|
MD960230A MD960230A (ro) | 1997-10-31 |
MD1688F2 MD1688F2 (ro) | 2001-06-30 |
MD1688G2 true MD1688G2 (ro) | 2002-01-31 |
Family
ID=22770077
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD96-0230A MD1688G2 (ro) | 1994-03-07 | 1995-01-30 | Benzotiofen, benzofuran şi indoltiazepinone, oxazepinone şi diazepinone, compoziţie farmaceutică, metodă de inhibare a aderării leucocitelor la celulele endoteliale pentru tratamentul proceselor inflamatorii şi metodă de tratament al mamiferelor infectate cu HIV infecţie . |
Country Status (28)
Country | Link |
---|---|
US (2) | US5489586A (ro) |
EP (1) | EP0749434B1 (ro) |
JP (1) | JPH09509961A (ro) |
KR (2) | KR100325881B1 (ro) |
AT (1) | ATE187728T1 (ro) |
AU (1) | AU688466B2 (ro) |
BG (1) | BG62698B1 (ro) |
CA (1) | CA2181354A1 (ro) |
CZ (1) | CZ292009B6 (ro) |
DE (1) | DE69513961T2 (ro) |
DK (1) | DK0749434T3 (ro) |
ES (1) | ES2141922T3 (ro) |
FI (1) | FI963462A (ro) |
GE (1) | GEP19991835B (ro) |
GR (1) | GR3032861T3 (ro) |
HU (1) | HUT77403A (ro) |
MD (1) | MD1688G2 (ro) |
NO (1) | NO313384B1 (ro) |
NZ (1) | NZ279737A (ro) |
PH (1) | PH31163A (ro) |
PL (1) | PL180457B1 (ro) |
RO (1) | RO117919B1 (ro) |
RU (1) | RU2144033C1 (ro) |
SK (1) | SK282962B6 (ro) |
TJ (1) | TJ252B (ro) |
UA (1) | UA45967C2 (ro) |
WO (1) | WO1995024408A1 (ro) |
ZA (1) | ZA951844B (ro) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5612330A (en) * | 1994-03-07 | 1997-03-18 | Warner-Lambert Company | Methods for inhibiting and controlling viral growth |
DE19818964A1 (de) * | 1998-04-28 | 1999-11-04 | Dresden Arzneimittel | Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung |
ATE330955T1 (de) | 1998-04-28 | 2006-07-15 | Elbion Ag | Indolderivate und deren verwendung als inhibitoren der phosphodiesterase 4. |
US7015212B1 (en) | 1999-05-12 | 2006-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Thiazepine inhibitors of HIV-1 integrase |
DE19944829A1 (de) * | 1999-09-18 | 2001-06-13 | Kundo Systemtechnik Gmbh | Ultraschall-Durchflußmesser |
AU2001281142A1 (en) * | 2000-08-16 | 2002-02-25 | Japan Tobacco Inc. | Diazepinones as antiviral agents |
JP2005089298A (ja) * | 2001-09-18 | 2005-04-07 | Japan Tobacco Inc | ナフタレン化合物及びその医薬用途 |
GB0217920D0 (en) * | 2002-04-23 | 2002-09-11 | Aventis Pharm Prod Inc | Interleukin-4 Gene Expression inhibitors |
AU2003225131A1 (en) * | 2002-04-23 | 2003-11-10 | Aventis Pharmaceuticals Inc. | 3-substituted amino-1h-indole-2-carboxylic acid and 3-substituted amino-benzo' b! thiophene-2-carboxylic acid derivatives as interieukin-4 gene expression inhibitors |
BRPI0409560A (pt) * | 2003-04-15 | 2006-04-18 | Warner Lambert Co | derivados bicìclicos [b]-condensados de prolina e sua utilização para tratar condições artrìticas |
CN1238357C (zh) * | 2003-10-22 | 2006-01-25 | 中国科学院昆明植物研究所 | 炭球菌素及其制备方法和应用 |
WO2005081960A2 (en) * | 2004-02-25 | 2005-09-09 | Wyeth | Inhibitors of protein tyrosine phosphatase 1b |
SI1799696T1 (sl) | 2004-09-17 | 2009-04-30 | Idenix Pharmaceuticals Inc | Fosfoindoli kot hiv inhibitorji |
US7674822B2 (en) | 2004-11-24 | 2010-03-09 | Wyeth | PTP1b inhibitors |
JP2009062278A (ja) * | 2005-12-29 | 2009-03-26 | Nippon Chemiphar Co Ltd | P2x4受容体拮抗剤 |
GEP20115359B (en) | 2006-06-27 | 2011-12-26 | Takeda Pharmaceutical | Fused cyclic compounds |
MX2009003410A (es) * | 2006-09-29 | 2009-07-17 | Idenix Pharmaceuticals Inc | Fosfoindoles enantiomericamente puros como inhibidores de vih. |
CN105330675A (zh) * | 2010-11-15 | 2016-02-17 | Viiv保健英国有限公司 | Hiv复制的抑制剂 |
RU2506082C2 (ru) * | 2011-05-24 | 2014-02-10 | Государственное учебно-научное учреждение Химический факультет Московского государственного университета им. М.В. Ломоносова | Антигипотоническое средство |
US10870663B2 (en) | 2018-11-30 | 2020-12-22 | Glaxosmithkline Intellectual Property Development Limited | Compounds useful in HIV therapy |
WO2023150374A1 (en) * | 2022-02-07 | 2023-08-10 | Riparian Pharmaceuticals, Inc. | Inducers of klf2 and methods of use thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4013641A (en) * | 1975-10-08 | 1977-03-22 | Xerox Corporation | Indolobenzoxazepines |
WO1994017075A1 (en) * | 1993-01-20 | 1994-08-04 | A. Menarini Industrie Farmaceutiche Riunite S.R.L. | Diazepin derivatives and antiviral compositions |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1222294A (en) * | 1968-09-19 | 1971-02-10 | Upjohn Co | Oxazinobenzodiazepine derivatives |
-
1994
- 1994-12-12 US US08/351,611 patent/US5489586A/en not_active Expired - Fee Related
-
1995
- 1995-01-30 CZ CZ19962597A patent/CZ292009B6/cs not_active IP Right Cessation
- 1995-01-30 SK SK1141-96A patent/SK282962B6/sk unknown
- 1995-01-30 ES ES95908760T patent/ES2141922T3/es not_active Expired - Lifetime
- 1995-01-30 NZ NZ279737A patent/NZ279737A/en unknown
- 1995-01-30 AT AT95908760T patent/ATE187728T1/de not_active IP Right Cessation
- 1995-01-30 DK DK95908760T patent/DK0749434T3/da active
- 1995-01-30 TJ TJ96000405A patent/TJ252B/xx unknown
- 1995-01-30 AU AU16973/95A patent/AU688466B2/en not_active Ceased
- 1995-01-30 KR KR1020017012173A patent/KR100325881B1/ko not_active IP Right Cessation
- 1995-01-30 CA CA002181354A patent/CA2181354A1/en not_active Abandoned
- 1995-01-30 RO RO96-01756A patent/RO117919B1/ro unknown
- 1995-01-30 DE DE69513961T patent/DE69513961T2/de not_active Expired - Fee Related
- 1995-01-30 KR KR1019960704928A patent/KR100338017B1/ko not_active IP Right Cessation
- 1995-01-30 GE GEAP19953361A patent/GEP19991835B/en unknown
- 1995-01-30 EP EP95908760A patent/EP0749434B1/en not_active Expired - Lifetime
- 1995-01-30 JP JP7523448A patent/JPH09509961A/ja not_active Ceased
- 1995-01-30 HU HU9602451A patent/HUT77403A/hu unknown
- 1995-01-30 MD MD96-0230A patent/MD1688G2/ro not_active IP Right Cessation
- 1995-01-30 UA UA96093473A patent/UA45967C2/uk unknown
- 1995-01-30 PL PL95316197A patent/PL180457B1/pl not_active IP Right Cessation
- 1995-01-30 RU RU96120173A patent/RU2144033C1/ru not_active IP Right Cessation
- 1995-01-30 WO PCT/US1995/001275 patent/WO1995024408A1/en active IP Right Grant
- 1995-03-03 PH PH50062A patent/PH31163A/en unknown
- 1995-03-06 ZA ZA951844A patent/ZA951844B/xx unknown
- 1995-05-19 US US08/444,975 patent/US5565446A/en not_active Expired - Fee Related
-
1996
- 1996-09-04 FI FI963462A patent/FI963462A/fi unknown
- 1996-09-05 BG BG100829A patent/BG62698B1/bg unknown
- 1996-09-06 NO NO19963744A patent/NO313384B1/no not_active IP Right Cessation
-
2000
- 2000-03-03 GR GR20000400553T patent/GR3032861T3/el not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4013641A (en) * | 1975-10-08 | 1977-03-22 | Xerox Corporation | Indolobenzoxazepines |
WO1994017075A1 (en) * | 1993-01-20 | 1994-08-04 | A. Menarini Industrie Farmaceutiche Riunite S.R.L. | Diazepin derivatives and antiviral compositions |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PD99 | Pending application | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |