TJ252B - Benzothiophene benzofuran indolethiazepinone oxazepinone and diazepinone derivatives pharmaceutical composition having activity which is inhibited the cellular adhesion or hiv method of inhibition of the adhesion leukocytes to endothelial cells at treatment of the illnesses caused by it method of treatment of the mammalian infected hiv - Google Patents

Benzothiophene benzofuran indolethiazepinone oxazepinone and diazepinone derivatives pharmaceutical composition having activity which is inhibited the cellular adhesion or hiv method of inhibition of the adhesion leukocytes to endothelial cells at treatment of the illnesses caused by it method of treatment of the mammalian infected hiv

Info

Publication number
TJ252B
TJ252B TJ96000405A TJ96000405A TJ252B TJ 252 B TJ252 B TJ 252B TJ 96000405 A TJ96000405 A TJ 96000405A TJ 96000405 A TJ96000405 A TJ 96000405A TJ 252 B TJ252 B TJ 252B
Authority
TJ
Tajikistan
Prior art keywords
treatment
hiv
adhesion
benzothiophene
benzofuran
Prior art date
Application number
TJ96000405A
Inventor
Diane Harris Boschelli
David Thomas Connor
James Bernard Kramer
Paul Charles Unangst
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of TJ252B publication Critical patent/TJ252B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Benzothiophene, benzofuran and indole-thiazepinones, oxazepinones and diazepinones as well as methods of preparation thereof are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases.
TJ96000405A 1994-03-07 1995-01-30 Benzothiophene benzofuran indolethiazepinone oxazepinone and diazepinone derivatives pharmaceutical composition having activity which is inhibited the cellular adhesion or hiv method of inhibition of the adhesion leukocytes to endothelial cells at treatment of the illnesses caused by it method of treatment of the mammalian infected hiv TJ252B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20733094A 1994-03-07 1994-03-07
PCT/US1995/001275 WO1995024408A1 (en) 1994-03-07 1995-01-30 Benzothiophene, benzofuran and indolethiazepinones, oxazepinones and diazepinones as inhibitors of cell adhesion and as inhibitors of hiv

Publications (1)

Publication Number Publication Date
TJ252B true TJ252B (en) 1999-12-23

Family

ID=22770077

Family Applications (1)

Application Number Title Priority Date Filing Date
TJ96000405A TJ252B (en) 1994-03-07 1995-01-30 Benzothiophene benzofuran indolethiazepinone oxazepinone and diazepinone derivatives pharmaceutical composition having activity which is inhibited the cellular adhesion or hiv method of inhibition of the adhesion leukocytes to endothelial cells at treatment of the illnesses caused by it method of treatment of the mammalian infected hiv

Country Status (28)

Country Link
US (2) US5489586A (en)
EP (1) EP0749434B1 (en)
JP (1) JPH09509961A (en)
KR (2) KR100338017B1 (en)
AT (1) ATE187728T1 (en)
AU (1) AU688466B2 (en)
BG (1) BG62698B1 (en)
CA (1) CA2181354A1 (en)
CZ (1) CZ292009B6 (en)
DE (1) DE69513961T2 (en)
DK (1) DK0749434T3 (en)
ES (1) ES2141922T3 (en)
FI (1) FI963462A (en)
GE (1) GEP19991835B (en)
GR (1) GR3032861T3 (en)
HU (1) HUT77403A (en)
MD (1) MD1688G2 (en)
NO (1) NO313384B1 (en)
NZ (1) NZ279737A (en)
PH (1) PH31163A (en)
PL (1) PL180457B1 (en)
RO (1) RO117919B1 (en)
RU (1) RU2144033C1 (en)
SK (1) SK282962B6 (en)
TJ (1) TJ252B (en)
UA (1) UA45967C2 (en)
WO (1) WO1995024408A1 (en)
ZA (1) ZA951844B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612330A (en) * 1994-03-07 1997-03-18 Warner-Lambert Company Methods for inhibiting and controlling viral growth
TR200003130T2 (en) 1998-04-28 2001-01-22 Arzneimittelwerk Dresden Gmbh Novel hydroxyindoles, processes for their use and preparation as phosphodiesterase 4 inhibitors
DE19818964A1 (en) * 1998-04-28 1999-11-04 Dresden Arzneimittel New hydroxy-indole derivatives useful in treatment of degenerative joint disease, viral and parasitic infections, bronchial, dermatological, neurodegenerative and prostate disorders, etc.
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase
DE19944829A1 (en) * 1999-09-18 2001-06-13 Kundo Systemtechnik Gmbh Ultrasonic flow meter
WO2002014324A2 (en) * 2000-08-16 2002-02-21 Warner-Lambert Company Diazepinones as antiviral agents
JP2005089298A (en) * 2001-09-18 2005-04-07 Japan Tobacco Inc Naphthalene compound and its pharmaceutical use
GB0217920D0 (en) * 2002-04-23 2002-09-11 Aventis Pharm Prod Inc Interleukin-4 Gene Expression inhibitors
JP4497930B2 (en) * 2002-04-23 2010-07-07 アベンティス・ファーマスーティカルズ・インコーポレイテツド 3-Substituted amino-1H-indole-2-carboxylic acid and 3-substituted amino-benzo (b) thiophene-2-carboxylic acid derivatives as interleukin-4 gene expression inhibitors
MXPA05011168A (en) * 2003-04-15 2005-12-14 Warner Lambert Co [b]-fused bicyclic proline derivatives and their use for treating arthritic conditions.
CN1238357C (en) * 2003-10-22 2006-01-25 中国科学院昆明植物研究所 Hypoxylonin and its preparation method and application
WO2005081960A2 (en) * 2004-02-25 2005-09-09 Wyeth Inhibitors of protein tyrosine phosphatase 1b
CA2583409C (en) 2004-09-17 2014-06-17 Idenix Pharmaceuticals, Inc. Phospho-indoles as hiv inhibitors
US7674822B2 (en) 2004-11-24 2010-03-09 Wyeth PTP1b inhibitors
JP2009062278A (en) * 2005-12-29 2009-03-26 Nippon Chemiphar Co Ltd P2x4 receptor antagonist
EP2431367A3 (en) 2006-06-27 2012-07-04 Takeda Pharmaceutical Company Limited Fused cyclic compounds as GPR40 receptor modulators
KR20090077813A (en) * 2006-09-29 2009-07-15 아이데닉스 파마슈티칼스, 인코포레이티드 Enantiomerically pure phosphoindoles as hiv inhibitors
WO2012066442A1 (en) * 2010-11-15 2012-05-24 Pfizer Limited Inhibitors of hiv replication
RU2506082C2 (en) * 2011-05-24 2014-02-10 Государственное учебно-научное учреждение Химический факультет Московского государственного университета им. М.В. Ломоносова Antihypotonic agent
US10870663B2 (en) 2018-11-30 2020-12-22 Glaxosmithkline Intellectual Property Development Limited Compounds useful in HIV therapy
WO2023150374A1 (en) * 2022-02-07 2023-08-10 Riparian Pharmaceuticals, Inc. Inducers of klf2 and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1222294A (en) * 1968-09-19 1971-02-10 Upjohn Co Oxazinobenzodiazepine derivatives
US4013641A (en) * 1975-10-08 1977-03-22 Xerox Corporation Indolobenzoxazepines
WO1994017075A1 (en) * 1993-01-20 1994-08-04 A. Menarini Industrie Farmaceutiche Riunite S.R.L. Diazepin derivatives and antiviral compositions

Also Published As

Publication number Publication date
EP0749434B1 (en) 1999-12-15
UA45967C2 (en) 2002-05-15
PH31163A (en) 1998-03-20
US5565446A (en) 1996-10-15
HU9602451D0 (en) 1996-11-28
RO117919B1 (en) 2002-09-30
AU1697395A (en) 1995-09-25
CZ292009B6 (en) 2003-07-16
NO313384B1 (en) 2002-09-23
SK282962B6 (en) 2003-01-09
CA2181354A1 (en) 1995-09-14
DE69513961D1 (en) 2000-01-20
NZ279737A (en) 1997-07-27
SK114196A3 (en) 1997-03-05
US5489586A (en) 1996-02-06
FI963462A0 (en) 1996-09-04
GR3032861T3 (en) 2000-07-31
MD1688G2 (en) 2002-01-31
BG100829A (en) 1997-10-31
CZ259796A3 (en) 1997-06-11
ZA951844B (en) 1995-12-12
PL316197A1 (en) 1996-12-23
GEP19991835B (en) 1999-11-05
MD960230A (en) 1997-10-31
ES2141922T3 (en) 2000-04-01
NO963744D0 (en) 1996-09-06
WO1995024408A1 (en) 1995-09-14
KR100325881B1 (en) 2002-03-20
AU688466B2 (en) 1998-03-12
DK0749434T3 (en) 2000-05-29
BG62698B1 (en) 2000-05-31
EP0749434A1 (en) 1996-12-27
KR100338017B1 (en) 2002-11-23
JPH09509961A (en) 1997-10-07
HUT77403A (en) 1998-04-28
ATE187728T1 (en) 2000-01-15
MD1688F2 (en) 2001-06-30
NO963744L (en) 1996-09-06
PL180457B1 (en) 2001-02-28
DE69513961T2 (en) 2000-06-29
FI963462A (en) 1996-09-04
RU2144033C1 (en) 2000-01-10

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