ATE67180T1 - P-guanidinbenzoesaeurederivate und pharmazeutische mittel, die sie als aktiven inhaltsstoff enthalten. - Google Patents

P-guanidinbenzoesaeurederivate und pharmazeutische mittel, die sie als aktiven inhaltsstoff enthalten.

Info

Publication number
ATE67180T1
ATE67180T1 AT86308724T AT86308724T ATE67180T1 AT E67180 T1 ATE67180 T1 AT E67180T1 AT 86308724 T AT86308724 T AT 86308724T AT 86308724 T AT86308724 T AT 86308724T AT E67180 T1 ATE67180 T1 AT E67180T1
Authority
AT
Austria
Prior art keywords
sup
sub
coor
benzoacid
guanidine
Prior art date
Application number
AT86308724T
Other languages
English (en)
Inventor
Katsuhiro Imaki
Yoshinobu Arai
Hiroyuki Ohno
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP25206785A external-priority patent/JPS62111963A/ja
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Application granted granted Critical
Publication of ATE67180T1 publication Critical patent/ATE67180T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/02—Monothiocarbonic acids; Derivatives thereof
    • C07C329/04—Esters of monothiocarbonic acids
    • C07C329/10—Esters of monothiocarbonic acids having sulfur atoms of thiocarbonic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT86308724T 1985-11-12 1986-11-10 P-guanidinbenzoesaeurederivate und pharmazeutische mittel, die sie als aktiven inhaltsstoff enthalten. ATE67180T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP25206685 1985-11-12
JP25206785A JPS62111963A (ja) 1985-11-12 1985-11-12 ｐ−グアニジノ安息香酸チオフエニルエステル誘導体及びそれらを含有する医薬品
JP19211786 1986-08-19
EP86308724A EP0222608B1 (de) 1985-11-12 1986-11-10 p-Guanidinbenzoesäurederivate und pharmazeutische Mittel, die sie als aktiven Inhaltsstoff enthalten

Publications (1)

Publication Number Publication Date
ATE67180T1 true ATE67180T1 (de) 1991-09-15

Family

ID=27326565

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86308724T ATE67180T1 (de) 1985-11-12 1986-11-10 P-guanidinbenzoesaeurederivate und pharmazeutische mittel, die sie als aktiven inhaltsstoff enthalten.

Country Status (6)

Country Link
US (2) US4975464A (de)
EP (1) EP0222608B1 (de)
AT (1) ATE67180T1 (de)
DE (1) DE3681408D1 (de)
ES (1) ES2039356T3 (de)
GR (1) GR3002731T3 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5247084A (en) * 1985-11-12 1993-09-21 Ono Pharmaceutical Co., Ltd. Derivatives of p-guanidinobenzoic acid
GB8928383D0 (en) * 1989-12-15 1990-02-21 Ici Plc Insecticidal compounds
EP0475531B1 (de) * 1990-09-10 1995-01-18 Asahi Kasei Kogyo Kabushiki Kaisha Benzoesäurephenylesterverbindungen und diese enthaltende Elastase inhibitierende Zusammensetzungen
NZ240442A (en) * 1990-11-07 1994-11-25 Cortech Inc 2-heterocyclic substituted aliphatic carboxylic acid esters of (optionally substituted) phenol and pharmaceutical compositions
US5240956A (en) * 1990-11-07 1993-08-31 Cortech, Inc. Ester inhibitors
US5508262A (en) * 1993-12-15 1996-04-16 University Of South Florida Interleukin-1 receptor antagonist decreases severity of acute pancreatitis
US5795890A (en) * 1995-09-27 1998-08-18 Ono Pharmaceutical Co., Ltd. Sulfonamide derivatives
PT889876E (pt) 1996-03-29 2001-11-30 Searle & Co Derivados de fenilenossulfonamidas meta-substituidas
DE69705300T2 (de) * 1996-03-29 2002-05-02 G.D. Searle & Co., Chicago Cyclopropylalkansäurederivate
EP0893437A4 (de) 1996-04-10 2000-12-27 Ono Pharmaceutical Co Tryptase-Inhibitor und Guanidino-Derivate
US6063600A (en) * 1997-05-23 2000-05-16 Uab Research Foundation DNA encoding canine interleukin-1 receptor antagonist
AU3511500A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
US6849605B1 (en) * 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
WO2000051625A1 (en) * 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
US7850970B2 (en) 2003-08-26 2010-12-14 The Regents Of The University Of Colorado Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
CN1810777B (zh) * 2005-01-24 2010-09-29 上海东浩医药生物企业有限公司 一类治疗或预防细菌感染的化合物及其制备方法和用途
WO2007143880A1 (fr) * 2006-06-09 2007-12-21 Shanghai East Best Biopharmaceutical Enterprises Co., Ltd. Composés pour la prévention et le traitement des infections bactériennes, leur préparation et utilisation
CN114805141A (zh) * 2021-01-27 2022-07-29 中国科学院上海药物研究所 4-胍基苯甲酸芳基酯类化合物及其在抗SARS-CoV-2病毒中的用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3520918A (en) * 1968-03-08 1970-07-21 Atomic Energy Commission P-nitrophenyl-p'-guanidinobenzoate hci
DE1905813A1 (de) * 1968-07-04 1970-03-05 Akad Wissenschaften Ddr 3- oder 4-Guanidobenzoesaeurebenzyl- oder -phenylestern und deren Verwendung als Inhibitoren
US3824267A (en) * 1971-08-19 1974-07-16 Ono Pharmaceutical Co Thiolesters of guanidino organic acids
JPS5470241A (en) * 1977-11-09 1979-06-05 Ono Pharmaceut Co Ltd Guanidinobenzoic acid derivative and its preparation
JPS55100356A (en) * 1979-01-29 1980-07-31 Kowa Co Benzenediol derivative
GB2044760B (en) * 1979-03-01 1983-03-23 Ono Pharmaceutical Co Guanidinobenzoic acid derivatives
FR2456731A1 (fr) * 1979-05-16 1980-12-12 Choay Sa Nouveaux derives substitues d'ary
US4359046A (en) * 1979-07-09 1982-11-16 Shaw Jr Seth T IUD Arrangement
JPS5634662A (en) * 1979-08-31 1981-04-06 Ono Pharmaceut Co Ltd Guanidinobenzoic acid derivative and its preparation
US4423069A (en) * 1982-01-20 1983-12-27 University Of Illinois Foundation Contraceptive method
DE3429114A1 (de) * 1984-08-03 1986-02-13 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte guanidinobenzoesaeurephenylester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4843094A (en) * 1985-11-12 1989-06-27 Ono Pharmaceutical Co., Ltd. Derivatives of p-guantidinobenzoic acid and pharmaceutical agents containing them as active ingredient

Also Published As

Publication number Publication date
ES2039356T3 (es) 1993-10-01
DE3681408D1 (de) 1991-10-17
GR3002731T3 (en) 1993-01-25
EP0222608B1 (de) 1991-09-11
EP0222608A2 (de) 1987-05-20
US4975464A (en) 1990-12-04
US5077428A (en) 1991-12-31
EP0222608A3 (en) 1988-09-07

Similar Documents

Publication Publication Date Title
ATE67180T1 (de) P-guanidinbenzoesaeurederivate und pharmazeutische mittel, die sie als aktiven inhaltsstoff enthalten.
ES2071725T3 (es) Diesteres fosfato de acido ascorbico y tocoferilo para la inhibicion de la reaccion de maillard.
RU93047799A (ru) Композиции, содержащие ретиноевые кислоты и токоферол
BE904421A (fr) Derives heterocycliques aromatiques et leur application dans les domaines therapeutique et cosmetique.
ATE84967T1 (de) Verwendung von pentoxifyllin zur behandlung entzuendlicher erkrankungen.
US5080909A (en) Anti-viral compositions
MD1688G2 (ro) Benzotiofen, benzofuran şi indoltiazepinone, oxazepinone şi diazepinone, compoziţie farmaceutică, metodă de inhibare a aderării leucocitelor la celulele endoteliale pentru tratamentul proceselor inflamatorii şi metodă de tratament al mamiferelor infectate cu HIV infecţie .
ATE113043T1 (de) 7-(3-(aminomethyl)-3-alkyl-1- pyrrolidinyl>chinolin-3-carbonsäure-derivate und diese enthaltende pharmazeutische zusammensetzungen.
HUP0003571A2 (hu) 6,9-Hídkötésű eritromicin-származékok
ATE63747T1 (de) Antivirale verbindungen.
EP0535446B1 (de) Pharmazeutische Zusammensetzungen zur topischen Anwendung die ein Chelatierungsmittel, ein Tocopherol und einen antimikrobiellen Wirkstoff enthalten
ES2111352T3 (es) Uso de diester fosfato para el tratamiento de enfermedades retinianas.
AU530678B2 (en) Phosphono-hydroxy-acetic acid
MC1930A1 (fr) Produit antiviral
RU93052161A (ru) Лекарственные средства, содержащие производные имидазол-1-ила
WO1991015200A3 (en) Use of trinitrobenzenes or carminic acid in the treatment of cancer or viral diseases
IT1197516B (it) Derivati teofillinmetilanici e teofillinmetilditianici procedimento per la loro preparazione e composizioni farmaceutiche che li comprendono
SE8203856D0 (sv) Novel derivatives of guanine ii
ES2092562T3 (es) Agente antiviral derivado de la cascara de la nuez kukui.
CA1207238A (en) Use of haloprogin in the treatment of herpes labialis
IE781226L (en) Antithrombatic compound
CA1227754A (en) Use of tolnaftate in the treatment of herpes labialis
Eales et al. Symptomatic porphyria in a case of Felty’s syndrome. I. Clinical and routine biochemical studies
ATE104676T1 (de) Antivirale wirkstoffe.
ATE94551T1 (de) Antibakterielles mittel fuer anwendung bei saeugetieren mit cephalosporinverbindungen als effektiven bestandteil.