LU90192I2 - Desirudine et ses sels et dérivés pharmaceutiquement acceptables (revasc) - Google Patents

Desirudine et ses sels et dérivés pharmaceutiquement acceptables (revasc)

Info

Publication number
LU90192I2
LU90192I2 LU90192C LU90192C LU90192I2 LU 90192 I2 LU90192 I2 LU 90192I2 LU 90192 C LU90192 C LU 90192C LU 90192 C LU90192 C LU 90192C LU 90192 I2 LU90192 I2 LU 90192I2
Authority
LU
Luxembourg
Prior art keywords
desirudine
revasc
derivatives
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
LU90192C
Other languages
English (en)
Original Assignee
Ciba Geigy Ag
Ucp Gen Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6214920&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU90192(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy Ag, Ucp Gen Pharma Ag filed Critical Ciba Geigy Ag
Publication of LU90192I2 publication Critical patent/LU90192I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
LU90192C 1983-11-22 1997-12-31 Desirudine et ses sels et dérivés pharmaceutiquement acceptables (revasc) LU90192I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833342139 DE3342139A1 (de) 1983-11-22 1983-11-22 Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel

Publications (1)

Publication Number Publication Date
LU90192I2 true LU90192I2 (fr) 1998-03-02

Family

ID=6214920

Family Applications (1)

Application Number Title Priority Date Filing Date
LU90192C LU90192I2 (fr) 1983-11-22 1997-12-31 Desirudine et ses sels et dérivés pharmaceutiquement acceptables (revasc)

Country Status (19)

Country Link
US (3) US4654302A (fr)
EP (1) EP0142860B1 (fr)
JP (1) JP2551551B2 (fr)
AT (1) ATE56021T1 (fr)
AU (1) AU578050B2 (fr)
CA (1) CA1239606A (fr)
CY (1) CY1737A (fr)
DD (1) DD232498A5 (fr)
DE (3) DE3342139A1 (fr)
DK (1) DK165696C (fr)
HK (1) HK121293A (fr)
IE (1) IE57885B1 (fr)
IL (1) IL73570A (fr)
LU (1) LU90192I2 (fr)
MX (1) MX9203370A (fr)
NL (1) NL970045I2 (fr)
NZ (1) NZ210275A (fr)
PH (1) PH23831A (fr)
ZA (1) ZA849068B (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
FR2562088B1 (fr) * 1984-03-27 1987-11-13 Transgene Sa Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
US5705355A (en) * 1984-03-27 1998-01-06 Transgene, S.A. Hirudin, pharmaceutical compositions comprising it and their use
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
EP0168342B1 (fr) * 1984-06-14 1991-07-03 Ciba-Geigy Ag Procédé pour la préparation d'inhibiteurs de thrombine
DE3429430A1 (de) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3506992A1 (de) * 1985-02-27 1986-08-28 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
JPS6229997A (ja) * 1985-04-08 1987-02-07 Sankyo Co Ltd Ｃ末端にプロリンアミドを有するペプチドの製法
DE3738541A1 (de) * 1987-11-13 1989-05-24 Hoechst Ag Verfahren zur isolierung und reinigung von hirudin
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
MY101203A (en) * 1985-12-12 1991-08-17 Ucp Gen Pharma Ag Production of thrombin iinhibitors.
US5789540A (en) * 1987-01-23 1998-08-04 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US6005071A (en) * 1987-01-23 1999-12-21 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5192745A (en) * 1987-05-21 1993-03-09 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5256559A (en) * 1988-03-04 1993-10-26 Biogen, Inc. Methods and compositions for inhibiting platelet aggregation
EP0333356A3 (fr) * 1988-03-04 1990-12-19 Biogen, Inc. Peptides de hirudine
AU614121B2 (en) * 1988-05-04 1991-08-22 Novartis Ag Improvements in the production of polypeptides
US4971953A (en) * 1988-05-10 1990-11-20 Merrell Dow Pharmaceuticals Anticoagulant peptide alcohols
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
DE58907266T2 (de) * 1988-06-11 1994-09-29 Ciba Geigy Ag Polypeptide mit einer die Koagulierung hemmenden Wirkung.
US5112615A (en) * 1988-08-03 1992-05-12 New England Deaconess Hospital Corporation Soluble hirudin conjugates
US5167960A (en) * 1988-08-03 1992-12-01 New England Deaconess Hospital Corporation Hirudin-coated biocompatible substance
GB8822147D0 (en) * 1988-09-21 1988-10-26 Ciba Geigy Ag Pharmaceutically active combination
JPH04500802A (ja) * 1988-09-29 1992-02-13 バイオジェン インコーポレイテッド ヒルジンペプチド
US4994367A (en) * 1988-10-07 1991-02-19 East Carolina University Extended shelf life platelet preparations and process for preparing the same
DE3835815A1 (de) * 1988-10-21 1990-04-26 Hoechst Ag Neue isohirudine
JPH04503660A (ja) * 1988-12-05 1992-07-02 バイオジェン インコーポレイテッド 血小板凝集抑制の方法及び組成物
US4861865A (en) * 1989-01-23 1989-08-29 Washington University Novel antithrombin peptide
US5179196A (en) * 1989-05-04 1993-01-12 Sri International Purification of proteins employing ctap-iii fusions
US6239101B1 (en) * 1989-07-05 2001-05-29 Oklahoma Medical Research Foundation Thrombin binding polypeptides
US5192747A (en) * 1989-10-03 1993-03-09 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
CA2035917C (fr) * 1990-02-13 2001-10-02 John L. Krstenansky Derives sulfonate, sulfate, phosphonate et phosphate stabilises de hirudine
US5118790A (en) * 1990-07-24 1992-06-02 Sri International Analogs of hirudin
US5837808A (en) * 1991-08-20 1998-11-17 Baxter International Inc. Analogs of hirudin
DE4209110A1 (de) * 1991-11-26 1993-05-27 Basf Ag Neue thrombininhibitorische proteine aus landblutegeln
DE4140381A1 (de) * 1991-12-07 1993-06-09 Hoechst Ag, 6230 Frankfurt, De Neue synthetische isohirudine mit verbesserter stabilitaet
GB9401447D0 (en) * 1994-01-26 1994-03-23 Ciba Geigy Ag Pharmaceutical compositions
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
DE19607239A1 (de) 1996-02-27 1997-08-28 Behringwerke Ag Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung
KR20000070338A (ko) * 1997-01-20 2000-11-25 나가시마 카쭈시게, 노미야마 아키히코 펩티드의 안정화 방법 및 당해 방법을 이용한 펩티드 함유 동결건조 의약조성물
DE19755682A1 (de) * 1997-12-15 1999-06-17 Knoll Ag Verfahren zur Ermittlung eines Dosierungschemas für Thrombininhibitoren
DE10149678A1 (de) 2001-10-09 2009-03-12 Novel Science International Gmbh Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
DE10301255A1 (de) 2003-01-15 2004-07-29 Cpi Creative Pharma International Gmbh Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel

Also Published As

Publication number Publication date
US4745177A (en) 1988-05-17
DK165696B (da) 1993-01-04
CA1239606A (fr) 1988-07-26
AU578050B2 (en) 1988-10-13
IE842979L (en) 1985-05-22
US4801576A (en) 1989-01-31
HK121293A (en) 1993-11-12
DE19775096I2 (de) 2002-07-04
DD232498A5 (de) 1986-01-29
IL73570A (en) 1988-05-31
ATE56021T1 (de) 1990-09-15
NZ210275A (en) 1988-08-30
DK552684D0 (da) 1984-11-21
DE3483085D1 (de) 1990-10-04
US4654302A (en) 1987-03-31
JPS60136597A (ja) 1985-07-20
DK165696C (da) 1993-05-24
EP0142860B1 (fr) 1990-08-29
ZA849068B (en) 1985-07-31
NL970045I1 (nl) 1998-03-02
DE3342139A1 (de) 1985-05-30
IL73570A0 (en) 1985-02-28
CY1737A (en) 1995-10-20
DK552684A (da) 1985-05-23
EP0142860A3 (en) 1987-03-11
JP2551551B2 (ja) 1996-11-06
NL970045I2 (nl) 1998-08-03
MX9203370A (es) 1992-09-01
IE57885B1 (en) 1993-05-05
PH23831A (en) 1989-11-23
EP0142860A2 (fr) 1985-05-29
AU3575984A (en) 1985-05-30

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