DK552684D0 - Desulfatohirudiner samt deres fremstilling og anvendelse - Google Patents

Desulfatohirudiner samt deres fremstilling og anvendelse

Info

Publication number
DK552684D0
DK552684D0 DK552684A DK552684A DK552684D0 DK 552684 D0 DK552684 D0 DK 552684D0 DK 552684 A DK552684 A DK 552684A DK 552684 A DK552684 A DK 552684A DK 552684 D0 DK552684 D0 DK 552684D0
Authority
DK
Denmark
Prior art keywords
preparation
hirudines
desulphato
desulfatohirudins
hirudin
Prior art date
Application number
DK552684A
Other languages
English (en)
Other versions
DK165696B (da
DK552684A (da
DK165696C (da
Inventor
Hans Fritz
Johannes Dodt
Ursula Seemueller
Ernst Fink
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6214920&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK552684(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK552684D0 publication Critical patent/DK552684D0/da
Publication of DK552684A publication Critical patent/DK552684A/da
Publication of DK165696B publication Critical patent/DK165696B/da
Application granted granted Critical
Publication of DK165696C publication Critical patent/DK165696C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK552684A 1983-11-22 1984-11-21 Desulfatohirudiner og deres farmaceutisk acceptable salte, deres fremstilling, farmaceutisk praeparat indeholdende disse forbindelser og anvendelse af forbindelserne til fremstilling af farmaceutisk middel og som analytisk reagens DK165696C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833342139 DE3342139A1 (de) 1983-11-22 1983-11-22 Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3342139 1983-11-22

Publications (4)

Publication Number Publication Date
DK552684D0 true DK552684D0 (da) 1984-11-21
DK552684A DK552684A (da) 1985-05-23
DK165696B DK165696B (da) 1993-01-04
DK165696C DK165696C (da) 1993-05-24

Family

ID=6214920

Family Applications (1)

Application Number Title Priority Date Filing Date
DK552684A DK165696C (da) 1983-11-22 1984-11-21 Desulfatohirudiner og deres farmaceutisk acceptable salte, deres fremstilling, farmaceutisk praeparat indeholdende disse forbindelser og anvendelse af forbindelserne til fremstilling af farmaceutisk middel og som analytisk reagens

Country Status (19)

Country Link
US (3) US4654302A (da)
EP (1) EP0142860B1 (da)
JP (1) JP2551551B2 (da)
AT (1) ATE56021T1 (da)
AU (1) AU578050B2 (da)
CA (1) CA1239606A (da)
CY (1) CY1737A (da)
DD (1) DD232498A5 (da)
DE (3) DE3342139A1 (da)
DK (1) DK165696C (da)
HK (1) HK121293A (da)
IE (1) IE57885B1 (da)
IL (1) IL73570A (da)
LU (1) LU90192I2 (da)
MX (1) MX9203370A (da)
NL (1) NL970045I2 (da)
NZ (1) NZ210275A (da)
PH (1) PH23831A (da)
ZA (1) ZA849068B (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
FR2562088B1 (fr) * 1984-03-27 1987-11-13 Transgene Sa Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
US5705355A (en) * 1984-03-27 1998-01-06 Transgene, S.A. Hirudin, pharmaceutical compositions comprising it and their use
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
EP0168342B1 (de) * 1984-06-14 1991-07-03 Ciba-Geigy Ag Verfahren zur Herstellung von Thrombin-Inhibitoren
DE3429430A1 (de) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3506992A1 (de) * 1985-02-27 1986-08-28 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
JPS6229997A (ja) * 1985-04-08 1987-02-07 Sankyo Co Ltd Ｃ末端にプロリンアミドを有するペプチドの製法
DE3738541A1 (de) * 1987-11-13 1989-05-24 Hoechst Ag Verfahren zur isolierung und reinigung von hirudin
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
MY101203A (en) * 1985-12-12 1991-08-17 Ucp Gen Pharma Ag Production of thrombin iinhibitors.
US5789540A (en) * 1987-01-23 1998-08-04 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US6005071A (en) * 1987-01-23 1999-12-21 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5192745A (en) * 1987-05-21 1993-03-09 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
AU3098289A (en) * 1988-03-04 1989-09-07 Biogen, Inc. Hirudin peptides
US5256559A (en) * 1988-03-04 1993-10-26 Biogen, Inc. Methods and compositions for inhibiting platelet aggregation
AU614121B2 (en) * 1988-05-04 1991-08-22 Novartis Ag Improvements in the production of polypeptides
US4971953A (en) * 1988-05-10 1990-11-20 Merrell Dow Pharmaceuticals Anticoagulant peptide alcohols
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
EP0347376B1 (en) * 1988-06-11 1994-03-23 Ciba-Geigy Ag Novel polypeptides with an anticoagulant activity
US5167960A (en) * 1988-08-03 1992-12-01 New England Deaconess Hospital Corporation Hirudin-coated biocompatible substance
US5112615A (en) * 1988-08-03 1992-05-12 New England Deaconess Hospital Corporation Soluble hirudin conjugates
GB8822147D0 (en) * 1988-09-21 1988-10-26 Ciba Geigy Ag Pharmaceutically active combination
JPH04500802A (ja) * 1988-09-29 1992-02-13 バイオジェン インコーポレイテッド ヒルジンペプチド
US4994367A (en) * 1988-10-07 1991-02-19 East Carolina University Extended shelf life platelet preparations and process for preparing the same
DE3835815A1 (de) * 1988-10-21 1990-04-26 Hoechst Ag Neue isohirudine
HUT57060A (en) * 1988-12-05 1991-11-28 Biogen Inc Process for producing compositions for inhibiting blood platelet aggregation
US4861865A (en) * 1989-01-23 1989-08-29 Washington University Novel antithrombin peptide
US5179196A (en) * 1989-05-04 1993-01-12 Sri International Purification of proteins employing ctap-iii fusions
US6239101B1 (en) * 1989-07-05 2001-05-29 Oklahoma Medical Research Foundation Thrombin binding polypeptides
US5192747A (en) * 1989-10-03 1993-03-09 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
CA2035917C (en) * 1990-02-13 2001-10-02 John L. Krstenansky Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
US5118790A (en) * 1990-07-24 1992-06-02 Sri International Analogs of hirudin
US5837808A (en) * 1991-08-20 1998-11-17 Baxter International Inc. Analogs of hirudin
DE4209110A1 (de) * 1991-11-26 1993-05-27 Basf Ag Neue thrombininhibitorische proteine aus landblutegeln
DE4140381A1 (de) * 1991-12-07 1993-06-09 Hoechst Ag, 6230 Frankfurt, De Neue synthetische isohirudine mit verbesserter stabilitaet
GB9401447D0 (en) 1994-01-26 1994-03-23 Ciba Geigy Ag Pharmaceutical compositions
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
DE19607239A1 (de) 1996-02-27 1997-08-28 Behringwerke Ag Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung
EP0998942A4 (en) * 1997-01-20 2006-08-16 Japan Energy Corp METHOD FOR STABILIZING PEPTIDES AND FREEZERED MEDICINAL COMPOSITIONS THEREOF
DE19755682A1 (de) * 1997-12-15 1999-06-17 Knoll Ag Verfahren zur Ermittlung eines Dosierungschemas für Thrombininhibitoren
DE10149678A1 (de) 2001-10-09 2009-03-12 Novel Science International Gmbh Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
DE10301255A1 (de) 2003-01-15 2004-07-29 Cpi Creative Pharma International Gmbh Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel

Also Published As

Publication number Publication date
DD232498A5 (de) 1986-01-29
NL970045I1 (nl) 1998-03-02
JP2551551B2 (ja) 1996-11-06
EP0142860A2 (de) 1985-05-29
MX9203370A (es) 1992-09-01
IL73570A0 (en) 1985-02-28
IL73570A (en) 1988-05-31
ZA849068B (en) 1985-07-31
DK165696B (da) 1993-01-04
PH23831A (en) 1989-11-23
EP0142860A3 (en) 1987-03-11
US4654302A (en) 1987-03-31
CY1737A (en) 1995-10-20
DE3342139A1 (de) 1985-05-30
JPS60136597A (ja) 1985-07-20
AU578050B2 (en) 1988-10-13
ATE56021T1 (de) 1990-09-15
US4745177A (en) 1988-05-17
DK552684A (da) 1985-05-23
NL970045I2 (nl) 1998-08-03
IE842979L (en) 1985-05-22
EP0142860B1 (de) 1990-08-29
DE3483085D1 (de) 1990-10-04
DK165696C (da) 1993-05-24
DE19775096I2 (de) 2002-07-04
HK121293A (en) 1993-11-12
LU90192I2 (fr) 1998-03-02
IE57885B1 (en) 1993-05-05
US4801576A (en) 1989-01-31
CA1239606A (en) 1988-07-26
AU3575984A (en) 1985-05-30
NZ210275A (en) 1988-08-30

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Legal Events

Date Code Title Description
CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1997 00045, 971120

PUP Patent expired