DK552684A - Desulfatohirudiner samt deres fremstilling og anvendelse - Google Patents
Desulfatohirudiner samt deres fremstilling og anvendelse Download PDFInfo
- Publication number
- DK552684A DK552684A DK552684A DK552684A DK552684A DK 552684 A DK552684 A DK 552684A DK 552684 A DK552684 A DK 552684A DK 552684 A DK552684 A DK 552684A DK 552684 A DK552684 A DK 552684A
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- hirudines
- desulphato
- desulfatohirudins
- hirudin
- Prior art date
Links
- 102000007625 Hirudins Human genes 0.000 abstract 1
- 108010007267 Hirudins Proteins 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000023555 blood coagulation Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 abstract 1
- 229940006607 hirudin Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3342139 | 1983-11-22 | ||
| DE19833342139 DE3342139A1 (de) | 1983-11-22 | 1983-11-22 | Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK552684D0 DK552684D0 (da) | 1984-11-21 |
| DK552684A true DK552684A (da) | 1985-05-23 |
| DK165696B DK165696B (da) | 1993-01-04 |
| DK165696C DK165696C (da) | 1993-05-24 |
Family
ID=6214920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK552684A DK165696C (da) | 1983-11-22 | 1984-11-21 | Desulfatohirudiner og deres farmaceutisk acceptable salte, deres fremstilling, farmaceutisk praeparat indeholdende disse forbindelser og anvendelse af forbindelserne til fremstilling af farmaceutisk middel og som analytisk reagens |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US4654302A (da) |
| EP (1) | EP0142860B1 (da) |
| JP (1) | JP2551551B2 (da) |
| AT (1) | ATE56021T1 (da) |
| AU (1) | AU578050B2 (da) |
| CA (1) | CA1239606A (da) |
| CY (1) | CY1737A (da) |
| DD (1) | DD232498A5 (da) |
| DE (3) | DE3342139A1 (da) |
| DK (1) | DK165696C (da) |
| HK (1) | HK121293A (da) |
| IE (1) | IE57885B1 (da) |
| IL (1) | IL73570A (da) |
| LU (1) | LU90192I2 (da) |
| MX (1) | MX9203370A (da) |
| NL (1) | NL970045I2 (da) |
| NZ (1) | NZ210275A (da) |
| PH (1) | PH23831A (da) |
| ZA (1) | ZA849068B (da) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3342139A1 (de) * | 1983-11-22 | 1985-05-30 | Ciba-Geigy Ag, Basel | Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel |
| FR2562088B1 (fr) * | 1984-03-27 | 1987-11-13 | Transgene Sa | Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine |
| US5705355A (en) * | 1984-03-27 | 1998-01-06 | Transgene, S.A. | Hirudin, pharmaceutical compositions comprising it and their use |
| DE3438296A1 (de) * | 1984-04-18 | 1985-11-07 | Hoechst Ag, 6230 Frankfurt | Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel |
| EP0168342B1 (de) * | 1984-06-14 | 1991-07-03 | Ciba-Geigy Ag | Verfahren zur Herstellung von Thrombin-Inhibitoren |
| DE3429430A1 (de) * | 1984-08-10 | 1986-02-20 | Hoechst Ag, 6230 Frankfurt | Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens |
| DE3445532A1 (de) * | 1984-12-13 | 1986-06-19 | Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn | Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten |
| DE3506992A1 (de) * | 1985-02-27 | 1986-08-28 | Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn | Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten |
| JPS6229997A (ja) * | 1985-04-08 | 1987-02-07 | Sankyo Co Ltd | Ｃ末端にプロリンアミドを有するペプチドの製法 |
| DE3738541A1 (de) * | 1987-11-13 | 1989-05-24 | Hoechst Ag | Verfahren zur isolierung und reinigung von hirudin |
| DE3689525D1 (de) * | 1985-07-17 | 1994-02-24 | Hoechst Ag | Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel. |
| MY101203A (en) * | 1985-12-12 | 1991-08-17 | Ucp Gen Pharma Ag | Production of thrombin iinhibitors. |
| US5789540A (en) * | 1987-01-23 | 1998-08-04 | Merrell Pharmaceuticals Inc. | Anticoagulant peptides |
| US6005071A (en) * | 1987-01-23 | 1999-12-21 | Merrell Pharmaceuticals Inc. | Anticoagulant peptides |
| US5236898A (en) * | 1987-05-21 | 1993-08-17 | Merrell Dow Pharmaceuticals Inc. | Cyclic anticoagulant peptides |
| US5192745A (en) * | 1987-05-21 | 1993-03-09 | Merrell Dow Pharmaceuticals Inc. | Cyclic anticoagulant peptides |
| US5256559A (en) * | 1988-03-04 | 1993-10-26 | Biogen, Inc. | Methods and compositions for inhibiting platelet aggregation |
| EP0333356A3 (en) * | 1988-03-04 | 1990-12-19 | Biogen, Inc. | Hirudin peptides |
| AU614121B2 (en) * | 1988-05-04 | 1991-08-22 | Novartis Ag | Improvements in the production of polypeptides |
| US4971953A (en) * | 1988-05-10 | 1990-11-20 | Merrell Dow Pharmaceuticals | Anticoagulant peptide alcohols |
| US5268296A (en) * | 1988-06-11 | 1993-12-07 | Ciba-Geigy Corporation | DNA vector and recombinant host cell for production of hirullin P6 and P18 |
| DE58907266T2 (de) * | 1988-06-11 | 1994-09-29 | Ciba Geigy Ag | Polypeptide mit einer die Koagulierung hemmenden Wirkung. |
| US5112615A (en) * | 1988-08-03 | 1992-05-12 | New England Deaconess Hospital Corporation | Soluble hirudin conjugates |
| US5167960A (en) * | 1988-08-03 | 1992-12-01 | New England Deaconess Hospital Corporation | Hirudin-coated biocompatible substance |
| GB8822147D0 (en) * | 1988-09-21 | 1988-10-26 | Ciba Geigy Ag | Pharmaceutically active combination |
| JPH04500802A (ja) * | 1988-09-29 | 1992-02-13 | バイオジェン インコーポレイテッド | ヒルジンペプチド |
| US4994367A (en) * | 1988-10-07 | 1991-02-19 | East Carolina University | Extended shelf life platelet preparations and process for preparing the same |
| DE3835815A1 (de) * | 1988-10-21 | 1990-04-26 | Hoechst Ag | Neue isohirudine |
| JPH04503660A (ja) * | 1988-12-05 | 1992-07-02 | バイオジェン インコーポレイテッド | 血小板凝集抑制の方法及び組成物 |
| US4861865A (en) * | 1989-01-23 | 1989-08-29 | Washington University | Novel antithrombin peptide |
| US5179196A (en) * | 1989-05-04 | 1993-01-12 | Sri International | Purification of proteins employing ctap-iii fusions |
| US6239101B1 (en) * | 1989-07-05 | 2001-05-29 | Oklahoma Medical Research Foundation | Thrombin binding polypeptides |
| US5192747A (en) * | 1989-10-03 | 1993-03-09 | Merrell Dow Pharmaceuticals Inc. | Anticoagulant peptides |
| CA2035917C (en) * | 1990-02-13 | 2001-10-02 | John L. Krstenansky | Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin |
| US5118790A (en) * | 1990-07-24 | 1992-06-02 | Sri International | Analogs of hirudin |
| US5837808A (en) * | 1991-08-20 | 1998-11-17 | Baxter International Inc. | Analogs of hirudin |
| DE4209110A1 (de) * | 1991-11-26 | 1993-05-27 | Basf Ag | Neue thrombininhibitorische proteine aus landblutegeln |
| DE4140381A1 (de) * | 1991-12-07 | 1993-06-09 | Hoechst Ag, 6230 Frankfurt, De | Neue synthetische isohirudine mit verbesserter stabilitaet |
| GB9401447D0 (en) * | 1994-01-26 | 1994-03-23 | Ciba Geigy Ag | Pharmaceutical compositions |
| DE4404168A1 (de) * | 1994-02-10 | 1995-08-17 | Hoechst Ag | Hirudinderivate und Verfahren zu deren Herstellung |
| DE19607239A1 (de) | 1996-02-27 | 1997-08-28 | Behringwerke Ag | Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung |
| KR20000070338A (ko) * | 1997-01-20 | 2000-11-25 | 나가시마 카쭈시게, 노미야마 아키히코 | 펩티드의 안정화 방법 및 당해 방법을 이용한 펩티드 함유 동결건조 의약조성물 |
| DE19755682A1 (de) * | 1997-12-15 | 1999-06-17 | Knoll Ag | Verfahren zur Ermittlung eines Dosierungschemas für Thrombininhibitoren |
| DE10149678A1 (de) | 2001-10-09 | 2009-03-12 | Novel Science International Gmbh | Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung |
| DE10301255A1 (de) | 2003-01-15 | 2004-07-29 | Cpi Creative Pharma International Gmbh | Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3342139A1 (de) * | 1983-11-22 | 1985-05-30 | Ciba-Geigy Ag, Basel | Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel |
| DE3438296A1 (de) * | 1984-04-18 | 1985-11-07 | Hoechst Ag, 6230 Frankfurt | Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel |
-
1983
- 1983-11-22 DE DE19833342139 patent/DE3342139A1/de not_active Withdrawn
-
1984
- 1984-11-20 DE DE1997175096 patent/DE19775096I2/de active Active
- 1984-11-20 AT AT84114038T patent/ATE56021T1/de active
- 1984-11-20 IL IL73570A patent/IL73570A/xx not_active IP Right Cessation
- 1984-11-20 CA CA000468216A patent/CA1239606A/en not_active Expired
- 1984-11-20 DD DD84269667A patent/DD232498A5/de not_active IP Right Cessation
- 1984-11-20 DE DE8484114038T patent/DE3483085D1/de not_active Expired - Lifetime
- 1984-11-20 EP EP84114038A patent/EP0142860B1/de not_active Expired - Lifetime
- 1984-11-21 JP JP59244681A patent/JP2551551B2/ja not_active Expired - Lifetime
- 1984-11-21 AU AU35759/84A patent/AU578050B2/en not_active Expired
- 1984-11-21 DK DK552684A patent/DK165696C/da not_active IP Right Cessation
- 1984-11-21 ZA ZA849068A patent/ZA849068B/xx unknown
- 1984-11-21 NZ NZ210275A patent/NZ210275A/xx unknown
- 1984-11-21 IE IE2979/84A patent/IE57885B1/en not_active IP Right Cessation
- 1984-11-21 US US06/673,952 patent/US4654302A/en not_active Expired - Lifetime
-
1986
- 1986-11-13 US US06/929,710 patent/US4745177A/en not_active Expired - Lifetime
- 1986-11-20 PH PH31466A patent/PH23831A/en unknown
-
1988
- 1988-01-19 US US07/145,023 patent/US4801576A/en not_active Expired - Lifetime
-
1992
- 1992-06-25 MX MX9203370A patent/MX9203370A/es unknown
-
1993
- 1993-11-04 HK HK1212/93A patent/HK121293A/xx not_active IP Right Cessation
-
1995
- 1995-10-20 CY CY173795A patent/CY1737A/xx unknown
-
1997
- 1997-12-19 NL NL970045C patent/NL970045I2/nl unknown
- 1997-12-31 LU LU90192C patent/LU90192I2/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US4745177A (en) | 1988-05-17 |
| DK165696B (da) | 1993-01-04 |
| CA1239606A (en) | 1988-07-26 |
| AU578050B2 (en) | 1988-10-13 |
| LU90192I2 (fr) | 1998-03-02 |
| IE842979L (en) | 1985-05-22 |
| US4801576A (en) | 1989-01-31 |
| HK121293A (en) | 1993-11-12 |
| DE19775096I2 (de) | 2002-07-04 |
| DD232498A5 (de) | 1986-01-29 |
| IL73570A (en) | 1988-05-31 |
| ATE56021T1 (de) | 1990-09-15 |
| NZ210275A (en) | 1988-08-30 |
| DK552684D0 (da) | 1984-11-21 |
| DE3483085D1 (de) | 1990-10-04 |
| US4654302A (en) | 1987-03-31 |
| JPS60136597A (ja) | 1985-07-20 |
| DK165696C (da) | 1993-05-24 |
| EP0142860B1 (de) | 1990-08-29 |
| ZA849068B (en) | 1985-07-31 |
| NL970045I1 (nl) | 1998-03-02 |
| DE3342139A1 (de) | 1985-05-30 |
| IL73570A0 (en) | 1985-02-28 |
| CY1737A (en) | 1995-10-20 |
| EP0142860A3 (en) | 1987-03-11 |
| JP2551551B2 (ja) | 1996-11-06 |
| NL970045I2 (nl) | 1998-08-03 |
| MX9203370A (es) | 1992-09-01 |
| IE57885B1 (en) | 1993-05-05 |
| PH23831A (en) | 1989-11-23 |
| EP0142860A2 (de) | 1985-05-29 |
| AU3575984A (en) | 1985-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CTFF | Application for supplementary protection certificate (spc) filed |
Free format text: CA 1997 00045, 971120 |
|
| PUP | Patent expired |