DK0749434T3 - Benzothiophen-, benzofuran- og indol-thiazepinoner, -oxazepinoner og -diazepinoner som celleadhæsionsinhibitorer og HIV-inh - Google Patents

Benzothiophen-, benzofuran- og indol-thiazepinoner, -oxazepinoner og -diazepinoner som celleadhæsionsinhibitorer og HIV-inh

Info

Publication number
DK0749434T3
DK0749434T3 DK95908760T DK95908760T DK0749434T3 DK 0749434 T3 DK0749434 T3 DK 0749434T3 DK 95908760 T DK95908760 T DK 95908760T DK 95908760 T DK95908760 T DK 95908760T DK 0749434 T3 DK0749434 T3 DK 0749434T3
Authority
DK
Denmark
Prior art keywords
inhibitors
thiazepinones
oxazepinones
diazepinones
benzothiophene
Prior art date
Application number
DK95908760T
Other languages
English (en)
Inventor
David Thomas Connor
Paul Charles Unangst
Diane Harris Boschelli
James Bernard Kramer
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of DK0749434T3 publication Critical patent/DK0749434T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
DK95908760T 1994-03-07 1995-01-30 Benzothiophen-, benzofuran- og indol-thiazepinoner, -oxazepinoner og -diazepinoner som celleadhæsionsinhibitorer og HIV-inh DK0749434T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20733094A 1994-03-07 1994-03-07
US08/351,611 US5489586A (en) 1994-03-07 1994-12-12 Method for treating inflammatory disease in humans
PCT/US1995/001275 WO1995024408A1 (en) 1994-03-07 1995-01-30 Benzothiophene, benzofuran and indolethiazepinones, oxazepinones and diazepinones as inhibitors of cell adhesion and as inhibitors of hiv

Publications (1)

Publication Number Publication Date
DK0749434T3 true DK0749434T3 (da) 2000-05-29

Family

ID=22770077

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95908760T DK0749434T3 (da) 1994-03-07 1995-01-30 Benzothiophen-, benzofuran- og indol-thiazepinoner, -oxazepinoner og -diazepinoner som celleadhæsionsinhibitorer og HIV-inh

Country Status (28)

Country Link
US (2) US5489586A (da)
EP (1) EP0749434B1 (da)
JP (1) JPH09509961A (da)
KR (2) KR100338017B1 (da)
AT (1) ATE187728T1 (da)
AU (1) AU688466B2 (da)
BG (1) BG62698B1 (da)
CA (1) CA2181354A1 (da)
CZ (1) CZ292009B6 (da)
DE (1) DE69513961T2 (da)
DK (1) DK0749434T3 (da)
ES (1) ES2141922T3 (da)
FI (1) FI963462A (da)
GE (1) GEP19991835B (da)
GR (1) GR3032861T3 (da)
HU (1) HUT77403A (da)
MD (1) MD1688G2 (da)
NO (1) NO313384B1 (da)
NZ (1) NZ279737A (da)
PH (1) PH31163A (da)
PL (1) PL180457B1 (da)
RO (1) RO117919B1 (da)
RU (1) RU2144033C1 (da)
SK (1) SK282962B6 (da)
TJ (1) TJ252B (da)
UA (1) UA45967C2 (da)
WO (1) WO1995024408A1 (da)
ZA (1) ZA951844B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612330A (en) * 1994-03-07 1997-03-18 Warner-Lambert Company Methods for inhibiting and controlling viral growth
UA59443C2 (uk) 1998-04-28 2003-09-15 Арцнайміттельверк Дрезден Гмбх Гідроксііндол, спосіб його одержання, лікарська форма на його основі та спосіб її одержання
DE19818964A1 (de) * 1998-04-28 1999-11-04 Dresden Arzneimittel Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase
DE19944829A1 (de) * 1999-09-18 2001-06-13 Kundo Systemtechnik Gmbh Ultraschall-Durchflußmesser
WO2002014324A2 (en) * 2000-08-16 2002-02-21 Warner-Lambert Company Diazepinones as antiviral agents
JP2005089298A (ja) * 2001-09-18 2005-04-07 Japan Tobacco Inc ナフタレン化合物及びその医薬用途
GB0217920D0 (en) * 2002-04-23 2002-09-11 Aventis Pharm Prod Inc Interleukin-4 Gene Expression inhibitors
WO2003091214A1 (en) * 2002-04-23 2003-11-06 Aventis Pharmaceuticals Inc. 3-substituted amino-1h-indole-2-carboxylic acid and 3-substituted amino-benzo
CA2522195A1 (en) * 2003-04-15 2004-10-28 Warner-Lambert Company Llc [b]-fused bicyclic proline derivatives and their use for treating arthritic conditions
CN1238357C (zh) * 2003-10-22 2006-01-25 中国科学院昆明植物研究所 炭球菌素及其制备方法和应用
WO2005081960A2 (en) * 2004-02-25 2005-09-09 Wyeth Inhibitors of protein tyrosine phosphatase 1b
EP1799696B1 (en) 2004-09-17 2008-11-12 IDENIX Pharmaceuticals, Inc. Phosphoindoles as hiv inhibitors
US7674822B2 (en) 2004-11-24 2010-03-09 Wyeth PTP1b inhibitors
JP2009062278A (ja) * 2005-12-29 2009-03-26 Nippon Chemiphar Co Ltd Ｐ２ｘ４受容体拮抗剤
RS52307B (en) 2006-06-27 2012-12-31 Takeda Pharmaceutical Company Limited CONDENSED CYCLIC UNITS
AU2007305447A1 (en) 2006-09-29 2008-04-10 Idenix Pharmaceuticals, Inc Enantiomerically pure phosphoindoles as HIV inhibitors
BR112013011991A2 (pt) * 2010-11-15 2016-08-30 Viiv Healthcare Uk Ltd composto, composição farmacêutica, uso de um composto, método de tratamento, produto, e kit.
RU2506082C2 (ru) * 2011-05-24 2014-02-10 Государственное учебно-научное учреждение Химический факультет Московского государственного университета им. М.В. Ломоносова Антигипотоническое средство
US10870663B2 (en) 2018-11-30 2020-12-22 Glaxosmithkline Intellectual Property Development Limited Compounds useful in HIV therapy
TW202340207A (zh) * 2022-02-07 2023-10-16 美商河岸製藥公司 Ｋｌｆ２誘導劑及其使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1222294A (en) * 1968-09-19 1971-02-10 Upjohn Co Oxazinobenzodiazepine derivatives
US4013641A (en) * 1975-10-08 1977-03-22 Xerox Corporation Indolobenzoxazepines
WO1994017075A1 (en) * 1993-01-20 1994-08-04 A. Menarini Industrie Farmaceutiche Riunite S.R.L. Diazepin derivatives and antiviral compositions

Also Published As

Publication number Publication date
PL180457B1 (pl) 2001-02-28
JPH09509961A (ja) 1997-10-07
MD960230A (en) 1997-10-31
US5489586A (en) 1996-02-06
NZ279737A (en) 1997-07-27
KR100338017B1 (ko) 2002-11-23
CA2181354A1 (en) 1995-09-14
AU688466B2 (en) 1998-03-12
NO313384B1 (no) 2002-09-23
ATE187728T1 (de) 2000-01-15
NO963744L (no) 1996-09-06
FI963462A0 (fi) 1996-09-04
SK282962B6 (sk) 2003-01-09
HU9602451D0 (en) 1996-11-28
ZA951844B (en) 1995-12-12
TJ252B (en) 1999-12-23
NO963744D0 (no) 1996-09-06
WO1995024408A1 (en) 1995-09-14
RU2144033C1 (ru) 2000-01-10
CZ292009B6 (cs) 2003-07-16
UA45967C2 (uk) 2002-05-15
EP0749434A1 (en) 1996-12-27
DE69513961T2 (de) 2000-06-29
DE69513961D1 (de) 2000-01-20
US5565446A (en) 1996-10-15
RO117919B1 (ro) 2002-09-30
FI963462A (fi) 1996-09-04
AU1697395A (en) 1995-09-25
BG100829A (en) 1997-10-31
MD1688G2 (ro) 2002-01-31
BG62698B1 (bg) 2000-05-31
GR3032861T3 (en) 2000-07-31
EP0749434B1 (en) 1999-12-15
GEP19991835B (en) 1999-11-05
CZ259796A3 (en) 1997-06-11
HUT77403A (hu) 1998-04-28
MD1688F2 (en) 2001-06-30
KR100325881B1 (ko) 2002-03-20
ES2141922T3 (es) 2000-04-01
SK114196A3 (en) 1997-03-05
PH31163A (en) 1998-03-20
PL316197A1 (en) 1996-12-23

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