ITMI922006A1 - Esteri nitrici di derivati dell'acido 2-(2, 6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione - Google Patents
Esteri nitrici di derivati dell'acido 2-(2, 6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazioneInfo
- Publication number
- ITMI922006A1 ITMI922006A1 IT002006A ITMI922006A ITMI922006A1 IT MI922006 A1 ITMI922006 A1 IT MI922006A1 IT 002006 A IT002006 A IT 002006A IT MI922006 A ITMI922006 A IT MI922006A IT MI922006 A1 ITMI922006 A1 IT MI922006A1
- Authority
- IT
- Italy
- Prior art keywords
- pct
- preparation
- phenylacetic
- phenylamine
- halo
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 title 1
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI922006A IT1256345B (it) | 1992-08-20 | 1992-08-20 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione |
| EP93917596A EP0609415B1 (en) | 1992-08-20 | 1993-07-20 | Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation |
| CA002120942A CA2120942C (en) | 1992-08-20 | 1993-07-20 | Nitric esters of derivatives of the 2-(2,6-di-halo-phenylamino)phenyl-acetic acid and process for their preparation |
| DE69305322T DE69305322T2 (de) | 1992-08-20 | 1993-07-20 | Salpetersäureester von 2-(2,6-dihalophenylamino)phenylessigsäurederivaten und verfahren zu ihrer herstellung |
| RU94046148A RU2109009C1 (ru) | 1992-08-20 | 1993-07-20 | Производные 2-(2,6-дигалофениламино)фенилуксусной кислоты и способ их получения |
| JP50582694A JP3231042B2 (ja) | 1992-08-20 | 1993-07-20 | 2−(2,6−ジ−ハロ−フェニルアミノ)フェニル酢酸の誘導体の硝酸エステルおよびその製造法 |
| UA94005348A UA39172C2 (uk) | 1992-08-20 | 1993-07-20 | Похідні 2-(2,6-дигалофеніламіно) фенілоцтової кислоти і спосіб їх одержання |
| ES93917596T ES2093979T3 (es) | 1992-08-20 | 1993-07-20 | Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino)fenilacetico y su procedimiento de preparacion. |
| US08/211,447 US5597847A (en) | 1992-08-20 | 1993-07-20 | Nitric esters of derivatives of the 2-(2,6-di-halo-phenylamino) phenylacetic acid and process for their preparation |
| PCT/EP1993/001906 WO1994004484A1 (en) | 1992-08-20 | 1993-07-20 | Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation |
| HK98106190A HK1006967A1 (en) | 1992-08-20 | 1993-07-20 | Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation |
| DK93917596.4T DK0609415T3 (da) | 1992-08-20 | 1993-07-20 | Salpetersyreestere af 2-(2,6-di-halogen-phenylamino)phenyleddikesyrederivater og fremgangsmåde til deres fremstilling |
| AT93917596T ATE143941T1 (de) | 1992-08-20 | 1993-07-20 | Salpetersäureester von 2-(2,6- dihalophenylamino)phenylessigsäurederivaten und verfahren zu ihrer herstellung |
| KR1019940701286A KR100269727B1 (ko) | 1992-08-20 | 1993-07-20 | 2-(2,6-디-할로페닐아미노)페닐아세트산의 유도체의 니트릭에스테르 및 그들의 제조방법 |
| GR960402711T GR3021404T3 (en) | 1992-08-20 | 1996-10-21 | Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI922006A IT1256345B (it) | 1992-08-20 | 1992-08-20 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI922006A0 ITMI922006A0 (it) | 1992-08-20 |
| ITMI922006A1 true ITMI922006A1 (it) | 1994-02-20 |
| IT1256345B IT1256345B (it) | 1995-12-01 |
Family
ID=11363881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI922006A IT1256345B (it) | 1992-08-20 | 1992-08-20 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5597847A (it) |
| EP (1) | EP0609415B1 (it) |
| JP (1) | JP3231042B2 (it) |
| KR (1) | KR100269727B1 (it) |
| AT (1) | ATE143941T1 (it) |
| CA (1) | CA2120942C (it) |
| DE (1) | DE69305322T2 (it) |
| DK (1) | DK0609415T3 (it) |
| ES (1) | ES2093979T3 (it) |
| GR (1) | GR3021404T3 (it) |
| HK (1) | HK1006967A1 (it) |
| IT (1) | IT1256345B (it) |
| RU (1) | RU2109009C1 (it) |
| UA (1) | UA39172C2 (it) |
| WO (1) | WO1994004484A1 (it) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9407749A (pt) * | 1993-10-06 | 1997-02-12 | Nicox Sa | Derivados de ácido processo para a preparaçao dos mesmos e composiçoes farmacêuticas |
| DE69512232T2 (de) * | 1994-05-10 | 2000-02-24 | Nicox S.A., Paris | Nitroverbindingen und ihre zubereitungen mit entzündungsremmenden, schmertzlindernden und antithrombotischen wirkungen |
| ES2092962B1 (es) * | 1995-04-19 | 1997-07-16 | Prodes Sa | Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino) fenilacetoxiacetico y sus procedimientos de preparacion. |
| US5703073A (en) | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
| US6043232A (en) * | 1997-07-23 | 2000-03-28 | Nitromed, Inc. | Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
| US5792758A (en) * | 1995-12-08 | 1998-08-11 | G. D. Searle & Co. | Steroid nitrite ester derivatives useful as anti-inflammatory drugs |
| SE9600070D0 (sv) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
| US6355680B1 (en) * | 1996-02-20 | 2002-03-12 | Exocell, Inc. | Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies |
| IT1282686B1 (it) | 1996-02-26 | 1998-03-31 | Nicox Sa | Composti in grado di ridurre la tossicita' da farmaci |
| BR9612730A (pt) * | 1996-08-16 | 1999-08-24 | Handforth Invest Ltd | Derivado de clonixin analg-sico/antinflamatÄrio nÆo-ulcerog-nico |
| IT1288123B1 (it) | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
| IT1285770B1 (it) | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
| IT1295694B1 (it) | 1996-11-14 | 1999-05-27 | Nicox Sa | Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica |
| FR2757159B1 (fr) * | 1996-12-12 | 1999-12-17 | Hoechst Marion Roussel Inc | Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments |
| ID24062A (id) * | 1997-07-25 | 2000-07-06 | Kissei Pharmaceutical | Turunan-turunan asam aminoetilfenoksiasetat dan obat untuk mengurangi nyeri dan membantu penyingkiran dalam litiasis saluran air kencing |
| CO4960662A1 (es) | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
| JP2002528495A (ja) | 1998-10-30 | 2002-09-03 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化された非ステロイド抗炎症性化合物、組成物および使用方法 |
| IT1308633B1 (it) * | 1999-03-02 | 2002-01-09 | Nicox Sa | Nitrossiderivati. |
| IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1311923B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| TWI243672B (en) | 1999-06-01 | 2005-11-21 | Astrazeneca Ab | New use of compounds as antibacterial agents |
| IT1312115B1 (it) * | 1999-06-24 | 2002-04-04 | Nicox Sa | Composti amorfi e relative composizioni farmaceutiche |
| IT1314184B1 (it) | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
| US6713454B1 (en) | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
| GB9922830D0 (en) * | 1999-09-27 | 1999-11-24 | Novartis Ag | Processes |
| RU2172309C2 (ru) * | 1999-10-06 | 2001-08-20 | Государственный научный центр Российской Федерации "НИОПИК" | Способ получения производных 2-(фениламино)фенилуксусной кислоты |
| US6436990B1 (en) | 1999-10-27 | 2002-08-20 | Nobex Corporation | 6-methoxy-2-naphthylacetic acid prodrugs |
| US6552078B2 (en) | 1999-10-27 | 2003-04-22 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
| TWI262791B (en) | 1999-10-27 | 2006-10-01 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
| AU782971B2 (en) | 1999-12-23 | 2005-09-15 | Nicox S.A. | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
| SE0000773D0 (sv) * | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
| SE0000774D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
| IT1319201B1 (it) * | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per il diabete. |
| IT1319202B1 (it) | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per le malattie a base infiammatoria. |
| AU2002249812B2 (en) | 2000-12-21 | 2005-11-10 | Nicox S.A. | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| ITMI20010985A1 (it) * | 2001-05-15 | 2002-11-15 | Nicox Sa | Farmaci per il morbo di alzheimer |
| ITMI20011744A1 (it) * | 2001-08-09 | 2003-02-09 | Nicox Sa | Farmaci per le vasculopatie |
| SE0102993D0 (sv) | 2001-09-07 | 2001-09-07 | Astrazeneca Ab | New self emulsifying drug delivery system |
| CA2487414A1 (en) | 2002-06-11 | 2003-12-18 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| AU2003279622A1 (en) | 2002-06-28 | 2004-01-19 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use |
| WO2004004648A2 (en) | 2002-07-03 | 2004-01-15 | Nitromed, Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| EP1542972A4 (en) | 2002-07-29 | 2008-01-23 | Nitromed Inc | CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITION AND METHOD OF USE |
| SE0203093D0 (en) * | 2002-10-18 | 2002-10-18 | Astrazeneca Uk Ltd | New use |
| AR042206A1 (es) | 2002-11-26 | 2005-06-15 | Novartis Ag | Acidos fenilaceticos y derivados |
| US8067464B2 (en) | 2004-10-04 | 2011-11-29 | Nitromed, Inc. | Compositions and methods using apocynin compounds and nitric oxide donors |
| AR061623A1 (es) | 2006-06-26 | 2008-09-10 | Novartis Ag | Derivados de acido fenilacetico |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL133740C (it) * | 1965-04-08 | |||
| US3558690A (en) * | 1965-04-08 | 1971-01-26 | Gelgy Chemical Corp | Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation |
| US3552690A (en) * | 1968-05-31 | 1971-01-05 | Lloyd S Turner | Kite control device |
| DE3407507A1 (de) * | 1984-03-01 | 1985-09-05 | A. Nattermann & Cie GmbH, 5000 Köln | Neue o-(2,6-dichloranilino)-phenylessigsaeureester, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| US5021576A (en) * | 1989-10-27 | 1991-06-04 | American Home Products Corporation | 2-Anilino phenylacetic acid derivatives |
-
1992
- 1992-08-20 IT ITMI922006A patent/IT1256345B/it active IP Right Grant
-
1993
- 1993-07-20 CA CA002120942A patent/CA2120942C/en not_active Expired - Fee Related
- 1993-07-20 WO PCT/EP1993/001906 patent/WO1994004484A1/en active IP Right Grant
- 1993-07-20 HK HK98106190A patent/HK1006967A1/en not_active IP Right Cessation
- 1993-07-20 ES ES93917596T patent/ES2093979T3/es not_active Expired - Lifetime
- 1993-07-20 DK DK93917596.4T patent/DK0609415T3/da active
- 1993-07-20 UA UA94005348A patent/UA39172C2/uk unknown
- 1993-07-20 JP JP50582694A patent/JP3231042B2/ja not_active Expired - Fee Related
- 1993-07-20 EP EP93917596A patent/EP0609415B1/en not_active Expired - Lifetime
- 1993-07-20 AT AT93917596T patent/ATE143941T1/de not_active IP Right Cessation
- 1993-07-20 RU RU94046148A patent/RU2109009C1/ru not_active IP Right Cessation
- 1993-07-20 KR KR1019940701286A patent/KR100269727B1/ko not_active Expired - Fee Related
- 1993-07-20 DE DE69305322T patent/DE69305322T2/de not_active Expired - Lifetime
- 1993-07-20 US US08/211,447 patent/US5597847A/en not_active Expired - Lifetime
-
1996
- 1996-10-21 GR GR960402711T patent/GR3021404T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0609415B1 (en) | 1996-10-09 |
| UA39172C2 (uk) | 2001-06-15 |
| ES2093979T3 (es) | 1997-01-01 |
| KR100269727B1 (ko) | 2000-10-16 |
| US5597847A (en) | 1997-01-28 |
| JP3231042B2 (ja) | 2001-11-19 |
| GR3021404T3 (en) | 1997-01-31 |
| WO1994004484A1 (en) | 1994-03-03 |
| IT1256345B (it) | 1995-12-01 |
| ATE143941T1 (de) | 1996-10-15 |
| JPH07500355A (ja) | 1995-01-12 |
| CA2120942C (en) | 2005-09-27 |
| DE69305322T2 (de) | 1997-02-20 |
| DE69305322D1 (de) | 1996-11-14 |
| DK0609415T3 (da) | 1996-11-18 |
| CA2120942A1 (en) | 1994-03-03 |
| HK1006967A1 (en) | 1999-03-26 |
| RU2109009C1 (ru) | 1998-04-20 |
| ITMI922006A0 (it) | 1992-08-20 |
| EP0609415A1 (en) | 1994-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970723 |