FR2757159B1 - Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments - Google Patents

Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

Info

Publication number
FR2757159B1
FR2757159B1 FR9615272A FR9615272A FR2757159B1 FR 2757159 B1 FR2757159 B1 FR 2757159B1 FR 9615272 A FR9615272 A FR 9615272A FR 9615272 A FR9615272 A FR 9615272A FR 2757159 B1 FR2757159 B1 FR 2757159B1
Authority
FR
France
Prior art keywords
application
ranges
radical
carbon atoms
niter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9615272A
Other languages
English (en)
Other versions
FR2757159A1 (fr
Inventor
Serge Droux
Giuseppe Gigliotti
Pascal Joly
Francis Petit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel, Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel
Priority to FR9615272A priority Critical patent/FR2757159B1/fr
Priority to PCT/FR1997/002255 priority patent/WO1998025918A1/fr
Publication of FR2757159A1 publication Critical patent/FR2757159A1/fr
Application granted granted Critical
Publication of FR2757159B1 publication Critical patent/FR2757159B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/08—Esters of nitric acid having nitrate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
FR9615272A 1996-12-12 1996-12-12 Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments Expired - Fee Related FR2757159B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR9615272A FR2757159B1 (fr) 1996-12-12 1996-12-12 Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments
PCT/FR1997/002255 WO1998025918A1 (fr) 1996-12-12 1997-12-10 Esters analgesiques, anti-inflammatoires et anti-thrombotiques d'alcools cycloaliphatiques nitres

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9615272A FR2757159B1 (fr) 1996-12-12 1996-12-12 Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

Publications (2)

Publication Number Publication Date
FR2757159A1 FR2757159A1 (fr) 1998-06-19
FR2757159B1 true FR2757159B1 (fr) 1999-12-17

Family

ID=9498594

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9615272A Expired - Fee Related FR2757159B1 (fr) 1996-12-12 1996-12-12 Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

Country Status (2)

Country Link
FR (1) FR2757159B1 (fr)
WO (1) WO1998025918A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7115661B1 (en) 1999-12-29 2006-10-03 Queen's University At Kingston Methods and compositions for mitigating pain
IT1313596B1 (it) 1999-08-04 2002-09-09 Nicox Sa Processo per la preparazione di nitrossialchil esteri del naproxene
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022409A1 (it) * 2002-11-14 2004-05-15 Dinamite Dipharma S P A Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
KR20100032856A (ko) 2007-06-28 2010-03-26 니콕스 에스. 에이. 1,4-부탄디올 모노니트레이트의 제조방법
TW201139337A (en) * 2010-03-31 2011-11-16 Lonza Ag Process for the production of esters of nitric acid
TWI417276B (zh) 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
WO2012152438A1 (fr) 2011-05-11 2012-11-15 Nicox S.A. Procédé pour la préparation d'ester d'acide de nitrate de composés organiques

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
IT1256345B (it) * 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
ATE168986T1 (de) * 1993-10-06 1998-08-15 Nicox Sa Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung
RU2145595C1 (ru) * 1994-05-10 2000-02-20 Никокс С.А. Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности
DE19515970A1 (de) * 1995-05-02 1996-11-07 Bayer Ag Acetylsalicylsäurenitrate

Also Published As

Publication number Publication date
WO1998025918A1 (fr) 1998-06-18
FR2757159A1 (fr) 1998-06-19

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse

Effective date: 20090831