ATE168986T1 - Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung - Google Patents

Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung

Info

Publication number
ATE168986T1
ATE168986T1 AT94928801T AT94928801T ATE168986T1 AT E168986 T1 ATE168986 T1 AT E168986T1 AT 94928801 T AT94928801 T AT 94928801T AT 94928801 T AT94928801 T AT 94928801T AT E168986 T1 ATE168986 T1 AT E168986T1
Authority
AT
Austria
Prior art keywords
pct
inflammatory
pain
production
acid esters
Prior art date
Application number
AT94928801T
Other languages
English (en)
Inventor
Soldato Piero Del
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9320599A external-priority patent/GB2283238B/en
Priority claimed from ITMI940916A external-priority patent/IT1269735B/it
Application filed by Nicox Sa filed Critical Nicox Sa
Application granted granted Critical
Publication of ATE168986T1 publication Critical patent/ATE168986T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
AT94928801T 1993-10-06 1994-09-23 Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung ATE168986T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9320599A GB2283238B (en) 1993-10-06 1993-10-06 Nitric esters of derivatives of propionic acid and process for their preparation
ITMI940916A IT1269735B (it) 1994-05-10 1994-05-10 Prodotti provvisti di un gruppo nitroestere terminale dotati di attivita' anti-infiammatoria e/o analgesica

Publications (1)

Publication Number Publication Date
ATE168986T1 true ATE168986T1 (de) 1998-08-15

Family

ID=26303642

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94928801T ATE168986T1 (de) 1993-10-06 1994-09-23 Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung

Country Status (15)

Country Link
US (2) US5700947A (de)
EP (1) EP0722434B1 (de)
JP (1) JP3775796B2 (de)
KR (1) KR100343243B1 (de)
AT (1) ATE168986T1 (de)
AU (1) AU678063B2 (de)
BR (1) BR9407749A (de)
CA (1) CA2173582C (de)
DE (1) DE69412109T2 (de)
DK (1) DK0722434T3 (de)
ES (1) ES2120070T3 (de)
HU (1) HU218923B (de)
RU (1) RU2136653C1 (de)
SI (1) SI0722434T1 (de)
WO (1) WO1995009831A1 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043232A (en) * 1997-07-23 2000-03-28 Nitromed, Inc. Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
IT1282686B1 (it) 1996-02-26 1998-03-31 Nicox Sa Composti in grado di ridurre la tossicita' da farmaci
US5985862A (en) * 1996-05-02 1999-11-16 G.D. Searle & Co. Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
US6310052B1 (en) 1996-06-04 2001-10-30 Queen's University At Kingston Nitrate esters and their use for neurological conditions
US20050137191A1 (en) * 1996-06-04 2005-06-23 Thatcher Gregory R. Nitrate esters and their use for mitigating cellular damage
US7115661B1 (en) 1999-12-29 2006-10-03 Queen's University At Kingston Methods and compositions for mitigating pain
IT1288123B1 (it) 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
IT1285770B1 (it) 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
IT1295694B1 (it) 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
FR2757159B1 (fr) * 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments
IL120531A (en) * 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
GB9801398D0 (en) 1998-01-22 1998-03-18 Anggard Erik E Chemical compounds
IT1298338B1 (it) * 1998-03-05 1999-12-20 Nicox Sa Composizioni farmaceutiche per l'ulcera
IT1303672B1 (it) * 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
EP1126838A4 (de) * 1998-10-30 2005-02-16 Nitromed Inc Nitrosierte und nitrosylierte nichtsteroidale antiphlogistishe verbindungen, zusammenstellungen und verwendungsmethoden
IT1308633B1 (it) * 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
IT1311924B1 (it) 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1311923B1 (it) 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
TWI243672B (en) * 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
ITMI991517A1 (it) * 1999-07-09 2001-01-09 Nicox Sa Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico
IT1313596B1 (it) 1999-08-04 2002-09-09 Nicox Sa Processo per la preparazione di nitrossialchil esteri del naproxene
IT1314184B1 (it) 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
TWI262791B (en) 1999-10-27 2006-10-01 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs
US6436990B1 (en) 1999-10-27 2002-08-20 Nobex Corporation 6-methoxy-2-naphthylacetic acid prodrugs
US6552078B2 (en) 1999-10-27 2003-04-22 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs
AP2002002582A0 (en) 1999-12-23 2002-09-30 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
SE0000773D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0000774D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
WO2002060378A2 (en) 2000-12-21 2002-08-08 Nitromed, Inc. Substituted aryl compounds as cyclooxygenase-2 selective inhibitors, compositions and methods of use
EP1219306A1 (de) 2000-12-29 2002-07-03 Nicox S.A. Zyklodextrin und NO-abgebende Arzneimittlen enthaltende Zusammensetzungen
GB0111872D0 (en) 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
ITMI20011744A1 (it) * 2001-08-09 2003-02-09 Nicox Sa Farmaci per le vasculopatie
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
JP4771659B2 (ja) * 2001-11-27 2011-09-14 ニコックス・ソシエテ・アノニム 新規な方法
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
EP1476168A2 (de) 2002-02-04 2004-11-17 ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda. Verwendung von co-freisetzenden molekülen zur behandlung von entzündlichen krankheiten
AU2003248642A1 (en) 2002-06-11 2003-12-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
ITMI20021391A1 (it) 2002-06-25 2003-12-29 Nicox Sa Nitroderivati di inibitori della cicloossigenasi-2
JP2005535642A (ja) * 2002-06-28 2005-11-24 ニトロメッド インコーポレーティッド オキシムおよび／またはヒドラゾンを含有するニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
CA2491127A1 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
AU2003261281A1 (en) 2002-07-29 2004-02-16 Nicox S.A. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
CA2498943A1 (en) * 2002-09-20 2004-04-01 Nicox S.A. Manufacturing process for no-donating compounds such as no-donating diclofenac
SE0203093D0 (en) * 2002-10-18 2002-10-18 Astrazeneca Uk Ltd New use
AU2003278565A1 (en) * 2002-10-25 2004-05-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
ITMI20022658A1 (it) 2002-12-17 2004-06-18 Nicox Sa Farmaci per il dolore cronico.
US20070207217A1 (en) * 2003-02-03 2007-09-06 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO
JP2006517953A (ja) * 2003-02-19 2006-08-03 アルタナ　ファルマ　アクチエンゲゼルシャフト フェニルアミノチオフェン酢酸誘導体の硝酸塩エステル
SE0301880D0 (sv) * 2003-06-25 2003-06-25 Astrazeneca Uk Ltd New drug delivery composition
WO2006041855A2 (en) 2004-10-04 2006-04-20 Nitromed, Inc. Compositions and methods using apocynin compounds and nitric oxide donors
DE102005057555B3 (de) 2005-11-21 2007-05-16 Meissner Gmbh & Co Kg Josef Verfahren zur Herstellung von Salpetersäureestern einwertiger Alkohole
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
US8802726B2 (en) * 2006-02-03 2014-08-12 Nicox S.A. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
JP2007275193A (ja) * 2006-04-04 2007-10-25 Fujifilm Corp 光プローブおよび光断層画像化装置
RU2009147930A (ru) 2007-06-28 2011-08-10 Никокс С.А. (Fr) Способ получения мононитрата 1,4-бутандиола
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
ITRM20080325A1 (it) * 2008-06-20 2009-12-21 Nicox Sa Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
US20100286271A1 (en) * 2009-05-08 2010-11-11 Perricone Nicholas V Nitro-alkyl Compound Compositions
US20100286257A1 (en) * 2009-05-08 2010-11-11 Perricone Nicholas V Methods Of Use Of Nitroalkane Compositions In Dermatologic Applications To Prevent or Treat Skin Aging
US20100286272A1 (en) * 2009-05-08 2010-11-11 Perricone Nicholas V Methods Of Use Of Nitroalkene Compositions In Dermatologic Applications
WO2011012400A2 (en) 2009-07-28 2011-02-03 Nicox S.A. Nitric oxide releasing naproxen
WO2011041870A1 (en) * 2009-10-07 2011-04-14 Nitrogenix Inc. Non-steroidal anti-inflammatory drugs coadministered with nitric oxide amino acid ester compounds as prophylaxis in hypertensive patients
AU2011243947A1 (en) 2010-04-23 2012-12-06 Piramal Enterprises Limited Nitric oxide releasing prodrugs of therapeutic agents
IT1402177B1 (it) 2010-09-07 2013-08-28 Rottapharm Spa Nitroesteri di 1,5-diaril-2-alchil-pirroli-3-sostituiti, inibitori selettivi di cox-2 e donatori di ossido nitroso
CN102442908A (zh) * 2010-10-14 2012-05-09 天津药物研究院 制备萘普西诺的中间体及方法
TWI417276B (zh) 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
EP2699242B1 (de) 2011-04-19 2017-11-01 Alfama, Inc. Kohlenmonoxidfreisetzende moleküle und ihre verwendungen
WO2012152438A1 (en) 2011-05-11 2012-11-15 Nicox S.A. Process for the preparation of nitrate acid ester of organic compounds
JP6134710B2 (ja) 2011-07-21 2017-05-24 アルファーマ インコーポレイテッドＡｌｆａｍａ，Ｉｎｃ． 一酸化ルテニウム放出分子およびその使用
CN103058861B (zh) * 2013-01-08 2015-03-18 安徽赛诺医药化工有限公司 一种萘普西诺中间体的合成新方法
US9844599B2 (en) 2013-01-21 2017-12-19 Apparao Satyam Nitric oxide releasing produgs of therapeutic agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB971700A (en) * 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents
DE1793825C3 (de) * 1967-01-13 1980-11-27 Syntex Corp., Panama 2-(6'-substituierte-2'-Naphthyl)propionsäurederivate und deren Herstellung
US3758544A (en) * 1968-07-30 1973-09-11 Syntex Corp 2-hydroxy-2(6{40 -methoxynaphth-2{40 - yl) propionitrile and 5{40 -halo derivatives thereof
US4161538A (en) * 1977-04-05 1979-07-17 Sankyo Company Limited Substituted phenylacetic acid derivatives and process for the preparation thereof
NL8802276A (nl) * 1988-09-15 1990-04-02 Cedona Pharm Bv Geneesmiddel met relaxerende werking, dat als aktieve stof een nitraatester bevat.
IT1256345B (it) * 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione

Also Published As

Publication number Publication date
JPH09503214A (ja) 1997-03-31
AU678063B2 (en) 1997-05-15
HU9600874D0 (en) 1996-06-28
CA2173582A1 (en) 1995-04-13
EP0722434B1 (de) 1998-07-29
AU7809294A (en) 1995-05-01
WO1995009831A1 (en) 1995-04-13
DE69412109T2 (de) 1999-01-21
EP0722434A1 (de) 1996-07-24
HU218923B (hu) 2000-12-28
JP3775796B2 (ja) 2006-05-17
CA2173582C (en) 2006-11-28
DK0722434T3 (da) 1998-11-16
SI0722434T1 (en) 1998-12-31
KR100343243B1 (ko) 2003-02-14
RU2136653C1 (ru) 1999-09-10
HUT74446A (en) 1996-12-30
KR960704834A (ko) 1996-10-09
DE69412109D1 (de) 1998-09-03
US5780495A (en) 1998-07-14
BR9407749A (pt) 1997-02-12
US5700947A (en) 1997-12-23
ES2120070T3 (es) 1998-10-16

Similar Documents

Publication Publication Date Title
ATE168986T1 (de) Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung
LV12794B (en) Pharmaceutically active bicyclic-heterocyclic amines
DE69939532D1 (de) Gamma-aminobuttersäurederivate enthaltende, feste arzneimittel und verfahren zu ihrer herstellung
RU94040170A (ru) Изохинолины
ATE208772T1 (de) Pharmacologisch wirksame pyridinderivate und verfahren zu deren herstellung
ATE175201T1 (de) Mono-n-substituierte 1,4,7,10- tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
HK1006841A1 (en) Substituted heterocyclic carboxylic acid amides their preparation and their use as medicaments
IT1256345B (it) Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
ES2101421T3 (es) Amidas de acidos carboxilicos heterociclicos sustituidos, su preparacion y su utilizacion como medicamentos.
RU2005108492A (ru) Фенилсодержащие n-ацильные производные аминов, способ их получения, фармацевтическая композиция и их применение в качестве противовоспалительных и анальгетических средств
ATE140918T1 (de) Derivate in der vitamin d-reihe mit modifikationen in der 20 position, verfahren zu ihrer herstellung, zwischenprodukte für dieses verfahren, diese derivate enthaltende pharmazeutische präparate sowie deren verwendung zur herstellung von arzneimitteln
DE59006893D1 (de) Pyrimidin-4,6-dicarbonsäurediamide, Verfahren zu deren Herstellung sowie Verwendung derselben sowie Arzneimittel auf Basis dieser Verbindungen.
DE69939721D1 (de) Fulvinsäure und deren Verwendung in der Behandlung von Candida Infektionen
DE59107784D1 (de) Codeinsalz einer substituierten Carbonsäure, Verfahren zu seiner Herstellung, seine Verwendung und pharmazeutische Präparate
PT82987A (de) Neue carbonsaeurederivate verfahren zu ihrer herstellung ihre verwendung sowie arzneimittel die diese verbindungen enthalten
DE68926115D1 (de) Verfahren zur behandlung von akne
ATE31300T1 (de) Imidazol-2-yl-mercaptoalkansaeuren, verfahren zu deren herstellung und pharmazeutische formulierungen welche diese enthalten.
ATE153342T1 (de) Adenosinderivate, verfahren zu deren herstellung und pharmazeutische mittel
BRPI0407578A (pt) derivados da purina, processo de preparação, sua aplicação a tìtulo de medicamentos, composições farmacêuticas e utilização
CA2170485A1 (en) Compositions Containing an Amino Acid Salt of Propionic Acid Non-Steroidal Anti-Inflammatory Agents and Caffeine
ATE462706T1 (de) 7h-pyrroloä2,3-düpyrimidinderivate sowie deren therapeutisch annehmbare salze, pharmazeutische zubereitungen, die diese enthalten, und verfahren zur herstellung des wirkstoffs
DE69332947T2 (de) Arzneimittel enthaltend 2-(3-benzoylphenyl)-propionsäure zur verwendung als analgetikum
DE58907678D1 (de) 6-Fluor-3,5-dihydroxycarbonsäuren und deren Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, pharmazeutische Präparate und Zwischenprodukte.
KR920012079A (ko) 15-니트로-2β, 3β-디히드로-및 15-니트로 2β, 3β, 6, 7-테트라히드로태버소닌 유도체, 이들을 포함하는 제약조성물 및 이들의 제조방법
NZ223334A (en) Imidazo and triazolo-thiadiazine derivatives and pharmaceutical compositions

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification