IT1402177B1 - Nitroesteri di 1,5-diaril-2-alchil-pirroli-3-sostituiti, inibitori selettivi di cox-2 e donatori di ossido nitroso - Google Patents

Nitroesteri di 1,5-diaril-2-alchil-pirroli-3-sostituiti, inibitori selettivi di cox-2 e donatori di ossido nitroso

Info

Publication number
IT1402177B1
IT1402177B1 ITTO2010A000739A ITTO20100739A IT1402177B1 IT 1402177 B1 IT1402177 B1 IT 1402177B1 IT TO2010A000739 A ITTO2010A000739 A IT TO2010A000739A IT TO20100739 A ITTO20100739 A IT TO20100739A IT 1402177 B1 IT1402177 B1 IT 1402177B1
Authority
IT
Italy
Prior art keywords
alchil
nitrosus
nitroesters
pyrrol
diaryl
Prior art date
Application number
ITTO2010A000739A
Other languages
English (en)
Inventor
Lucio Claudio Rovati
Antonio Giordani
Mariangela Biava
Vincenzo Calderone
Original Assignee
Rottapharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rottapharm Spa filed Critical Rottapharm Spa
Priority to ITTO2010A000739A priority Critical patent/IT1402177B1/it
Priority to CA2808724A priority patent/CA2808724A1/en
Priority to JP2013527725A priority patent/JP2013536876A/ja
Priority to PCT/IB2011/053914 priority patent/WO2012032479A1/en
Priority to EP11768129.6A priority patent/EP2614050B1/en
Priority to US13/820,533 priority patent/US9162979B2/en
Priority to ES11768129.6T priority patent/ES2568253T3/es
Publication of ITTO20100739A1 publication Critical patent/ITTO20100739A1/it
Application granted granted Critical
Publication of IT1402177B1 publication Critical patent/IT1402177B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
ITTO2010A000739A 2010-09-07 2010-09-07 Nitroesteri di 1,5-diaril-2-alchil-pirroli-3-sostituiti, inibitori selettivi di cox-2 e donatori di ossido nitroso IT1402177B1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ITTO2010A000739A IT1402177B1 (it) 2010-09-07 2010-09-07 Nitroesteri di 1,5-diaril-2-alchil-pirroli-3-sostituiti, inibitori selettivi di cox-2 e donatori di ossido nitroso
CA2808724A CA2808724A1 (en) 2010-09-07 2011-09-07 1,5-diaryl-2-alkylpyrrole-3-substituted nitro esters, selective cox-2 inhibitors and nitric oxide donors
JP2013527725A JP2013536876A (ja) 2010-09-07 2011-09-07 選択性ｃｏｘ−２阻害剤および一酸化窒素ドナーである１，５−ジアリール−２−アルキルピロール−３−置換ニトロエステル
PCT/IB2011/053914 WO2012032479A1 (en) 2010-09-07 2011-09-07 L,5-diaryl-2-alkvlpvrrole-3-substituted nitro esters, selective cox-2 inhibitors and nitric oxide donors
EP11768129.6A EP2614050B1 (en) 2010-09-07 2011-09-07 1,5-diaryl-2-alkylpyrrole-3-substituted nitro esters, selective cox-2 inhibitors and nitric oxide donors
US13/820,533 US9162979B2 (en) 2010-09-07 2011-09-07 1,5-Diary1-2-alkylpyrrole-3-substituted nitro esters, selective COX-2 inhibitors and nitric oxide donors
ES11768129.6T ES2568253T3 (es) 2010-09-07 2011-09-07 Nitroésteres de 1,5-diaril-2-alquilpirrol-3-sustituidos, inhibidores de COX-2 selectivos y donadores de óxido nítrico

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITTO2010A000739A IT1402177B1 (it) 2010-09-07 2010-09-07 Nitroesteri di 1,5-diaril-2-alchil-pirroli-3-sostituiti, inibitori selettivi di cox-2 e donatori di ossido nitroso

Publications (2)

Publication Number Publication Date
ITTO20100739A1 ITTO20100739A1 (it) 2012-03-08
IT1402177B1 true IT1402177B1 (it) 2013-08-28

Family

ID=43739132

Family Applications (1)

Application Number Title Priority Date Filing Date
ITTO2010A000739A IT1402177B1 (it) 2010-09-07 2010-09-07 Nitroesteri di 1,5-diaril-2-alchil-pirroli-3-sostituiti, inibitori selettivi di cox-2 e donatori di ossido nitroso

Country Status (7)

Country Link
US (1) US9162979B2 (it)
EP (1) EP2614050B1 (it)
JP (1) JP2013536876A (it)
CA (1) CA2808724A1 (it)
ES (1) ES2568253T3 (it)
IT (1) IT1402177B1 (it)
WO (1) WO2012032479A1 (it)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
WO1995009831A1 (en) 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
MXPA02006312A (es) * 1999-12-23 2004-06-21 Nitromed Inc Inhibidores de ciclooxigenasa-2 nitrosilatados y nitrosados, composiciones y metodos para utilizarse.
CN1914169A (zh) 2004-01-27 2007-02-14 默克弗罗斯特公司 作为环氧合酶－2抑制剂的二芳基－2－(5h)－呋喃酮的氧化氮释放前药
WO2006099416A1 (en) * 2005-03-11 2006-09-21 Nitromed, Inc. 2-methyl indole cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2008014821A1 (en) * 2006-08-03 2008-02-07 Rottapharm S.P.A. 3-substituted-1,5-diarly-2-alkyl-pyrroles highly selective and orally effective cox-2 inhibitors
AU2008244441A1 (en) 2007-04-25 2008-11-06 Nicox S.A. Use of 4-(Nitrooxy)-butyl-(S)-2-(6-methoxy-2-naphtyl)-propanoate for treating pain and inflammation

Also Published As

Publication number Publication date
ES2568253T3 (es) 2016-04-28
US20130165494A1 (en) 2013-06-27
EP2614050A1 (en) 2013-07-17
JP2013536876A (ja) 2013-09-26
WO2012032479A1 (en) 2012-03-15
EP2614050B1 (en) 2016-01-20
US9162979B2 (en) 2015-10-20
CA2808724A1 (en) 2012-03-15
ITTO20100739A1 (it) 2012-03-08
WO2012032479A8 (en) 2012-07-12

Similar Documents

Publication Publication Date Title
DK3329919T3 (da) Acc-inhibitorer og anvendelser deraf
SMT201500271B (it) Inibitori di neprilisina
BR112013010725A2 (pt) método, e, composição
BR112012017441A2 (pt) compostos e métodos
ZA201206223B (en) Certain kynurenine-3-monooxygenase inhibitors,pharmaceutical compositions, and methods of use thereof
EP2619184A4 (en) DEUBIQUITINASE INHIBITORS AND METHOD FOR THEIR USE
BR112013013896A2 (pt) sistemas de acesso e armazenamento e respectivo método de operação
BR112014013594A8 (pt) composição e substrato revestido
DK3178818T3 (da) Pyrazolylquinoxalinkinasehæmmere
CO6821886A2 (es) Inhibidores potentes y selectivos de nav1.3 y nav1.7
EP2751086A4 (en) KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHOD OF USE THEREOF
BR112013023776A2 (pt) composição e abertura vedada com selante
BR112012031855A2 (pt) composição e artigo
BR112012027159A2 (pt) estrutura e método
BR112014003774A2 (pt) inibidores de dyrk1 e usos dos mesmos
BR112012027165A2 (pt) composição e artigo
HK1198619A1 (en) Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof -3-
BR112013011448A2 (pt) composto, composição farnmacêutica, e, uso do composto
BR112014014213A2 (pt) agentes hemostáticos e método de utilização
EP2750677A4 (en) KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHOD OF USE THEREOF
ITTO20110641A1 (it) Composizioni farmaceutiche e metodi di trattamento
BR112013009579A2 (pt) método e comprimido
IT1403845B1 (it) Sonda di tastaggio e relativo metodo di controllo
EP2688901A4 (en) INHIBITORS OF 17SS-HSD1, 17SS-HSD3 AND 17SS-HSD10
BR112012021749A2 (pt) processos e compostos