IT1308633B1 - Nitrossiderivati. - Google Patents

Nitrossiderivati.

Info

Publication number
IT1308633B1
IT1308633B1 IT1999MI000413A ITMI990413A IT1308633B1 IT 1308633 B1 IT1308633 B1 IT 1308633B1 IT 1999MI000413 A IT1999MI000413 A IT 1999MI000413A IT MI990413 A ITMI990413 A IT MI990413A IT 1308633 B1 IT1308633 B1 IT 1308633B1
Authority
IT
Italy
Prior art keywords
formula
nitrossiderivati
coxu
nr1c
salified
Prior art date
Application number
IT1999MI000413A
Other languages
English (en)
Inventor
Francesca Benedini
Soldato Piero Del
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT1999MI000413A priority Critical patent/IT1308633B1/it
Application filed by Nicox Sa filed Critical Nicox Sa
Priority to AU31588/00A priority patent/AU770642B2/en
Priority to DE60042013T priority patent/DE60042013D1/de
Priority to PCT/EP2000/001454 priority patent/WO2000051988A1/en
Priority to KR1020017011034A priority patent/KR100614600B1/ko
Priority to CA002361164A priority patent/CA2361164A1/en
Priority to EP00909234A priority patent/EP1154999B1/en
Priority to JP2000602215A priority patent/JP2002538142A/ja
Priority to IL14468600A priority patent/IL144686A0/xx
Priority to CNB008044600A priority patent/CN1225459C/zh
Priority to RU2001124271/04A priority patent/RU2240997C2/ru
Priority to AT00909234T priority patent/ATE428696T1/de
Priority to BR0008582-0A priority patent/BR0008582A/pt
Priority to US09/926,095 priority patent/US6613784B1/en
Priority to ES00909234T priority patent/ES2324329T3/es
Priority to HU0200386A priority patent/HUP0200386A3/hu
Publication of ITMI990413A1 publication Critical patent/ITMI990413A1/it
Priority to ZA200106650A priority patent/ZA200106650B/en
Application granted granted Critical
Publication of IT1308633B1 publication Critical patent/IT1308633B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IT1999MI000413A 1999-03-02 1999-03-02 Nitrossiderivati. IT1308633B1 (it)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IT1999MI000413A IT1308633B1 (it) 1999-03-02 1999-03-02 Nitrossiderivati.
RU2001124271/04A RU2240997C2 (ru) 1999-03-02 2000-02-23 Соли нитроксипроизводных и фармацевтические составы на их основе
PCT/EP2000/001454 WO2000051988A1 (en) 1999-03-02 2000-02-23 Nitroxyderivatives having antiinflammatory, analgesic and antithrombotic activity
KR1020017011034A KR100614600B1 (ko) 1999-03-02 2000-02-23 항염증성, 진통성 및 항혈전 활성을 갖는 니트록시 유도체
CA002361164A CA2361164A1 (en) 1999-03-02 2000-02-23 Nitroxyderivatives having antiinflammatory, analgesic and antithrombotic activity
EP00909234A EP1154999B1 (en) 1999-03-02 2000-02-23 Nitroxyderivatives having antiinflammatory, analgesic and antithrombotic activity
JP2000602215A JP2002538142A (ja) 1999-03-02 2000-02-23 抗炎症、鎮痛性および抗血栓症活性を有するニトロキシ誘導体
IL14468600A IL144686A0 (en) 1999-03-02 2000-02-23 Nitroxy derivatives having antinflammatory, analgesic and antithrombotic activity
AU31588/00A AU770642B2 (en) 1999-03-02 2000-02-23 Nitroxyderivatives having antiinflammatory, analgesic and antithrombotic activity
DE60042013T DE60042013D1 (de) 1999-03-02 2000-02-23 Nitroxyderivate mit entzündungshemmender, analgetischer und antithrombotischer wirkung
AT00909234T ATE428696T1 (de) 1999-03-02 2000-02-23 Nitroxyderivate mit entzündungshemmender, analgetischer und antithrombotischer wirkung
BR0008582-0A BR0008582A (pt) 1999-03-02 2000-02-23 Sais orgânicos e inorgânicos, uso dos mesmos, formulações farmacêuticas para uso oral e parental, e, compostos
US09/926,095 US6613784B1 (en) 1999-03-02 2000-02-23 Nitroxyderivatives having antinflammatory, analgesic and antithrombotic activity
ES00909234T ES2324329T3 (es) 1999-03-02 2000-02-23 Nitroderivados que tienen una actividad anti-inflamatoria, analgesica y anti-trombotica.
HU0200386A HUP0200386A3 (en) 1999-03-02 2000-02-23 Nitroxyderivatives having antiinflammatory, analgesic and antithrombotic activity and pharmaceutical compositions containing them and their use
CNB008044600A CN1225459C (zh) 1999-03-02 2000-02-23 具有抗炎、止痛和抗血栓形成活性的硝基氧基衍生物
ZA200106650A ZA200106650B (en) 1999-03-02 2001-08-13 Nitroxyderivatives having antiinflammatory, analgesic and antithrombotic activity.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI000413A IT1308633B1 (it) 1999-03-02 1999-03-02 Nitrossiderivati.

Publications (2)

Publication Number Publication Date
ITMI990413A1 ITMI990413A1 (it) 2000-09-02
IT1308633B1 true IT1308633B1 (it) 2002-01-09

Family

ID=11382095

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1999MI000413A IT1308633B1 (it) 1999-03-02 1999-03-02 Nitrossiderivati.

Country Status (17)

Country Link
US (1) US6613784B1 (it)
EP (1) EP1154999B1 (it)
JP (1) JP2002538142A (it)
KR (1) KR100614600B1 (it)
CN (1) CN1225459C (it)
AT (1) ATE428696T1 (it)
AU (1) AU770642B2 (it)
BR (1) BR0008582A (it)
CA (1) CA2361164A1 (it)
DE (1) DE60042013D1 (it)
ES (1) ES2324329T3 (it)
HU (1) HUP0200386A3 (it)
IL (1) IL144686A0 (it)
IT (1) IT1308633B1 (it)
RU (1) RU2240997C2 (it)
WO (1) WO2000051988A1 (it)
ZA (1) ZA200106650B (it)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1288123B1 (it) 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
IT1303671B1 (it) * 1998-07-28 2001-02-23 Nicox Sa Sali dell'acido nitrico con farmaci attivi nel trattamento dipatologie del sistema respiratorio
WO2000025776A1 (en) 1998-10-30 2000-05-11 Nitromed, Inc. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
JP2003523958A (ja) 1999-12-23 2003-08-12 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−２の阻害剤、組成物ならびに使用法
US8519005B2 (en) 2000-07-27 2013-08-27 Thomas N. Thomas Compositions and methods to prevent toxicity of antiinflammatory agents and enhance their efficacy
IT1318674B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Faramaci per l'incontinenza.
IT1318673B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Farmaci per le disfunzioni sessuali.
IT1319202B1 (it) * 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
IT1319201B1 (it) * 2000-10-12 2003-09-26 Nicox Sa Farmaci per il diabete.
US6706724B2 (en) 2000-12-21 2004-03-16 Nitromed, Inc. Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
EP1406608B1 (en) 2001-05-02 2009-07-29 Nitromed, Inc. Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use
ITMI20011240A1 (it) * 2001-06-13 2002-12-13 Nicox Sa Farmaci per le vasculopatie
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
ITMI20011744A1 (it) * 2001-08-09 2003-02-09 Nicox Sa Farmaci per le vasculopatie
CA2487414A1 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
ITMI20021391A1 (it) 2002-06-25 2003-12-29 Nicox Sa Nitroderivati di inibitori della cicloossigenasi-2
ITMI20021399A1 (it) * 2002-06-25 2003-12-29 Nicox Sa Inibitori della cicloossigenasi 2
WO2004002420A2 (en) 2002-06-28 2004-01-08 Nitromed, Inc. Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use
EP1539729A4 (en) * 2002-07-03 2008-02-20 Nitromed Inc NITROSED NON-TESTED OXIDE COMPOUNDS, COMPOSITIONS, AND APPLICATION METHODS
JP2005538110A (ja) 2002-07-29 2005-12-15 ニトロメッド インコーポレーティッド シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
ATE515703T1 (de) 2005-05-23 2011-07-15 Phadia Ab Verfahren und vorrichtungen für lateralfluss- tests mit zwei schritten
EP1951653B1 (en) 2005-11-23 2010-10-20 NicOx S.A. Salicylic acid derivatives
JP2007275193A (ja) * 2006-04-04 2007-10-25 Fujifilm Corp 光プローブおよび光断層画像化装置
WO2011012400A2 (en) 2009-07-28 2011-02-03 Nicox S.A. Nitric oxide releasing naproxen
MX2012012225A (es) 2010-04-23 2013-08-27 Piramal Entpr Ltd Profármacos de agentes tearapéuticos de liberación de óxido nítrico.
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
CN105985283B (zh) * 2015-01-30 2018-08-24 安徽省新星药物开发有限责任公司 一种布洛芬吡甲酯的合成方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2396145A (en) 1940-12-14 1946-03-05 Pharmscia Ab Heterocyclic sulphonamido azo compounds
US2998450A (en) 1958-05-19 1961-08-29 Warner Lambert Pharmaceutical Process of preparing nu-acetyl-p-amino phenol
GB971700A (en) 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents
AT290523B (de) 1962-01-05 1971-06-11 Merck & Co Inc Verfahren zur Herstellung neuer α-(3-Indolyl)-carbonsäuren
GB1091403A (en) 1964-01-24 1967-11-15 Boots Pure Drug Co Ltd Therapeutically active phenylalkane derivatives
US3558690A (en) 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation
US3337570A (en) 1965-10-23 1967-08-22 Schering Corp Substituted nicotinic acids and method for the manufacture thereof
US3904682A (en) 1967-01-13 1975-09-09 Syntex Corp 2-(6{40 -Methoxy-2{40 -naphthyl)acetic acid
FR1546478A (fr) 1967-01-27 1968-11-22 Rhone Poulenc Sa Nouveaux dérivés de l'acide benzoyl-3 phénylacétique et leur préparation
SE338993B (it) 1967-07-26 1971-09-27 Mcneilab Inc
US3652589A (en) 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3600437A (en) 1969-05-28 1971-08-17 Lilly Co Eli Substituted phenylalkanoic acids and derivatives thereof
US3591584A (en) 1968-08-27 1971-07-06 Pfizer Benzothiazine dioxides
US3689653A (en) 1970-07-06 1972-09-05 Schering Corp Compositions and methods for treating inflammation using substituted nicotinic acids
US3784701A (en) 1970-09-21 1974-01-08 American Cyanamid Co Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain
US3843681A (en) 1971-06-01 1974-10-22 American Home Prod 1-carboxamido pyrano(thiopyrano)(3,4-6)indole derivatives
GB1403487A (en) 1972-07-21 1975-08-28 Yoshitomi Pharmaceutical Heterocyclic substituted alkanoic acids and derivatives
US3896145A (en) 1972-07-24 1975-07-22 Hoffmann La Roche Carbazoles
US4035376A (en) 1972-10-24 1977-07-12 Janssen Pharmaceutica N.V. Aroyl-substituted phenylacetic acid derivatives
US3997669A (en) 1972-12-26 1976-12-14 Ciba-Geigy Corporation Tertiary aminoacids
US4061779A (en) 1973-09-11 1977-12-06 Beecham Group Limited Naphthalene derivatives having anti-inflammatory activity
IL47877A (en) 1974-08-26 1978-10-31 Sparamedica Ag Thienothiazine carboxamide derivatives,their manufacture and pharmaceutical compositions containing them
US4089969A (en) 1976-07-14 1978-05-16 Syntex (U.S.A.) Inc. 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4161538A (en) 1977-04-05 1979-07-17 Sankyo Company Limited Substituted phenylacetic acid derivatives and process for the preparation thereof
JPS5432460A (en) 1977-08-16 1979-03-09 Sankyo Co Ltd Cycloalkylidenemethylphenylacetic acid derivative and their preparation
AU518216B2 (en) 1977-09-06 1981-09-17 Hafslund Nycomed Pharma Aktiengesellschaft Thienothiazine derivatives
DE2756113A1 (de) 1977-12-16 1979-06-21 Thomae Gmbh Dr K Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
JPS54122284A (en) 1978-02-17 1979-09-21 Dainippon Pharmaceut Co Ltd Dibenzb,foxepin derivative
JPS5553282A (en) 1978-10-17 1980-04-18 Nippon Chemiphar Co Ltd Dibenzothiepin derivative and its preparation
CA1128526A (en) 1979-10-05 1982-07-27 Cdc Life Sciences Inc. 3,4-diarylisoxazol-5-acetic acids
SE8002321L (sv) 1980-03-26 1981-09-27 Pharmacia Ab Sett och mellanprodukter for framstellning av bensoesyraderivat
DE3049405A1 (de) 1980-12-23 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue derivate von antiphlogistisch wirksamen carbonsaeuren, ihre herstellung und medizinische anwendung
US4551452A (en) 1983-12-21 1985-11-05 Pfizer Inc. Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
US4556672A (en) 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
NZ219403A (en) 1986-03-11 1989-11-28 American Home Prod 1,3,4,9-tetrahydropyrano(3,4-b indole-1-acetic acid derivatives and pharmaceutical compositions
IT1243367B (it) 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
IT1256345B (it) 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
GB2283238B (en) 1993-10-06 1997-11-26 Hct Health Care Trading Ltd Nitric esters of derivatives of propionic acid and process for their preparation
US5700947A (en) * 1993-10-06 1997-12-23 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
WO1995030641A1 (en) * 1994-05-10 1995-11-16 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria

Also Published As

Publication number Publication date
AU3158800A (en) 2000-09-21
HUP0200386A3 (en) 2002-11-28
AU770642B2 (en) 2004-02-26
US6613784B1 (en) 2003-09-02
ZA200106650B (en) 2002-11-13
EP1154999A1 (en) 2001-11-21
EP1154999B1 (en) 2009-04-15
ATE428696T1 (de) 2009-05-15
HUP0200386A2 (en) 2002-06-29
ITMI990413A1 (it) 2000-09-02
DE60042013D1 (de) 2009-05-28
KR100614600B1 (ko) 2006-08-25
BR0008582A (pt) 2002-02-13
JP2002538142A (ja) 2002-11-12
KR20010103782A (ko) 2001-11-23
CN1225459C (zh) 2005-11-02
RU2240997C2 (ru) 2004-11-27
CN1342147A (zh) 2002-03-27
WO2000051988A1 (en) 2000-09-08
CA2361164A1 (en) 2000-09-08
IL144686A0 (en) 2002-06-30
ES2324329T3 (es) 2009-08-05

Similar Documents

Publication Publication Date Title
IT1308633B1 (it) Nitrossiderivati.
AP2003002841A0 (en) Quinazolines as MMP-13 inhibitors
ES2187473T3 (es) Triarylimidazoles.
ES8603408A1 (es) Un procedimiento para la preparacion de un compuesto de 2-oxindol-1-carboxamida
ATE60761T1 (de) Chinazolinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DK0412404T3 (da) Thiazolderivater, fremgangsmåder til fremstilling deraf og farmaceutiske præparater omfattende derivaterne
DK0790987T3 (da) Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorer
NO175256C (no) Analogifremgangsmåte til fremstilling av terapeutisk aktive 4-oksokinolin-3-karboksylsyrederivater
ES8802517A1 (es) Un procedimiento para preparar fenoxialquil (substituido con heterocido)-isoxazoles y furanos.
FI943142A0 (fi) Amidi- ja ureajohdannaiset, joilla on veren korkeita kolesteroliarvoja vastustava vaikutus, niiden valmistus ja terapeuttiset käytöt
DK0452873T3 (da) 1,8-naphthyridin-2-on-derivater
GB9408185D0 (en) New benzamide derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
NO180196C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive amino- og nitroholdige, tricykliske forbindelser
NO944371L (no) Kjemisk forbindelse med blodplateaggregeringsinhibiotoraktivitet
ES2021182A6 (es) Procedimiento para preparar derivados de capsaicina.
DE3684457D1 (de) Organische verbindungen und ihre pharmazeutische verwendung.
ATE137759T1 (de) S'-adenosyl-methionin-decarboxylase-inhibitoren
DE68927554D1 (de) Cephalosporinverbindungen und Verfahren zu ihrer Herstellung
LV10504A (lv) Mikrobiologiskais panemiens slapekli saturoso heterociklisko karbonskabju hidroksilesanai
DK599885A (da) Trienamidforbindelser og farmaceutisk acceptable salte heraf med antiinflammatorisk og analgetisk virkning samt farmaceutisk komposition indeholdende disse
DE3460467D1 (en) Hydroquinone derivatives and production thereof
PT1040096E (pt) Agentes neuroprotectores
GR3002958T3 (en) Thiophene derivatives
DK0998464T3 (da) Polyhydroxyalkylpyrazinderivater, deres fremstilling samt medikamenter indeholdende disse forbindelser
TH13254A (th) ฟธาแลซีนชนิดใหม่ที่ประกอบด้วยอีเธอร์หรือไธโออีเธอร์ที่ตำแหน่ง 1-และกรรมวิธีการเตรียม