IT1243367B - Derivati acidi benzoici sostituiti ad attivita' cardiovascolare - Google Patents
Derivati acidi benzoici sostituiti ad attivita' cardiovascolareInfo
- Publication number
- IT1243367B IT1243367B IT02107590A IT2107590A IT1243367B IT 1243367 B IT1243367 B IT 1243367B IT 02107590 A IT02107590 A IT 02107590A IT 2107590 A IT2107590 A IT 2107590A IT 1243367 B IT1243367 B IT 1243367B
- Authority
- IT
- Italy
- Prior art keywords
- benzoic acid
- acid derivatives
- derivatives substituted
- cardiovascular activity
- cardiovascular
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/08—Esters of nitric acid having nitrate groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/62—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT02107590A IT1243367B (it) | 1990-07-26 | 1990-07-26 | Derivati acidi benzoici sostituiti ad attivita' cardiovascolare |
CA002087442A CA2087442A1 (en) | 1990-07-26 | 1991-07-15 | Benzoic acid substituted derivatives having cardiovascular activity |
JP91511861A JPH05508841A (ja) | 1990-07-26 | 1991-07-15 | 心臓血管活性を有する安息香酸置換誘導体 |
AU80974/91A AU8097491A (en) | 1990-07-26 | 1991-07-15 | Benzoic acid substituted derivatives having cardiovascular activity |
PCT/EP1991/001326 WO1992001668A1 (en) | 1990-07-26 | 1991-07-15 | Benzoic acid substituted derivatives having cardiovascular activity |
DE199191912464T DE540544T1 (de) | 1990-07-26 | 1991-07-15 | Benzosaeure substituierte derivate mit kardiovasculaerer wirkung. |
US07/966,078 US5366992A (en) | 1990-07-26 | 1991-07-15 | Benzoic acid substituted derivatives having cardiovascular activity |
HU9300095A HU213405B (en) | 1990-07-26 | 1991-07-15 | Process for producing new benzoic acid derivatives having cardiovascular activity and pharmaceutical compns. comprising the said compds. |
DK91912464.4T DK0540544T3 (da) | 1990-07-26 | 1991-07-15 | Benzoesyresubstituerede derivater mad cardiovaskulær virkning |
AT91912464T ATE118478T1 (de) | 1990-07-26 | 1991-07-15 | Benzosäure substituierte derivate mit kardiovasculärer wirkung. |
DE69107459T DE69107459T2 (de) | 1990-07-26 | 1991-07-15 | Benzosäure substituierte derivate mit kardiovasculärer wirkung. |
EP91912464A EP0540544B1 (en) | 1990-07-26 | 1991-07-15 | Benzoic acid substituted derivatives having cardiovascular activity |
ES91912464T ES2056783T3 (es) | 1990-07-26 | 1991-07-15 | Derivados sustituidos del acido benzoico con actividad cardiovascular. |
NO93930215A NO930215L (no) | 1990-07-26 | 1993-01-22 | Benzosyresubstituerte derivater med kardiovaskulaer aktivitet |
GR930300079T GR930300079T1 (en) | 1990-07-26 | 1993-10-31 | Benzoic acid substituted derivatives having cardiovascular activity. |
US08/254,779 US5589490A (en) | 1990-07-26 | 1994-06-06 | Benzoic acid substituted derivatives having cardiovascular activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT02107590A IT1243367B (it) | 1990-07-26 | 1990-07-26 | Derivati acidi benzoici sostituiti ad attivita' cardiovascolare |
Publications (3)
Publication Number | Publication Date |
---|---|
IT9021075A0 IT9021075A0 (it) | 1990-07-26 |
IT9021075A1 IT9021075A1 (it) | 1992-01-26 |
IT1243367B true IT1243367B (it) | 1994-06-10 |
Family
ID=11176367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT02107590A IT1243367B (it) | 1990-07-26 | 1990-07-26 | Derivati acidi benzoici sostituiti ad attivita' cardiovascolare |
Country Status (14)
Country | Link |
---|---|
US (2) | US5366992A (it) |
EP (1) | EP0540544B1 (it) |
JP (1) | JPH05508841A (it) |
AT (1) | ATE118478T1 (it) |
AU (1) | AU8097491A (it) |
CA (1) | CA2087442A1 (it) |
DE (2) | DE540544T1 (it) |
DK (1) | DK0540544T3 (it) |
ES (1) | ES2056783T3 (it) |
GR (1) | GR930300079T1 (it) |
HU (1) | HU213405B (it) |
IT (1) | IT1243367B (it) |
NO (1) | NO930215L (it) |
WO (1) | WO1992001668A1 (it) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1243367B (it) * | 1990-07-26 | 1994-06-10 | Italfarmaco Spa | Derivati acidi benzoici sostituiti ad attivita' cardiovascolare |
WO1994003421A2 (en) * | 1992-07-30 | 1994-02-17 | Cal International Limited | Esters and combinations of an organic nitrate and a salicylate |
IT1256450B (it) * | 1992-11-26 | 1995-12-05 | Soldato Piero Del | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
ES2065291B1 (es) * | 1993-07-30 | 1995-10-01 | Prodesfarma Sa | "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente" |
EP0759899B1 (en) * | 1994-05-10 | 1999-09-15 | Nicox S.A. | Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities |
ES2092962B1 (es) * | 1995-04-19 | 1997-07-16 | Prodes Sa | Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino) fenilacetoxiacetico y sus procedimientos de preparacion. |
DE19515970A1 (de) * | 1995-05-02 | 1996-11-07 | Bayer Ag | Acetylsalicylsäurenitrate |
IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
IT1288123B1 (it) * | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
FR2757159B1 (fr) * | 1996-12-12 | 1999-12-17 | Hoechst Marion Roussel Inc | Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments |
IT1292377B1 (it) | 1997-06-19 | 1999-02-08 | Nicox Sa | Composizioni farmaceutiche a base di prostaglandine |
IT1307928B1 (it) * | 1999-01-26 | 2001-11-29 | Nicox Sa | Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina. |
IT1308633B1 (it) | 1999-03-02 | 2002-01-09 | Nicox Sa | Nitrossiderivati. |
IT1312115B1 (it) * | 1999-06-24 | 2002-04-04 | Nicox Sa | Composti amorfi e relative composizioni farmaceutiche |
ITMI991517A1 (it) * | 1999-07-09 | 2001-01-09 | Nicox Sa | Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico |
IT1313596B1 (it) | 1999-08-04 | 2002-09-09 | Nicox Sa | Processo per la preparazione di nitrossialchil esteri del naproxene |
US6538033B2 (en) | 2000-08-29 | 2003-03-25 | Huntington Medical Research Institutes | Nitric oxide donor compounds |
TW200821303A (en) * | 2006-08-08 | 2008-05-16 | Speedel Experimenta Ag | Organic compounds |
TW200831079A (en) | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Angiotensin II receptor antagonists |
WO2010118968A1 (en) | 2009-04-16 | 2010-10-21 | Nicox S.A. | No-donor aspirin derivatives |
WO2011041872A1 (en) * | 2009-10-07 | 2011-04-14 | Nitrogenix Inc. | Nitric oxide amino acid ester compounds for the prophylaxis of angina pectoris |
JO3350B1 (ar) | 2011-03-07 | 2019-03-13 | Merck Sharp & Dohme | مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات |
US20140271923A1 (en) | 2013-03-14 | 2014-09-18 | Christopher Brian Reid | Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions |
CN113893242B (zh) * | 2021-10-12 | 2023-10-13 | 广东宝康生物医药有限公司 | Ash在心肌保护中用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3096336A (en) * | 1962-01-22 | 1963-07-02 | Amfre Grant Inc | Glyceryl mononitrate dinicotiante |
US4200640A (en) * | 1976-04-02 | 1980-04-29 | Chugai Seiyaku Kabushiki Kaisha | Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use |
JPS58109461A (ja) * | 1981-12-24 | 1983-06-29 | Kowa Co | 新規ベンズアミド誘導体 |
GB8717068D0 (en) * | 1987-07-20 | 1987-08-26 | Fujisawa Pharmaceutical Co | Nitric ester derivative |
NL8802276A (nl) * | 1988-09-15 | 1990-04-02 | Cedona Pharm Bv | Geneesmiddel met relaxerende werking, dat als aktieve stof een nitraatester bevat. |
DE3836084A1 (de) * | 1988-10-22 | 1990-04-26 | Boehringer Mannheim Gmbh | Cyclische azaaliphaten mit nitroxyfunktion, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
IT1243367B (it) * | 1990-07-26 | 1994-06-10 | Italfarmaco Spa | Derivati acidi benzoici sostituiti ad attivita' cardiovascolare |
-
1990
- 1990-07-26 IT IT02107590A patent/IT1243367B/it active IP Right Grant
-
1991
- 1991-07-15 ES ES91912464T patent/ES2056783T3/es not_active Expired - Lifetime
- 1991-07-15 DK DK91912464.4T patent/DK0540544T3/da active
- 1991-07-15 EP EP91912464A patent/EP0540544B1/en not_active Expired - Lifetime
- 1991-07-15 JP JP91511861A patent/JPH05508841A/ja active Pending
- 1991-07-15 AU AU80974/91A patent/AU8097491A/en not_active Abandoned
- 1991-07-15 WO PCT/EP1991/001326 patent/WO1992001668A1/en active IP Right Grant
- 1991-07-15 CA CA002087442A patent/CA2087442A1/en not_active Abandoned
- 1991-07-15 DE DE199191912464T patent/DE540544T1/de active Pending
- 1991-07-15 HU HU9300095A patent/HU213405B/hu not_active IP Right Cessation
- 1991-07-15 DE DE69107459T patent/DE69107459T2/de not_active Expired - Fee Related
- 1991-07-15 US US07/966,078 patent/US5366992A/en not_active Expired - Fee Related
- 1991-07-15 AT AT91912464T patent/ATE118478T1/de active
-
1993
- 1993-01-22 NO NO93930215A patent/NO930215L/no unknown
- 1993-10-31 GR GR930300079T patent/GR930300079T1/el unknown
-
1994
- 1994-06-06 US US08/254,779 patent/US5589490A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH05508841A (ja) | 1993-12-09 |
AU8097491A (en) | 1992-02-18 |
NO930215D0 (no) | 1993-01-22 |
ES2056783T1 (es) | 1994-10-16 |
HUT63374A (en) | 1993-08-30 |
EP0540544B1 (en) | 1995-02-15 |
DE540544T1 (de) | 1993-09-23 |
IT9021075A0 (it) | 1990-07-26 |
ES2056783T3 (es) | 1995-04-16 |
DE69107459D1 (de) | 1995-03-23 |
NO930215L (no) | 1993-01-22 |
US5589490A (en) | 1996-12-31 |
HU213405B (en) | 1997-06-30 |
ATE118478T1 (de) | 1995-03-15 |
WO1992001668A1 (en) | 1992-02-06 |
GR930300079T1 (en) | 1993-10-31 |
DK0540544T3 (da) | 1995-06-26 |
EP0540544A1 (en) | 1993-05-12 |
US5366992A (en) | 1994-11-22 |
CA2087442A1 (en) | 1992-01-27 |
IT9021075A1 (it) | 1992-01-26 |
HU9300095D0 (en) | 1993-04-28 |
DE69107459T2 (de) | 1995-06-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970730 |