IT1276071B1 - Compositi ad attivita' anti-infiammatoria - Google Patents

Compositi ad attivita' anti-infiammatoria

Info

Publication number
IT1276071B1
IT1276071B1 IT95MI002263A ITMI952263A IT1276071B1 IT 1276071 B1 IT1276071 B1 IT 1276071B1 IT 95MI002263 A IT95MI002263 A IT 95MI002263A IT MI952263 A ITMI952263 A IT MI952263A IT 1276071 B1 IT1276071 B1 IT 1276071B1
Authority
IT
Italy
Prior art keywords
pct
inflammatory activity
composites
sec
date
Prior art date
Application number
IT95MI002263A
Other languages
English (en)
Inventor
Soldato Piero Del
Francesco Sannicolo'
Original Assignee
Nicox Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Ltd filed Critical Nicox Ltd
Publication of ITMI952263A0 publication Critical patent/ITMI952263A0/it
Priority to IT95MI002263A priority Critical patent/IT1276071B1/it
Priority to JP51706097A priority patent/JP3880067B2/ja
Priority to KR1019980703206A priority patent/KR100546038B1/ko
Priority to AT96937282T priority patent/ATE193883T1/de
Priority to HU9802986A priority patent/HUP9802986A3/hu
Priority to BRPI9611175-5A priority patent/BR9611175B1/pt
Priority to US09/066,344 priority patent/US6040341A/en
Priority to ES96937282T priority patent/ES2148808T3/es
Priority to EP96937282A priority patent/EP0871606B1/en
Priority to PCT/EP1996/004696 priority patent/WO1997016405A1/en
Priority to PT96937282T priority patent/PT871606E/pt
Priority to DE69608916T priority patent/DE69608916T2/de
Priority to AU74950/96A priority patent/AU709338B2/en
Priority to DK96937282T priority patent/DK0871606T3/da
Priority to CA002235996A priority patent/CA2235996C/en
Priority to SI9630170T priority patent/SI0871606T1/xx
Priority to RU98110565/04A priority patent/RU2165921C2/ru
Publication of ITMI952263A1 publication Critical patent/ITMI952263A1/it
Application granted granted Critical
Publication of IT1276071B1 publication Critical patent/IT1276071B1/it
Priority to GR20000401528T priority patent/GR3033827T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
IT95MI002263A 1995-10-31 1995-10-31 Compositi ad attivita' anti-infiammatoria IT1276071B1 (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT95MI002263A IT1276071B1 (it) 1995-10-31 1995-10-31 Compositi ad attivita' anti-infiammatoria
EP96937282A EP0871606B1 (en) 1995-10-31 1996-10-29 New compounds and their compositions having anti-inflammatory and anti-thrombotic activities
PT96937282T PT871606E (pt) 1995-10-31 1996-10-29 Novos compostos e suas composicoes com actividade anti-inflamatoria e anti-trombonica
AT96937282T ATE193883T1 (de) 1995-10-31 1996-10-29 Verbindungen und ihre zusammensetzungen mit entzündungshemmenden und anti-thrombotischen wirkungen
HU9802986A HUP9802986A3 (en) 1995-10-31 1996-10-29 New compounds and their compositions having anti-inflammatory and anti-thrombotic activities
BRPI9611175-5A BR9611175B1 (pt) 1995-10-31 1996-10-29 compostos e composiÇÕes farmacÊuticas.
US09/066,344 US6040341A (en) 1995-10-31 1996-10-29 Compounds and their compositions having anti-inflammatory and anti-thrombotic activities
ES96937282T ES2148808T3 (es) 1995-10-31 1996-10-29 Nuevos compuestos y sus composiciones que tienen actividades anti-inflamatorias y anti-tromboticas.
JP51706097A JP3880067B2 (ja) 1995-10-31 1996-10-29 新規化合物並びに抗炎症及び抗血栓活性を有する組成物
PCT/EP1996/004696 WO1997016405A1 (en) 1995-10-31 1996-10-29 New compounds and their compositions having anti-inflammatory and anti-thrombotic activities
KR1019980703206A KR100546038B1 (ko) 1995-10-31 1996-10-29 항염증및항혈전성활성을지닌새로운화합물및그조성물
DE69608916T DE69608916T2 (de) 1995-10-31 1996-10-29 Verbindungen und ihre zusammensetzungen mit entzündungshemmenden und anti-thrombotischen wirkungen
AU74950/96A AU709338B2 (en) 1995-10-31 1996-10-29 New compounds and their compositions having anti-inflammatory and anti-thrombotic activities
DK96937282T DK0871606T3 (da) 1995-10-31 1996-10-29 Nye forbindelser og deres præparat med anti-inflammatorisk og anti-thrombotisk aktivitet
CA002235996A CA2235996C (en) 1995-10-31 1996-10-29 New compounds and their compositions having anti-inflammatory and anti-thrombotic activities
SI9630170T SI0871606T1 (en) 1995-10-31 1996-10-29 New compounds and their compositions having anti-inflammatory and anti-thrombotic activities
RU98110565/04A RU2165921C2 (ru) 1995-10-31 1996-10-29 Нитросоединения и фармацевтическая композиция, обладающие противовоспалительной и антитромботической активностями
GR20000401528T GR3033827T3 (en) 1995-10-31 2000-06-30 New compounds and their compositions having anti-inflammatory and anti-thrombotic activities

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI002263A IT1276071B1 (it) 1995-10-31 1995-10-31 Compositi ad attivita' anti-infiammatoria

Publications (3)

Publication Number Publication Date
ITMI952263A0 ITMI952263A0 (it) 1995-10-31
ITMI952263A1 ITMI952263A1 (it) 1997-05-01
IT1276071B1 true IT1276071B1 (it) 1997-10-24

Family

ID=11372460

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI002263A IT1276071B1 (it) 1995-10-31 1995-10-31 Compositi ad attivita' anti-infiammatoria

Country Status (18)

Country Link
US (1) US6040341A (it)
EP (1) EP0871606B1 (it)
JP (1) JP3880067B2 (it)
KR (1) KR100546038B1 (it)
AT (1) ATE193883T1 (it)
AU (1) AU709338B2 (it)
BR (1) BR9611175B1 (it)
CA (1) CA2235996C (it)
DE (1) DE69608916T2 (it)
DK (1) DK0871606T3 (it)
ES (1) ES2148808T3 (it)
GR (1) GR3033827T3 (it)
HU (1) HUP9802986A3 (it)
IT (1) IT1276071B1 (it)
PT (1) PT871606E (it)
RU (1) RU2165921C2 (it)
SI (1) SI0871606T1 (it)
WO (1) WO1997016405A1 (it)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
US6043232A (en) * 1997-07-23 2000-03-28 Nitromed, Inc. Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
US7115661B1 (en) 1999-12-29 2006-10-03 Queen's University At Kingston Methods and compositions for mitigating pain
US20050137191A1 (en) * 1996-06-04 2005-06-23 Thatcher Gregory R. Nitrate esters and their use for mitigating cellular damage
IT1288123B1 (it) * 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
US20040082652A1 (en) * 1996-09-04 2004-04-29 Nicox S.A. Nitric ester derivatives and their use in treating gastrointestinal tumors
GB9801398D0 (en) 1998-01-22 1998-03-18 Anggard Erik E Chemical compounds
US6136804A (en) 1998-03-13 2000-10-24 Merck & Co., Inc. Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions
EP1061908A4 (en) * 1998-03-13 2007-01-24 Merck & Co Inc COMBINATION THERAPY AND COMPOSITION FOR ACUTE CORONARY MIXING SYNDROME AND ASSOCIATED CONDITIONS
ES2136581B1 (es) 1998-05-27 2000-09-16 Uriach & Cia Sa J Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb.
JP2002517423A (ja) 1998-06-08 2002-06-18 アドバンスド メディスン インコーポレーテッド シクロオキシゲナーゼ−２の多結合インヒビター
CA2345641A1 (en) * 1998-09-28 2000-04-06 Merck & Co., Inc. A method for treating inflammatory diseases by administering a thrombin inhibitor
EP1126838A4 (en) 1998-10-30 2005-02-16 Nitromed Inc NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
IT1307928B1 (it) * 1999-01-26 2001-11-29 Nicox Sa Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.
IT1308633B1 (it) * 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
IT1311924B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
US6509377B1 (en) * 1999-05-26 2003-01-21 J. Uriach & Cia, S.A. Use of a 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-κB
IT1312115B1 (it) * 1999-06-24 2002-04-04 Nicox Sa Composti amorfi e relative composizioni farmaceutiche
ITMI991517A1 (it) * 1999-07-09 2001-01-09 Nicox Sa Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico
IT1313596B1 (it) * 1999-08-04 2002-09-09 Nicox Sa Processo per la preparazione di nitrossialchil esteri del naproxene
AP2002002582A0 (en) 1999-12-23 2002-09-30 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
US6538033B2 (en) * 2000-08-29 2003-03-25 Huntington Medical Research Institutes Nitric oxide donor compounds
IT1319201B1 (it) * 2000-10-12 2003-09-26 Nicox Sa Farmaci per il diabete.
IT1319202B1 (it) * 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
WO2002060378A2 (en) 2000-12-21 2002-08-08 Nitromed, Inc. Substituted aryl compounds as cyclooxygenase-2 selective inhibitors, compositions and methods of use
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
ITMI20011240A1 (it) * 2001-06-13 2002-12-13 Nicox Sa Farmaci per le vasculopatie
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
EP1476168A2 (en) 2002-02-04 2004-11-17 ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda. Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
WO2003094924A1 (en) * 2002-05-10 2003-11-20 Merck & Co., Inc. Combination therapy for treating cyclooxygenase-2 mediated diseases in patients at risk of thrombotic cardiovascular events
US20050215611A1 (en) * 2002-05-10 2005-09-29 Hunt Richard H Combination therapy for treating cyclooxygenase-2 mediated diseases in patients at risk of thrombotic cardiovascular events
AU2003248642A1 (en) 2002-06-11 2003-12-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
US7087630B2 (en) * 2002-06-27 2006-08-08 Nitromed, Inc. Cyclooxygenase 2 selective inhibitors, compositions and methods of use
JP2005535642A (ja) * 2002-06-28 2005-11-24 ニトロメッド インコーポレーティッド オキシムおよび／またはヒドラゾンを含有するニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
CA2491127A1 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
CA2493082A1 (en) 2002-07-26 2004-02-05 Merck Frosst Canada & Co. Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
AU2003261281A1 (en) 2002-07-29 2004-02-16 Nicox S.A. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
AU2003278565A1 (en) * 2002-10-25 2004-05-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
ITMI20022658A1 (it) 2002-12-17 2004-06-18 Nicox Sa Farmaci per il dolore cronico.
US20070207217A1 (en) * 2003-02-03 2007-09-06 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO
US7166638B2 (en) 2003-05-27 2007-01-23 Nicox S.A. Statin derivatives
US7169805B2 (en) 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
KR20060021900A (ko) 2003-06-19 2006-03-08 니콕스 에스. 에이. 심혈관질환의 치료를 위한 ａｃｅ 저해제로서의에날라프릴-니트로옥시유도체 유도체들 및 관련화합물
US7585997B2 (en) * 2003-12-31 2009-09-08 Chesterford Enterprises Limited Compounds and compositions for treating dysproliferative diseases, and methods of use thereof
WO2006027711A2 (en) 2004-08-26 2006-03-16 Nicholas Piramal India Limited Prodrugs and codrugs containing bio- cleavable disulfide linkers
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
US7521435B2 (en) * 2005-02-18 2009-04-21 Pharma Diagnostics, N.V. Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same
ATE485261T1 (de) 2005-11-23 2010-11-15 Nicox Sa Salicylsäurederivate
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
JP2007275193A (ja) * 2006-04-04 2007-10-25 Fujifilm Corp 光プローブおよび光断層画像化装置
CA2705463C (en) * 2007-08-10 2014-10-07 Basil Rigas Anti-inflammatory compounds and uses thereof
WO2010118968A1 (en) 2009-04-16 2010-10-21 Nicox S.A. No-donor aspirin derivatives
WO2011160974A2 (en) 2010-06-21 2011-12-29 Nicox S.A. Statin derivatives
EP2699242B1 (en) 2011-04-19 2017-11-01 Alfama, Inc. Carbon monoxide releasing molecules and uses thereof
JP6134710B2 (ja) 2011-07-21 2017-05-24 アルファーマ インコーポレイテッドＡｌｆａｍａ，Ｉｎｃ． 一酸化ルテニウム放出分子およびその使用
US9844599B2 (en) 2013-01-21 2017-12-19 Apparao Satyam Nitric oxide releasing produgs of therapeutic agents
US20140271923A1 (en) 2013-03-14 2014-09-18 Christopher Brian Reid Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
ATE168986T1 (de) * 1993-10-06 1998-08-15 Nicox Sa Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung
CA2190087C (en) * 1994-05-10 2005-08-02 Piero Del Soldato Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria

Also Published As

Publication number Publication date
DK0871606T3 (da) 2000-07-31
AU7495096A (en) 1997-05-22
RU2165921C2 (ru) 2001-04-27
JP3880067B2 (ja) 2007-02-14
EP0871606B1 (en) 2000-06-14
AU709338B2 (en) 1999-08-26
CA2235996A1 (en) 1997-05-09
PT871606E (pt) 2000-11-30
JPH11514636A (ja) 1999-12-14
EP0871606A1 (en) 1998-10-21
WO1997016405A1 (en) 1997-05-09
BR9611175B1 (pt) 2009-01-13
US6040341A (en) 2000-03-21
ITMI952263A1 (it) 1997-05-01
CA2235996C (en) 2007-01-02
HUP9802986A2 (hu) 1999-04-28
DE69608916T2 (de) 2001-01-11
HUP9802986A3 (en) 1999-12-28
DE69608916D1 (de) 2000-07-20
GR3033827T3 (en) 2000-10-31
ATE193883T1 (de) 2000-06-15
BR9611175A (pt) 1999-03-30
ITMI952263A0 (it) 1995-10-31
KR19990067247A (ko) 1999-08-16
KR100546038B1 (ko) 2006-10-04
ES2148808T3 (es) 2000-10-16
SI0871606T1 (en) 2000-08-31

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