ES2136581B1 - Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb. - Google Patents
Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb.Info
- Publication number
- ES2136581B1 ES2136581B1 ES009801154A ES9801154A ES2136581B1 ES 2136581 B1 ES2136581 B1 ES 2136581B1 ES 009801154 A ES009801154 A ES 009801154A ES 9801154 A ES9801154 A ES 9801154A ES 2136581 B1 ES2136581 B1 ES 2136581B1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- transcription factor
- derivatives
- trifluorometilbenzoico
- hidroxi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La invención se refiere a la utilización de derivados del ácido 2-hidroxi-4-trifluorometilbenzoico para la preparación de medicamentos útiles para inhibir la activación del factor transcripción NF-kB. La invención se refiere también a la utilización de derivados del ácido 2-hidroxi-4- trifluorometilbenzoico para la preparación de medicamentos destinados al tratamiento o prevención de patologías mediadas por la activación de NF-kB y/o la expresión de sus genes dependientes en mamíferos, incluido el hombre.
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009801154A ES2136581B1 (es) | 1998-05-27 | 1998-05-27 | Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb. |
JP2000550490A JP2002516283A (ja) | 1998-05-27 | 1999-05-26 | 核転写因子NF−κBの活性化の阻害剤としての2−ヒドロキシ−4−トリフルオロメチル安息香酸誘導体の使用 |
EP99920872A EP1082962B1 (en) | 1998-05-27 | 1999-05-26 | Utilization of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factors nf-(k)b |
PCT/ES1999/000154 WO1999061030A1 (es) | 1998-05-27 | 1999-05-26 | USO DE DERIVADOS DEL ACIDO 2-HIDROXI-4-TRIFLUOROMETILBENZOICO COMO INHIBIDORES DE LA ACTIVACION DEL FACTOR DE TRANSCRIPCION NUCLEAR NF-λB |
CA002332863A CA2332863A1 (en) | 1998-05-27 | 1999-05-26 | Use of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor nf-.kappa.b |
US09/701,270 US6414025B1 (en) | 1998-05-27 | 1999-05-26 | Utilization of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factors NF-κβ |
KR1020007013316A KR100713601B1 (ko) | 1998-05-27 | 1999-05-26 | 핵전사인자 NF-κB의 활성화의 억제제로서의2-히드록시-4-트리플루오로메틸벤조산 유도체의 용도 |
KR1020067026281A KR100762156B1 (ko) | 1998-05-27 | 1999-05-26 | 핵전사인자 NF-κB의 활성화의 억제제로서의2-히드록시-4-트리플루오로메틸벤조산 유도체의 용도 |
DE69910019T DE69910019T2 (de) | 1998-05-27 | 1999-05-26 | Verwendung von derivaten der 2-hydroxy-4-trifluormethylbenzoe säure als hemmer der aktivierung des nuklearischen transkriptionsfaktors nf-(k)b |
EP03012255A EP1362592A1 (en) | 1998-05-27 | 1999-05-26 | Use of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-kB |
PT99920872T PT1082962E (pt) | 1998-05-27 | 1999-05-26 | Utilizacao de derivados do acido 2-hidroxi-4-trifluorometilbenzoico como inibidores da activacao dos factores de transcricao nucleares nf-(k)b |
AU38286/99A AU3828699A (en) | 1998-05-27 | 1999-05-26 | Utilization of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitorsof the activation of the nuclear transcription factors nf-Kappa |
AT99920872T ATE245987T1 (de) | 1998-05-27 | 1999-05-26 | Verwendung von derivaten der 2-hydroxy-4- trifluormethylbenzoe säure als hemmer der aktivierung des nuklearischen transkriptionsfaktors nf-(k)b |
DK99920872T DK1082962T3 (da) | 1998-05-27 | 1999-05-26 | Anvendelse af 2-hydroxy-4-trifluormethylbenzoesyrederivater som inhibitorer af aktiveringen af de nukleare transskriptionsfaktorer NF-(K)B |
BR9911598-0A BR9911598A (pt) | 1998-05-27 | 1999-05-26 | Uso de derivados do ácido 2-hidróxi-4-trifluormetilbenzóico como inibidores da ativação do fator de transcrição nuclear nf-kb |
ES99920872T ES2204129T3 (es) | 1998-05-27 | 1999-05-26 | Uso de derivados del acido 2-hidroxi-4-trifluorometilbenzoico como inhibidores de la activacion del factor de transcripcion nuclear nf- (k)b. |
NO20005981A NO20005981L (no) | 1998-05-27 | 2000-11-27 | Anvendelse av 2-hydroksy-4-trifluorbenzosyrederivater som inhibitorer av aktivering av den nukleære transkripsjonsfaktor NF- <kappa>B |
US10/115,140 US6610745B2 (en) | 1998-05-27 | 2002-04-04 | Use of 2-hydroxy-4-trifluoromethyl-benzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-KS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009801154A ES2136581B1 (es) | 1998-05-27 | 1998-05-27 | Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2136581A1 ES2136581A1 (es) | 1999-11-16 |
ES2136581B1 true ES2136581B1 (es) | 2000-09-16 |
Family
ID=8304002
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009801154A Expired - Fee Related ES2136581B1 (es) | 1998-05-27 | 1998-05-27 | Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb. |
ES99920872T Expired - Lifetime ES2204129T3 (es) | 1998-05-27 | 1999-05-26 | Uso de derivados del acido 2-hidroxi-4-trifluorometilbenzoico como inhibidores de la activacion del factor de transcripcion nuclear nf- (k)b. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99920872T Expired - Lifetime ES2204129T3 (es) | 1998-05-27 | 1999-05-26 | Uso de derivados del acido 2-hidroxi-4-trifluorometilbenzoico como inhibidores de la activacion del factor de transcripcion nuclear nf- (k)b. |
Country Status (14)
Country | Link |
---|---|
US (2) | US6414025B1 (es) |
EP (2) | EP1082962B1 (es) |
JP (1) | JP2002516283A (es) |
KR (2) | KR100762156B1 (es) |
AT (1) | ATE245987T1 (es) |
AU (1) | AU3828699A (es) |
BR (1) | BR9911598A (es) |
CA (1) | CA2332863A1 (es) |
DE (1) | DE69910019T2 (es) |
DK (1) | DK1082962T3 (es) |
ES (2) | ES2136581B1 (es) |
NO (1) | NO20005981L (es) |
PT (1) | PT1082962E (es) |
WO (1) | WO1999061030A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2154242B1 (es) * | 1999-09-03 | 2001-10-16 | Uriach & Cia Sa J | Nuevos sistemas polimericos biocompatibles portadores de triflusal o htb. |
US20040101488A1 (en) * | 2000-03-24 | 2004-05-27 | Balaram Ghosh | Method for the prevention of septic shock lethality using curcumin |
ES2190373B1 (es) * | 2001-12-07 | 2004-10-16 | J. URIACH & CIA, S.A. | Uso del acido 2-hidroxi- o 2-acetiloxi-4-trifluorometilbenzoico como agente para el tratamiento y prevencion del deterioro cognitivo ligero. |
JP2006502183A (ja) | 2002-09-20 | 2006-01-19 | アルコン,インコーポレイテッド | ドライアイ障害の処置のためのサイトカイン合成インヒビターの使用 |
CA2725008C (en) | 2008-05-28 | 2017-09-05 | Validus Biopharma, Inc. | Non-hormonal steroid modulators of nf-.kappa.b for treatment of disease |
EP2408454A2 (en) | 2009-03-18 | 2012-01-25 | Resverlogix Corp. | Novel anti-inflammatory agents |
US9198921B2 (en) | 2010-04-05 | 2015-12-01 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-κB for treatment of disease |
CN103665012B (zh) * | 2013-12-06 | 2016-06-22 | 辽宁师范大学 | 新型三氟柳无机药物化合物及合成方法 |
WO2017004205A1 (en) | 2015-06-29 | 2017-01-05 | Reveragen Biopharma, Inc. | NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE |
US20180016314A1 (en) * | 2016-07-12 | 2018-01-18 | Children's Hospital Medical Center | Treatment of disease via transcription factor modulation |
KR101975603B1 (ko) | 2018-09-14 | 2019-08-28 | 이영문 | 조력 발전장치 |
US11382922B2 (en) | 2019-03-07 | 2022-07-12 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4096252A (en) * | 1976-06-10 | 1978-06-20 | J. Uriach & Cia S.A. | 4-Trifluoromethylbenzoic acid derivatives as thromboembolic agents |
IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
-
1998
- 1998-05-27 ES ES009801154A patent/ES2136581B1/es not_active Expired - Fee Related
-
1999
- 1999-05-26 CA CA002332863A patent/CA2332863A1/en not_active Abandoned
- 1999-05-26 KR KR1020067026281A patent/KR100762156B1/ko not_active IP Right Cessation
- 1999-05-26 ES ES99920872T patent/ES2204129T3/es not_active Expired - Lifetime
- 1999-05-26 EP EP99920872A patent/EP1082962B1/en not_active Expired - Lifetime
- 1999-05-26 PT PT99920872T patent/PT1082962E/pt unknown
- 1999-05-26 DE DE69910019T patent/DE69910019T2/de not_active Expired - Fee Related
- 1999-05-26 BR BR9911598-0A patent/BR9911598A/pt not_active Application Discontinuation
- 1999-05-26 US US09/701,270 patent/US6414025B1/en not_active Expired - Fee Related
- 1999-05-26 WO PCT/ES1999/000154 patent/WO1999061030A1/es active IP Right Grant
- 1999-05-26 DK DK99920872T patent/DK1082962T3/da active
- 1999-05-26 AU AU38286/99A patent/AU3828699A/en not_active Abandoned
- 1999-05-26 EP EP03012255A patent/EP1362592A1/en not_active Withdrawn
- 1999-05-26 AT AT99920872T patent/ATE245987T1/de not_active IP Right Cessation
- 1999-05-26 KR KR1020007013316A patent/KR100713601B1/ko not_active IP Right Cessation
- 1999-05-26 JP JP2000550490A patent/JP2002516283A/ja active Pending
-
2000
- 2000-11-27 NO NO20005981A patent/NO20005981L/no not_active Application Discontinuation
-
2002
- 2002-04-04 US US10/115,140 patent/US6610745B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR100713601B1 (ko) | 2007-05-02 |
KR20010052404A (ko) | 2001-06-25 |
DE69910019T2 (de) | 2004-05-06 |
DE69910019D1 (de) | 2003-09-04 |
CA2332863A1 (en) | 1999-12-02 |
PT1082962E (pt) | 2003-11-28 |
NO20005981D0 (no) | 2000-11-27 |
KR100762156B1 (ko) | 2007-10-04 |
US20030032630A1 (en) | 2003-02-13 |
EP1362592A1 (en) | 2003-11-19 |
KR20070006943A (ko) | 2007-01-11 |
NO20005981L (no) | 2000-12-12 |
DK1082962T3 (da) | 2003-11-24 |
AU3828699A (en) | 1999-12-13 |
BR9911598A (pt) | 2001-02-13 |
ES2204129T3 (es) | 2004-04-16 |
US6414025B1 (en) | 2002-07-02 |
US6610745B2 (en) | 2003-08-26 |
ES2136581A1 (es) | 1999-11-16 |
EP1082962A1 (en) | 2001-03-14 |
JP2002516283A (ja) | 2002-06-04 |
WO1999061030A1 (es) | 1999-12-02 |
EP1082962B1 (en) | 2003-07-30 |
ATE245987T1 (de) | 2003-08-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1120313T1 (el) | Φαρμακευτικη συνθεση για δερματικη χρηση για να θεραπευεται ψωριαση που περιλαμβανει βιταμινη d και κορτικοστεοειδες | |
BR9611802A (pt) | Composições farmacêuticas | |
BR9714517A (pt) | Cicloalquila, lactama, lactona e compostos correlatos, composições farmacêuticas compreendendo os mesmos e processos para inibir liberação de peptìdeo beta-amilóide e/ou sua sìntese por uso de tais compostos | |
ES2136581B1 (es) | Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb. | |
MX9205937A (es) | Sistema de penetracion incrementada de la piel para surtido topico mejorado de farmacos | |
AR030068A1 (es) | Composiciones farmaceuticas para el tratamiento de condiciones dolorosas, inflamatorias y ulcerosas de superficies epiteliales humedas como por ejemplo mucositis, estomatitis y sindrome de behcet | |
BR0107246A (pt) | Agentes diazabicìclicos ativos no sistema nervoso central | |
BR9910583A (pt) | Aminotetralinas n-substituìdas como ligantes para o receptor de neuropeptìdeo y y5 úteis no tratamento de obesidade e outros distúrbios | |
ES2161785T3 (es) | Emplasto para el tratamiento de micosis ungulares. | |
UY28931A1 (es) | Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis | |
BRPI0411699A (pt) | compostos para uso como substáncia terapeuticamente ativa; método para o tratamento e/ou profilaxia de doenças que estão associadas à modulação de receptores cb1 e uso destes compostos | |
MX9202407A (es) | Composicion farmaceutica que contiene un compuesto de alilamina como el agente activo y proceso para su preparacion. | |
BRPI0415121A (pt) | material particulado, forma de dosagem sólida, método para fabricar a mesma, e, uso de um material particulado ou de uma forma de dosagem sólida | |
TR199903053T2 (xx) | Benzimidazol t�revleri. | |
BRPI0418270A (pt) | métodos de tratamento e de controle, de tratamento ou prevenção, de controle de um distúrbio do sistema nervoso central, e para reduzir ou evitar um efeito adverso, e, composição farmacêutica | |
DE69920757D1 (de) | Immunsuppressive wirkungen von pteridinderivaten | |
BR9916575A (pt) | Composição farmacêutica de liberação controlada com mesilato de tilidina como substância-ativa | |
EP1157698A3 (en) | Treatment of inflammatory diseases with oxypurine nucleosides | |
AR001790A1 (es) | Formulaciones para parches transdermicos que sirven para el tratamiento de condiciones modeladas de receptores muscarinicos | |
ATE381533T1 (de) | Pharmazeutisch wirksame verbindungen und methoden zu ihrer anwendung | |
BR9712141A (pt) | Aplicação de 1-hifróxi-2-piridonas para tratamento de infecções cutâneas. | |
BR0113165A (pt) | Derivados de 4-pirimidinamina, composições farmacêuticas e métodos relacionados | |
BR9608255A (pt) | Sistema terapéutico transdérmico (stt) para a administração de testosterona | |
AR023781A1 (es) | Formulaciones farmaceuticas | |
NO20014081L (no) | Anvendelse av tianeptin i produksjonen av medikamenter til behandling av nevrodegenerative patologier |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19991116 Kind code of ref document: A1 Effective date: 19991116 |
|
FD1A | Patent lapsed |
Effective date: 20050528 |