DE69608916T2 - Verbindungen und ihre zusammensetzungen mit entzündungshemmenden und anti-thrombotischen wirkungen - Google Patents
Verbindungen und ihre zusammensetzungen mit entzündungshemmenden und anti-thrombotischen wirkungenInfo
- Publication number
- DE69608916T2 DE69608916T2 DE69608916T DE69608916T DE69608916T2 DE 69608916 T2 DE69608916 T2 DE 69608916T2 DE 69608916 T DE69608916 T DE 69608916T DE 69608916 T DE69608916 T DE 69608916T DE 69608916 T2 DE69608916 T2 DE 69608916T2
- Authority
- DE
- Germany
- Prior art keywords
- compositions
- inflammatory
- connections
- pct
- thrombotic effects
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95MI002263A IT1276071B1 (it) | 1995-10-31 | 1995-10-31 | Compositi ad attivita' anti-infiammatoria |
PCT/EP1996/004696 WO1997016405A1 (en) | 1995-10-31 | 1996-10-29 | New compounds and their compositions having anti-inflammatory and anti-thrombotic activities |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69608916D1 DE69608916D1 (de) | 2000-07-20 |
DE69608916T2 true DE69608916T2 (de) | 2001-01-11 |
Family
ID=11372460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69608916T Expired - Fee Related DE69608916T2 (de) | 1995-10-31 | 1996-10-29 | Verbindungen und ihre zusammensetzungen mit entzündungshemmenden und anti-thrombotischen wirkungen |
Country Status (18)
Country | Link |
---|---|
US (1) | US6040341A (de) |
EP (1) | EP0871606B1 (de) |
JP (1) | JP3880067B2 (de) |
KR (1) | KR100546038B1 (de) |
AT (1) | ATE193883T1 (de) |
AU (1) | AU709338B2 (de) |
BR (1) | BR9611175B1 (de) |
CA (1) | CA2235996C (de) |
DE (1) | DE69608916T2 (de) |
DK (1) | DK0871606T3 (de) |
ES (1) | ES2148808T3 (de) |
GR (1) | GR3033827T3 (de) |
HU (1) | HUP9802986A3 (de) |
IT (1) | IT1276071B1 (de) |
PT (1) | PT871606E (de) |
RU (1) | RU2165921C2 (de) |
SI (1) | SI0871606T1 (de) |
WO (1) | WO1997016405A1 (de) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6043232A (en) * | 1997-07-23 | 2000-03-28 | Nitromed, Inc. | Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
US20050137191A1 (en) * | 1996-06-04 | 2005-06-23 | Thatcher Gregory R. | Nitrate esters and their use for mitigating cellular damage |
US7115661B1 (en) | 1999-12-29 | 2006-10-03 | Queen's University At Kingston | Methods and compositions for mitigating pain |
IT1288123B1 (it) * | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
US20040082652A1 (en) * | 1996-09-04 | 2004-04-29 | Nicox S.A. | Nitric ester derivatives and their use in treating gastrointestinal tumors |
GB9801398D0 (en) | 1998-01-22 | 1998-03-18 | Anggard Erik E | Chemical compounds |
US6136804A (en) | 1998-03-13 | 2000-10-24 | Merck & Co., Inc. | Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions |
CA2322824A1 (en) * | 1998-03-13 | 1999-09-16 | Merck & Co., Inc. | Combination therapy and composition for acute coronary ischemic syndrome and related conditions |
ES2136581B1 (es) | 1998-05-27 | 2000-09-16 | Uriach & Cia Sa J | Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb. |
JP2002517423A (ja) | 1998-06-08 | 2002-06-18 | アドバンスド メディスン インコーポレーテッド | シクロオキシゲナーゼ−2の多結合インヒビター |
EP1117398A2 (de) * | 1998-09-28 | 2001-07-25 | Merck & Co., Inc. | Verfahren zur behandlung von enzündlichen erkrankungen durch verabreichubg eines thrombininhibitors |
EP1126838A4 (de) | 1998-10-30 | 2005-02-16 | Nitromed Inc | Nitrosierte und nitrosylierte nichtsteroidale antiphlogistishe verbindungen, zusammenstellungen und verwendungsmethoden |
IT1307928B1 (it) * | 1999-01-26 | 2001-11-29 | Nicox Sa | Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina. |
IT1308633B1 (it) * | 1999-03-02 | 2002-01-09 | Nicox Sa | Nitrossiderivati. |
IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
US6509377B1 (en) * | 1999-05-26 | 2003-01-21 | J. Uriach & Cia, S.A. | Use of a 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-κB |
IT1312115B1 (it) * | 1999-06-24 | 2002-04-04 | Nicox Sa | Composti amorfi e relative composizioni farmaceutiche |
ITMI991517A1 (it) * | 1999-07-09 | 2001-01-09 | Nicox Sa | Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico |
IT1313596B1 (it) | 1999-08-04 | 2002-09-09 | Nicox Sa | Processo per la preparazione di nitrossialchil esteri del naproxene |
BR0017037A (pt) * | 1999-12-23 | 2003-06-10 | Nitromed Inc | Inibidores de ciclooxigenase-2 nitrosados e nitrosilados, composições e métodos de uso |
US6538033B2 (en) * | 2000-08-29 | 2003-03-25 | Huntington Medical Research Institutes | Nitric oxide donor compounds |
IT1319201B1 (it) * | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per il diabete. |
IT1319202B1 (it) * | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per le malattie a base infiammatoria. |
ATE338544T1 (de) * | 2000-12-21 | 2006-09-15 | Nitromed Inc | Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren |
GB0111872D0 (en) * | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
US6696592B2 (en) | 2001-05-22 | 2004-02-24 | Nicox-S.A. | Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof |
ITMI20011240A1 (it) * | 2001-06-13 | 2002-12-13 | Nicox Sa | Farmaci per le vasculopatie |
ITMI20011308A1 (it) | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per il dolore cronico |
ITMI20011307A1 (it) * | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per l'epilessia |
US20080026984A1 (en) * | 2002-02-04 | 2008-01-31 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
US7968605B2 (en) * | 2002-02-04 | 2011-06-28 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
US7011854B2 (en) | 2002-02-04 | 2006-03-14 | Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda | Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof |
AU2003229005A1 (en) * | 2002-05-10 | 2003-11-11 | Merck And Co., Inc. | Combination therapy for treating cyclooxygenase-2 mediated diseases in patients at risk of thrombotic cardiovascular events |
US20050215611A1 (en) * | 2002-05-10 | 2005-09-29 | Hunt Richard H | Combination therapy for treating cyclooxygenase-2 mediated diseases in patients at risk of thrombotic cardiovascular events |
JP2006501161A (ja) | 2002-06-11 | 2006-01-12 | ニトロメッド インク. | ニトロソ化および/またはニトロシル化シクロオキシゲナーゼ−2選択的阻害剤、組成物ならびに使用方法 |
US7087630B2 (en) | 2002-06-27 | 2006-08-08 | Nitromed, Inc. | Cyclooxygenase 2 selective inhibitors, compositions and methods of use |
WO2004002420A2 (en) * | 2002-06-28 | 2004-01-08 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use |
JP2005539089A (ja) * | 2002-07-03 | 2005-12-22 | ニトロメッド インコーポレーティッド | ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法 |
EP1527045A1 (de) | 2002-07-26 | 2005-05-04 | Merck Frosst Canada & Co. | Stickstoffmonoxid freisetzende prodrugs von diaryl-2-(5h)-furanonen als cyclooxygenase-2-inhibitoren |
US7244753B2 (en) | 2002-07-29 | 2007-07-17 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
ITMI20021861A1 (it) * | 2002-08-29 | 2004-02-29 | Nicox Sa | Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione. |
WO2004037843A2 (en) * | 2002-10-25 | 2004-05-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments |
GB2395432B (en) * | 2002-11-20 | 2005-09-14 | Northwick Park Inst For Medica | Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs |
ITMI20022658A1 (it) | 2002-12-17 | 2004-06-18 | Nicox Sa | Farmaci per il dolore cronico. |
US7166638B2 (en) * | 2003-05-27 | 2007-01-23 | Nicox S.A. | Statin derivatives |
US7169805B2 (en) | 2003-05-28 | 2007-01-30 | Nicox S.A. | Captopril derivatives |
BRPI0411430A (pt) | 2003-06-19 | 2006-07-25 | Nicox Sa | composto, uso do mesmo, composição farmacêutica, kit farmacêutico, e, método de sìntese de compostos |
WO2005065361A2 (en) * | 2003-12-31 | 2005-07-21 | Khosrow Kashfi | Compounds and compositions for treating dysproliferative diseases, and methods of use thereof |
TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
MX2007002210A (es) | 2004-08-26 | 2007-05-07 | Nicholas Piramal India Ltd | Profarmacos que contienen enlazantes bioescindibles novedosos. |
US7521435B2 (en) * | 2005-02-18 | 2009-04-21 | Pharma Diagnostics, N.V. | Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same |
WO2007060112A1 (en) | 2005-11-23 | 2007-05-31 | Nicox S.A. | Salicylic acid derivatives |
WO2007073226A1 (en) * | 2005-12-20 | 2007-06-28 | Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda | Method for treating a mammal by administration of a compound having the ability to release co |
GB0601394D0 (en) | 2006-01-24 | 2006-03-01 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
JP2007275193A (ja) * | 2006-04-04 | 2007-10-25 | Fujifilm Corp | 光プローブおよび光断層画像化装置 |
PL2180788T3 (pl) * | 2007-08-10 | 2017-06-30 | Basil Rigas | Związki przeciwzapalne i ich zastosowanie |
WO2010118968A1 (en) | 2009-04-16 | 2010-10-21 | Nicox S.A. | No-donor aspirin derivatives |
WO2011160974A2 (en) | 2010-06-21 | 2011-12-29 | Nicox S.A. | Statin derivatives |
US9163044B2 (en) | 2011-04-19 | 2015-10-20 | Alfama, Inc. | Carbon monoxide releasing molecules and uses thereof |
JP6134710B2 (ja) | 2011-07-21 | 2017-05-24 | アルファーマ インコーポレイテッドAlfama,Inc. | 一酸化ルテニウム放出分子およびその使用 |
US9844599B2 (en) | 2013-01-21 | 2017-12-19 | Apparao Satyam | Nitric oxide releasing produgs of therapeutic agents |
US20140271923A1 (en) | 2013-03-14 | 2014-09-18 | Christopher Brian Reid | Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1243367B (it) * | 1990-07-26 | 1994-06-10 | Italfarmaco Spa | Derivati acidi benzoici sostituiti ad attivita' cardiovascolare |
IT1256450B (it) * | 1992-11-26 | 1995-12-05 | Soldato Piero Del | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
US5700947A (en) * | 1993-10-06 | 1997-12-23 | Nicox S.A. | Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation |
DE69512232T2 (de) * | 1994-05-10 | 2000-02-24 | Nicox Sa | Nitroverbindingen und ihre zubereitungen mit entzündungsremmenden, schmertzlindernden und antithrombotischen wirkungen |
IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
-
1995
- 1995-10-31 IT IT95MI002263A patent/IT1276071B1/it active IP Right Grant
-
1996
- 1996-10-29 PT PT96937282T patent/PT871606E/pt unknown
- 1996-10-29 KR KR1019980703206A patent/KR100546038B1/ko not_active IP Right Cessation
- 1996-10-29 ES ES96937282T patent/ES2148808T3/es not_active Expired - Lifetime
- 1996-10-29 US US09/066,344 patent/US6040341A/en not_active Expired - Fee Related
- 1996-10-29 DK DK96937282T patent/DK0871606T3/da active
- 1996-10-29 JP JP51706097A patent/JP3880067B2/ja not_active Expired - Fee Related
- 1996-10-29 EP EP96937282A patent/EP0871606B1/de not_active Expired - Lifetime
- 1996-10-29 AT AT96937282T patent/ATE193883T1/de not_active IP Right Cessation
- 1996-10-29 SI SI9630170T patent/SI0871606T1/xx unknown
- 1996-10-29 WO PCT/EP1996/004696 patent/WO1997016405A1/en active IP Right Grant
- 1996-10-29 CA CA002235996A patent/CA2235996C/en not_active Expired - Fee Related
- 1996-10-29 AU AU74950/96A patent/AU709338B2/en not_active Ceased
- 1996-10-29 HU HU9802986A patent/HUP9802986A3/hu unknown
- 1996-10-29 RU RU98110565/04A patent/RU2165921C2/ru not_active IP Right Cessation
- 1996-10-29 BR BRPI9611175-5A patent/BR9611175B1/pt not_active IP Right Cessation
- 1996-10-29 DE DE69608916T patent/DE69608916T2/de not_active Expired - Fee Related
-
2000
- 2000-06-30 GR GR20000401528T patent/GR3033827T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH11514636A (ja) | 1999-12-14 |
CA2235996A1 (en) | 1997-05-09 |
RU2165921C2 (ru) | 2001-04-27 |
PT871606E (pt) | 2000-11-30 |
AU709338B2 (en) | 1999-08-26 |
SI0871606T1 (en) | 2000-08-31 |
ITMI952263A1 (it) | 1997-05-01 |
CA2235996C (en) | 2007-01-02 |
ATE193883T1 (de) | 2000-06-15 |
EP0871606A1 (de) | 1998-10-21 |
KR19990067247A (ko) | 1999-08-16 |
IT1276071B1 (it) | 1997-10-24 |
US6040341A (en) | 2000-03-21 |
WO1997016405A1 (en) | 1997-05-09 |
BR9611175A (pt) | 1999-03-30 |
ITMI952263A0 (de) | 1995-10-31 |
EP0871606B1 (de) | 2000-06-14 |
DE69608916D1 (de) | 2000-07-20 |
ES2148808T3 (es) | 2000-10-16 |
BR9611175B1 (pt) | 2009-01-13 |
AU7495096A (en) | 1997-05-22 |
GR3033827T3 (en) | 2000-10-31 |
HUP9802986A3 (en) | 1999-12-28 |
DK0871606T3 (da) | 2000-07-31 |
KR100546038B1 (ko) | 2006-10-04 |
HUP9802986A2 (hu) | 1999-04-28 |
JP3880067B2 (ja) | 2007-02-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: NICOX S.A., SOPHIA ANTIPOLIS, VALBONNE, FR |
|
8339 | Ceased/non-payment of the annual fee |