ITMI20021391A1 - Nitroderivati di inibitori della cicloossigenasi-2 - Google Patents

Nitroderivati di inibitori della cicloossigenasi-2

Info

Publication number
ITMI20021391A1
ITMI20021391A1 IT2002MI001391A ITMI20021391A ITMI20021391A1 IT MI20021391 A1 ITMI20021391 A1 IT MI20021391A1 IT 2002MI001391 A IT2002MI001391 A IT 2002MI001391A IT MI20021391 A ITMI20021391 A IT MI20021391A IT MI20021391 A1 ITMI20021391 A1 IT MI20021391A1
Authority
IT
Italy
Prior art keywords
cyclooxygenase
nitro
inhibitors
derivatives
Prior art date
Application number
IT2002MI001391A
Other languages
English (en)
Inventor
Giancarlo Santus
Soldato Piero Del
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Priority to IT2002MI001391A priority Critical patent/ITMI20021391A1/it
Publication of ITMI20021391A0 publication Critical patent/ITMI20021391A0/it
Priority to CNB038146827A priority patent/CN100516037C/zh
Priority to IL16547503A priority patent/IL165475A0/xx
Priority to PCT/EP2003/006502 priority patent/WO2004000781A2/en
Priority to PL03374279A priority patent/PL374279A1/xx
Priority to RU2004138552/04A priority patent/RU2339617C2/ru
Priority to AU2003245972A priority patent/AU2003245972B2/en
Priority to US10/516,938 priority patent/US7776902B2/en
Priority to MXPA04012851A priority patent/MXPA04012851A/es
Priority to HK06100164.4A priority patent/HK1080069A1/zh
Priority to JP2004514803A priority patent/JP4445854B2/ja
Priority to EP03738069A priority patent/EP1517889A2/en
Priority to NZ537043A priority patent/NZ537043A/en
Priority to CA002491209A priority patent/CA2491209A1/en
Publication of ITMI20021391A1 publication Critical patent/ITMI20021391A1/it
Priority to ZA200410060A priority patent/ZA200410060B/en
Priority to NO20050346A priority patent/NO20050346L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/49—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
IT2002MI001391A 2002-06-25 2002-06-25 Nitroderivati di inibitori della cicloossigenasi-2 ITMI20021391A1 (it)

Priority Applications (16)

Application Number Priority Date Filing Date Title
IT2002MI001391A ITMI20021391A1 (it) 2002-06-25 2002-06-25 Nitroderivati di inibitori della cicloossigenasi-2
CA002491209A CA2491209A1 (en) 2002-06-25 2003-06-20 Nitrooxyderivatives of cyclooxygenase-2 inhibitors
AU2003245972A AU2003245972B2 (en) 2002-06-25 2003-06-20 Nitrooxyderivatives of cyclooxygenase-2 inhibitors
MXPA04012851A MXPA04012851A (es) 2002-06-25 2003-06-20 Nitrooxiderivados de inhibidores de la ciclooxigenasa-2.
PCT/EP2003/006502 WO2004000781A2 (en) 2002-06-25 2003-06-20 Nitrooxyderivatives of cyclooxygenase-2 inhibitors
PL03374279A PL374279A1 (en) 2002-06-25 2003-06-20 Nitrooxyderivatives of cyclooxygenase-2 inhibitors
RU2004138552/04A RU2339617C2 (ru) 2002-06-25 2003-06-20 Нитрооксипроизводные ингибиторов циклооксигеназы-2
CNB038146827A CN100516037C (zh) 2002-06-25 2003-06-20 环氧酶2-抑制剂的硝酰氧基衍生物
US10/516,938 US7776902B2 (en) 2002-06-25 2003-06-20 Nitrooxyderivatives of cyclooxygenase-2 inhibitors
IL16547503A IL165475A0 (en) 2002-06-25 2003-06-20 Nitrooxyderivatives of eyclooxygenase-2 inhibitors
HK06100164.4A HK1080069A1 (zh) 2002-06-25 2003-06-20 环氧酶2-抑制剂的硝酰氧基衍生物
JP2004514803A JP4445854B2 (ja) 2002-06-25 2003-06-20 シクロオキシゲナーゼ−２阻害剤のニトロオキシ誘導体
EP03738069A EP1517889A2 (en) 2002-06-25 2003-06-20 Nitrooxyderivatives of cyclooxygenase-2 inhibitors
NZ537043A NZ537043A (en) 2002-06-25 2003-06-20 Nitrooxyderivatives of cyclooxygenase-2 inhibitors
ZA200410060A ZA200410060B (en) 2002-06-25 2004-12-13 Nitrooxyderivatives of cyclooxygenase-2 inhibitors.
NO20050346A NO20050346L (no) 2002-06-25 2005-01-21 Nitro-oksyderivater av syklooksygenase-2-inhibitorer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002MI001391A ITMI20021391A1 (it) 2002-06-25 2002-06-25 Nitroderivati di inibitori della cicloossigenasi-2

Publications (2)

Publication Number Publication Date
ITMI20021391A0 ITMI20021391A0 (it) 2002-06-25
ITMI20021391A1 true ITMI20021391A1 (it) 2003-12-29

Family

ID=11450078

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2002MI001391A ITMI20021391A1 (it) 2002-06-25 2002-06-25 Nitroderivati di inibitori della cicloossigenasi-2

Country Status (16)

Country Link
US (1) US7776902B2 (it)
EP (1) EP1517889A2 (it)
JP (1) JP4445854B2 (it)
CN (1) CN100516037C (it)
AU (1) AU2003245972B2 (it)
CA (1) CA2491209A1 (it)
HK (1) HK1080069A1 (it)
IL (1) IL165475A0 (it)
IT (1) ITMI20021391A1 (it)
MX (1) MXPA04012851A (it)
NO (1) NO20050346L (it)
NZ (1) NZ537043A (it)
PL (1) PL374279A1 (it)
RU (1) RU2339617C2 (it)
WO (1) WO2004000781A2 (it)
ZA (1) ZA200410060B (it)

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AU782971B2 (en) 1999-12-23 2005-09-15 Nicox S.A. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
CA2487414A1 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
US20060003996A1 (en) * 2002-06-17 2006-01-05 Stephen Roth Intralesional treatment of psoriasis
JP2006501179A (ja) 2002-06-27 2006-01-12 ニトロメッド インコーポレーティッド シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
AU2003279622A1 (en) 2002-06-28 2004-01-19 Nitromed, Inc. Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use
CA2493082A1 (en) 2002-07-26 2004-02-05 Merck Frosst Canada & Co. Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
CA2503063A1 (en) * 2002-10-22 2004-05-06 Merck Frosst Canada & Co./Merck Frosst Canada & Cie Nitric oxide releasing selective cyclooxygenase-2 inhibitors
EP1601644B1 (en) 2003-03-05 2009-05-27 Merck Frosst Company Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
CA2577490A1 (en) 2004-08-26 2006-03-16 Nicholas Piramal India Limited Prodrugs containing alkyldisulfide linker groups
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
US7521435B2 (en) 2005-02-18 2009-04-21 Pharma Diagnostics, N.V. Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same
US7807716B2 (en) * 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
EP2968440B1 (en) 2013-03-15 2019-06-05 Zymeworks Inc. Cytotoxic and anti-mitotic compounds, and methods of using the same
US9889145B2 (en) * 2013-04-23 2018-02-13 The Administrators Of The Tulane Educational Fund Methods to treat infections
SG11201605260VA (en) 2013-12-27 2016-07-28 Zymeworks Inc Var2csa-drug conjugates
PL3086815T3 (pl) * 2013-12-27 2022-06-13 Zymeworks Inc. Układy łącznikowe dla koniugatów leków zawierające ugrupowanie sulfonamidowe
BR112016016386B1 (pt) 2014-01-14 2023-02-23 Euclises Pharmaceuticals, Inc Composto ou um sal ou solvato do mesmo, composição farmacêutica e uso de um composto na preparação de um medicamento
CN107001415B (zh) 2014-09-17 2021-06-18 酵活有限公司 细胞毒性和抗有丝分裂化合物、及其使用方法
CN105503883B (zh) * 2015-12-30 2018-03-02 西安交通大学 一类西格列汀‑硝酸酯杂合体及其制备方法和应用
CN110396064B (zh) * 2019-07-25 2020-07-10 南京大学 甲磺酰胺衍生物及其制备方法和防治阿尔茨海默病的应用
CN112898201A (zh) * 2021-01-21 2021-06-04 南京理工大学 硝酸酯化合物以及合成吡啶亚砜亚胺导向的c-h硝酸酯化的方法

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US5604260A (en) 1992-12-11 1997-02-18 Merck Frosst Canada Inc. 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
BR9407749A (pt) 1993-10-06 1997-02-12 Nicox Sa Derivados de ácido processo para a preparaçao dos mesmos e composiçoes farmacêuticas
US5466823A (en) 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
DE69512232T2 (de) 1994-05-10 2000-02-24 Nicox S.A., Paris Nitroverbindingen und ihre zubereitungen mit entzündungsremmenden, schmertzlindernden und antithrombotischen wirkungen
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IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.

Also Published As

Publication number Publication date
NO20050346L (no) 2005-02-28
IL165475A0 (en) 2006-01-15
NO20050346D0 (no) 2005-01-21
ITMI20021391A0 (it) 2002-06-25
HK1080069A1 (zh) 2006-04-21
CN100516037C (zh) 2009-07-22
AU2003245972A1 (en) 2004-01-06
EP1517889A2 (en) 2005-03-30
CA2491209A1 (en) 2003-12-31
WO2004000781A2 (en) 2003-12-31
JP2005530836A (ja) 2005-10-13
RU2004138552A (ru) 2005-10-20
ZA200410060B (en) 2005-10-20
MXPA04012851A (es) 2005-02-24
CN1662490A (zh) 2005-08-31
JP4445854B2 (ja) 2010-04-07
US20060106082A1 (en) 2006-05-18
US7776902B2 (en) 2010-08-17
PL374279A1 (en) 2005-10-03
AU2003245972B2 (en) 2009-09-17
RU2339617C2 (ru) 2008-11-27
NZ537043A (en) 2006-09-29
WO2004000781A3 (en) 2004-10-14

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