IT1303672B1 - Sali nitrati di farmaci attivi nei disordini ossei - Google Patents
Sali nitrati di farmaci attivi nei disordini osseiInfo
- Publication number
- IT1303672B1 IT1303672B1 IT1998MI001744A ITMI981744A IT1303672B1 IT 1303672 B1 IT1303672 B1 IT 1303672B1 IT 1998MI001744 A IT1998MI001744 A IT 1998MI001744A IT MI981744 A ITMI981744 A IT MI981744A IT 1303672 B1 IT1303672 B1 IT 1303672B1
- Authority
- IT
- Italy
- Prior art keywords
- salts
- nitrated
- bone disorders
- drugs active
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
- C07C229/58—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/64—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/5765—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1998MI001744A IT1303672B1 (it) | 1998-07-28 | 1998-07-28 | Sali nitrati di farmaci attivi nei disordini ossei |
PT99940026T PT1100805E (pt) | 1998-07-28 | 1999-07-20 | Sais de nitrato medicinais |
ES99940026T ES2189464T3 (es) | 1998-07-28 | 1999-07-20 | Sales de nitrato como compuestos medicos. |
US09/743,801 US6573252B1 (en) | 1998-07-28 | 1999-07-20 | Medicine nitrate salts |
CNB998090212A CN1151161C (zh) | 1998-07-28 | 1999-07-20 | 药物硝酸盐 |
KR1020017000763A KR20010071962A (ko) | 1998-07-28 | 1999-07-20 | 약제질산염들 |
EP99940026A EP1100805B1 (en) | 1998-07-28 | 1999-07-20 | Medicine nitrate salts |
CA002338912A CA2338912A1 (en) | 1998-07-28 | 1999-07-20 | Medicine nitrate salts |
IL14068499A IL140684A0 (en) | 1998-07-28 | 1999-07-20 | Medicine nitrate salts |
AT99940026T ATE229533T1 (de) | 1998-07-28 | 1999-07-20 | Nitrat-salze als arzneimittel |
PCT/EP1999/005170 WO2000006585A1 (en) | 1998-07-28 | 1999-07-20 | Medicine nitrate salts |
AU54120/99A AU756440B2 (en) | 1998-07-28 | 1999-07-20 | Medicine nitrate salts |
HU0102866A HUP0102866A3 (en) | 1998-07-28 | 1999-07-20 | Medicine nitrate salts |
BR9912376-2A BR9912376A (pt) | 1998-07-28 | 1999-07-20 | Sais de nitrato, composições farmacêuticas, udo de sais e composições, e, processo para preparação de sais de nitrato. |
DK99940026T DK1100805T3 (da) | 1998-07-28 | 1999-07-20 | Nitratsalte som lægemiddel |
SI9930195T SI1100805T1 (en) | 1998-07-28 | 1999-07-20 | Medicine nitrate salts |
DE69904483T DE69904483T2 (de) | 1998-07-28 | 1999-07-20 | Nitrat-salze als arzneimittel |
JP2000562382A JP2002521487A (ja) | 1998-07-28 | 1999-07-20 | 硝酸塩薬 |
RU2001102263A RU2238932C2 (ru) | 1998-07-28 | 1999-07-20 | Нитратные соли и фармацевтическая композиция на их основе |
ZA200100453A ZA200100453B (en) | 1998-07-28 | 2001-01-16 | Medicine nitrate salts. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1998MI001744A IT1303672B1 (it) | 1998-07-28 | 1998-07-28 | Sali nitrati di farmaci attivi nei disordini ossei |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI981744A0 ITMI981744A0 (it) | 1998-07-28 |
ITMI981744A1 ITMI981744A1 (it) | 2000-01-28 |
IT1303672B1 true IT1303672B1 (it) | 2001-02-23 |
Family
ID=11380536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT1998MI001744A IT1303672B1 (it) | 1998-07-28 | 1998-07-28 | Sali nitrati di farmaci attivi nei disordini ossei |
Country Status (19)
Country | Link |
---|---|
US (1) | US6573252B1 (it) |
EP (1) | EP1100805B1 (it) |
JP (1) | JP2002521487A (it) |
KR (1) | KR20010071962A (it) |
CN (1) | CN1151161C (it) |
AT (1) | ATE229533T1 (it) |
AU (1) | AU756440B2 (it) |
BR (1) | BR9912376A (it) |
CA (1) | CA2338912A1 (it) |
DE (1) | DE69904483T2 (it) |
DK (1) | DK1100805T3 (it) |
ES (1) | ES2189464T3 (it) |
HU (1) | HUP0102866A3 (it) |
IL (1) | IL140684A0 (it) |
IT (1) | IT1303672B1 (it) |
PT (1) | PT1100805E (it) |
RU (1) | RU2238932C2 (it) |
WO (1) | WO2000006585A1 (it) |
ZA (1) | ZA200100453B (it) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA02006312A (es) | 1999-12-23 | 2004-06-21 | Nitromed Inc | Inhibidores de ciclooxigenasa-2 nitrosilatados y nitrosados, composiciones y metodos para utilizarse. |
IT1317735B1 (it) * | 2000-01-26 | 2003-07-15 | Nicox Sa | Sali di agenti antimicrobici. |
ATE448194T1 (de) | 2000-08-29 | 2009-11-15 | Biocon Ltd | Verwendung einer pharmazeutischen zusammensetzung mit einem para-aminophenylessigsäurederivat für die behandlung von entzündlichen erkrankungen des magen-darmtrakts |
EP1406609B1 (en) | 2000-12-21 | 2006-09-06 | Nitromed, Inc. | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
US8048924B2 (en) | 2001-08-29 | 2011-11-01 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
KR100638122B1 (ko) * | 2001-12-21 | 2006-10-24 | 더 프록터 앤드 갬블 캄파니 | 골 장애의 치료 방법 |
JP2005530819A (ja) * | 2002-05-02 | 2005-10-13 | オステオスクリーン,インコーポレイテッド | 一酸化窒素を放出するビスホスホネート結合体(no−ビスホスホネート)を使用して骨増殖を刺激するための、方法および組成物 |
CN1939314A (zh) * | 2002-05-10 | 2007-04-04 | 弗·哈夫曼-拉罗切有限公司 | 用于治疗和预防骨质疏松症的二膦酸 |
CA2487414A1 (en) | 2002-06-11 | 2003-12-18 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
JP2005535642A (ja) * | 2002-06-28 | 2005-11-24 | ニトロメッド インコーポレーティッド | オキシムおよび/またはヒドラゾンを含有するニトロソ化および/またはニトロシル化シクロオキシゲナーゼ−2選択的阻害剤、組成物、および使用方法 |
WO2004004648A2 (en) | 2002-07-03 | 2004-01-15 | Nitromed, Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
US7244753B2 (en) | 2002-07-29 | 2007-07-17 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
DK1790347T3 (en) * | 2002-12-20 | 2015-01-19 | Hoffmann La Roche | Ibandronate high-dose-formulation |
DK1773767T3 (en) | 2004-07-07 | 2016-03-21 | Biocon Ltd | Synthesis of azo bound in immune regulatory relations |
PL1848727T3 (pl) * | 2005-02-01 | 2015-11-30 | Hoffmann La Roche | Polimorf b ibandronianu |
CN101111504B (zh) * | 2005-02-01 | 2011-12-21 | 霍夫曼-拉罗奇有限公司 | 伊班膦酸盐多晶型物a |
JP2007275193A (ja) * | 2006-04-04 | 2007-10-25 | Fujifilm Corp | 光プローブおよび光断層画像化装置 |
US20090118239A1 (en) * | 2007-11-05 | 2009-05-07 | Teva Pharmaceutical Industries Ltd. | Amorphous and crystalline forms of ibandronate disodium |
WO2010032254A1 (en) * | 2008-09-22 | 2010-03-25 | Kamud Drugs Pvt . Ltd . | Industrial process for cis(+m-2-r(dimethylamino)-methyl-1-(3- methoxyphenyl) cyclohexanol hydrochloride |
EP2287154A1 (en) | 2009-07-14 | 2011-02-23 | KRKA, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast |
WO2011121091A1 (en) | 2010-03-31 | 2011-10-06 | Krka, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
FR2973378B1 (fr) * | 2011-03-28 | 2013-10-04 | Atlanthera | Derives d'acide hydroxybisphosphonique bifonctionnels |
PL407922A1 (pl) * | 2014-04-16 | 2015-10-26 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością | Nowe bisfosfoniany i ich zastosowanie |
CN105596361A (zh) * | 2015-09-30 | 2016-05-25 | 王松灵 | 硝酸盐防治骨质疏松的新用途 |
US11404148B2 (en) | 2017-08-10 | 2022-08-02 | Nuance Communications, Inc. | Automated clinical documentation system and method |
CN113321667B (zh) * | 2021-05-26 | 2022-04-22 | 中国药科大学 | 氯诺昔康钠螯合物及其制备方法和应用 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2118261A1 (de) * | 1971-04-15 | 1972-11-02 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue N-haltige Bicyclen, deren Säureadditionssalze sowie Verfahren zu deren Herstellung |
US3788949A (en) * | 1972-08-22 | 1974-01-29 | Lilly Co Eli | Sterility testing antigen products |
DE2259160A1 (de) * | 1972-12-02 | 1974-06-06 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylaminoimidazoline, deren saeureadditionssalze und verfahren zur herstellung derselben sowie ihre verwendung als arzneimittel |
IL47885A (en) * | 1974-09-23 | 1979-01-31 | Syntex Inc | Imidazole derivatives,their preparation and antifungal and antibacterial compositions containing them |
ATE2269T1 (de) | 1978-12-21 | 1983-02-15 | Gruppo Lepetit S.P.A. | 3h-naphtho(1,2-d)imidazole, verfahren zu deren herstellung, verbindungen zur verwendung als entzuendungshemmende und antimikrobielle mittel und sie enthaltende zusammensetzungen zu dieser verwendung. |
IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
US4761406A (en) * | 1985-06-06 | 1988-08-02 | The Procter & Gamble Company | Regimen for treating osteoporosis |
JPH0782656B2 (ja) | 1986-07-11 | 1995-09-06 | 株式会社日立製作所 | 光デイスク装置 |
CA1339805C (en) | 1988-01-20 | 1998-04-07 | Yasuo Isomura | (cycloalkylamino)methylenebis(phosphonic acid) and medicines containing the same as an active |
JPH04356496A (ja) | 1990-08-03 | 1992-12-10 | Takeda Chem Ind Ltd | ホスホン酸誘導体およびその医薬 |
JPH0532684A (ja) | 1990-09-18 | 1993-02-09 | Kaken Pharmaceut Co Ltd | ビスホスホン酸誘導体 |
IT1247034B (it) | 1991-06-26 | 1994-12-12 | Gentili Ist Spa | Acidi dimetilamino-idrossi alchil difosfonici e loro sali, loro procedimento produttivo e composizioni farmaceutiche che li comprendono |
JPH05194563A (ja) | 1991-07-12 | 1993-08-03 | Hoechst Ag | 置換アミノエタン−1,1−ビスホスホン酸およびアミノエタン−1,1−アルキルホスフィノホスホン酸 |
ATE147396T1 (de) | 1991-08-27 | 1997-01-15 | Ciba Geigy Ag | N-substituierte aminomethandiphosphonsäuren |
TW222637B (it) | 1991-12-12 | 1994-04-21 | Hoechst Ag | |
DE4141928A1 (de) | 1991-12-19 | 1993-06-24 | Boehringer Mannheim Gmbh | Neue phosphonobernsteinsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
JPH05222073A (ja) | 1992-02-13 | 1993-08-31 | Sumitomo Pharmaceut Co Ltd | 骨選択性エストロゲン |
JPH05345791A (ja) | 1992-03-18 | 1993-12-27 | Hoechst Japan Ltd | 環状アミノメチレンビスホスホン酸誘導体 |
US5380738A (en) | 1993-05-21 | 1995-01-10 | Monsanto Company | 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents |
US5700947A (en) * | 1993-10-06 | 1997-12-23 | Nicox S.A. | Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation |
US5475018A (en) | 1993-11-30 | 1995-12-12 | G. D. Searle & Co. | 1,5-diphenyl pyrazole compounds for treatment of inflammation |
EP0759899B1 (en) | 1994-05-10 | 1999-09-15 | Nicox S.A. | Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities |
US6090856A (en) * | 1997-04-11 | 2000-07-18 | Nippon Shinyaku Co., Ltd. | Remedies for frequent urination and urinary incontinence |
IT1292426B1 (it) * | 1997-06-27 | 1999-02-08 | Nicox Sa | Sali nitrati di ace-inibitori |
-
1998
- 1998-07-28 IT IT1998MI001744A patent/IT1303672B1/it active
-
1999
- 1999-07-20 JP JP2000562382A patent/JP2002521487A/ja active Pending
- 1999-07-20 EP EP99940026A patent/EP1100805B1/en not_active Expired - Lifetime
- 1999-07-20 DK DK99940026T patent/DK1100805T3/da active
- 1999-07-20 WO PCT/EP1999/005170 patent/WO2000006585A1/en not_active Application Discontinuation
- 1999-07-20 US US09/743,801 patent/US6573252B1/en not_active Expired - Fee Related
- 1999-07-20 ES ES99940026T patent/ES2189464T3/es not_active Expired - Lifetime
- 1999-07-20 AT AT99940026T patent/ATE229533T1/de not_active IP Right Cessation
- 1999-07-20 DE DE69904483T patent/DE69904483T2/de not_active Expired - Fee Related
- 1999-07-20 HU HU0102866A patent/HUP0102866A3/hu unknown
- 1999-07-20 IL IL14068499A patent/IL140684A0/xx not_active IP Right Cessation
- 1999-07-20 RU RU2001102263A patent/RU2238932C2/ru not_active IP Right Cessation
- 1999-07-20 CA CA002338912A patent/CA2338912A1/en not_active Abandoned
- 1999-07-20 KR KR1020017000763A patent/KR20010071962A/ko not_active Application Discontinuation
- 1999-07-20 PT PT99940026T patent/PT1100805E/pt unknown
- 1999-07-20 CN CNB998090212A patent/CN1151161C/zh not_active Expired - Fee Related
- 1999-07-20 BR BR9912376-2A patent/BR9912376A/pt not_active IP Right Cessation
- 1999-07-20 AU AU54120/99A patent/AU756440B2/en not_active Ceased
-
2001
- 2001-01-16 ZA ZA200100453A patent/ZA200100453B/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20010071962A (ko) | 2001-07-31 |
ZA200100453B (en) | 2002-01-16 |
CN1151161C (zh) | 2004-05-26 |
RU2238932C2 (ru) | 2004-10-27 |
ATE229533T1 (de) | 2002-12-15 |
ES2189464T3 (es) | 2003-07-01 |
HUP0102866A2 (hu) | 2001-12-28 |
WO2000006585A1 (en) | 2000-02-10 |
JP2002521487A (ja) | 2002-07-16 |
DE69904483T2 (de) | 2003-10-23 |
EP1100805B1 (en) | 2002-12-11 |
US6573252B1 (en) | 2003-06-03 |
IL140684A0 (en) | 2002-02-10 |
ITMI981744A0 (it) | 1998-07-28 |
HUP0102866A3 (en) | 2002-12-28 |
DE69904483D1 (de) | 2003-01-23 |
PT1100805E (pt) | 2003-03-31 |
ITMI981744A1 (it) | 2000-01-28 |
EP1100805A1 (en) | 2001-05-23 |
AU5412099A (en) | 2000-02-21 |
BR9912376A (pt) | 2001-04-17 |
DK1100805T3 (da) | 2003-03-31 |
AU756440B2 (en) | 2003-01-16 |
CA2338912A1 (en) | 2000-02-10 |
CN1310721A (zh) | 2001-08-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IT1303672B1 (it) | Sali nitrati di farmaci attivi nei disordini ossei | |
EA199800943A1 (ru) | Производные мочевины и их применение в качестве ингибиторов инозин-5`-монофосфат- дегидрогеназы | |
TW200510375A (en) | New compounds | |
UA40578C2 (uk) | Сульфоніламінопіримідини і фармацевтичний препарат на їх основі | |
ES2133785T3 (es) | Inhibidores de metaloproteinasas. | |
DK1235826T3 (da) | Quinuclidinacrylamider | |
NO961687L (no) | Nye (R)-5-karbamoyl-8-fluor-3-N,N-disubstituerte-amino-3,4-dihydro-2H-1-benzopyraner | |
BR9814375A (pt) | Inibição de raf cinase usando difenil uréias substituìdas simétricas e assimétricas | |
IT8123602A0 (it) | Sali stabili della s-adenosilmetionina, processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo. | |
ATE369355T1 (de) | Pyrimidinamid derivate und deren verwendung | |
ATE495187T1 (de) | Dalda-analoge und ihre verwendung | |
CA2277990A1 (en) | 2-amino-6-(2-substituted-4-phenoxy)-substituted-pyridines | |
NZ512526A (en) | 4-sulfonamido-6-sulfamidoalkoxypyrimidine derivatives, pharmaceuticals thereof, and their use for the treatment of disorders associated with a role of endothelin. | |
SE9802208D0 (sv) | Novel compounds | |
TR200201089T2 (tr) | Dipiridamol veya mopidamolün fibrine bağlı mikrodolaşım bozukluklarının tedavisi | |
DE69927977D1 (de) | Nitratsalz von Cetirizine | |
TW324662B (en) | Benzamide-containing pharmaceutical composition | |
IT8123603A0 (it) | Sali stabili della s-adenosilmetionina, processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo. | |
ZA971891B (en) | Use of aryl N-substituted carboxamides directly and as radio- and chemosensitizers for killing tumor and cancer cells and novel compounds for such use | |
MX9504023A (es) | Composicion farmaceutica y transdermicamente activa que contiene acido 5-aminolaevulinico y procedimiento para su preparacion. | |
SE9802209D0 (sv) | Novel compounds | |
BR9810433A (pt) | Composições anti-helmìnticas | |
ES8403487A1 (es) | "procedimiento para la preparacion de n-(2-metoxietil)-noroximorfona". | |
IT8023161A0 (it) | Composti ad attivita' mucolitica non assimilabili, processo per laloro preparazione e composizioni terapeutiche che li comprendono come principio attivo. | |
MY116362A (en) | Use of selegiline for the treatment of epileptic disorders |