IT1292426B1 - Sali nitrati di ace-inibitori - Google Patents

Sali nitrati di ace-inibitori

Info

Publication number
IT1292426B1
IT1292426B1 IT97MI001523A ITMI971523A IT1292426B1 IT 1292426 B1 IT1292426 B1 IT 1292426B1 IT 97MI001523 A IT97MI001523 A IT 97MI001523A IT MI971523 A ITMI971523 A IT MI971523A IT 1292426 B1 IT1292426 B1 IT 1292426B1
Authority
IT
Italy
Prior art keywords
nitrated
ace
inhibitors
salts
activity
Prior art date
Application number
IT97MI001523A
Other languages
English (en)
Inventor
Soldato Piero Del
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of ITMI971523A0 publication Critical patent/ITMI971523A0/it
Priority to IT97MI001523A priority Critical patent/IT1292426B1/it
Priority to DE69810498T priority patent/DE69810498T2/de
Priority to EP98938668A priority patent/EP1019370B1/en
Priority to CNB988062763A priority patent/CN1205186C/zh
Priority to KR10-1999-7011984A priority patent/KR100512892B1/ko
Priority to AT98938668T priority patent/ATE230393T1/de
Priority to ES98938668T priority patent/ES2190095T3/es
Priority to RU2000100825/04A priority patent/RU2194037C2/ru
Priority to US09/423,287 priority patent/US6218417B1/en
Priority to AU87300/98A priority patent/AU740411B2/en
Priority to IL13269198A priority patent/IL132691A/en
Priority to JP50529499A priority patent/JP2002506456A/ja
Priority to BRPI9810459-4A priority patent/BR9810459A/pt
Priority to DK98938668T priority patent/DK1019370T3/da
Priority to SI9830175T priority patent/SI1019370T1/xx
Priority to PCT/EP1998/003946 priority patent/WO1999000361A1/en
Priority to HU0003133A priority patent/HUP0003133A3/hu
Priority to CA002292794A priority patent/CA2292794A1/en
Publication of ITMI971523A1 publication Critical patent/ITMI971523A1/it
Application granted granted Critical
Publication of IT1292426B1 publication Critical patent/IT1292426B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0217—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -C(=O)-C-N-C(=O)-N-C-C(=O)-
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
IT97MI001523A 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori IT1292426B1 (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT97MI001523A IT1292426B1 (it) 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori
US09/423,287 US6218417B1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
IL13269198A IL132691A (en) 1997-06-27 1998-06-24 Ace-inhibitor nitrate salts and pharmaceutical compositions containing them
CNB988062763A CN1205186C (zh) 1997-06-27 1998-06-24 Ace－抑制剂硝酸盐
KR10-1999-7011984A KR100512892B1 (ko) 1997-06-27 1998-06-24 에이스저해제 질산염
AT98938668T ATE230393T1 (de) 1997-06-27 1998-06-24 Ace-inhibitoren stickstoffsalze
ES98938668T ES2190095T3 (es) 1997-06-27 1998-06-24 Sales nitricas de inhibidores del enzima de conversion.
RU2000100825/04A RU2194037C2 (ru) 1997-06-27 1998-06-24 Нитрат асе-ингибитора
DE69810498T DE69810498T2 (de) 1997-06-27 1998-06-24 Ace-inhibitoren stickstoffsalze
AU87300/98A AU740411B2 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
EP98938668A EP1019370B1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
JP50529499A JP2002506456A (ja) 1997-06-27 1998-06-24 Ａｃｅ（アンギオテンシン変換酵素）阻害剤硝酸塩
BRPI9810459-4A BR9810459A (pt) 1997-06-27 1998-06-24 sais nìtricos dos inibidores de ace
DK98938668T DK1019370T3 (da) 1997-06-27 1998-06-24 Nitratsalte af ACE-inhibitorer
SI9830175T SI1019370T1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
PCT/EP1998/003946 WO1999000361A1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
HU0003133A HUP0003133A3 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts and use of them for producing pharmaceutical compositions
CA002292794A CA2292794A1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI001523A IT1292426B1 (it) 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori

Publications (3)

Publication Number Publication Date
ITMI971523A0 ITMI971523A0 (it) 1997-06-27
ITMI971523A1 ITMI971523A1 (it) 1998-12-27
IT1292426B1 true IT1292426B1 (it) 1999-02-08

Family

ID=11377450

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI001523A IT1292426B1 (it) 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori

Country Status (17)

Country Link
US (1) US6218417B1 (it)
EP (1) EP1019370B1 (it)
JP (1) JP2002506456A (it)
KR (1) KR100512892B1 (it)
CN (1) CN1205186C (it)
AT (1) ATE230393T1 (it)
AU (1) AU740411B2 (it)
BR (1) BR9810459A (it)
CA (1) CA2292794A1 (it)
DE (1) DE69810498T2 (it)
DK (1) DK1019370T3 (it)
ES (1) ES2190095T3 (it)
HU (1) HUP0003133A3 (it)
IL (1) IL132691A (it)
IT (1) IT1292426B1 (it)
RU (1) RU2194037C2 (it)
WO (1) WO1999000361A1 (it)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1301759B1 (it) * 1998-06-19 2000-07-07 Nicox Sa Sali nitrati di farmaci antiipertensivi
IT1303672B1 (it) * 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
CA2383974A1 (en) 1999-09-08 2001-03-15 Nitromed Inc. Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
US7708989B2 (en) * 1999-10-29 2010-05-04 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7537785B2 (en) 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
US7235237B2 (en) 1999-10-29 2007-06-26 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
JP2003514020A (ja) 1999-10-29 2003-04-15 ニトロメド インコーポレーテッド 酸化窒素不足により特徴付けられる血管疾患の治療法
DE60233140D1 (de) 2001-05-02 2009-09-10 Nitromed Inc Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US7011854B2 (en) 2002-02-04 2006-03-14 Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof
US20060247216A1 (en) * 2002-10-25 2006-11-02 Haj-Yehia Abdullah I Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
US7169805B2 (en) * 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
AU2005274763A1 (en) * 2004-07-16 2006-02-23 Nitromed, Inc. Compositions and methods related to heart failure
CA2577084A1 (en) 2004-08-25 2006-03-02 Olivier Bezencon Bicyclononene derivatives as renin inhibitors
DE602005009918D1 (de) * 2005-01-06 2008-11-06 Ipca Lab Ltd Verfahren zur Synthese von (2S,3aS,7aS)-1-(S)-Alanyl-octahydro-1H-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril
AU2006244446A1 (en) * 2005-05-05 2006-11-16 Keryx Biopharmaceuticals, Inc. Combination therapy with sulodexide and a blood pressure reducing agent in the treatment of diabetic nephropathy
US7799805B2 (en) * 2005-05-27 2010-09-21 Actelion Pharmaceuticals Ltd. Piperidine carboxylic acid amide derivatives
EP1934186A2 (en) * 2005-10-18 2008-06-25 NicOx S.A. Renin inhibitors nitroderivatives
WO2007073226A1 (en) * 2005-12-20 2007-06-28 Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda Method for treating a mammal by administration of a compound having the ability to release co
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
WO2007088514A1 (en) 2006-02-02 2007-08-09 Actelion Pharmaceuticals Ltd Secondary amines as renin inhibitors
CA2634473A1 (en) * 2006-02-17 2007-08-30 Nitromed, Inc. Methods using hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
JP2009529033A (ja) * 2006-03-08 2009-08-13 アクテリオン ファーマシューティカルズ リミテッド 新規アミン
EP2024337A4 (en) * 2006-05-16 2011-09-14 Nitromed Inc SOLID DOSAGE FORMULATIONS OF HYDRALAZIN COMPOUNDS
NZ589019A (en) 2008-05-05 2012-10-26 Merck Frosst Canada Ltd 3, 4 - substituted piperidine derivatives as renin inhibitors
ES2656237T3 (es) 2011-04-19 2018-02-26 Alfama, Inc. Moléculas liberadoras de monóxido de carbono y usos de las mismas
JP6134710B2 (ja) 2011-07-21 2017-05-24 アルファーマ インコーポレイテッドＡｌｆａｍａ，Ｉｎｃ． 一酸化ルテニウム放出分子およびその使用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE463851B (sv) 1988-09-02 1991-02-04 Amsu Ltd Komposition foer behandling av erektil dysfunktion via uretra
US5352708A (en) 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5328933A (en) 1992-10-28 1994-07-12 Allergan, Inc. Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl aliphatic derivatives and homologues
RU2145595C1 (ru) 1994-05-10 2000-02-20 Никокс С.А. Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности
US5625083A (en) 1995-06-02 1997-04-29 Bezuglov; Vladimir V. Dinitroglycerol esters of unsaturated fatty acids and prostaglandins
US5645839A (en) * 1995-06-07 1997-07-08 Trustees Of Boston University Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis
CN1141771A (zh) * 1995-08-02 1997-02-05 贾力 巯-亚硝基化合物及其医学用途

Also Published As

Publication number Publication date
JP2002506456A (ja) 2002-02-26
WO1999000361A1 (en) 1999-01-07
EP1019370B1 (en) 2003-01-02
IL132691A (en) 2004-06-01
HUP0003133A2 (en) 2001-03-28
KR100512892B1 (ko) 2005-09-07
AU8730098A (en) 1999-01-19
ITMI971523A1 (it) 1998-12-27
DE69810498D1 (de) 2003-02-06
BR9810459A (pt) 2006-10-03
DE69810498T2 (de) 2003-10-30
US6218417B1 (en) 2001-04-17
AU740411B2 (en) 2001-11-01
RU2194037C2 (ru) 2002-12-10
DK1019370T3 (da) 2003-05-05
IL132691A0 (en) 2001-03-19
ATE230393T1 (de) 2003-01-15
CN1205186C (zh) 2005-06-08
ITMI971523A0 (it) 1997-06-27
KR20010013958A (ko) 2001-02-26
ES2190095T3 (es) 2003-07-16
CA2292794A1 (en) 1999-01-07
CN1260780A (zh) 2000-07-19
EP1019370A1 (en) 2000-07-19
HUP0003133A3 (en) 2002-10-28

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Legal Events

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